Polycystic ovary syndrome

Researchers are testing whether intravenous infusions of donated mesenchymal stem cells from umbilical cord or placental tissue are safe for people with polycystic ovary syndrome (PCOS). The trial enrolls about 20 participants with ultrasound-confirmed PCOS. Doctors monitor for a…

This trial tests whether adding inositol or metformin to either a Mediterranean or low-carbohydrate diet improves insulin resistance in obese women with polycystic ovary syndrome (PCOS). About 90 to 102 participants will be randomly assigned to one of six groups and followed for …

This study tests whether exemestane, a drug typically used for breast cancer, can help women with polycystic ovary syndrome (PCOS) ovulate. Participants take either a low or high dose of exemestane or a placebo for 5 to 10 days. Researchers track ovulation through blood tests and…

This trial investigates whether taking capsules containing freeze-dried fecal matter from healthy donors—known as fecal microbiota transplantation (FMT)—can improve pregnancy outcomes and metabolic health in overweight or obese women with polycystic ovary syndrome (PCOS) who are …

This study tests whether a weekly injection of semaglutide (a GLP-1 drug used for obesity) can improve the brain's reproductive hormone signals in obese adolescent girls with polycystic ovary syndrome (PCOS). Twenty girls aged 12–18 will receive the drug plus lifestyle advice for…

This trial tests whether semaglutide, a drug used for diabetes and weight loss, can help restore ovulation in girls and women aged 12 to 35 with polycystic ovary syndrome (PCOS) and obesity. Participants receive semaglutide for 10 months, with doses increased over time. Researche…

This pilot study tests whether a 12-week diet that includes at least one daily serving of lean beef, as part of a healthy meal plan, can improve blood sugar control in adolescent girls with PCOS. Participants will receive nutrition counseling and free beef, and researchers will m…

This study tests whether taking vitamin D daily for 6 months can improve menstrual regularity and mood in teenage girls with PCOS who also have low vitamin D levels. Sixty participants will be randomly assigned to receive either vitamin D or a placebo, and neither they nor their …

This trial tests whether orlistat, a weight-loss medication, can improve hormonal and metabolic features in women with polycystic ovary syndrome (PCOS). Women aged 18-45 with PCOS will receive either orlistat or a placebo, alongside standard lifestyle advice, for three months. Th…

This study compares two common ovarian stimulation protocols used during IVF in women with polycystic ovary syndrome (PCOS). The PPOS protocol uses a progestin hormone to suppress ovulation, while the antagonist protocol uses a different drug. Researchers will track which method …

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This study is for non-diabetic women aged 21-40 with polycystic ovary syndrome (PCOS). It tests whether taking alpha lipoic acid and myo-inositol, either alone or with metformin, can improve menstrual regularity and ovulation. The goal is to manage PCOS symptoms and support ferti…

This study tests whether a daily fiber supplement (resistant starch, like Benefiber) can improve heart health markers and gut bacteria in women with polycystic ovary syndrome (PCOS). One hundred women will take either the fiber or a placebo for 12 weeks, alongside standard birth …

This study tests a new weekly injection called HEC88473 in 30 women with polycystic ovary syndrome (PCOS). The drug targets two pathways to improve hormone levels and menstrual cycles. Researchers will track changes in free androgen index and menstrual regularity over 24 weeks.

This early-stage study tests whether bicalutamide, a drug that blocks male hormones, can improve liver health in women aged 18-42 who have both polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD). About 50 participants will receive either bicalutamide or…

This phase 3 trial tests whether adding myo-inositol (a natural supplement) to standard clomiphene citrate treatment helps women with polycystic ovary syndrome (PCOS) ovulate more successfully. 276 women who want to become pregnant will be randomly assigned to receive either the …

This study tests a physical activity program called ActiveGirls in 40 girls ages 8-12 who are at higher risk for PCOS and insulin resistance. Some girls get health coaching plus text messages, while others get only texts. Researchers will see if the program is acceptable and if i…

