Milton S. Hershey Medical Center

This study tests whether a short video of cancer survivors sharing their stories can encourage parents to get their 9- to 12-year-old children the HPV vaccine. About 200 parents of unvaccinated kids will watch either the survivor video or a general health video before a doctor's …

This study tests whether giving low-income adults with type 2 diabetes vouchers to buy fruits and vegetables helps them attend diabetes education classes and improve their blood sugar control. About 120 participants will be randomly assigned to receive the vouchers or not. The go…

This study looks at how much exercise works best to lower liver fat in people with nonalcoholic steatohepatitis (NASH), a serious liver condition. Researchers will enroll 45 sedentary adults aged 18-69 with NASH and early-stage liver scarring. Participants will follow different e…

This study tests an experimental oral drug called AMXT 1501 combined with another drug, eflornithine (DFMO), in children and young adults up to age 21 with certain cancers like neuroblastoma, brain tumors, and sarcomas. The first part finds the safest dose, and the second part ch…

This study looks at whether nicotine pouches can help people who smoke at least 5 cigarettes a day reduce their smoking by 75% over 16 weeks. Participants will be assigned to different nicotine strengths and flavors of pouches. Researchers will measure changes in harmful chemical…

This study tests a lower dose of a drug called cyclophosphamide to prevent graft-versus-host disease (GVHD) in people receiving a stem cell transplant for blood cancers like leukemia. GVHD occurs when donor cells attack the patient's body. The goal is to see if the lower dose wor…

This study tests whether strictly avoiding low blood sugar (hypoglycemia) can help adults with type 1 diabetes regain the ability to feel warning symptoms. About 324 participants with impaired awareness of hypoglycemia will use a closed-loop insulin system and education. The goal…

This study tests an herbal supplement called INM176 (made from Angelica gigas Nakai root) in 45 men with prostate cancer whose PSA levels are rising after prior treatment or who are on active surveillance. The goal is to find a safe dose and see if the supplement can stabilize or…

This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors (like neuroblastoma, Ewing sarcoma, or osteosarcoma) have come back or not responded to treatment. The goal is to find a safe …

This study tests a transitional care program for 20 adults with cirrhosis and fluid overload (swelling) after they leave the hospital. Participants get a digital scale, educational materials, weekly check-in calls, and a follow-up appointment. Researchers want to see if this prog…

This study is testing a new, low-cost skin sensor that measures salt in sweat to diagnose cystic fibrosis. Researchers will compare the sensor's results to standard lab tests in 30 adults—some with CF and some healthy. The goal is to see if this wearable device can make diagnosis…

This study tests whether a single, short mindfulness session before endometriosis surgery can help reduce pain and the need for painkillers afterward. About 20 adults with endometriosis will either receive the mindfulness training or standard education before their operation. Res…

This study looks at how well different medical treatments reduce pain after a limb is surgically removed. Researchers will track pain levels at rest and during movement for up to one year in 350 adults. The goal is to find better ways to manage pain and improve daily function.

This study tests whether practicing yoga can reduce pain in women with endometriosis. About 30 women aged 18-45 who have had surgery-confirmed endometriosis and moderate pain will participate. They will do yoga sessions and report their pain levels using questionnaires. The goal …

This study looks at whether a technique called 'open weighing'—where patients see their weight during treatment—can reduce anxiety about weight gain in teens and young adults with eating disorders like anorexia. About 70 participants will be randomly assigned to open weighing or …

This study tests a new therapy called Phase-Based Treatment (PBT) for preteen children with problematic sexual behavior. About 42 children aged 4 to 12 and their caregivers will take part. The goal is to see if PBT works better than usual care in reducing these behaviors.

