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Beetroot juice and exercise: a new hope for leg pain from clogged arteries?

NCT ID NCT06657976

NEW Recruiting now Disease control Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 27, 2026

Summary

This trial tests whether a 12-week supervised treadmill exercise program can improve blood flow and walking distance in people with peripheral artery disease (PAD). It also explores whether adding nitrate-rich beetroot juice helps those who don't respond to exercise alone. Two hundred participants will be randomly assigned to exercise or educational sessions, with some later receiving beetroot juice.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
supervised treadmill exercise and nitrate-rich beetroot juice
What this could lead to
If successful, this could point toward a simple, non-drug way to improve walking ability and blood flow in people with peripheral artery disease.
What could go wrong
This is a mid-stage trial, so results may not be definitive. The benefits of beetroot juice may be modest, and not everyone may respond to exercise.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intermittent vascular claudication Mobility Limitation Motor Activity peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXERCISE INTERMITTENT CLAUDICATION NITRIC OXIDE PERIPHERAL ARTERY DISEASE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Northwestern University Feinberg School of Medicine

    RECRUITING

    Chicago, Illinois, 60611, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Chicago

    NOT_YET_RECRUITING

    Chicago, Illinois, 60637, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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