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Researchers track osteosarcoma treatments to find what works best

NCT ID NCT04890067

Knowledge-focused Sponsor: Italian Sarcoma Group Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 03, 2026 · Updated 3 times

Summary

This study follows 120 patients with localized osteosarcoma (a bone cancer) to collect information on their treatments and outcomes. It does not test a new drug but observes standard care to learn which approaches lead to better survival and fewer side effects. The goal is to improve future treatment guidelines.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could provide valuable insights to refine treatment strategies for localized osteosarcoma, potentially improving survival rates.
What could go wrong
This is an observational study, not a test of a new treatment. It collects data only, so it cannot directly prove what works best. Results may take years and might not lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2021

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with localized high grade ostesarcoma of the extremities

Ages

Up to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of high grade OS of the extremities * Age at diagnosis ≤ 40 years at the time of diagnosis * Localized disease (skip metastases are allowed) * Adequate organ function according the AIEOP/ISG OS 2021 recommendation * Patients or parents oe guardians of minors who have given their written informed consent to participate in the study Exclusion Criteria: * Presence of metastases * Diagnosis of periosteal OS, of parosteal OS or secondary OS * Any medical condition which can not allowed the use of the treatments recommended by AIEOP/ISG OS 2021

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Conditions

The condition(s) this trial relates to.

localized osteosarcoma osteosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Localized osteosarcoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    16 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • A.O. Universitaria Meyer

    RECRUITING

    Florence, 50139, Italy

  • A.O. Universitaria Policlinico S. Orsola Malpighi di Bologna

    RECRUITING

    Bologna, 40138, Italy

  • ARNAS P. O. "Civico e Benfratelli"

    RECRUITING

    Palermo, 90127, Italy

  • AUO Policnico G. Rodolico San Marco

    RECRUITING

    Catania, 95123, Italy

  • Azienda Ospedaliera di Padova UOC Oncoematologia Pediatrica

    RECRUITING

    Padova, Italy

  • Azienda Ospedaliero Universitaria Consorziale Policlinico - Bari

    RECRUITING

    Bari, 70124, Italy

  • Azienda Ospedaliero-Universitaria Pisana

    RECRUITING

    Pisa, 56126, Italy

  • Centro di Riferimento Oncologico - Unit of Medical Oncology

    RECRUITING

    Aviano, Pordenone, 33081, Italy

  • FONDAZIONE IRCCS Istituto Nazionale dei Tumori

    RECRUITING

    Milan, Italy

  • Fondazione IRCCS INT Milano SC Pediatria Oncologica

    RECRUITING

    Milan, Italy

  • IRCCS Istituto ortopedico Rizzoli

    RECRUITING

    Bologna, 40136, Italy

  • IRCCS materno infantile Burlo Garofolo

    RECRUITING

    Trieste, T, 34137, Italy

  • Istituti Fisioterapici Ospitalieri di Roma

    RECRUITING

    Roma, Italy

  • Istituto Giannina Gaslini

    RECRUITING

    Genova, Italy

  • Ospedale Pediatrico Bambin Gesu'

    NOT_YET_RECRUITING

    Roma, Italy

  • Sandra Aliberti

    RECRUITING

    Candiolo, Torino, 10060, Italy

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