Could a vitamin B3 pill boost blood flow and brainpower in PAD patients?

NCT ID NCT06534944

Completed Disease control Sponsor: University of Oklahoma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether taking a daily supplement called nicotinamide riboside (a form of vitamin B3) for 4 weeks could improve blood vessel function and thinking skills in 8 older adults with peripheral artery disease. Researchers measured changes in blood flow in the arm and brain, as well as memory and attention. The study was small and open-label, meaning everyone knew they were getting the supplement, so results are very early and need confirmation in larger trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicotinamide riboside (a form of vitamin B3)
What this could lead to: If it works, this could point toward a simple supplement to improve blood flow and thinking in people with peripheral artery disease.
What could go wrong: This is a very small, early pilot study with only 8 participants and no placebo group. Results may not apply to everyone, and the supplement may not show clear benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIPHERAL ARTERY DISEASE

Contacts and locations

Locations

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

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