Milton S. Hershey Medical Center

This study tests whether a short video of cancer survivors sharing their stories can encourage parents to get their 9- to 12-year-old children the HPV vaccine, which prevents several cancers. About 200 parents of unvaccinated children will be randomly assigned to watch either the…

This study tests two oral drugs, eflornithine (DFMO) and AMXT 1501, in children and young adults up to age 26 with certain cancers that have come back or not responded to treatment. The cancers include neuroblastoma, brain tumors, and sarcomas. The goal is to find a safe dose and…

This study tests whether adding eflornithine (DFMO) to standard chemotherapy can help teens and young adults with Ewing sarcoma or osteosarcoma live longer without their cancer coming back. About 406 participants will join one of five groups based on their cancer type and stage. …

This study tests a computer program that alerts doctors and nurses when hospital patients have dangerously high or low blood sugar. The tool suggests care steps to improve glucose control. Researchers will track over 15,000 adults across multiple hospitals to see if the tool redu…

This study tests a daily herbal supplement called INM176 (made from Angelica Gigas Nakai) in 45 men with prostate cancer whose PSA levels are rising after prior treatment or who are on active surveillance. The goal is to see if the supplement is safe and can stabilize or lower PS…

This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors (like neuroblastoma, Ewing sarcoma, or osteosarcoma) have come back or not responded to treatment. The goal is to find a safe …

This study tests whether a lower dose of the drug cyclophosphamide can prevent graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. GVHD is a serious complication where donor cells attack the patient's body. The trial will enroll 41 adults and give the…

This pilot study tests an intensive monitoring program for people with cirrhosis and severe swelling (fluid overload) after they leave the hospital. Participants receive a digital scale, educational materials, weekly phone calls, and a follow-up appointment with a liver specialis…

This study tests whether combining automated insulin pumps (Omnipod 5 or Medtronic 780G) with specialized education can help adults with type 1 diabetes who have lost the ability to feel low blood sugar (hypoglycemia). The trial will enroll 324 participants and follow them for up…

This study tests a new skills-based therapy called Phase-Based Treatment (PBT) for preteens aged 4-12 who show problematic sexual behavior. The therapy works mainly with caregivers over 12 weekly sessions to teach healthy information about sex and manage behaviors. Researchers wi…

This study tests whether giving low-income adults with type 2 diabetes vouchers for fruits and vegetables helps them attend diabetes education classes and improve their diet and blood sugar control. 120 participants will be split into three groups: usual care, vouchers alone, or …

This study aims to find the most effective amount of exercise to reduce liver fat in people with NASH, a serious liver disease. Researchers will compare different exercise doses in 45 sedentary adults aged 18-69 with NASH and early-stage liver scarring. The goal is to provide cle…

This study tests whether nicotine pouches can help smokers reduce their cigarette use. 375 smokers who smoke at least 5 cigarettes a day will be given different strengths and flavors of nicotine pouches to use for 16 weeks. Researchers will measure changes in cigarette smoking an…

This early-phase trial is testing whether a naturally occurring peptide, angiotensin-(1-7), can improve blood vessel function and nerve activity in people with obesity and high blood pressure. Researchers will compare the effects of the drug against a placebo (saline) in 52 adult…

This study tests a new, low-cost skin sensor that measures salt in sweat to diagnose cystic fibrosis. Researchers will compare the device to the standard lab test in 30 adults—some with CF and some healthy. The goal is to see if the sensor is accurate enough for routine use.

This study tests whether short, calming virtual reality (VR) sessions can safely reduce anxiety, agitation, and delirium in adult intensive care unit (ICU) patients. Thirty participants will watch nature-based VR content using a headset. The main goal is to see if this approach i…

This study tests whether a long-acting form of the numbing drug bupivacaine (liposomal bupivacaine) provides better pain relief than the standard version after minimally invasive chest surgery. Forty adults undergoing thoracoscopic procedures will receive one of the two drugs inj…

This study tests whether a 12-week virtual yoga program can reduce pain in women with endometriosis. Researchers will enroll 30 women aged 18-45 who have moderate pain and a confirmed diagnosis. Participants will attend online yoga classes and report their pain levels using quest…

This study tests a communication coaching program for adolescent and young adult cancer survivors (ages 18-35) who have finished treatment at least a year ago. Participants complete online sessions and AI coaching to improve how they talk with peers. The goal is to see if the pro…

This pilot study is testing whether a commercially available CBG/CBD oil is safe and can help reduce nerve pain, numbness, and tingling caused by platinum-based chemotherapy. Twelve adults with gastrointestinal cancers who have completed chemotherapy will take the oil under the t…

This study follows 350 adults who have had a limb amputated to see which medical treatments work best for pain. Researchers will measure pain at rest and during movement over one year. The goal is to find more effective ways to manage pain and improve quality of life after amputa…

