PERIPHERAL ARTERY DISEASE

This study tested whether a physical activity program delivered by mail and website could improve the health of nearly 50,000 older women already in the Women's Health Initiative. The program included aerobic, balance, strength, and flexibility exercises, and encouraged reducing …

This study tested a device that uses sound waves to break up calcium buildup in the arteries below the knee in 250 people with peripheral artery disease (PAD). The goal was to safely restore blood flow and avoid serious complications like amputation. Results showed the procedure …

This study tested two ways to treat blocked leg arteries in 47 people with leg pain when walking. One group had a special device to remove plaque (atherectomy) followed by a drug-coated balloon, while the other had standard balloon angioplasty followed by the same drug-coated bal…

This study tested whether taking metformin daily for six months can improve how far people with peripheral artery disease can walk in six minutes. 203 participants were randomly assigned to receive metformin or a placebo. The goal was to see if this common diabetes drug could eas…

This pilot study tested whether taking a daily supplement called nicotinamide riboside (a form of vitamin B3) for 4 weeks could improve blood vessel function and thinking skills in 8 older adults with peripheral artery disease. Researchers measured changes in blood flow in the ar…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the leg arteries of people with peripheral artery disease (PAD). Twenty-four adults with PAD received either colchicine or a placebo. Researchers used special scans and blood tests to measure c…

This study looked at 50 people who had a procedure to clear hardened blockages in their leg arteries using a special device (Jetstream) followed by a drug-coated balloon (Ranger). Researchers checked how many patients avoided needing another procedure on the same spot after 3 yea…

This study tested a special balloon coated with sirolimus, a drug that helps keep arteries open, in 34 people with peripheral artery disease (narrowed leg arteries). The goal was to see if the balloon is safe and works well at improving blood flow and symptoms like leg pain. Part…

This study tested a special device called the Orbital Atherectomy System in 81 Japanese adults with hardened blockages in their leg arteries. The device was used to safely remove calcium buildup and improve blood flow. The goal was to see if the device works well enough to be app…

This study tested several simple bedside tests—like ankle and toe blood pressure measurements and handheld Dopplers—to see how well they detect poor leg circulation (peripheral arterial disease) in 604 people with diabetes. The results were compared to advanced imaging scans (CTA…

This study tested whether listening to music during wound dressing changes can reduce pain in people with severe arteritis (stage 5 or 6). Twenty-five patients were asked to listen to music during their daily wound care. The main goal was to see if pain levels were lower on a 0-1…

This phase 2 trial tests whether daily injections of unacylated ghrelin, a natural hormone, can improve walking ability in people aged 55 and older with peripheral artery disease (PAD). Participants receive either the hormone or a placebo for four months. The study measures chang…

This study tested if a gentle electrical stimulation on the ear (transcutaneous vagal stimulation) could improve blood vessel function in 11 people with peripheral artery disease (PAD). The goal was to see if this non-invasive method could help blood vessels relax and work better…

This study tested whether specially designed shoes (carbon fiber or spring-loaded) could help people with peripheral artery disease (PAD) walk farther and with less pain. Ten veterans with PAD wore the shoes for three months. Researchers measured changes in walking distance and c…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This completed study tested a special guidewire with a sensor that measures electrical properties of tissues in people with peripheral artery disease. The goal was to see if the sensor could tell the difference between various tissues, like the artery wall and surrounding areas. …

This study looked at whether asking people to "opt in" or "opt out" of a clinical trial changes how many people with peripheral artery disease (PAD) actually join. Over 5,000 adults with PAD were contacted by email. The goal was to see which approach leads to more enrollment and …

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…

This study looked at how a special balloon coated with a drug called sirolimus derivative releases medication into the blood after being used to open blocked leg arteries. Six people with peripheral artery disease took part. The goal was to measure drug levels over time, not to t…