OSTEOSARCOMA

This study is testing if taking a drug called regorafenib for up to a year can help prevent bone cancers (sarcomas) from returning after patients finish their initial chemotherapy and surgery. It will compare patients who take the drug to those who receive standard monitoring wit…

This early-stage study is testing the safety of a three-part treatment for osteosarcoma (a type of bone cancer) that has come back only in the lungs. The treatment combines a drug that helps the immune system fight cancer (atezolizumab), targeted radiation (SBRT), and surgery to …

This study is testing whether adding four targeted drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy works better than standard chemo alone for people with metastatic osteosarcoma, a serious bone cancer. It will enroll about 45 participants, includ…

This study aims to find out which of two surgical methods is better for removing lung tumors that have spread from bone cancer (osteosarcoma) in patients under 50. It directly compares traditional open-chest surgery with a less invasive 'keyhole' camera-guided surgery. The main g…

This is the first human study of an experimental oral drug called AOH1996 for patients with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose and understand how the body processes the drug. Researchers will enrol…

This study is testing a combination of two drugs, apatinib and liposomal irinotecan, for people with advanced osteosarcoma (a type of bone cancer) that has come back or spread after standard chemotherapy. The main goals are to find the safest and most effective dose of the two dr…

This study is testing a new, unapproved pill called silmitasertib, given alongside standard chemotherapy drugs. It aims to find a safe and effective dose for children and young adults under 30 whose solid tumors (like neuroblastoma or sarcoma) have come back or stopped responding…

This study aims to understand how well patients recover function and how their bones heal after surgery to remove bone tumors. Researchers will follow 300 patients for three years after their reconstructive surgery, which may use bone grafts or artificial devices. The goal is to …

This early-stage study is testing whether combining two existing drugs—losartan and sunitinib—is safe and might help control osteosarcoma that has returned or stopped responding to other treatments. The main goal is to find the highest dose patients can tolerate without severe si…

This early-stage study is testing a new type of personalized cell therapy for children and young adults whose neuroblastoma or osteosarcoma has come back or hasn't responded to standard treatments. Doctors take a patient's own immune cells (T cells), modify them in a lab to bette…

This study is testing a new oral drug, AMXT 1501, combined with an existing drug called DFMO, for children and young adults with aggressive cancers that have come back or didn't respond to standard treatments. The first part aims to find a safe dose, and the second part will comp…

This study is testing if surgically removing bone tumors before starting chemotherapy leads to better limb function and quality of life for patients. It will follow 10 people with newly diagnosed osteosarcoma in their arms or legs. Researchers will use questionnaires to track how…

This program provides access to an unapproved drug called L-MTP-PE for people with osteosarcoma (a type of bone cancer). The drug aims to help the body's own immune system fight and control the cancer after surgery. It is for patients whose doctors believe it could be beneficial …

This study is testing the safety of a new type of stem cell transplant for children whose cancers have come back or are very hard to treat. Doctors use a half-matched family donor and a special process to remove certain immune cells from the transplant, aiming to reduce complicat…

This is a first-in-human study testing a new type of personalized cell therapy for children and young adults (up to age 21) whose solid tumors have come back or haven't responded to standard treatments. Doctors will collect a patient's own immune cells (T cells), genetically modi…

This program provides access to an experimental treatment called DNG64-CAR-V for patients with advanced pancreatic cancer, sarcoma, or breast cancer who have no other effective options left. The treatment uses a specially engineered virus designed to target and kill cancer cells …

This study is testing if a drug called regorafenib can help control aggressive bone cancers like osteosarcoma when standard treatments haven't fully eliminated the disease. It will involve 36 patients aged 12 and older who still have detectable cancer after their initial therapy.…

This early-stage study is testing the safety of a two-part treatment for advanced sarcomas that have stopped responding to standard therapies. Doctors take a patient's own immune cells, genetically modify them to recognize and attack cancer cells, and then infuse them back. These…

This study is testing a new personalized cell therapy called afamitresgene autoleucel in children and young adults with advanced cancers like sarcoma and neuroblastoma. The main goals are to see if the treatment is safe and if it can shrink tumors. Researchers will enroll up to 2…

This study is testing a new type of stem cell transplant for children and young adults whose solid tumors have returned or not responded to standard treatments. Doctors are using a donor's stem cells that have been specially processed to remove certain immune cells, then combinin…

This study is testing a new drug called PEEL-224 combined with two existing cancer drugs to see if it can help control aggressive sarcomas that have returned or stopped responding to standard treatments. It will involve about 63 adolescents and young adults (ages 12-49) with spec…

This early-stage study is testing the safety and initial effectiveness of combining two drugs, cabozantinib and high-dose ifosfamide, for children and adults whose bone or soft tissue sarcomas have returned or not responded to standard chemotherapy. The main goal is to find the s…

This trial is testing whether combining two existing cancer drugs—pembrolizumab and cabozantinib—can help control advanced sarcomas that have stopped responding to standard treatments. It will enroll about 119 adults with specific types of advanced sarcoma. The main goal is to se…

This study aims to find the best imaging method for detecting tumors in children and young adults. Researchers will compare three types of scans—whole-body MRI, combined PET/MR, and PET/CT—to see which is most accurate at finding tumors. The goal is to improve diagnosis for young…

This study is testing whether 3D printed models of a patient's bones help surgeons plan tumor removal surgeries better than standard medical images alone. About 150 people with bone-invading tumors like sarcoma will be randomly assigned to have their surgery planned with a 3D mod…

This study aims to see if growing tiny 3D models of a patient's bone cancer (called organoids) in a lab can help doctors predict which chemotherapy drugs will work best for them. Researchers will take tissue from biopsies or surgeries of 40 osteosarcoma patients and test differen…

This early study aims to see how two new radioactive tracers travel through the body and gather in tumors. Researchers will give a single, tiny dose of one tracer to up to 32 patients with various solid tumors and then use PET/CT scans to track where it goes. The main goal is to …

This study looks back at cases since 1980 and follows new patients to understand why high-grade bone cancer sometimes returns locally after treatment. Researchers will track 150 patients who experienced cancer recurrence to identify what factors influence survival after the cance…

This study aims to understand how well patients follow a personalized home exercise program after major leg surgery for bone cancer. Researchers will track 50 patients for six months to see how consistently they do their exercises and what factors might influence their commitment…

This study is testing whether a smartwatch can detect changes in walking stability and daily activities in people being treated for bone cancer. The goal is to see if this data can help doctors monitor treatment response and predict potential complications. Researchers will also …