This Phase 4 trial tests whether adding pioglitazone (a diabetes drug) to standard clomiphene citrate improves ovarian stimulation and pregnancy rates in 62 infertile women with polycystic ovary syndrome (PCOS). Participants are randomly assigned to receive either pioglitazone or…

This study looks at whether a 6-month diet low in sugar and high in fiber can improve insulin resistance, hormone levels, and menstrual cycles in 56 women with PCOS living in remote Yunnan, China. The diet is adapted to local eating habits to make it easier to follow. The goal is…

This early-stage trial is testing whether adding a natural extract called DLBS3233 to the standard fertility drug clomiphene citrate works better than clomiphene alone for women with PCOS. Researchers will measure changes in insulin resistance, ovarian function, and menstrual cyc…

This study tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve irregular periods and ovulation in women with PCOS who are overweight or have obesity. About 198 women will receive either tirzepatide or a placebo for 72 weeks, along with lifesty…

This study looks at whether adding melatonin to the standard drug metformin can improve insulin resistance in women with polycystic ovary syndrome (PCOS) better than metformin alone. Sixty women with PCOS and insulin resistance will be split into two groups: one gets melatonin pl…

This study looks at whether taking levocarnitine together with myoinositol works better than myoinositol alone for improving insulin resistance and hormone levels in women with PCOS who have trouble getting pregnant. 72 women aged 18-40 with insulin-resistant PCOS will take eithe…

This study compares three common treatments—birth control pills, progesterone, and inositol—to see which works best for restoring regular periods in women with PCOS. About 150 women aged 18-40 will take one of the treatments for 6 months. The goal is to find effective options tha…

This study looks at whether adding cabergoline to letrozole helps women with PCOS ovulate more often than letrozole alone. About 72 women aged 18-35 with PCOS-related infertility will take either the combo or just letrozole for up to 3 menstrual cycles. The goal is to see which a…

This study looks at whether taking fish oil and/or metformin for 12 months can improve heart health in women with Polycystic Ovary Syndrome (PCOS). PCOS raises the risk of heart disease and diabetes. The trial will enroll 146 women with PCOS who are overweight and have high blood…

This study looks at how losing weight and then regaining it (weight cycling) affects hormone levels and insulin resistance in women with Polycystic Ovary Syndrome (PCOS). Researchers will follow 425 women with PCOS, some at normal weight and some with overweight or obesity, as th…

This study compares taking the fertility drug letrozole for 10 days versus the usual 5 days in women with PCOS who want to get pregnant. About 20 women aged 18-40 will be randomly assigned to one of the two groups. The goal is to see if the longer treatment leads to more ovulatio…

This study compares two fertility treatments for women with polycystic ovary syndrome (PCOS): a simpler in vitro maturation (IVM) method with fresh embryo transfer versus standard in vitro fertilization (IVF) with frozen embryo transfer. The goal is to see which approach leads to…

This study tests whether adding quercetin or alpha lipoic acid to standard metformin therapy can improve hormone levels, blood sugar, and quality of life in women with PCOS. About 150 women aged 18-40 will be randomly assigned to one of three groups for three months. Researchers …

This study tests whether a higher protein diet (30% of calories from protein) can improve metabolic health in women with polycystic ovary syndrome (PCOS). Sixty women with PCOS will follow a calorie-restricted diet for 16 weeks, with some eating more protein. Researchers will mea…

This study tests whether adding levothyroxine (a thyroid hormone) to the standard fertility drug letrozole helps women with PCOS and mild underactive thyroid ovulate and get pregnant. Two hundred women will be randomly assigned to receive either letrozole alone or letrozole plus …

Researchers at Sohag University Hospital want to know how many women with acne also have polyendocrine metabolic ovarian syndrome, a hormonal and metabolic condition. The study enrolls 90 women aged 15 to 49 who have been diagnosed with acne. Doctors will check each participant f…

Researchers are testing transcranial direct current stimulation (tDCS), a non-invasive technique that applies a weak electrical current to the scalp, in people with neurological conditions like stroke and spinal cord disorders, and in women with gynecological conditions such as e…

