PERIPHERAL ARTERY DISEASE

This study tests if a weight loss program combined with a walking exercise plan helps people with peripheral artery disease (PAD) and overweight maintain or improve their walking ability better than walking exercise alone. About 212 adults with PAD and a BMI over 25 will take par…

This study is testing a drug-coated balloon to open blocked arteries below the knee in people with severe leg artery disease that threatens the limb. The goal is to improve blood flow, reduce pain, and avoid the need for amputation. About 1,000 participants will be followed for o…

This study compares two balloon treatments used after placing a stent in long blockages (over 10 cm) in the leg arteries of people with peripheral artery disease. One balloon is coated with a drug to help keep the artery open, while the other is a standard balloon. The goal is to…

This study tests a device called the Thor system in 155 adults with peripheral artery disease (PAD) who have new blockages in their leg arteries. The goal is to see if the device is safe and works well to open the blockages. Participants get the treatment and are followed for one…

This study compares two ways to deliver a home-based walking program for veterans with peripheral artery disease (PAD), a condition that causes leg pain when walking. Participants will be randomly assigned to a web-based program, a telehealth program, or usual care. The goal is t…

This study tests a new type of supervised exercise for people with peripheral artery disease (PAD), where leg arteries are blocked and walking becomes painful. The program uses muscle oxygen levels to guide exercise, aiming to help patients walk farther and reduce muscle damage. …

This study tests two walking training programs to help veterans with leg amputation walk more evenly. The goal is to reduce pain, improve mobility, and protect the skin of the remaining limb. About 54 veterans who have had a leg amputation due to diabetes or artery disease will t…

This study tests whether combining a heart-healthy DASH diet with a home walking program can help people with peripheral artery disease (PAD) walk longer and feel better. Researchers will measure changes in treadmill walking time, quality of life, and leg muscle oxygen levels ove…

This study tests whether a single dose of the drug Vumerity can improve blood vessel function and walking ability in people with peripheral artery disease (PAD). Researchers will give 20 adults aged 50-75 either Vumerity or a placebo and measure changes in blood flow, oxygen use,…

This study tests a home-based exercise program for Veterans with peripheral artery disease (PAD), a condition that limits walking and raises amputation risk. Participants use a wearable activity monitor and join group coaching sessions to improve walking ability. The goal is to s…

This study tests whether shining a specific red light on the legs each day before a walking workout can help people with peripheral artery disease (PAD) walk farther. PAD causes leg pain and difficulty walking due to narrowed arteries. The trial will involve 32 adults aged 50 and…

This study tests whether drinking beetroot juice for four months helps people with peripheral artery disease (PAD) walk farther. PAD narrows leg arteries, causing pain and difficulty walking. The trial will compare beetroot juice to a placebo in 210 adults aged 50 and older, meas…

This study looks at whether a structured exercise program in a community setting can improve walking ability and heart health in people with peripheral artery disease who have recently had a procedure to restore blood flow in their legs. About 30 participants will take part. The …

This study tests a program for people with leg pain caused by narrowed arteries (peripheral artery disease). Participants get four remote sessions with a physical therapist plus a small device (TENS) that may reduce leg pain during walking. The goal is to see if this approach hel…

This study tests whether daily leg heat therapy can improve walking ability and quality of life in people with peripheral artery disease (PAD). About 106 adults over age 50 with PAD will use heated trousers at home for 90 minutes each day. The main goal is to see if this treatmen…

This study tests whether a computer alert system can help doctors remember to prescribe cholesterol-lowering medications to people with peripheral artery disease (PAD) who aren't currently taking them. About 400 adults with PAD will take part. The goal is to see if the alerts lea…

This study is testing a new, advanced ultrasound technique that can see the smallest blood vessels in the legs. Researchers want to know if images of these tiny vessels can help predict future problems like limb pain or amputation in people with peripheral artery disease (PAD). T…

This study looks at how lower extremity arterial disease (LEAD) might affect the heart's pumping ability. Researchers will use special ultrasound techniques to measure heart function in 162 participants with and without LEAD. The goal is to find early signs of heart trouble and u…

This study follows 2,000 people with chronic coronary artery disease who take long-term blood thinners. Researchers track how many have heart attacks, strokes, or serious bleeding. The goal is to better understand the balance of risks and benefits, not to test a new treatment.

This study looks at whether a device that gently moves the legs back and forth (like paddling) can improve blood flow and walking ability in people with peripheral artery disease (PAD) during long periods of sitting. About 24 adults aged 50-85 with PAD and healthy controls will e…

This study collects blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. The samples are stored in a biobank for future research on inflammation, metabolism, and other disease pathways. No treatments or interventions are given; the …

This study looks at how often sleep apnea occurs in people with peripheral artery disease (PAD), a condition where leg arteries become narrowed. Researchers will monitor 295 adults with PAD using a sleep test called polygraphy. The goal is to better understand the connection betw…

This study tests whether a single 5-minute exposure to a specific type of light (670 nm) can increase blood flow in the calf muscles of people with peripheral artery disease (PAD). Researchers will measure blood flow using ultrasound and take blood samples to check for nitric oxi…