New pill combo offers hope for kids with tough cancers
NCT ID NCT06541262
First seen Feb 02, 2026 · Last updated May 07, 2026 · Updated 17 times
Summary
This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors (like neuroblastoma, Ewing sarcoma, or osteosarcoma) have come back or not responded to treatment. The goal is to find a safe dose and see if the combination helps shrink tumors or delay their growth. About 104 participants will take part across two phases.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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All Children's Hospital Johns Hopkins Medicine
RECRUITINGSt. Petersburg, Florida, 33701, United States
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Arnold Palmer Hospital for Children
RECRUITINGOrlando, Florida, 32806, United States
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Cardinal Glennon Children's Medical Center
RECRUITINGSt Louis, Missouri, 63104, United States
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Children's Medical Center
RECRUITINGDallas, Texas, 75235, United States
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Children's Mercy Hospitals and Clinics
RECRUITINGKansas City, Missouri, 64108, United States
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
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Hasbro Children's Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
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Kapiolani Medical Center for Women and Children
RECRUITINGHonolulu, Hawaii, 96813, United States
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Monroe Carrell Jr. Children's Hospital at Vanderbilt
RECRUITINGNashville, Tennessee, 37232, United States
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Nicklaus Children's Hospital
RECRUITINGMiami, Florida, 33155, United States
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Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine
RECRUITINGLouisville, Kentucky, 40202, United States
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Penn State Milton S. Hershey Medical Center and Children's Hospital
RECRUITINGHershey, Pennsylvania, 17033, United States
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Phoenix Children's Hospital
RECRUITINGPhoenix, Arizona, 85016, United States
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Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84113, United States
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Rady Children's Hospital
RECRUITINGSan Diego, California, 92123, United States
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St. Joseph's Children's Hospital
RECRUITINGTampa, Florida, 33614, United States
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UCSF Benioff Children's Hospital Oakland
RECRUITINGOakland, California, 94609, United States
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UHC Sainte-Justine
RECRUITINGMontreal, Quebec, QC H3S 2G4, Canada
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University of Alabama/Children's of Alabama
RECRUITINGBirmingham, Alabama, 35233, United States
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University of Florida
RECRUITINGGainesville, Florida, 32611, United States
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23284, United States
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Contact Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.