University Of Oklahoma

This pilot study tests whether an inhaled drug called AER101 can reduce glycolysis—the process cancer cells use to break down sugar for energy—in early-stage non-small cell lung cancer. Participants inhale the drug three times daily for two weeks before their scheduled surgery. T…

This early-phase study tests whether a special dye (methylene blue) activated by blue light can safely reduce bacteria in burn wounds. About 50 adults with partial- or full-thickness burns will receive either the light treatment or light alone during two dressing changes. The goa…

This study tests whether adding echothiophate iodide eye drops to standard atropine therapy can improve vision in children aged 3 to 18 with refractory amblyopia (lazy eye that hasn't improved with standard treatment). Twenty participants will use atropine nightly for 12 weeks, a…

This phase 2 trial tests whether disulfiram, a drug already approved for alcohol use disorder, can safely reduce joint inflammation in people with rheumatoid arthritis who are overweight. Twenty adults with active arthritis despite standard treatment will take either disulfiram o…

This study will test whether a smartphone app can help people with HIV in Laos quit smoking. About 1,200 smokers from eight HIV clinics will be split into two groups: one gets the app with tailored messages and videos, the other gets printed self-help materials. The goal is to se…

This study focuses on American Indian communities, who face high colorectal cancer death rates. Researchers will test a program where a navigator helps clinics and patients schedule diagnostic colonoscopies within 60 days after a positive screening. The goal is to improve early d…

This study aims to increase the number of Native Americans who get a follow-up colonoscopy after an abnormal home stool test. Colorectal cancer is a leading cause of cancer death, and Native Americans are affected more than others. Researchers will work with the community to crea…

This study tests if a ketamine oral rinse can relieve pain from mouth sores (mucositis) caused by radiation therapy in head and neck cancer patients. About 62 adults receiving radiation will use the rinse and report their pain levels. The goal is to see if this simple rinse impro…

This study tests three different types of tinted lenses—FL41 glasses, Biomedics55 contacts, and Altius grey-green contacts—to see which works best for reducing light sensitivity (photophobia) in people who get migraines or have other eye conditions. About 200 volunteers who have …

This study tests whether adding nicotine lozenges to standard smoking-cessation medication (varenicline) and using a smartphone app with medication reminders helps more people quit smoking. About 500 adults who smoke daily will be randomly assigned to different treatment combinat…

This early-phase study tests whether applying cannabidiol (CBD) with silicone ointment helps scars heal better after paramedian forehead flap surgery. Twenty-two adults will have half their scar treated with CBD plus silicone and the other half with silicone alone. Researchers wi…

This study tests whether applying cannabidiol (CBD) oil along with silicone patches can improve the appearance of scars after paramedian forehead flap surgery—a procedure often used to rebuild the nose. About 22 adults who have had this surgery will use CBD oil on one part of the…

This study tests a 6-week sleep health program for cancer survivors who have poor sleep and daytime fatigue. About 10 survivors will join weekly Zoom sessions to learn sleep tips and relaxation techniques. The goal is to see if the program is easy to use and helps improve sleep, …

This early study tests whether selpercatinib, a drug already used for certain cancers, can help with cachexia (severe weight loss and appetite loss) in people with advanced lung, colon, or pancreatic cancer. Seven participants will take the drug twice daily for 12 weeks, with reg…

This early-stage study tests whether adding a ketone supplement to a carbohydrate drink helps trained cyclists ride longer before fatigue sets in. Fifteen healthy cyclists aged 18-55 will do intense cycling tests, taking either the ketone drink or a plain carb drink. Researchers …

This study looks at whether eating chia seeds while breastfeeding can change the makeup of breast milk and reduce inflammation in mothers who are overweight. About 80 mothers will take chia seeds for 6 weeks, and researchers will measure nutrients and health markers in their milk…