Milton S. Hershey Medical Center

This study tests whether adding eflornithine (DFMO) to standard chemotherapy helps people with Ewing sarcoma or osteosarcoma live longer without their cancer returning. About 406 participants with different stages of these bone cancers will receive DFMO alongside their usual trea…

This study tests whether giving a short infusion of amino acids during heart surgery can help prevent acute kidney injury, a common complication. Researchers will measure kidney damage markers in the urine of 130 adult patients before and after surgery. The first group receives s…

This study tests a communication coaching program for young adults (ages 18-35) who have finished cancer treatment at least a year ago. The goal is to help them talk more easily with friends, which may reduce anxiety, depression, and feelings of isolation. Ten participants will t…

This study will test a behavioral program to improve sleep and daily rhythms in autistic adults aged 18-65 who have sleep problems. The goal is to see if the treatment can improve overall sleep health and well-being. The study involves 24 participants and focuses on making the pr…

This study tests whether a special collagen shield placed on the eye can reduce pain and the need for painkillers in people who come to the ER with a scratched cornea (the clear front part of the eye). About 60 adults with a scratch in one eye will be randomly assigned to get eit…

This study tests whether doing dermabrasion (a procedure that sands the top layer of skin) several times can make surgical scars from head and neck reconstruction look better. About 40 adults who had a free flap surgery at least 3 months ago will take part. Half of each scar will…

This study compares two methods of radiofrequency ablation (a heat-based treatment) for chronic low back pain caused by lumbar spondylosis. 25 adults with long-term pain will be randomly assigned to one of two approaches. The goal is to see which method provides better pain relie…

This study tests whether a low-intensity program of educational texts and emails can reduce stress and burden for people caring for a loved one with dementia. Twenty caregivers who previously joined an observational study will receive automated supportive messages for six weeks. …

This study tests whether messages about losing the ability to walk well can motivate older adults with walking difficulty to exercise daily. About 148 people will do a 5-minute home exercise program for 4 months and answer surveys. The goal is to see if these messages increase re…

This study looks at whether vitamin B6 can reduce the sharp rise in blood pressure that happens during exercise after a leg injury. Researchers will test 30 healthy adults aged 21-70 by temporarily restricting blood flow to the leg and then measuring blood pressure, heart rate, a…

This study looks at how the loss of estrogen after menopause might increase the risk of heart disease. Researchers will measure blood pressure, nerve activity, and signs of inflammation in 20 healthy postmenopausal women. The goal is to understand the link between estrogen defici…

This study looks at whether a specially adapted card game, called the Hello game, can help members of the Washoe Tribe talk about and plan for future medical care. About 108 adults will play the game in groups and answer surveys. The goal is to see if this approach is acceptable …

This pilot study tests whether an automated system that gives personalized coping tips can help stroke survivors become more physically active. Fifty adults who had a stroke 3 months to 3 years ago will use the system for 3 months. The main goal is to see if the approach is feasi…

This study tests whether using ultrasound guidance helps doctors place a brain drain (external ventricular drain) more accurately in adults with hydrocephalus. The goal is to reduce the number of needle passes needed and avoid complications. Ten participants will be enrolled, and…