New pill plus chemo shows promise for kids with tough cancers

NCT ID NCT06541262

Recruiting now Disease control Sponsor: Milton S. Hershey Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors (like neuroblastoma, Ewing sarcoma, or osteosarcoma) have come back or not responded to treatment. The goal is to find a safe dose and see if the combination can shrink tumors or slow their growth. About 104 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: silmitasertib (CX-4945) taken as a pill, combined with chemotherapy drugs irinotecan, temozolomide, and vincristine
What this could lead to: If it works, this could offer a new treatment option for children and young adults with certain hard-to-treat cancers that have come back.
What could go wrong: This is an early-phase trial (Phase I/II) with only 104 participants, so it's too soon to know if the combination is effective. There may be side effects from adding silmitasertib to standard chemo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Ewing sarcoma liposarcoma neuroblastoma osteosarcoma rhabdomyosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EWING SARCOMA LIPOSARCOMA NEUROBLASTOMA OSTEOSARCOMA RHABDOMYOSARCOMA

Contacts and locations

Locations

All Children's Hospital Johns Hopkins Medicine
RECRUITING

St. Petersburg, Florida, 33701, United States
Arnold Palmer Hospital for Children
RECRUITING

Orlando, Florida, 32806, United States
Cardinal Glennon Children's Medical Center
RECRUITING

St Louis, Missouri, 63104, United States
Children's Medical Center
RECRUITING

Dallas, Texas, 75235, United States
Children's Mercy Hospitals and Clinics
RECRUITING

Kansas City, Missouri, 64108, United States
Connecticut Children's Hospital
RECRUITING

Hartford, Connecticut, 06106, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Hasbro Children's Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Kapiolani Medical Center for Women and Children
RECRUITING

Honolulu, Hawaii, 96813, United States
Monroe Carrell Jr. Children's Hospital at Vanderbilt
RECRUITING

Nashville, Tennessee, 37232, United States
Nicklaus Children's Hospital
RECRUITING

Miami, Florida, 33155, United States
Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine
RECRUITING

Louisville, Kentucky, 40202, United States
Penn State Milton S. Hershey Medical Center and Children's Hospital
RECRUITING

Hershey, Pennsylvania, 17033, United States
Phoenix Children's Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84113, United States
Rady Children's Hospital
RECRUITING

San Diego, California, 92123, United States
St. Joseph's Children's Hospital
RECRUITING

Tampa, Florida, 33614, United States
UCSF Benioff Children's Hospital Oakland
RECRUITING

Oakland, California, 94609, United States
UHC Sainte-Justine
RECRUITING

Montreal, Quebec, QC H3S 2G4, Canada
University of Alabama/Children's of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States
University of Florida
RECRUITING

Gainesville, Florida, 32611, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23284, United States

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