New hope for rare cancer: trabectedin vs gemcitabine in leiomyosarcoma trial
NCT ID NCT04383119
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial compares the chemotherapy drugs trabectedin and gemcitabine in 100 people with advanced leiomyosarcoma that has worsened after initial treatment. The study aims to see which drug better delays cancer progression. It also includes an observational group for those who cannot or choose not to be randomized.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Trabectedin and gemcitabine (chemotherapy drugs)
What this could lead to
If trabectedin works better than gemcitabine, it could become a new standard second-line treatment for advanced leiomyosarcoma.
What could go wrong
This is a phase II trial with only 100 participants, so results may not be definitive. Both drugs have side effects, and the study may not show a clear benefit.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for LEIOMYOSARCOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
A.O.U.San Luigi Gonzaga
RECRUITINGOrbassano, Torino, 10043, Italy
Contact Email: •••••@•••••
-
ASL Città di Torino (Dipartimento di Oncologia)
RECRUITINGTorino, 10153, Italy
Contact Email: •••••@•••••
Contact
Contact
-
Azienda Ospedaliera S. Orsola-Malpighi
RECRUITINGBologna, BO, 40138, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Centro di Riferimento Oncologico di Aviano
NOT_YET_RECRUITINGAviano, PD, 33081, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Fondazione IRCCS INT Milano
NOT_YET_RECRUITINGMilan, 20133, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
H.San Martino di Genova
RECRUITINGGenova, Italy
Contact Email: •••••@•••••
-
IRCCS Fondazione Piemonte per l'Oncologia
RECRUITINGCandiolo, Torino, 10060, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
IRCCS Istituto nazionale Tumori "Fondazione G.Pascale"
RECRUITINGNaples, Italy
Contact Email: •••••@•••••
-
Irccs Istituto Oncologico Veneto (Iov)
RECRUITINGPadova, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Istituto Clinico Humanitas
RECRUITINGRozzano, MI, 20089, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Istituto Europeo di Oncologia
RECRUITINGMilan, Italy
Contact Email: •••••@•••••
-
Istituto Ortopedico Rizzoli - Unit of Chemotherapy of Muscoloskeletal Tumors
RECRUITINGBologna, 40136, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Istituto Regina Elena - IFO
RECRUITINGRome, 00100, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori - IRST
RECRUITINGMeldola, FC, Italy
Contact Email: •••••@•••••
Contact
-
Nuovo Ospedale di Prato
RECRUITINGPrato, Firenze, 59100, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Ospedale Giaccone
RECRUITINGPalermo, Italy
Contact Email: •••••@•••••
Contact
-
Policlinico Universitario Campus Biomedico
RECRUITINGRoma, RM, 00128, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact