Could a vitamin B3 pill boost blood flow and brainpower in PAD patients?
NCT ID NCT06534944
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested whether taking a daily supplement called nicotinamide riboside (a form of vitamin B3) for 4 weeks could improve blood vessel function and thinking skills in 8 older adults with peripheral artery disease. Researchers measured changes in blood flow in the arm and brain, as well as memory and attention. The study was small and open-label, meaning everyone knew they were getting the supplement, so results are very early and need confirmation in larger trials.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nicotinamide riboside (a form of vitamin B3)
What this could lead to
If it works, this could point toward a simple supplement to improve blood flow and thinking in people with peripheral artery disease.
What could go wrong
This is a very small, early pilot study with only 8 participants and no placebo group. Results may not apply to everyone, and the supplement may not show clear benefits.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States