Researchers are testing whether a personalized acupuncture program combined with lifestyle coaching can improve insulin resistance in women with polycystic ovary syndrome (PCOS). The trial enrolls 210 women aged 18 to 40 with a BMI of 25 to 40. Participants receive acupuncture se…

This study tests whether a four-week online mindfulness-based education program can help women with Polycystic Ovary Syndrome (PCOS) manage menstrual symptoms, lower stress, and improve quality of life. About 78 women with PCOS will be randomly assigned to either the program or r…

This trial tests whether a dietary supplement called MILAMEND Hormone Balance can improve quality of life and hormonal health in women aged 18-40 who have PCOS or likely have it. Participants take the supplement or a placebo daily for several months, tracking their menstrual cycl…

This trial investigates whether diaphragmatic breathing exercises can improve sleep quality in women with polycystic ovarian syndrome (PCOS). Fifty-four women aged 25-35 with PCOS and poor sleep will practice breathing exercises three times a week for eight weeks. The study measu…

This study tests two hands-on treatments—nerve stretches and muscle pressure release—to see which better reduces menstrual cramps, improves sleep quality, and lowers stress in women with Polycystic Ovary Syndrome (PCOS). 38 women aged 18-35 with PCOS and painful periods will be r…

This study tests whether a physical activity program can improve hormone levels and body measures in 40 women with PCOS who also have fatty pancreas and mild thyroid problems. Participants will follow an exercise plan, and researchers will track changes in sex hormones, blood sug…

This 12-week study at Ohio State University tests whether a keto diet or a mixed diet with ketone supplements can help women with PCOS have regular periods and improve hormone balance. About 40 women aged 18-40 will be randomly assigned to one of two groups. The goal is to see if…

This study looks at whether a special nutritional supplement (a mix of myo-inositol and D-chiro-inositol) can improve symptoms of Polycystic Ovary Syndrome (PCOS), like hair growth, acne, and irregular periods. Researchers will also check if it helps with metabolism, inflammation…

This study looks at whether adding regular walking to a low-calorie diet and metformin can improve lung function and weight in women who have both PCOS and asthma. Forty obese women will be split into two groups: one does exercise plus diet and metformin, the other only diet and …

This study looks at whether lifestyle changes can improve dry eyes in obese women with polycystic ovary syndrome (PCOS). Researchers will measure tear production and eye comfort in 40 women before and after the program. The goal is to see if weight loss and healthy habits can eas…

This study looks at whether taking magnesium and levocarnitine together can improve blood sugar, cholesterol, and unwanted hair growth in women with polycystic ovary syndrome (PCOS). About 84 women aged 19-65 with PCOS will take these supplements or a placebo for 12 weeks. The go…

This study looks at whether adding treadmill walking to a low-calorie diet can improve psoriasis and polycystic ovary syndrome (PCOS) in women. Forty obese women with both conditions will be split into two groups: one does diet plus walking, the other does diet only. The trial la…

This study tests whether combining virtual reality with plyometric exercises (jump training) can improve exercise capacity and reduce abdominal obesity in teenage girls aged 13 to 18. One hundred participants with a BMI of 30 or higher and a waist circumference over 80 cm will be…

Researchers at the University of Chicago are studying how obstructive sleep apnea affects mitochondrial function and cellular metabolism in women with Polyendocrine Metabolic Ovarian Syndrome (PMOS). Ten women aged 18 to 40 with PMOS and sleep apnea will receive two nights of CPA…

This study follows healthy girls ages 8-14 and teens with irregular periods to learn how their menstrual cycles become regular after their first period. Researchers also include girls at risk for PCOS and compare them to women with and without PCOS. The goal is to understand norm…

This study aims to understand how blood sugar levels change in women with Polycystic Ovarian Syndrome (PCOS). Participants will wear a continuous glucose monitor on their arm for certain periods over 6 months, have two blood draws, and complete a questionnaire. The goal is to gat…

This study looks at how things in your environment—like pollution, chemicals, diet, and sleep—might affect your hormones and reproductive health. Researchers will follow 300 people aged 8 and older who have conditions like low or high hormone levels, early or late puberty, or inf…

