New pill plus chemo shows promise for kids with tough cancers
NCT ID NCT06541262
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors (like neuroblastoma, Ewing sarcoma, or osteosarcoma) have come back or not responded to treatment. The goal is to find a safe dose and see if the combination can shrink tumors or slow their growth. About 104 participants will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
silmitasertib (CX-4945) taken as a pill, combined with chemotherapy drugs irinotecan, temozolomide, and vincristine
What this could lead to
If it works, this could offer a new treatment option for children and young adults with certain hard-to-treat cancers that have come back.
What could go wrong
This is an early-phase trial (Phase I/II) with only 104 participants, so it's too soon to know if the combination is effective. There may be side effects from adding silmitasertib to standard chemo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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All Children's Hospital Johns Hopkins Medicine
RECRUITINGSt. Petersburg, Florida, 33701, United States
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Arnold Palmer Hospital for Children
RECRUITINGOrlando, Florida, 32806, United States
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Cardinal Glennon Children's Medical Center
RECRUITINGSt Louis, Missouri, 63104, United States
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Children's Medical Center
RECRUITINGDallas, Texas, 75235, United States
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Children's Mercy Hospitals and Clinics
RECRUITINGKansas City, Missouri, 64108, United States
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
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Hasbro Children's Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
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Kapiolani Medical Center for Women and Children
RECRUITINGHonolulu, Hawaii, 96813, United States
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Monroe Carrell Jr. Children's Hospital at Vanderbilt
RECRUITINGNashville, Tennessee, 37232, United States
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Nicklaus Children's Hospital
RECRUITINGMiami, Florida, 33155, United States
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Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine
RECRUITINGLouisville, Kentucky, 40202, United States
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Penn State Milton S. Hershey Medical Center and Children's Hospital
RECRUITINGHershey, Pennsylvania, 17033, United States
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Phoenix Children's Hospital
RECRUITINGPhoenix, Arizona, 85016, United States
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Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84113, United States
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Rady Children's Hospital
RECRUITINGSan Diego, California, 92123, United States
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St. Joseph's Children's Hospital
RECRUITINGTampa, Florida, 33614, United States
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UCSF Benioff Children's Hospital Oakland
RECRUITINGOakland, California, 94609, United States
Contact Email: •••••@•••••
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UHC Sainte-Justine
RECRUITINGMontreal, Quebec, QC H3S 2G4, Canada
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University of Alabama/Children's of Alabama
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Email: •••••@•••••
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University of Florida
RECRUITINGGainesville, Florida, 32611, United States
Contact Email: •••••@•••••
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23284, United States
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Contact Email: •••••@•••••