PCOS fertility boost? supplement myo-inositol tested in major trial
NCT ID NCT03059173
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether adding myo-inositol (a natural supplement) to standard clomiphene citrate treatment helps women with polycystic ovary syndrome (PCOS) ovulate more successfully. 276 women who want to become pregnant will be randomly assigned to receive either the supplement or a placebo, alongside their fertility medication. The goal is to see if the supplement reduces the number of women who do not ovulate at all during treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- myo-inositol and levomefolic acid (dietary supplement) plus clomiphene citrate (drug)
- What this could lead to
- If it works, this could offer a simple, low-cost supplement to help women with PCOS ovulate and become pregnant with fewer failed cycles.
- What could go wrong
- This is a phase 3 trial, but the supplement may not improve ovulation rates. Results may not apply to all PCOS patients, and side effects from clomiphene citrate are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU de Lille hôpital Jeanne de Flandre
RECRUITINGLille, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Weight-Loss drug tame PCOS hormones?
- Could interval training and fasting tame PCOS insulin resistance?
- New PCOS study aims to map hidden patterns of the condition
- New hope for PCOS: extended letrozole or adding inositol may help ovulation
- New hope for PCOS: supplement combo aims to restore ovulation
- Could a protein boost make a PCOS supplement work better?