This study investigates why women with type 1 diabetes (T1D) frequently develop polycystic ovary syndrome (PCOS), a condition of high androgen levels. Researchers will compare five groups of 12 participants each, including women with T1D and PCOS, women with T1D alone, men with T…

This study uses MRI scans to compare brain structure, blood flow, and thinking skills in women with and without polycystic ovary syndrome (PCOS). Researchers want to understand whether PCOS affects overall brain health in reproductive-aged women. Participants complete two visits …

This study aims to find out whether some women diagnosed with polycystic ovary syndrome (PCOS) actually have a rare genetic condition causing severe insulin resistance. Researchers will compare 25 women with a known LMNA gene mutation (linked to lipodystrophy) to 50 women with cl…

This study is creating a risk assessment system to predict blood clotting abnormalities in women with polycystic ovary syndrome (PCOS). Researchers will analyze hormone, metabolic, and genetic factors in 100 participants aged 14 to 45. The goal is to help doctors personalize care…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that may explain why some groups face higher metabolic risks. The goal is to be…

This study looks at how androgens (a type of sex hormone) might affect fatty liver disease in young women. Researchers will compare changes in liver fat and stiffness over time in 150 women with and without PCOS. The goal is to understand the connection, not to test a treatment.

This study compares two ways to screen embryos in women with polycystic ovary syndrome (PCOS) undergoing IVF. One method looks at DNA methylation patterns (PIMS), while the other checks for chromosome issues (PGT-A). The goal is to see if PIMS can lower the rate of early pregnanc…

Polycystic ovary syndrome (PCOS) affects many women and raises the risk of type 2 diabetes. This study will use a continuous glucose monitor worn for 14 days to track blood sugar patterns in 80 women with different PCOS subtypes. The goal is to see which subtypes have the worst g…

This study looks at inflammation markers in the blood of women with PCOS, with or without insulin resistance, and compares them to women without PCOS. The goal is to understand how inflammation relates to metabolic problems in PCOS. Participants will have blood tests but no treat…

This study is measuring three proteins (kisspeptin, ghrelin, and zonulin) in the blood of women with and without PCOS to see if they can serve as early warning signs of insulin resistance. Researchers will compare levels among three groups: women with PCOS and insulin resistance,…

This study looks at three hormones (leptin, resistin, omentin-1) in women with PCOS, with or without insulin resistance, and compares them to women without PCOS. The goal is to better understand how these hormones relate to metabolic health. No treatments or interventions are giv…

This study aims to better understand polycystic ovary syndrome (PCOS) by collecting data and blood samples from 3000 women aged 18-45. Researchers will analyze factors like body measurements, skin health, diet, sleep, and hormones to find new biomarkers. The goal is to improve pe…

This study is observing 100 women with polycystic ovary syndrome (PCOS) in Alsace, France. Researchers want to understand why diagnosis is often delayed and how the condition varies from person to person. They will measure things like obesity rates and insulin resistance. No new …

This study is testing a new, safe imaging technique called photoacoustic imaging to look at brown adipose tissue (BAT), a type of body fat that burns energy. Researchers will compare BAT in healthy adults and people with metabolic syndrome to see if the imaging can spot differenc…

This pilot study looks at gene activity in cumulus cells (cells that surround eggs) from 10 women with PCOS undergoing a special lab-based egg maturation technique called CAPA-IVM. Researchers want to see if these gene patterns can predict which eggs will develop into healthy emb…

This study looks at whether chlordecone, a pesticide still present in the environment in Guadeloupe, is linked to fertility problems in women. Researchers will measure a key fertility hormone (AMH) and count egg follicles in 634 women seeking fertility treatment. The goal is to u…

This study looks at how different treatments for Polycystic Ovary Syndrome (PCOS) affect the heart and blood vessels. Researchers will compare four approaches: a GLP-1 receptor agonist, birth control pills, metformin, and lifestyle changes alone. They will measure changes in hear…

This study compares how a single meal with plant protein versus animal protein affects metabolism, appetite, and energy use in 30 women with PCOS. Participants will eat a test meal and have their responses measured for 4 hours. The goal is to see if one protein source leads to be…