University Of Oklahoma

This study tests whether a 30-day alcohol abstinence challenge, supported by a mobile app, is feasible and helps reduce heavy drinking. Researchers will enroll 150 adults in Oklahoma who drink regularly. Participants will try to completely avoid alcohol for one month, and the stu…

This study tests a smoking cessation program for sexual and gender minority (SGM) adults in Oklahoma, Arkansas, and Texas. Participants get nicotine replacement therapy, a quit-smoking app, and join online volunteer activities to build social support. The goal is to help people q…

This study tests a smartphone app called Smart-T Alcohol that sends personalized messages to help homeless adults reduce their drinking. About 600 people from shelters in Dallas and Oklahoma City will either get the app plus usual care, or usual care alone. The goal is to see if …

This study tests whether offering money to couples who both smoke can help them quit. About 900 couples will be split into three groups: one gets standard quit-smoking help, another adds rewards for the main smoker, and a third rewards both partners. The goal is to see if rewardi…

This study tests whether a daily dose of nicotinamide riboside (a form of vitamin B3) can improve blood flow and activity in the brains of healthy adults aged 60 to 85. Over 8 weeks, 214 participants will take either the supplement or a placebo. Researchers will measure brain blo…

This pilot study tests whether a mild electrical pulse to the ear (vagus nerve stimulation) can reduce inflammation and improve heart rate balance in people with septic shock. 34 participants will be randomly assigned to receive either active stimulation or a sham (placebo) for 4…

This study tests whether dapagliflozin, a diabetes medication, can reduce the amount of time people with diabetes spend in atrial fibrillation (an irregular heart rhythm). About 28 adults with both conditions will wear a heart monitor and complete quality-of-life surveys. The goa…

This study tests whether giving antibiotics to obese first-time mothers during labor induction can lower their chance of needing a C-section. About 787 women with a BMI of 30 or higher will be randomly assigned to receive either antibiotics or a placebo. The goal is to see if thi…

This early-phase trial is testing whether taking two hormone-blocking pills—relugolix and enzalutamide—before and after standard radiation or surgery can help cure high-risk locally advanced prostate cancer. About 46 men will participate to first find a safe dose, then see if the…

This study tests the safety of a new drug called OK-1 (SHetA2) in adults with advanced or recurrent solid tumors that have not responded to other treatments. About 50 participants will receive the drug to see what side effects occur and to find the best dose for future studies. T…

This study tests two immunotherapy drugs, cemiplimab and fianlimab, given after targeted radiation for kidney cancer that has spread to a few spots in the body. The goal is to see if adding fianlimab helps control the cancer longer than cemiplimab alone. About 72 adults with clea…

This study is testing whether people with advanced bladder cancer can switch to a milder treatment after an initial strong combination therapy. Participants first receive two drugs (pembrolizumab and enfortumab vedotin) for 24 weeks. If their cancer is controlled, they then recei…

This early study tests if a mild electrical pulse to a nerve in the ear (vagus nerve) can help protect the heart in people receiving strong chemotherapy for breast cancer or lymphoma. About 104 adults who recently started chemo and have extra heart risks will be randomly assigned…

This study tests whether a combination of two drugs, VS-6766 and defactinib, can shrink or control certain gynecological cancers that have come back. It includes women with endometrioid, ovarian, or cervical cancers that have specific gene changes (RAS, BRAF, or NF1). The goal is…

This study looks at whether eating more fiber and limiting when you eat can lower signs of cancer risk. Researchers will enroll 90 adults with obesity who currently eat little fiber. Participants will follow different diet plans to see how these changes affect weight, blood press…

This study tests if shining a special light on the head (transcranial photobiomodulation) can improve memory and thinking in people with mild cognitive impairment. Forty participants will receive either real or fake light sessions for 12 weeks. Researchers will measure brain acti…

This study tests a new, pain-free exercise program for people with peripheral artery disease (PAD), which causes leg pain when walking. Researchers will compare it to standard painful exercise over 3 months in 100 adults aged 40 and older. The goal is to see if the pain-free prog…

This study tests a single, 2-hour online pain management class called Empowered Relief for cancer survivors who have chronic pain. About 215 participants will be randomly assigned to take the class right away or wait 3 months. Researchers will measure pain intensity, how much pai…

This study tests an 8-week telehealth occupational therapy program designed to help breast cancer survivors increase physical activity after breast-conserving surgery or mastectomy. The program is delivered via Zoom and focuses on each survivor's preferred activities. Researchers…

This study tests whether warming the contrast dye used in a hysterosalpingogram (HSG) — a standard X-ray test for blocked fallopian tubes — can reduce pain and cramping during the procedure. About 240 women aged 18–45 will be randomly assigned to receive either warm or room-tempe…

This study tests whether practicing balance on a moving platform while blindfolded can help adults over 65 rely more on their body's internal sense of position (somatosensory input) rather than vision. Thirty participants will train for two weeks, with half wearing blindfolds dur…

This study tests whether combining the DASH diet (a heart-healthy eating plan) with a home-based walking program can improve walking ability and quality of life in people with peripheral artery disease (PAD). PAD causes leg pain during walking due to narrowed arteries. The study …

This study tests whether a vibrating ice pack shaped like a bee, called the Buzzy System, can reduce pain and fear in children aged 3 to 10 when their elbow fracture pins are removed. About 75 children will either get the Buzzy System plus distraction cards or just standard care.…