This study is testing whether college students can be trained to deliver cognitive-behavioral therapy (CBT) to high school students in rural areas. The goal is to reduce symptoms of depression, anxiety, and stress in teens aged 13 to 18. The program aims to make mental health sup…

This early study is testing whether a commercially available CBG/CBD oil is safe and can reduce nerve pain, numbness, and tingling caused by chemotherapy in people who have finished treatment for gastrointestinal cancers. Twelve adults will take the oil under their tongue twice d…

This study is creating and testing a friendly AI chatbot that talks with teens and young adults (ages 12-26) who have eating disorders like anorexia or bulimia. The chatbot is used alongside their regular treatment to help them feel less scared about gaining weight. About 20 peop…

This pilot study tests a virtual exposure therapy for 16 teens aged 14-17 with anorexia nervosa. The therapy helps them face fears about weight gain through exercises like weighing themselves and reading fear scripts. Parents join sessions as supporters. The goal is to reduce anx…

This study tests a new type of therapy for people with anorexia nervosa that helps them face their fears about eating and gaining weight. Participants will do real-life and mental exercises, like eating a feared food while listening to a recording about weight gain fears. The goa…

This study looks at two treatments for chronic insomnia: cognitive behavioral therapy (CBT-I) and a low-dose medication called trazodone. Researchers want to see which works better for different types of insomnia and whether improving sleep also helps lower blood pressure. About …

This study tests whether sending information and making two phone calls can encourage older adults with osteoarthritis to use their free SilverSneakers exercise program. About 1,454 seniors across the U.S. who have not used SilverSneakers before will take part. The goal is to see…

This study looks at how smoking little cigars affects levels of harmful chemicals called oxidants in the body. Researchers will compare two types of little cigars (high and low oxidant) to regular cigarettes in 50 daily smokers. The goal is to understand the health risks of littl…

This study looks at whether a parent's ability to handle their own emotions can change how well behavioral training works for children with ADHD. Researchers will work with 65 parents and their children (ages 5-12) to see if parents who struggle with emotions get less benefit fro…

This study follows 800 people who recently had acute pancreatitis to understand why some develop diabetes afterward. Participants will be monitored for 36 months with tests and surveys. No new treatments are tested—the goal is to learn more about the link between pancreatitis and…

This study aims to find brain markers that can predict whether stimulant medication will help reduce irritability and aggression in children with ADHD. About 136 children with ADHD and high levels of irritability or aggression will take part. Researchers will measure brain activi…

This early-phase study tests whether angiotensin-(1-7), a natural hormone, can improve blood vessel function and lower blood pressure in healthy adults aged 65-80. Researchers will measure nerve activity and blood vessel responses during a hormone infusion. The goal is to underst…

This study looks at how stretching veins triggers a nerve reflex that affects blood pressure. Researchers will measure nerve activity and vein size in 18 healthy adults aged 21-35, using an IV anti-inflammatory drug to see if it changes the reflex. No treatment is tested; the goa…

This study follows 800 people who recently had acute pancreatitis to see if a continuous glucose monitor (CGM) can predict who will develop diabetes or pre-diabetes. Researchers will track participants for 36 months using CGM and other tests. The goal is to improve how doctors mo…

This study looks at whether a special computer program that works with electronic medical records can help doctors better manage blood sugar levels in hospitalized adults. About 15,700 patients across several hospitals will be included. The goal is to see if the tool reduces high…

This study aims to help people from underserved communities have important conversations about end-of-life care. Researchers will use trusted community networks to test two conversation tools that encourage people to discuss their wishes with loved ones and complete advance direc…

This study looks at whether a special ultrasound measurement of a large vein near the heart (the superior vena cava) can predict how a patient's body will respond to extra fluids during coronary artery bypass surgery. About 120 adults having this surgery will be monitored, and do…

This study looks at whether an online learning module called iLookOut can improve how well early childhood professionals understand and report suspected child abuse. Over 35,000 childcare workers in Pennsylvania will take the training and answer questions before and after to meas…

This study looks at whether stretching the veins in your legs can cause a rise in blood pressure when you stand up. Researchers will measure nerve signals and blood pressure in 30 healthy adults and people with high standing blood pressure. The goal is to better understand how th…

This study looks at whether small molecules called microRNAs in a newborn's saliva can help doctors predict how much medicine they need for opioid withdrawal and how their brain develops later. About 50 babies born to mothers who used opioids during pregnancy will provide spit sa…

This study is testing an experimental drug called angiotensin-(1-7) to see if it can improve how blood vessels and nerves work in people who have both obesity and high blood pressure. Researchers will measure nerve activity and artery size during a short infusion of the drug comp…