University Hospital, Lille

This study tests a new device called PAGETEX that uses light therapy to treat a rare skin condition of the vulva called Paget's disease. The condition often comes back after surgery, so researchers want to see if this light treatment can control it better. About 24 women with non…

This study tests whether a blood-filtering procedure called rheopheresis can help heal severe skin wounds caused by calciphylaxis, a rare complication in people on dialysis. About 138 adults with end-stage kidney disease and at least one open wound will receive either standard ca…

This study looks at people with a rare type of stomach cancer called signet ring cell adenocarcinoma. It compares two treatment strategies: having surgery first, or having chemotherapy first followed by surgery. The goal is to see which approach helps people live longer and with …

This study tests whether adding myo-inositol (a natural supplement) to standard fertility treatment helps women with polycystic ovary syndrome (PCOS) ovulate. About 276 women who want to get pregnant will receive either myo-inositol or a placebo alongside clomiphene citrate. The …

This study tests whether Diroximel Fumarate, a drug already used for multiple sclerosis, can reduce harmful brain swelling that often occurs after a hemorrhagic stroke. The trial will enroll 192 adults who have had a stroke, giving the drug within 48 hours of symptoms. The goal i…

This study looks at 300 adults with atrial fibrillation (an irregular heartbeat) who have had a brain bleed. It compares three approaches to prevent future strokes: restarting blood thinners, using a device to close a part of the heart (left atrial appendage closure), or avoiding…

This study tests if weight-loss surgery is better than standard medical treatment for getting rid of nonalcoholic steatohepatitis (NASH) in obese people with advanced liver scarring. About 100 participants will be randomly assigned to either surgery or medical care. The main goal…

This study tests two drug combinations (teclistamab plus daratumumab or lenalidomide) in people aged 65 and older with newly diagnosed multiple myeloma who are not eligible for a stem cell transplant. The goal is to see if these combinations are safe and can achieve a very good p…

This study looks at whether adding radiation therapy after targeted drug treatment (sonic hedgehog inhibitors) can stop advanced basal cell skin cancer from returning. About 82 adults whose cancer fully disappeared on the drugs will either get radiation or not. The goal is to see…

This study tests a surgery called total pancreatectomy (removing the whole pancreas) combined with islet cell transplantation (placing insulin-making cells into the liver) for people with pancreatic or related cancers who are at high risk of complications from standard surgery. T…

This study compares two versions of gastric bypass surgery in severely obese people with type 2 diabetes. The goal is to see which method leads to diabetes remission (normal blood sugar without medication). About 396 participants will be randomly assigned to one of the two surgic…

This study is for people with a single liver tumor (hepatocellular carcinoma) who are scheduled for surgery. The goal is to see if giving a short course of high-precision radiation before the operation is safe and does not cause delays or serious side effects that would prevent s…

This study looks at whether draining large ovarian cysts (6 cm or bigger) caused by endometriosis, followed by hormone therapy, can lower the chance of the cysts coming back and protect fertility. About 62 women of childbearing age will take part. The goal is to find a better way…

This study tests a combination of a healthy gut bacteria (EXL01) and the immunotherapy drug nivolumab for people with advanced non-small cell lung cancer that has stopped responding to standard treatments. About 21 participants will receive the combination to see if it can help c…

This early-phase study tests whether specially engineered immune cells (CD19 CAR-T cells) are safe for adults with relapsed or treatment-resistant acute myeloid leukemia (AML) that carries a specific marker (CD19). Only 5 participants will be enrolled. The main goal is to check f…

This study tests a new way to follow patients after weight-loss surgery. Instead of regular clinic visits, patients use a connected scale at home to track their weight. The care team then adjusts follow-up based on weight changes. The goal is to help more patients maintain health…

This study tests the drug rapamycin in children with severe lymphatic malformations in the head and neck area that cannot be safely removed with surgery. The goal is to see if taking rapamycin for 6 months can shrink these growths by at least one-fifth and improve symptoms like p…

This study looks at whether having surgery to remove endometriosis from the bowel before IVF helps women with infertility get pregnant. About 120 women with painful, deep endometriosis will be randomly assigned to either surgery plus IVF or IVF alone. The main goal is to see whic…

This study tests a new treatment for a rare and aggressive lung cancer called malignant pleural mesothelioma. The treatment combines a light-activated therapy (photodynamic therapy) given during a procedure inside the chest, followed by an immunotherapy drug (nivolumab) that help…

This study follows one Parkinson's patient who has been receiving A-dopamine directly into the brain for years. The goal is to monitor long-term safety and carefully reduce the dose to avoid sudden withdrawal. Researchers will also help transition to an alternative treatment if n…

