EWING SARCOMA

This study tests a stem cell transplant that removes certain immune cells (alpha/beta T cells and CD19+ B cells) and adds a drug called zoledronic acid. The goal is to help the donor cells attack the tumor without causing severe side effects. It is for children and young adults a…

This early-stage trial is testing a new drug called xaluritamig in about 50 people with Ewing sarcoma, a rare bone cancer, that has returned or stopped responding to standard treatments. The main goals are to find the safest dose and check for side effects. Researchers will also …

This early-phase study tests whether giving specially engineered immune cells (HER2-CAR T cells) together with an immune checkpoint inhibitor (pembrolizumab or nivolumab) is safe and can help people with advanced sarcoma. About 25 participants will receive chemotherapy to prepare…

This study is for children, teens, and young adults up to age 39 with sarcoma that has spread to a few other places in the body. Researchers want to see if giving extra radiation to those spread spots, along with usual treatment, can help patients live longer without the cancer g…

This study tests a new drug called zilovertamab vedotin in children and young adults (up to age 30) whose blood cancers or solid tumors have come back or not responded to treatment. The goal is to see if the drug is safe and can shrink or control the cancer. About 90 participants…

This study tests an experimental oral drug called AMXT 1501 combined with another drug, eflornithine (DFMO), in children and young adults up to age 21 with certain cancers like neuroblastoma, brain tumors, and sarcomas. The first part finds the safest dose, and the second part ch…

This early-stage trial tests a treatment where a child's own immune cells are collected, modified to better attack cancer, and given back as a one-time infusion. It is for children and young adults up to age 21 with solid tumors that have come back or not responded to standard th…

This study tests two drugs, pembrolizumab and cabozantinib, in people with advanced sarcomas that have not responded to standard treatments. The goal is to see if the combination can stop or shrink tumors for at least 6 months. About 119 adults with specific sarcoma types will ta…

This study tests a drug called lurbinectedin in children and young adults (ages 2 to 30) with Ewing sarcoma that has returned or not responded to prior treatments. The first part finds the safest dose and checks for side effects, and the second part measures how well the drug shr…

This early-phase study tests a combination of two types of immune cells (B7-H3 CAR T cells and PRAME-specific T cells) in children with relapsed or treatment-resistant cancers like rhabdomyosarcoma, Ewing sarcoma, neuroblastoma, and Wilms tumor. The main goal is to check safety a…

This early-phase study tests a four-drug combination (vorinostat, vincristine, irinotecan, and temozolomide) in children, teens, and young adults up to age 30 whose solid tumors or brain cancers have returned or not responded to standard treatment. The main goals are to find a sa…

This early-stage study tests a new drug, DXC008, for safety and the right dose in people with prostate cancer or other solid tumors like Ewing sarcoma. About 110 adults who have not responded to standard treatments will take part. The goal is to see if the drug is safe and to get…

This early-phase trial tests whether combining the drug cabozantinib with high-dose ifosfamide is safe and effective for children and adults with sarcomas that have returned or not responded to standard treatment. About 30 participants with bone or soft tissue sarcomas will recei…

This early-phase trial tests an experimental oral drug called ST-01156 in about 171 adults with advanced solid tumors, including Ewing sarcoma, liver cancer, and bile duct cancer. The drug works by breaking down a protein inside cancer cells. The main goals are to find a safe dos…

This study is testing a drug called lurbinectedin in people aged 10 and older whose solid tumors (like Ewing sarcoma) have come back or not responded to standard treatment. The goal is to see if the drug is safe and can shrink tumors or delay their growth. Participants must have …

This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors (like neuroblastoma, Ewing sarcoma, or osteosarcoma) have come back or not responded to treatment. The goal is to find a safe …

This early-stage study tests a new type of stem cell transplant for children whose blood cancers or solid tumors have come back or are hard to treat. Doctors use a special method to remove certain immune cells from the donor's stem cells and give a drug called zoledronate after t…

This study tests a new way of giving radiation for Ewing sarcoma, a rare bone and soft tissue cancer. The radiation dose is tailored to each patient's tumor size and features, with higher doses given over a shorter time. The goal is to better control the tumor at its original sit…

This study tests whether taking regorafenib for up to 12 months after initial treatment can delay or prevent bone sarcoma from coming back. About 168 patients with various bone sarcomas will be randomly assigned to receive the drug or just be monitored. The goal is to see if the …

This early-stage study tests whether a new treatment combining radiation and specially engineered immune cells (B7-H3-CAR T cells) is safe for children and young adults up to age 21 with sarcomas that have returned or not responded to standard therapy. The treatment aims to help …

This early-stage trial tests a new drug called INBRX-109, a lab-made antibody designed to target and kill cancer cells. It is for people with advanced solid tumors, including a type of bone cancer called Ewing sarcoma, that have not responded to other treatments. The main goals a…

This study looks at how well people with bone cancer follow a personalized exercise program at home after having surgery to remove a tumor from their leg. About 50 patients aged 12 and older will track their daily exercises for six months. The goal is to understand what helps or …

This study looks at children with neuroblastoma or Ewing sarcoma who had ovarian or testicular tissue frozen to preserve their fertility before cancer treatment. The problem is that this tissue might contain hidden cancer cells that could cause the cancer to return if the tissue …