Can a Sugar-Like supplement boost fertility in PCOS?
NCT ID NCT04407754
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding a myo-inositol supplement to the standard fertility drug letrozole helps women with polycystic ovary syndrome (PCOS) achieve pregnancy. About 168 women will receive either the supplement or a placebo alongside letrozole for up to 5 treatment cycles. The goal is to see if the combination leads to more clinical pregnancies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- myo-inositol and D-chiro inositol supplement
- What this could lead to
- If it works, this could offer a simple, low-cost supplement to boost pregnancy chances for women with PCOS taking letrozole.
- What could go wrong
- This is a small pilot trial, so results may not be definitive. The supplement might not improve pregnancy rates over letrozole alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
OUHSC Reproductive Medicine Clinic
Oklahoma City, Oklahoma, 73104, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Weight-Loss drug tame PCOS hormones?
- Could interval training and fasting tame PCOS insulin resistance?
- New PCOS study aims to map hidden patterns of the condition
- New hope for PCOS: extended letrozole or adding inositol may help ovulation
- New hope for PCOS: supplement combo aims to restore ovulation
- Could a protein boost make a PCOS supplement work better?