New hope for bone sarcoma: regorafenib maintenance trial launches

NCT ID NCT04698785

Recruiting now Disease control Sponsor: Centre Leon Berard Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether the drug regorafenib can help keep high-grade bone sarcomas from growing in patients who still have some disease after standard treatment. About 36 people aged 12 and older will take regorafenib daily for up to 12 months. The main goal is to see how many patients have stable disease or better after 4 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: regorafenib
What this could lead to: If successful, this could point toward a new maintenance option to delay disease progression in high-grade bone sarcoma patients.
What could go wrong: This is a small, early-phase trial with only 36 participants, so results may not apply broadly. Regorafenib can cause side effects like fatigue, diarrhea, and liver issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

angiosarcoma bone cancer bone sarcoma chondrosarcoma Ewing sarcoma leiomyosarcoma osteosarcoma undifferentiated pleomorphic sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BONE SARCOMA OSTEOSARCOMA

Contacts and locations

Locations

CHRU Hôpital Hautepierre
RECRUITING

Strasbourg, 67098, France
Centre Georges Francois Leclerc
NOT_YET_RECRUITING

Dijon, 21079, France
Centre Leon Berard
RECRUITING

Lyon, 69373, France
Centre Oscar Lambret
NOT_YET_RECRUITING

Lille, 59020, France
Chu Besancon
NOT_YET_RECRUITING

Besançon, 25030, France
Chu Saint-Etienne
NOT_YET_RECRUITING

Saint-Priest-en-Jarez, 42270, France
Hopital de La Timone
RECRUITING

Marseille, 13385, France
Hotel Dieu Nantes
NOT_YET_RECRUITING

Nantes, 44093, France
Hôpital COCHIN
RECRUITING

Paris, 75014, France
ICANS
NOT_YET_RECRUITING

Strasbourg, 67200, France
Icm Val D'Aurelle
NOT_YET_RECRUITING

Montpellier, 34298, France
Ico Rene Gauducheau
RECRUITING

Saint-Herblain, 44805, France
Institut Bergonie
RECRUITING

Bordeaux, 33076, France
Institut Curie
RECRUITING

Paris, 75005, France
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94805, France
Iuct Oncopole
RECRUITING

Toulouse, 31059, France

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