Italian Sarcoma Group

This study tests a combination of two chemotherapy drugs, lurbinectedin and irinotecan, in 20 patients aged 15 and older with advanced desmoplastic small round cell tumor (DSRCT) that cannot be surgically removed. The goal is to shrink or control the tumor and track side effects.…

This study tests the drug trabectedin in 16 people aged 16 and older with advanced mesenchymal chondrosarcoma, a rare bone cancer that has spread or cannot be removed by surgery. Participants must have already tried at least one chemotherapy. The goal is to see if trabectedin can…

This phase II trial compares the chemotherapy drugs trabectedin and gemcitabine in 100 people with advanced leiomyosarcoma that has worsened after initial treatment. The study aims to see which drug better delays cancer progression. It also includes an observational group for tho…

This study compares two standard treatments for a rare spinal tumor called sacral chordoma: surgery and radiation therapy. Researchers want to see which approach better prevents the tumor from coming back. About 100 adults with newly diagnosed, localized chordoma will take part.

This study follows 120 patients with localized osteosarcoma (a bone cancer) to collect information on their treatments and outcomes. It does not test a new drug but observes standard care to learn which approaches lead to better survival and fewer side effects. The goal is to imp…

This study is for people under 50 with a type of bone cancer called Ewing sarcoma. Researchers will collect information about patients' health, treatments, and results over time. The goal is to learn more about the disease and how it is treated, not to test a new drug or therapy.

This study reviews medical records of 300 people diagnosed with breast sarcoma between 2000 and 2020. Researchers will analyze symptoms, treatments, and outcomes to identify patterns that could guide future care. Because it is a retrospective study, it does not test a new treatme…

This study follows 100 people with a rare type of uterine tumor called endometrial stromal tumor. Researchers collect information on how the disease progresses and how it is diagnosed. No new treatments are tested; the goal is simply to learn more about the condition.

This study follows 250 people with localized angiosarcoma, a rare cancer of blood vessels. Researchers will collect information on tumor features, patient history, and standard treatments used in everyday practice. The goal is to better understand the disease and guide future car…

This study is observing 100 people with epithelioid sarcoma, a rare cancer. Researchers will track what treatments patients receive and how they respond. The goal is to better understand the disease and current care, not to test a new drug.