University Of Oklahoma

This study tests whether giving antibiotics to obese first-time mothers during induced labor can lower their chance of needing a C-section. About 787 women with a BMI of 30 or higher will be randomly assigned to receive either antibiotics or a placebo. The goal is to see if this …

This study tests a combination of two drugs—nab-sirolimus and fulvestrant—in people whose low-grade serous ovarian cancer has returned. The goal is to see if the combo can shrink tumors or stop them from growing. About 37 adults with measurable disease will take part, and researc…

This study tests two drugs, VS-6766 and defactinib, in people with certain gynecological cancers that have come back. The goal is to see if the combination can shrink tumors and how safe it is. About 55 adults with specific gene mutations (RAS, BRAF, or NF1) will take part.

This study tests whether adding a second drug (fianlimab) to the immunotherapy cemiplimab can help keep kidney cancer from growing after radiation treatment. About 72 adults with kidney cancer that has spread to a few other spots will receive either cemiplimab alone or both drugs…

This study tests whether stimulating a nerve in the ear (vagus nerve) can reduce inflammation and improve heart function in people with septic shock, a life-threatening condition. About 34 participants will receive either active or sham stimulation for 4 hours, alongside standard…

This study is for people with advanced bladder cancer that has spread. After 24 weeks of two powerful drugs (pembrolizumab and enfortumab vedotin), participants whose cancer is controlled may switch to just pembrolizumab alone. The goal is to see if this lighter treatment keeps t…

This study tests whether a mobile health program that provides high-fiber foods, education, and continuous glucose monitors can help young adults (ages 18-39) with prediabetes improve their blood sugar control. The study will enroll 80 participants in the Tulsa area and measure h…

This early study tests if a mild electrical pulse to a nerve in the ear can help protect the heart in people receiving chemotherapy for breast cancer or lymphoma. Researchers will check heart function and inflammation markers in 104 adults who recently started chemo. The goal is …

This early-phase study tests whether giving extra doses of the immunotherapy drug Sipuleucel-T can create a stronger immune response against advanced prostate cancer that has spread and no longer responds to hormone therapy. About 13 men will receive three infusions over 14 weeks…

This study looks at whether eating more fiber and limiting when you eat can help lower the risk of cancer. Researchers will enroll 90 adults with obesity who currently eat little fiber. Participants will follow different diet plans to see how these changes affect body weight, blo…

This study tests whether a vibrating ice pack shaped like a bee (called the Buzzy System) can reduce pain and fear in children aged 3 to 10 when their elbow fracture pins are removed. About 75 kids will be enrolled, and researchers will measure pain and anxiety using special face…

This study is testing a mobile health app designed to help Black men who have had prostate cancer feel better and track their quality of life. About 248 participants will use the app and share feedback on how easy it is to use and how it affects their physical, emotional, and soc…

This study tests a class called Empowered Relief for cancer survivors who have chronic pain. About 215 people who have finished cancer treatment and are cancer-free will be randomly assigned to take the class right away or wait 3 months. The goal is to see if the class reduces pa…

This study tests whether warming the contrast dye used during a hysterosalpingogram (HSG) — a common fertility test — can reduce pain and prevent false blockages in the fallopian tubes. About 240 women aged 18–45 will be randomly assigned to receive either warm or room-temperatur…

This study tests an 8-week occupational therapy program delivered by video call to help breast cancer survivors become more physically active. It includes 38 adults who had breast-conserving surgery or mastectomy in the last year. The program is designed to fit each person's pref…

This study looks at tumor samples from 150 Native American patients with prostate cancer. Researchers will compare their genetic profiles to those of Caucasian patients to find differences that may affect treatment and outcomes. The goal is to better understand how genes influenc…

This study tests a painless light therapy called transcranial photobiomodulation (tPBM) to see if it can improve blood flow and thinking in older adults. Thirty healthy people aged 21-85 will receive either real or fake light sessions over 4 weeks. Researchers will measure brain …

This study looks at whether Native American adults who smoke can lower their risk of long-term pain by quitting smoking for 4 weeks. Participants will get help to stop smoking and then have pain tests, like cold water and mild electric shocks, to see how their body handles pain. …

This study aims to understand why some pancreatic cancer patients lose weight and muscle (cachexia) more than others. Researchers will compare genes and weight changes in 100 patients, with a focus on African Americans. The goal is to find patterns that could lead to better care …

This study looks at whether patient navigators—people who guide and support patients through their care—can help more African American, Native American, and Hispanic patients complete radiation therapy for breast or prostate cancer. About 420 adults will take part. The goal is to…

This study looks at whether older adults (65+) can improve their balance by training with their vision restricted. For two weeks, participants practice standing on a moving platform, either with full sight or limited sight. The idea is that limiting vision forces the body to rely…

This study recruits 300 young adults aged 18-24 who smoke cigarillos to understand how different flavors influence their smoking behavior and perceptions. Researchers will measure puff counts and self-reported rewards from smoking, and simulate what might happen if certain flavor…

This study is looking for better ways to tell if a bone marrow transplant is successful. Researchers will use a special imaging scan and blood tests on transplant patients to see if the new donor cells are growing properly in the bone marrow. The goal is to find early signs that …