This study checks if a short questionnaire called T-ACE can correctly identify pregnant women who may be drinking alcohol at risky levels. Researchers will compare the questionnaire results with a blood test that measures alcohol use over the past three weeks. About 2,425 pregnan…

This study is developing a new blood test to quickly diagnose mucormycosis, a dangerous fungal infection that can be fatal if not treated early. Researchers will test the blood of 100 people, including those with the infection and those at high risk, to see if the test can accura…

This study tests a simple scale that general practitioners can use to spot frailty in independent seniors over 65. Frailty means increased weakness and risk of falls or hospital stays. The goal is to catch it early so doctors can help patients stay healthy longer. About 740 peopl…

This study is looking at whether two substances in the blood, called TFPI-1 and TFPI-2, can help tell apart people who have colorectal cancer from those who don't. About 303 adults aged 50 to 75 will take part. If these blood markers work well, it could lead to a simpler, less in…

This study looks at whether taking probiotics (good bacteria) along with regular tooth brushing can prevent gum inflammation in teenagers who have braces. Braces make it harder to clean teeth, often leading to gum problems. The study will involve 116 teens aged 12-16 and will com…

This study checks if pressing on the side of the neck can stop air from entering the stomach when children are given oxygen through a mask during anesthesia. It involves 72 children aged 2 to 10 having planned surgery. Researchers will use ultrasound to see if the maneuver works …

This study tests a new light therapy device called BUBOLight® for treating jaundice in newborns. Jaundice is common and usually harmless, but high bilirubin levels can be dangerous. The device uses two soft, light-emitting fabric strips placed on the baby. Researchers will check …

This study tests whether a new shoe called CHUT OTONOM® can help older adults who have fallen before walk better and lower their risk of falling again. Researchers will compare walking speed and stability when wearing these special shoes versus the person's usual shoes. About 94 …

This study compares a new surgical technique called TOETVA, which removes the thyroid through the mouth leaving no visible scar, to the standard neck incision surgery. The goal is to see if the new method is as safe and causes fewer complications in the first 24 hours after surge…

This study tests whether virtual reality exposure therapy (VRET) can help people with gambling disorder reduce their cravings and gambling behavior. About 124 participants will receive either VRET or standard imaginal exposure therapy as part of cognitive-behavioral therapy. The …

This study tests whether taking caffeine for 30 weeks can slow down memory and thinking problems in people with early-to-moderate Alzheimer's disease. About 248 participants will receive either caffeine pills or a placebo (fake pill) to see if caffeine helps keep their minds shar…

This study is for people with chronic sinusitis and nasal polyps who have trouble sleeping. Researchers want to see if endoscopic sinus surgery can improve sleep quality, especially deep sleep. Thirty adults will have their sleep measured before and three months after surgery to …

This study looks at whether regular exercise can help blood vessels work better in adults with type 1 diabetes who do not yet have complications. About 34 participants will be randomly assigned to an exercise program or usual care. The main goal is to measure changes in blood ves…

This study tests a device that sends mild electrical pulses to a nerve in the leg to help people with multiple sclerosis (MS) empty their bladder more completely. 68 adults with MS who use a catheter to urinate will use the device for 30 minutes daily for 12 weeks. Half will get …

This study looks at whether brain wave tests (EEG) done before and after heart surgery in babies under 1 year old can predict future learning, attention, or autism problems. About 50 infants will take part. The goal is to find early signs of brain injury so doctors can offer the …

This study follows 500 newborns from birth to age 4 to understand how breastfeeding influences gut health. Researchers collect cord blood and stool samples at key ages and track feeding habits. The goal is to see if exclusive breastfeeding leads to better gut health, measured by …

This study looks at whether increased pressure inside the belly (intra-abdominal hypertension) leads to tiny amounts of stomach fluid entering the lungs (microaspiration) in patients with severe liver disease (cirrhosis) who are on a breathing machine. Researchers will measure be…

This study follows 750 people with atrial fibrillation (AF) who are getting a catheter ablation procedure. The main goal is to find out which factors predict whether AF will return within 3 years. Researchers will also track serious heart problems and major bleeding. The results …

This study looks at how swelling around a brain bleed affects recovery. Researchers will follow 500 adults who had a spontaneous hemorrhagic stroke to see if the swelling is linked to long-term disability. The goal is to better understand this swelling so future treatments can ta…

This study looks at whether a toxin called deoxynivalenol (DON), often found in grains, might be a risk factor for inflammatory bowel disease (IBD). Researchers will measure DON levels in 100 adults—some with Crohn's disease and some without—to see how the body processes it and h…

