New hope for PCOS: extended letrozole or adding inositol may help ovulation

NCT ID NCT07635082

Completed Disease control Sponsor: Eman Basuni Ebrahim Mowad Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two approaches to help women with PCOS who did not ovulate after standard letrozole treatment. One group took letrozole for 7 days instead of 5, and the other took letrozole plus inositol. The goal was to see which method led to more ovulations and pregnancies. The trial involved 200 women aged 18-35 with a BMI of 30 or less.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: letrozole and inositol
What this could lead to: If successful, this could offer a new treatment option for women with PCOS who do not respond to standard letrozole therapy, potentially improving ovulation and pregnancy rates.
What could go wrong: This is a small, completed phase 2 trial, so results may not apply to all PCOS patients. The interventions may not work for everyone, and there are risks like multiple pregnancy or ovarian hyperstimulation.

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Conditions

The condition(s) this trial relates to.

polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POLYCYSTIC OVARY SYNDROME POLYCYSTIC OVARY SYNDROME (PCOS) WOMEN

Contacts and locations

Locations

Kafrelsheikh University Hospital

Kafr ash Shaykh, Kafr el-Sheikh Governorate, 33511, Egypt

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