This study tests whether a powered exoskeleton can improve walking and daily function for people recovering from a stroke. About 50 participants in inpatient rehab will use the device during therapy. Researchers will measure changes in walking distance, independence, and muscle s…

This study tests whether giving ketamine during hemorrhoid surgery can reduce the amount of strong pain pills patients need afterward. About 100 adults with severe hemorrhoids will be randomly assigned to receive either ketamine or a placebo during their operation. Researchers wi…

This study is testing a mobile health app designed to help Black men who have had prostate cancer feel better and track their quality of life. About 248 participants will use the app and share their feedback on how easy it is to use and how it affects their physical, emotional, a…

This study tests whether a digital chest tube system (Thopaz+) works better than the standard analog system for children who need a chest tube after lung surgery or a collapsed lung. The digital system measures air leaks precisely and keeps steady suction, which may shorten how l…

This study tests whether a remotely delivered program that combines mindfulness, physical activity tracking, and social support is acceptable and feasible for people with metastatic breast cancer. The program lasts 8-12 weeks and includes a wearable activity tracker and weekly ch…

This study looks at whether a single dose of meloxicam (a different anti-inflammatory) can control pain better than the usual ibuprofen after Mohs surgery for skin cancer. About 300 adults will be split into three groups, each getting a different pain medicine routine. They will …

This study compares three types of radiation therapy for cancer that has spread to the spine, with the goal of relieving pain. About 240 participants will be randomly assigned to receive either standard external beam radiation, standard-dose stereotactic body radiation, or higher…

This study is testing a program to help Native American cancer patients get better coordinated care. It brings together a cancer center and tribal health systems to improve communication and support. About 187 adults newly diagnosed with cancer will take part. The goal is to see …

This study looks at whether eating more fiber can help head and neck cancer patients avoid muscle loss (sarcopenia). Researchers will track 59 adults from diagnosis for six months, measuring their fiber intake, muscle mass, and inflammation. The goal is to understand the link bet…

This study is testing whether a smartphone-based program that provides high-fiber foods and continuous glucose monitors can help young adults (ages 18-39) with prediabetes improve their blood sugar control. The main goal is to see if people find the program easy to use and stick …

This study tests whether creatine gummies raise blood levels as effectively as traditional creatine powder. Sixteen healthy adults will take both forms and have their blood measured. The goal is to see if the gummy form is a good alternative for people who dislike mixing powder.

This study recruits 300 young adults aged 18-24 who smoke cigarillos to understand how different flavors influence their smoking behavior and perceptions. Researchers will measure puff counts and self-reported rewards from smoking, and simulate how changing flavor availability mi…

This study aims to understand what makes it easier or harder for African American smokers to use a smartphone app designed to help them quit. Researchers will first get feedback from a small group to improve the app, then test it with 30 people who want to quit. The app sends rem…

This study looks at how a 12-week physical activity program, delivered through smartphone apps and a Fitbit, affects brain function in cancer survivors who report 'chemo-brain' (cognitive problems after chemotherapy). Researchers will compare survivors with and without type 2 dia…

This study looks at how the drug propranolol and nicotine patches, alone or together, change brain activity and cravings when smokers see smoking-related cues. Eighty daily smokers will undergo brain scans while viewing these cues. The goal is to understand the brain mechanisms b…

This study tests whether a special PET scan (18F FLT) can detect signs of leukemia or myeloma after treatment. About 60 people aged 4 to 80 with relapsed or hard-to-treat blood cancers will get the scan before and after therapy. Researchers will compare the scan results with stan…

This study tests two ways to encourage colorectal cancer screening among American Indians in Oklahoma. Participants will either watch a video of a real community health educator or interact with a virtual health educator. The goal is to see which method reaches more people and he…

This study tests whether a weak electrical current applied to the neck or upper back can change how muscles work and how tired they get. Healthy adults aged 18 to 50 will attend up to 6 sessions to measure force, effort, and muscle signals. The goal is to understand the effects, …

This study is testing two new ways to check if donated bone marrow cells are growing well after a transplant. Researchers will use a special PET scan (FLT imaging) and blood tests (TK1 levels) in about 56 people who are at high risk for graft failure. The goal is to find better t…

This study is looking at tiny pieces of tumor DNA (ctDNA) in the blood of 50 people with pancreatic cancer that can be surgically removed. Researchers want to see how often ctDNA is found and whether it relates to how long patients live without the cancer getting worse. The goal …

This study looks at whether Native American adults who smoke can lower their risk of chronic pain by quitting smoking for 4 weeks. Researchers will measure pain sensitivity and other health markers before and after a stop-smoking program. The goal is to see if this approach is fe…

This study looks at tumor samples from 150 Native American patients with prostate cancer. Researchers want to find genetic differences that may affect how the cancer grows and responds to treatment. The goal is to learn more so that future care can be better tailored for this gro…

This study tests whether shining a special light on the head (transcranial photobiomodulation) can improve blood flow and thinking in older adults. 30 healthy volunteers aged 21-85 will receive either real or fake light therapy sessions every other day for 4 weeks. Researchers wi…

This study looks at whether patient navigators can help African American, Native American, and Hispanic patients complete their radiation therapy for breast or prostate cancer. About 420 participants will fill out surveys before and after treatment to identify barriers and measur…

This study tests whether a smartphone app called Connect2Care can help African American men ages 45-69 learn about prostate cancer and feel ready to take a PSA screening test. About 266 men in Oklahoma who haven't been screened recently will use either the Connect2Care app or a s…