Centre Leon Berard

This study tests whether adding the immunotherapy drug atezolizumab to the standard drug imatinib can better control advanced gastrointestinal stromal tumors (GIST) that have stopped responding to other treatments. About 110 adults with inoperable or spreading GIST will be random…

This study tests whether the drug regorafenib, taken for up to 12 months, can help control high-grade bone sarcomas (like osteosarcoma) that didn't fully respond to standard treatment. About 36 participants aged 12 and older will receive regorafenib plus supportive care. The goal…

This study tests a software tool called myDIET that helps manage nutrition for people with stomach or esophageal junction cancer who are scheduled for surgery. The goal is to see if using the app improves how quickly patients can start additional treatment after surgery. About 60…

This study tests cancer treatments that target specific genetic changes in tumors. It is for people with advanced solid tumors that have not responded to standard therapies. Participants receive a treatment chosen based on their tumor's molecular profile. The goal is to see if th…

This study tests whether adding radiation therapy after surgery helps prevent high-risk skin cancer from returning, compared to just monitoring. About 266 adults with completely removed, high-risk squamous cell carcinoma will be randomly assigned to receive radiation or regular c…

This study looks at whether it is safe to stop taking aromatase inhibitors (a type of hormone therapy) in people with a rare, slow-growing uterine cancer called low-grade endometrial stromal sarcoma that has spread. About 40 adults who have been on this treatment for at least 2-3…

This study tests two ideas for people with certain head and neck cancers: using a smaller radiation area to reduce side effects, and adding a drug called ATRA (a form of vitamin A) to help control the disease. About 460 adults will be randomly assigned to standard or smaller radi…

This phase 3 study compares a new two-drug immunotherapy (botensilimab + balstilimab) against the current standard treatment (chemotherapy plus nivolumab) in people with advanced or metastatic stomach or esophageal cancer that has a specific genetic feature (MSI-H/dMMR). The goal…

This study tests a combination of two drugs, tarlatamab and temozolomide, in teens and adults with high-grade brain tumors that have a specific marker called DLL3. The goal is to see if the combination is safe and can shrink or control the tumors. About 70 people will take part, …

This study tests whether taking regorafenib for up to 12 months after initial treatment can delay or prevent bone sarcoma from coming back. About 168 patients with various bone sarcomas will be randomly assigned to receive the drug or just be monitored. The goal is to see if the …

This study tests whether giving personalized diet and lifestyle advice to people at high risk for colorectal cancer helps them adopt healthier habits. About 800 participants who had a negative screening result will receive guidance based on cancer prevention recommendations. The …

This study tests a new program in middle and high schools to encourage HPV vaccination among 11-17 year olds. HPV is a common virus that can cause cancer, but vaccination rates in France are low. The program will be compared to standard care to see if it increases the number of t…

This study tests whether a one-day hospital visit that includes medical, psychological, and social support can improve the quality of life for teens and young adults (ages 15-25) who have just finished cancer treatment. About 214 participants will be randomly assigned to receive …

This study tests whether a one-year supervised physical activity program can reduce long-term fatigue in men who have had chemotherapy for metastatic testicular cancer. About 236 men will be randomly assigned to either the exercise program or standard recommendations. The goal is…

This study looks at how a 13-week physical activity program called KHEOPS changes motivation and psychological symptoms in 80 women being treated for breast cancer. Participants will fill out questionnaires about their feelings and attitudes toward exercise. The goal is to unders…

This study compares two methods for marking non-palpable breast tumors before surgery: a magnetic clip and a thin wire. Researchers will track costs, how well surgeons find and remove the tumor, patient satisfaction, and quality of life in 772 women. The goal is to see which meth…

This study looks at tumor samples from 300 people with exocrine pancreatic cancer to find links between the tumor's biology and how the disease behaves. Researchers will use advanced genetic sequencing to analyze tissue already collected during surgery or biopsies. The goal is to…

This study looks at how the drug venetoclax behaves in the bodies of people with acute myeloid leukemia (AML). Researchers will take extra blood samples to measure drug levels and see how they relate to treatment response. About 100 adults starting venetoclax plus azacitidine wil…

This study looks at how the immune system reacts to breast and ovarian cancer. Researchers will collect tumor and blood samples from 160 women before surgery to study immune cells and find clues that might predict survival. No new treatment is given—the goal is to learn more abou…

This study aims to find genetic changes in the tumors of 750 people with advanced or metastatic pancreatic cancer. By identifying these changes, doctors hope to match patients with targeted treatments that may work better for them. The study does not test a new drug but collects …

This study looks at the immune cells and bacteria inside the colon and rectum of people with or without colorectal cancer. By analyzing tissue samples, researchers hope to learn how the body's defenses change as cancer develops. No new treatments are tested; the goal is simply to…