Can a cancer pill keep bone sarcomas at bay?

NCT ID NCT04055220

Recruiting now Disease control Sponsor: Centre Leon Berard Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether the drug regorafenib can help prevent bone sarcomas from coming back after initial treatment. About 168 people aged 12 and older with various bone sarcomas will be randomly assigned to take regorafenib for up to 12 months or to receive standard monitoring. The goal is to see if regorafenib improves relapse-free survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Regorafenib (Stivarga)

What this could lead to

If it works, this could provide a new maintenance option to delay relapse in bone sarcoma patients after initial treatment.

What could go wrong

This is an early phase II exploratory study, so results are uncertain. Regorafenib has side effects like fatigue, hand-foot skin reaction, and liver issues.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

angiosarcoma bone cancer bone sarcoma chondrosarcoma Ewing sarcoma leiomyosarcoma osteosarcoma Pathologic Complete Response Patient Compliance undifferentiated pleomorphic sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANGIOSARCOMA BONE SARCOMA CHONDROSARCOMA EWING SARCOMA LEIOMYOSARCOMA OSTEOSARCOMA UNDIFFERENTIATED PLEOMORPHIC SARCOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

APHM - Hôpital Timone
RECRUITING

Marseille, 13385, France

Contact Email: •••••@•••••
APHP Hôpital Cochin
RECRUITING

Paris, 75014, France

Contact Email: •••••@•••••
Centre Hospitalier Régional de Strasbourg Hautepierre
RECRUITING

Strasbourg, 67098, France

Contact Email: •••••@•••••
Centre Hospitalier Universitaire de Poitiers
NOT_YET_RECRUITING

Poitiers, 86000, France

Contact Email: •••••@•••••
Centre Hospitalier Universitaire de Saint-Etienne (CHUSE)
RECRUITING

Saint-Etienne, 42055, France

Contact Email: •••••@•••••
Centre Léon Bérard
RECRUITING

Lyon, 69373, France

Contact Email: •••••@•••••
Centre Oscar Lambret
RECRUITING

Lille, 59020, France

Contact Email: •••••@•••••
Centre Paul Strauss - Strasbourg
RECRUITING

Strasbourg, 67033, France

Contact Email: •••••@•••••
Hôpital Jean Minjoz
RECRUITING

Besançon, 25000, France

Contact Email: •••••@•••••
ICL Alexis Vautrin
NOT_YET_RECRUITING

Vandœuvre-lès-Nancy, 54519, France

Contact Email: •••••@•••••
ICM Val d'Aurelle
NOT_YET_RECRUITING

Montpellier, 34298, France

Contact Email: •••••@•••••
ICO René Gauducheau
RECRUITING

Saint-Herblain, 44805, France

Contact Email: •••••@•••••
IUCT-Oncopole
NOT_YET_RECRUITING

Toulouse, 31059, France

Contact Email: •••••@•••••
Institut Bergonié
RECRUITING

Bordeaux, 33076, France

Contact Email: •••••@•••••
Institut Curie
RECRUITING

Paris, 75005, France

Contact Email: •••••@•••••
Institut Gustave Roussy
RECRUITING

Villejuif, 94805, France

Contact Email: •••••@•••••