Centre Leon Berard

This study is testing the safety and effectiveness of a new two-drug combination for aggressive brain tumors in adolescents and adults. The trial combines an experimental immunotherapy drug (tarlatamab) with a standard chemotherapy drug (temozolomide). It is open to patients whos…

This study is testing if taking a drug called regorafenib for up to a year can help prevent bone cancers (sarcomas) from returning after patients finish their initial chemotherapy and surgery. It will compare patients who take the drug to those who receive standard monitoring wit…

This study is for women with a rare, slow-growing uterine cancer called low-grade endometrial stromal sarcoma (LGESS). It aims to find out if patients whose cancer is stable after years of hormone therapy can safely stop that treatment for a while, compared to continuing it. The …

This large study is testing two ideas to improve treatment for certain head and neck cancers. It will see if using a smaller, more precise radiation area and/or adding a drug called ATRA (a form of vitamin A) works better than standard radiation alone. The goal is to better contr…

This study is comparing a new two-drug immunotherapy combination (botensilimab + balstilimab) against standard chemotherapy plus immunotherapy for adults with advanced stomach or esophageal cancer that has specific genetic features. The main goal is to see if the new combination …

This study is for people with advanced gastrointestinal stromal tumors (GIST) that have grown despite standard treatments. It tests if restarting the drug imatinib while adding a new immunotherapy drug (atezolizumab) works better than restarting imatinib alone. The goal is to see…

This trial is testing whether personalized cancer drugs, chosen based on the specific genetic changes found in a patient's tumor, can help control advanced cancers that have stopped responding to standard treatments. It will enroll about 455 adults with various advanced solid tum…

This study is testing if a drug called regorafenib can help control aggressive bone cancers like osteosarcoma when standard treatments haven't fully eliminated the disease. It will involve 36 patients aged 12 and older who still have detectable cancer after their initial therapy.…

This study is testing a new school-based program designed to increase HPV vaccination rates among teenagers aged 11-17 in France. Researchers want to see if this educational and support program, developed with local communities, can help more teens get the HPV vaccine within six …

This French study aims to compare the costs and satisfaction levels between two methods used to mark breast tumors before surgery: a magnetic clip versus the traditional metal wire. It will follow 772 women undergoing breast-conserving surgery for up to six months, collecting dat…

This study aims to understand how the amount of the leukemia drug venetoclax in a patient's blood relates to how well the treatment works and its side effects. It will observe 100 adults with acute myeloid leukemia who are starting standard treatment with venetoclax and azacitidi…