OSTEOSARCOMA

This study tests a stem cell transplant that removes certain immune cells (alpha/beta T cells and CD19+ B cells) and adds a drug called zoledronic acid. The goal is to help the donor cells attack the tumor without causing severe side effects. It is for children and young adults a…

This program provides access to an experimental drug called L-MTP-PE for people with osteosarcoma, a type of bone cancer. The drug works by activating white blood cells to help the immune system kill cancer cells. It is available to patients of any age who have had surgery to rem…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control tumors for at least 12 months. About 28 adults who have not responded to standard treatments will take part.

This early-phase study tests a new treatment called PeptiCRAd-1, a virus-based cancer vaccine, combined with the immunotherapy drug pembrolizumab. The goal is to see if this combination is safe and can boost the immune system to fight several types of solid tumors, including mela…

This early-phase study tests whether giving specially engineered immune cells (HER2-CAR T cells) together with an immune checkpoint inhibitor (pembrolizumab or nivolumab) is safe and can help people with advanced sarcoma. About 25 participants will receive chemotherapy to prepare…

This study tests whether the drug regorafenib, taken for up to 12 months, can help control high-grade bone sarcomas (like osteosarcoma) that didn't fully respond to standard treatment. About 36 participants aged 12 and older will receive regorafenib plus supportive care. The goal…

This early-stage study is testing a new treatment called DIT309 for people with advanced bone or soft tissue sarcomas that have not responded to standard therapies. DIT309 uses specially engineered immune cells (CAR-T cells) to attack the cancer. The main goals are to check the t…

This study tests an experimental oral drug called AMXT 1501 combined with another drug, eflornithine (DFMO), in children and young adults up to age 21 with certain cancers like neuroblastoma, brain tumors, and sarcomas. The first part finds the safest dose, and the second part ch…

This early-stage trial tests a treatment where a child's own immune cells are collected, modified to better attack cancer, and given back as a one-time infusion. It is for children and young adults up to age 21 with solid tumors that have come back or not responded to standard th…

This study tests two drugs, pembrolizumab and cabozantinib, in people with advanced sarcomas that have not responded to standard treatments. The goal is to see if the combination can stop or shrink tumors for at least 6 months. About 119 adults with specific sarcoma types will ta…

This pilot study looks at people with a new diagnosis of high-grade osteosarcoma in an arm or leg. The goal is to see if removing the tumor with surgery before starting chemotherapy leads to better movement and quality of life. Ten participants will fill out questionnaires about …

This study tests a combination of two drugs, apatinib and liposomal irinotecan, in people with advanced osteosarcoma (bone cancer) that has spread or returned after standard treatments. About 56 participants will receive the drugs to find the best dose and see if the combination …

This study tests whether adding four drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy helps people with osteosarcoma that has spread live longer. About 45 participants with newly diagnosed or advanced disease will be enrolled. Researchers will als…

This early-phase study is testing a new treatment called B7-H3 CAR T cells in children and young adults whose solid tumors (like neuroblastoma, sarcoma, or osteosarcoma) have come back or not responded to standard therapies. The treatment involves taking a patient's own immune ce…

This study offers expanded access to an experimental treatment called DNG64-CAR-V for people with advanced pancreatic cancer, sarcoma, or breast cancer. Up to 40 patients will receive the therapy intravenously or directly into tumors, alone or with other approved cancer drugs. Th…

This early-phase study tests a combination of losartan (a blood pressure medicine) and sunitinib (a targeted cancer drug) in people aged 10 and older with osteosarcoma that has returned or stopped responding to standard treatments. The main goals are to find the safest dose and t…

This early-phase study tests whether combining an immunotherapy drug (atezolizumab) with precise radiation and surgery is safe for people whose osteosarcoma has come back in the lungs. About 12 participants will receive the treatment to find the best dose and check for side effec…

This early-phase study tests a new treatment for children whose neuroblastoma or osteosarcoma has come back or not responded to standard therapy. The treatment uses the patient's own T cells (a type of immune cell) that have been genetically modified to recognize and attack GD2, …

This early-phase trial tests whether combining the drug cabozantinib with high-dose ifosfamide is safe and effective for children and adults with sarcomas that have returned or not responded to standard treatment. About 30 participants with bone or soft tissue sarcomas will recei…

This study compares two surgical methods—open surgery (one large cut) and keyhole surgery (several small cuts with a camera)—to remove osteosarcoma tumors that have spread to the lungs. About 62 patients under 50 with up to 4 lung nodules will be randomly assigned to one of the t…

This study tests a new drug called PEEL-224 combined with two standard chemotherapy drugs (vincristine and temozolomide) in adolescents and young adults whose sarcomas have come back or not responded to treatment. The goal is to find the safest dose and see if the combination shr…

This study tests a new treatment called afamitresgene autoleucel in children and young adults aged 2 to 21 with advanced cancers like synovial sarcoma, neuroblastoma, and osteosarcoma. The treatment uses the patient's own immune cells, modified to target a protein called MAGE-A4 …

This early-stage study is testing a new drug, AOH1996, in adults with solid tumors (like lung, ovarian, or pancreatic cancer) that have stopped responding to standard treatments. The main goals are to find a safe dose and understand side effects. The drug works by blocking certai…

This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors (like neuroblastoma, Ewing sarcoma, or osteosarcoma) have come back or not responded to treatment. The goal is to find a safe …

This early-stage study tests a new type of stem cell transplant for children whose blood cancers or solid tumors have come back or are hard to treat. Doctors use a special method to remove certain immune cells from the donor's stem cells and give a drug called zoledronate after t…

This study tests whether taking regorafenib for up to 12 months after initial treatment can delay or prevent bone sarcoma from coming back. About 168 patients with various bone sarcomas will be randomly assigned to receive the drug or just be monitored. The goal is to see if the …

This study looks at three types of scans—MRI, PET/MR, and PET/CT—to see which one works best for finding tumors in children and young adults with cancer. About 100 participants with solid tumors will be enrolled. The goal is to improve how doctors diagnose and monitor these cance…

This study looks at whether using 3D printed models of a patient's bones helps surgeons plan and perform tumor removal surgery. About 150 people with bone tumors will be randomly assigned to have their surgeon use either 3D models plus regular scans, or just scans alone. The main…

This study follows 150 people with high-grade osteosarcoma whose cancer returned near the original site. Researchers will look at medical records to find factors that affect survival after this relapse. The goal is to learn more, not to test a new treatment.

This study tests whether a smartwatch can track changes in walking and daily activities in 60 people with bone cancer (osteosarcoma or metastatic bone disease) in the legs or pelvis. Participants wear the watch at least 12 hours a day and complete weekly questionnaires for 12 wee…

This study looks at how well people with bone cancer follow a personalized exercise program at home after having surgery to remove a tumor from their leg. About 50 patients aged 12 and older will track their daily exercises for six months. The goal is to understand what helps or …

This study follows 300 people who had surgery to remove bone tumors and then had reconstruction using bone grafts or artificial parts. Researchers will measure how well the bone heals and how much function patients regain over 3 years. The goal is to better understand recovery af…

This study is testing whether growing a patient's tumor cells in the lab (called organoids) can help doctors predict which chemotherapy drugs will work best for that person. About 40 people with suspected or confirmed osteosarcoma will provide tumor samples during routine biopsie…

This study is testing whether a new radioactive imaging agent can safely and clearly show tumors in people with many types of solid cancers. About 32 adults will receive a single injection of the agent and then have PET/CT scans to see where it goes in the body. The goal is to le…