This study aims to see if college students can effectively deliver cognitive-behavioral therapy (CBT) to high school students in rural Pennsylvania to reduce symptoms of depression, anxiety, and stress. About 40 teens aged 13-18 with mild to moderate symptoms will participate. Th…

This study is testing an AI-powered chatbot called Exp-ED that guides teens and young adults through exposure therapy exercises to reduce anxiety about weight gain. Twenty participants in a partial hospitalization program for eating disorders will use the app for six weeks. Resea…

This pilot study is testing a new type of talk therapy, called Exposure Therapy for Anorexia (Exp-AN), delivered virtually to 16 teenagers aged 14-17 with anorexia nervosa. The therapy helps teens identify and face their fears about gaining weight through real-life and mental exe…

This study tests whether proactive outreach—sending materials and making two phone calls—can encourage older adults with osteoarthritis to use their free SilverSneakers exercise benefit. About 1,454 seniors across the U.S. will be followed for two years to see if they become more…

This pilot study tests whether a single, brief mindfulness session before endometriosis surgery can help women cope with pain and use fewer opioids afterward. Twenty adults with endometriosis will be split into two groups: one gets the mindfulness session plus usual care, the oth…

This study looks at 600 adults with chronic insomnia to see if those who sleep less than 6 hours respond differently to treatment than those who sleep longer. Participants first receive 8 weeks of cognitive behavioral therapy (CBT-I). If that doesn't help, they are randomly assig…

This study compares two ways of weighing teens and young adults with eating disorders like anorexia: open weighing (where they see their weight and talk about fears) and blind weighing (where they don't see it). The goal is to see if open weighing reduces anxiety about weight gai…

This study looks at how smoking little cigars affects levels of harmful chemicals called oxidants in the body. Researchers will compare three types of smoking: high-oxidant little cigars, low-oxidant little cigars, and regular cigarettes. Fifty daily smokers will provide breath, …

This study looks at how the rotator cuff muscles are doing one and two years after total shoulder replacement surgery. Researchers will use EMG and CT scans to check for nerve damage or tears in the muscles. About 30 adults who had shoulder replacement for osteoarthritis will tak…

This study tests whether using ultrasound to guide placement of a brain drain (external ventricular drain) in adults with hydrocephalus can improve accuracy and reduce the number of needle passes needed. Ten participants will have the drain placed with the SOLOPASS® ultrasound sy…

This early-stage study looks at how the body's nervous system controls blood pressure when veins are stretched. Researchers will use a blood pressure cuff to temporarily block blood flow in the arm and measure nerve activity in the leg, along with vein size using an MRI. They wil…

This study looks at whether a parent's ability to manage their own emotions can make behavioral training more effective for children with ADHD. Researchers will work with 65 parents and their children (ages 5-12) to see if better parental emotion regulation leads to fewer behavio…

This study tests whether a heart ultrasound measurement called the superior vena cava collapsibility index (SVC-CI) can predict how patients will respond to fluids during coronary artery bypass surgery. Researchers will tilt the operating table (head up then head down) to mimic g…

This study involves 136 children with ADHD who also have high levels of irritability or aggression. Researchers will measure tiny brain signals (called ERPs) while children do tasks, then see if those signals can predict which kids get the most benefit from stimulant medication. …

This study looks at whether stretching the veins in your legs causes a rise in blood pressure when you stand up, a condition called orthostatic hypertension. Researchers will use a tilt table and inflatable trousers to gently stretch leg veins in 30 healthy adults and people with…

This study looks at whether a continuous glucose monitor (CGM) can help predict who will develop diabetes after an episode of acute pancreatitis. Researchers will follow 800 people for up to 36 months, using the CGM device to track blood sugar levels. The goal is to see if CGM ca…

This study looks at tiny molecules called microRNAs in the saliva of newborns exposed to opioids before birth. Researchers want to see if these molecules can predict how severe withdrawal symptoms will be and guide treatment. The goal is to move away from one-size-fits-all care a…

This study tests an online training program called iLook Out for Child Abuse, designed for early childhood professionals like daycare staff. The goal is to see if the training improves their knowledge, attitudes, and readiness to report suspected child abuse or neglect. Over 35,0…

This study follows 800 people who recently had acute pancreatitis to see who develops diabetes and why. Participants are observed for 36 months with tests and surveys. No new treatments are tested; the goal is to learn how and why diabetes occurs after pancreatitis.

This early-phase study tests whether angiotensin-(1-7), a natural hormone, can improve blood vessel function and lower blood pressure in healthy adults aged 65-80. Researchers will measure nerve activity and blood vessel responses during a short infusion of the hormone compared t…