University Of Oklahoma

This phase 2 trial is testing a combination of nab-sirolimus (Fyarro) and fulvestrant (Faslodex) in 37 people with recurrent low-grade serous ovarian cancer. The goal is to see if the drugs can shrink tumors or stop them from growing. Participants receive the drugs intravenously …

This phase II trial is testing a combination of two drugs—atezolizumab (an immunotherapy) and bevacizumab (a drug that cuts off blood supply to tumors)—in 110 women with advanced, recurrent, or persistent endometrial cancer. The goal is to see how many patients experience tumor s…

This early-phase trial is testing whether giving an extra dose of the immunotherapy drug Sipuleucel-T can strengthen the immune system's attack on prostate cancer that has spread and stopped responding to hormone therapy. Fifteen men with this advanced cancer will receive three i…

This phase II trial tests a combination of the immunotherapy drug pembrolizumab and a short course of radiation called QUAD SHOT in 30 adults with recurrent head and neck cancer that cannot be cured. The goal is to see if the combination is safe and can shrink tumors or improve q…

This study tests whether adding a myo-inositol supplement to the standard fertility drug letrozole helps women with polycystic ovary syndrome (PCOS) achieve pregnancy. About 168 women will receive either the supplement or a placebo alongside letrozole for up to 5 treatment cycles…

This early-phase trial is testing whether adding the immunotherapy drug pembrolizumab to standard radiation and chemotherapy is safe and feasible for people with high-intermediate risk endometrial cancer. About 45 participants who have already had surgery to remove the uterus wil…

This early-phase trial tests whether combining two drugs—avelumab (an immunotherapy) and AVB-S6-500 (a targeted therapy)—is safe and can help people with advanced bladder cancer that has worsened after chemotherapy. Nineteen adults with inoperable or metastatic urothelial carcino…

This study tests whether offering financial incentives through a mobile phone app can help low-income adults quit smoking. 532 participants will receive either standard care (phone counseling and nicotine patches/gum) or standard care plus mobile rewards for verified abstinence. …

This Phase 2 trial is testing whether combining two drugs, niraparib and dostarlimab, can help shrink or control cervical cancer that has come back or spread. About 66 women with recurrent or progressive cervical cancer will receive the treatment. The goal is to see how many resp…

This study tests a drug called TPST-1495 in people with endometrial or colorectal cancer who are scheduled for surgery. The drug aims to help the immune system fight cancer by blocking certain signals. Researchers will check blood and tumor samples before and after treatment to s…

This early-stage study tests whether adding an experimental drug called OKN-007 to standard chemoradiotherapy is safe and tolerable for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 27 participants will receive the combination after surgery. The mai…

This study tests whether a simple 30-second ECG using a handheld device can find undiagnosed atrial fibrillation (an irregular heartbeat) in people aged 65 and older with cancer. About 500 participants will be randomly assigned to either get the quick screening or usual care. The…

This study compares two methods for detecting serious prostate cancer: MRI fusion biopsy and micro-ultrasound (ExactVu). Researchers want to see if micro-ultrasound can find dangerous cancers as well as MRI, and if it can be used in communities with limited healthcare access. The…

This study is testing a new imaging device called MSOT that uses light and sound to create detailed pictures of neck lymph nodes in people with head and neck cancer. The goal is to see if it can more accurately detect cancer spread and radiation-induced scarring than current meth…

This study aimed to test a new smoking cessation program for adults who identify as sexual or gender minorities and experience high social stress. The program combined standard support (behavioral counseling and nicotine replacement therapy) with remote volunteer activities to he…

This study tests whether a smartphone app designed for people with serious mental illness can help them quit smoking. About 64 adults who smoke heavily and have a mental illness will use one of two special apps or a standard app for 5 weeks. All participants also get nicotine pat…

This study tests whether an artificial intelligence (AI) device helps gastroenterology fellows (doctors in training) find more polyps during colonoscopy. Eight fellows will perform colonoscopies with or without AI assistance, and researchers will compare how many polyps they dete…

This study looks at whether taking melatonin can change how your heart and blood vessels respond to a cold stress test, both at rest and during exercise. Researchers will measure things like blood pressure, heart rate, and oxygen levels in muscles and the brain. The study involve…

This study looks at whether postural tachycardia syndrome (POTS) is caused by an autoimmune reaction. Researchers are testing if electrical stimulation of the vagus nerve can improve symptoms, reduce inflammation, and calm the immune system. The study includes 80 people with POTS…

This pilot study explores whether a mobile breath tester can measure dietary fiber intake by tracking hydrogen and methane levels. Researchers will enroll 30 adults already in a larger fiber study. Participants use a handheld device daily for three months, and the data is compare…

This study looks at a protein called DCAMKL-1, which may be a stem cell marker in pancreatic cancer. Researchers want to see how its levels change before and after treatment in 60 patients. The goal is to understand how current therapies affect this marker, not to test a new trea…

This study works with the Choctaw Nation to help more people get screened for lung cancer. Lung cancer is a leading cause of death in American Indian and Alaska Native communities, and screening can catch it early. The program will identify who is eligible, help them schedule and…

This study was designed to find out if people who use cannabis regularly need different amounts of sedation drugs during oral surgery. It planned to compare sedation needs between cannabis users and non-users having teeth extracted. However, the study was withdrawn before enrolli…

This pilot study tests whether a smartphone app called Prostate Cancer Genius can help African American men learn about prostate cancer and complete a home-based PSA test. Eighty men aged 55 to 69 from Oklahoma who haven't had a PSA test in two years will use either the new app o…

This early-phase study tests whether taking a low dose of aspirin daily for two weeks before surgery can change the immune environment of the fallopian tubes. Researchers will compare tissue from 18 women who take aspirin to control samples, looking for signs of reduced inflammat…

This study reviews medical records of 72 American Indian patients treated with immunotherapy for cancers like lung cancer, melanoma, and kidney cancer. Researchers compare their outcomes—such as how long the cancer is controlled and side effects—to those of White patients. The go…

This pilot study aimed to see if a mobile health app could help track symptoms and quality of life in people with recurrent head and neck or gynecologic cancers. Participants would have used the app to report their feelings, side effects, and barriers to care. However, the study …

This study planned to test whether an electromagnetic resonator could change how the autonomic nervous system works in people with heart failure. It would have included 20 heart failure patients and 20 healthy volunteers. However, the study was withdrawn before enrolling any part…