University Of Oklahoma

This early-stage trial is testing a new oral drug called OK-1 in adults with advanced solid tumors that have returned or spread despite other treatments. The main goal is to find a safe dose and understand the drug's side effects. Participants will take capsules twice daily in re…

This study is testing a new care coordination program designed specifically for Native American cancer patients. The program aims to improve communication between a cancer center and tribal health systems to provide better support. Researchers want to see if this culturally sensi…

This study is testing if patients with advanced bladder cancer who respond well to an initial 6-month combination treatment can safely switch to a single, less intensive drug. The goal is to see if this simpler maintenance therapy can control the cancer while reducing side effect…

This early study is testing if a simple, at-home device that gently stimulates a nerve in the ear can help protect the heart in people receiving chemotherapy for breast cancer or lymphoma. The goal is to see if this stimulation improves heart function and reduces inflammation. Ab…

This study is testing if a phone-based program can help young adults with prediabetes. The program teaches about high-fiber foods, delivers them to participants' homes, and uses a continuous glucose monitor to show how food affects blood sugar. Researchers want to see if this app…

This study is testing whether a combination of two drugs—nab-sirolimus and the hormone therapy fulvestrant—can help control recurrent low-grade ovarian cancer. It will enroll 37 patients who have seen their cancer return after prior treatment. Researchers will measure how well th…

This study is testing whether taking two oral drugs, VS-6766 and defactinib, together can help control recurrent gynecologic cancers like ovarian and cervical cancer. It is for women whose cancer has a specific genetic change and has come back or worsened after at least one prior…

This study aims to see if having patient navigators—guides who help patients through the healthcare system—improves completion rates of radiation therapy for breast and prostate cancer. It focuses on African American, Native American, and Hispanic/Latino patients. Researchers wil…

This study is testing if adding a dietary supplement called myo-inositol to the standard fertility drug letrozole helps women with Polycystic Ovary Syndrome (PCOS) get pregnant. About 168 women will be randomly assigned to take either the supplement or a placebo along with the dr…

This small, early-stage study is testing whether giving more doses of an existing prostate cancer immunotherapy, called Sipuleucel-T, can create a stronger immune response against the cancer. It will involve about 13 men with advanced prostate cancer that has spread and stopped r…

This study is testing whether adding a second immunotherapy drug (fianlimab) to a standard one (cemiplimab) works better at controlling cancer after patients receive precise, high-dose radiation. It will involve about 72 adults with clear cell kidney cancer that has spread to onl…

This early-stage trial is testing if combining two medications, relugolix and enzalutamide, can better control high-risk, locally advanced prostate cancer. About 46 men will take these drugs before and after their standard treatment, which is either surgery or radiation therapy. …

This study is testing a new type of imaging scan (FLT PET/CT) and a blood test to see if they can tell whether a patient's new bone marrow cells are growing successfully after a transplant. The goal is to find a better way to detect early graft failure so doctors can act faster. …

This study is testing a smartphone app designed to educate African American men about prostate cancer and encourage them to get screened. Researchers will compare the new app to an existing health app to see which one better increases knowledge and readiness for screening. The go…

This study is testing whether giving antibiotics during labor can help first-time mothers with obesity avoid C-sections and infections. It will involve about 787 women across multiple hospitals who are having their labor induced at or near their due date. Participants will be ran…

This study is testing whether a virtual health coach can help more American Indians in Oklahoma get screened for colorectal cancer. Researchers are working with tribal communities to create a digital program that provides culturally relevant information and makes it easy to order…

This study is testing whether two diet changes—eating more fiber and limiting daily eating to a specific time window—can lower markers linked to cancer risk. It will involve 90 adults with obesity who currently eat a low-fiber diet. Researchers will measure changes in weight, blo…

This study is testing a mobile app designed specifically for Black men who have or have had prostate cancer. The app provides education, tracks symptoms, and offers support to help improve daily life and well-being. Researchers want to see if using the app for a year helps partic…

This study is testing whether a remote program that combines mindfulness and gentle physical activity is helpful and practical for people living with metastatic breast cancer. The program is delivered through a smartphone app and aims to support mental, social, and spiritual well…

This study is testing if using warmed dye instead of cold dye during a standard fertility test (HSG) makes the procedure less painful and reduces false readings of blocked fallopian tubes. It will involve 240 women aged 18-45 who need this test as part of their fertility evaluati…

This study aims to find a better way to manage pain after Mohs surgery, a common procedure for skin cancer. Researchers are comparing three different pain relief plans, including a medication called meloxicam, to see which one works best. About 300 adults having this surgery will…

This study compares three different radiation therapy approaches to relieve pain caused by cancer that has spread to the spine. Researchers will randomly assign 240 patients to receive either standard external beam radiation or one of two more targeted, higher-dose radiation trea…

This research aims to understand the unique genetic makeup of prostate cancer in Native American men. By analyzing tumor samples from 150 participants, scientists will compare these genetic patterns to those in Caucasian patients. The goal is to discover differences that could le…

This early study is testing whether giving high doses of the common heartburn medication omeprazole is safe for pancreatic cancer patients before their surgery. Researchers want to see if the drug causes measurable changes in the cancer cells that might help future treatments. Th…

This study is testing a new type of imaging scan to see if it can find leftover cancer cells in people with leukemia or myeloma. Researchers want to know if the scan results match up with other standard lab tests. The goal is to see if this scan could one day help doctors better …

This study aims to understand why pancreatic cancer patients experience severe weight loss and muscle wasting (called cachexia). Researchers will examine tumor tissue from 100 patients undergoing surgery to identify genetic differences that might explain this condition. The study…

This pilot study aims to understand if quitting smoking for 4 weeks can improve the body's natural pain regulation systems in Native American smokers. Researchers will recruit 150 Native American daily smokers to test whether financial incentives for quitting smoking lead to meas…

This study is testing whether a non-invasive light therapy helmet can improve how the brain regulates blood flow during thinking tasks and if this helps memory and thinking skills in older adults. Researchers will compare the real light treatment to a fake one in 30 participants …

This study is testing a blood test that looks for tiny pieces of cancer DNA in people with pancreatic cancer that can be surgically removed. Researchers want to see if the test results are linked to how long patients live without their cancer getting worse. The goal is to gather …