Italian Sarcoma Group

This study tests a combination of two chemotherapy drugs, lurbinectedin and irinotecan, in 20 people with advanced desmoplastic small round cell tumor (DSRCT) that cannot be removed by surgery. The goal is to shrink or control the tumor and track side effects. An optional part of…

This study tests two chemotherapy drugs, trabectedin and gemcitabine, in people with advanced leiomyosarcoma (a rare soft tissue cancer) that has spread or cannot be removed by surgery. All participants have already received at least one prior chemotherapy treatment. The goal is …

This study compares two standard treatments—surgery and radiation therapy—for people with a rare spinal tumor called sacral chordoma that hasn't spread. About 100 adults will be assigned to one of the two treatments to see which better prevents the tumor from coming back or sprea…

This study tests the drug trabectedin in 16 people aged 16 and older with advanced mesenchymal chondrosarcoma, a rare bone cancer that has spread or cannot be removed. Participants must have already tried at least one chemotherapy. The main goal is to see if the drug can shrink t…

This study looks back at the medical records of 300 people diagnosed with breast sarcoma between 2000 and 2020. The goal is to understand what symptoms people had, what treatments they received, and how well those treatments worked. By analyzing this information, researchers hope…

This study is observing 120 people up to age 40 with localized osteosarcoma (a bone cancer that hasn't spread). Researchers will collect information on patient characteristics, treatments, and outcomes like cancer recurrence and survival. The goal is to better understand current …

This study is observing 100 people with endometrial stromal tumors, a rare type of uterine cancer. Researchers will collect information on how the disease progresses, how it is diagnosed, and what treatments patients receive. The goal is to better understand these tumors, not to …

This study is not testing a new drug or treatment. Instead, it collects information from 100 people diagnosed with Ewing sarcoma of the bone to learn about their disease, treatments, and outcomes. The goal is to better understand what happens over time, including how long patient…

This study is for 100 people with epithelioid sarcoma, a rare type of cancer. Researchers will watch how patients are treated (with chemotherapy, radiation, or other methods) and look for markers in tumor tissue that might predict how well treatments work. No new treatments are g…

This study follows 250 people with localized angiosarcoma (a rare cancer of blood vessels) to collect information about the tumor and patient characteristics. No new treatment is given; participants receive standard care. The goal is to better understand the disease and improve f…