PERIPHERAL ARTERY DISEASE

This study tests whether inclisiran, a twice-yearly injection that lowers cholesterol, can prevent major heart and limb events in 6,000 people who recently had artery-opening procedures. Participants receive either inclisiran or a placebo shot at the start, at 90 days, and every …

This study tests whether computer alerts can help doctors prescribe cholesterol-lowering drugs to people with peripheral artery disease (PAD) who aren't taking them. About 400 adults with PAD will be randomly assigned to have their doctors receive an alert or not. The goal is to …

This study is testing a new laser device called the Thor system to treat blockages in the leg arteries caused by peripheral artery disease (PAD). About 155 adults with PAD will receive the laser treatment and be followed for a year. The main goals are to see if the device is safe…

This study tests whether a personalized blood-thinning plan, guided by a blood test, can prevent dangerous blood clots better than the standard one-size-fits-all approach in people with peripheral artery disease who have had leg surgery. About 484 adults will be randomly assigned…

The PROVE trial is testing whether a weight loss program combined with walking exercise can improve or maintain walking ability in people with peripheral artery disease (PAD) who are overweight. 212 participants will be randomly assigned to either weight loss plus exercise or exe…

This study compares two balloon treatments used after placing a stent in long blockages of the leg arteries. About 180 people with peripheral artery disease will receive either a drug-coated balloon or a standard balloon. The goal is to see which keeps the artery open longer and …

This study is tracking 1,000 people with severe leg artery disease (chronic limb-threatening ischemia) who are getting a drug-coated balloon to open blocked arteries below the knee. The balloon releases a drug (paclitaxel) to help keep the artery open. Researchers want to see if …

This study is testing a device called Laser Speckle Contrast Imaging (LSCI) that uses a laser to measure blood flow in the leg. The goal is to see if it can help doctors monitor blood flow before, during, and after surgery to restore circulation. The study will enroll 30 people s…

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This pilot study tests whether a 12-week home-based exercise program using a small pedal exerciser can help people with moderate-to-severe peripheral artery disease (PAD) walk farther and feel better. Twelve adults with severe PAD will be randomly assigned to either the home exer…

This early-phase trial tests whether a single dose of Vumerity (diroximel fumarate) can improve blood vessel function and walking ability in 20 people aged 50-75 with peripheral artery disease (PAD). Participants will receive either Vumerity or a placebo, and researchers will mea…

This study tests a new, pain-free exercise program for people with peripheral artery disease (PAD), which causes leg pain when walking. Researchers will compare it to standard painful exercise over 3 months in 100 adults aged 40 and older. The goal is to see if the pain-free prog…

This study tests whether taking cocoa flavanols daily for six months can improve walking distance in people aged 55 and older with peripheral artery disease (PAD), a condition that causes leg pain and limits mobility. Researchers will compare a cocoa flavanol supplement to a plac…

This study tests two home-based walking programs for veterans with peripheral artery disease (PAD), a condition that causes leg pain when walking. Participants will either use a website, have telehealth coaching, or get usual care. The goal is to see if these programs help them w…

This study tests a home-based exercise program called Smart MOVE! for Veterans with peripheral artery disease (PAD), a condition that limits walking ability. Participants will use a wearable activity monitor and receive behavioral coaching via the MOVE! program. The goal is to se…

This study tests whether combining the DASH diet (a heart-healthy eating plan) with a home-based walking program can improve walking ability and quality of life in people with peripheral artery disease (PAD). PAD causes leg pain during walking due to narrowed arteries. The study …

This study tests whether drinking beetroot juice daily for 4 months can improve walking distance in people with peripheral artery disease (PAD). Researchers will compare a beetroot juice group to a placebo group in 210 adults aged 50 and older. The main goal is to see if beetroot…

This study tests whether shining a specific red light on the legs each day before a walking session can help people with peripheral artery disease (PAD) walk farther. PAD causes leg pain and difficulty walking due to poor blood flow. The trial will involve 32 adults aged 50 and o…

This study tests two walking training programs to help veterans with leg amputation walk more evenly. The goal is to reduce pain, improve mobility, and protect the skin of the remaining limb. About 54 veterans who lost a leg due to diabetes or artery disease will take part.

This study tests a new type of supervised exercise for people with peripheral artery disease (PAD), which causes leg pain when walking due to blocked arteries. Researchers want to see if using muscle oxygen levels to guide exercise is better than standard therapy. The study invol…

This study tests whether daily leg heat therapy can improve walking ability and quality of life in people with peripheral artery disease (PAD). About 106 adults over 50 with PAD will use special heated trousers for 90 minutes a day at home for 12 weeks. Researchers will measure c…

This study tests whether a community-based exercise program can improve walking ability and heart health in people with peripheral artery disease who have recently had a procedure to open blocked leg arteries. Researchers will enroll 30 participants and measure how long they can …

This study tests whether a TENS pain-relief device, combined with video coaching sessions from a physiotherapist, can help people with leg pain from peripheral artery disease (PAD) become more active. Forty-eight participants will either get the TENS device plus coaching or usual…

This study is testing whether a quick ultrasound measurement of blood flow in the foot (called systolic rise time) can predict major limb events like amputation or severe ischemia in people with critical limb ischemia. Researchers will follow 134 patients for 6 months after surge…

This study looks at how often sleep apnea occurs in people with peripheral artery disease (blocked leg arteries). Researchers will monitor 295 adults with leg artery disease using a sleep test. The goal is to better understand the connection between these two conditions, which ma…

This study is testing a new ultrasound technique called super-resolution ultrasound microvascular imaging (SRUMI) to see if it can predict how peripheral artery disease (PAD) will progress. Researchers will scan the legs of 300 people with PAD and compare the images to standard t…

This registry is following 2,000 people with chronic coronary artery disease who are taking long-term blood thinners (antiplatelet or anticoagulant drugs). The goal is to track how often serious bleeding or clotting events (like heart attacks or strokes) occur. By understanding t…

This study is testing whether shining a red light (670 nm) on the calf muscle for 5 minutes can increase blood flow in people with peripheral artery disease (PAD). Forty adults with PAD will receive the light treatment and an ultrasound contrast injection to measure blood flow. T…

This study is gathering information from 50 Canadians with Peripheral Artery Disease (PAD) who are treated in heart clinics and can still walk. Researchers want to measure inflammation levels and physical abilities to better understand the condition. The results will help doctors…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study looks at how narrowed leg arteries (peripheral artery disease) might affect heart function. Researchers will use advanced heart ultrasound to measure subtle changes in heart muscle strain in 162 participants. They will also check for links to metabolism and organ damag…

This study tests a simple, passive leg movement called LEAP therapy in people with peripheral artery disease (PAD). Participants sit for 2.5 hours with or without the leg movement, and researchers measure blood flow, walking ability, and other health markers. The goal is to see i…