Can a targeted pill stall advanced sarcomas?

NCT ID NCT04040205

Recruiting now Disease control Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This phase II trial is testing whether abemaciclib, a targeted cancer drug, can slow the growth of advanced bone and soft tissue sarcomas that have a specific alteration in the CDK pathway. Participants take the pill twice daily until their disease worsens or side effects become unacceptable. The study focuses on people whose tumors have not responded to other treatments and cannot be removed surgically.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a CDK inhibitor drug called abemaciclib (Verzenio)
What this could lead to: If it works, this could offer a new treatment option for people with advanced sarcomas that have a specific genetic change.
What could go wrong: This is an early-phase, single-arm trial with a small number of participants. It is not yet known if abemaciclib will meaningfully slow tumor growth, and side effects may occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chondrosarcoma chordoma dedifferentiated chondrosarcoma osteosarcoma retinoblastoma sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHONDROSARCOMA OSTEOSARCOMA SOFT TISSUE SARCOMA

Contacts and locations

Locations

Froedtert Hospital & the Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63130, United States

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