Vitamin B6 may tame blood pressure spikes during exercise in leg artery disease

NCT ID NCT06369350

Not yet recruiting Symptom relief Sponsor: Milton S. Hershey Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study tests whether taking vitamin B6 for up to 31 days can reduce the sharp rise in blood pressure that happens during exercise after a temporary lack of blood flow (like a leg injury). Researchers will measure blood pressure, heart rate, nerve activity, and walking time in 30 healthy adults. The goal is to see if this cheap, non-invasive vitamin could one day help people with peripheral artery disease exercise more comfortably.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin B6
What this could lead to: If it works, this could point toward a simple, low-cost way to help people with peripheral artery disease exercise more safely.
What could go wrong: This is a very early, small study in healthy volunteers, not patients. It only looks at short-term blood pressure changes, not long-term benefits or risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ischemia reperfusion injury peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ISCHEMIA REPERFUSION INJURY PERIPHERAL ARTERY DISEASE

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