This study follows 1000 people who had bariatric surgery 5 years ago to understand why some maintain weight loss while others do not. Researchers will track weight, surgery type, and other factors to identify predictors of success. The goal is to help doctors and patients choose …

This study tests a brain scanning technique called fNIRS to see how children with hearing loss respond to speech. Researchers will compare brain activity in 40 infants and toddlers, some with normal hearing and some using hearing aids. The goal is to develop a better way to evalu…

This study looks at how well pelvic organs move in women with endometriosis using dynamic MRI. Researchers want to see if measuring organ movement can help diagnose the disease better and explain why some treatments don't work. About 52 women with suspected endometriosis will tak…

This study is creating a large database and biobank from 2200 patients with chronic inflammatory diseases like lupus, multiple sclerosis, and severe asthma. Researchers will track disease activity, quality of life, and treatment responses over time. The goal is to identify new ma…

This study tests whether an AI tool can help doctors make more accurate diagnoses in kidney medicine. About 100 doctors will work through 10 online cases, with some getting AI suggestions and others not. The goal is to see if AI improves diagnostic accuracy and doctor confidence.

This study looks at how the body processes cortisol (a stress hormone) and bile acids (digestive fluids) in obese women before and after gastric bypass surgery. Researchers want to understand why these changes happen and how they might help with weight loss and metabolic health. …

This study is testing a new tool called PARKINSUN that helps people with Parkinson's disease talk with their doctors. The goal is to make sure patients' needs are heard and addressed during checkups. About 120 adults with Parkinson's will either use the tool or not during their v…

This study looks at whether a simple, non-invasive scalp exam (trichoscopy) can detect signs of organ damage in people with systemic scleroderma. Researchers will compare scalp images from 200 patients and healthy volunteers to find patterns linked to lung, kidney, or blood vesse…

This study observes 240 mothers (and optionally fathers) of children born with esophageal atresia, a condition where the esophagus doesn't connect properly to the stomach. Researchers want to see if learning about the condition before birth (antenatal) versus after birth (postnat…

This study looks at how weight-loss surgery changes bone marrow fat and bone density in 40 postmenopausal women with obesity. Researchers will compare two surgery types and check for links to diabetes, hormones, and other factors. The goal is to better understand why bone loss ha…

This study looks at how spinal anesthesia, commonly used for planned C-sections, affects the baby's nervous system. Researchers will monitor 50 pregnant women and their babies using a special device that tracks heart rate patterns. The goal is to see if the anesthesia causes any …

This study looks at how attention changes right after a seizure in people with epilepsy. Researchers will test attention and brain activity before and at several times after a seizure. The goal is to understand how seizures affect the brain's ability to focus. 100 adults with epi…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track inflammation, heart energy use, and thinking skills over time. The goal is to find early warning signs of heart failure and memory decline, so doctors can pers…

This study follows 320 people who had omega gastric bypass surgery 8-12 years ago to compare long-term side effects of two different loop lengths. The goal is to see which type causes fewer serious problems like hospital stays or disabilities. Results will help doctors choose saf…

This study looks at how people with Alzheimer's or frontotemporal degeneration process social information and how that relates to their behavior. Researchers will test 120 adults aged 40-85 using cognitive tasks and brain scans. The goal is to understand why some patients act dif…

This study looks at how often people with cystic fibrosis who take the drug combination ETI (Elexacaftor-Tezacaftor-Ivacaftor) have trouble breathing during exercise. Researchers will measure breathing during a 6-minute walk test and a step test. The goal is to understand if thes…

This study looks at how the inhaled medication BGF 160 changes the way people with stable COPD breathe. Researchers will measure breathing complexity and lung function in 35 adults aged 40-75. The goal is to understand how the drug works, not to test if it cures or controls the d…

This study is looking for DNA markers that might predict brain damage in older adults having a minimally invasive heart valve replacement (TAVR). Researchers will measure DNA methylation in blood before and after the procedure and compare it to brain scans. The goal is to find ne…

This study aims to better understand systemic sclerosis, a rare disease that causes skin hardening and organ damage. Researchers will analyze skin and blood samples from 40 adults to see how different cells behave. The goal is to find new clues for future treatments, not to test …

This study aims to understand why certain white blood cells (eosinophils) increase in DRESS syndrome, a serious and sometimes life-threatening drug allergy. Researchers will compare blood and skin samples from 80 adults with DRESS, other drug rashes, and healthy volunteers. The g…

This study is collecting information from 600 people with chronic high eosinophil levels (hypereosinophilia) or hypereosinophilic syndrome. Researchers want to understand the different symptoms, organ problems, and disease patterns over time. They will also look at genetic and en…

This study looks at why dumping syndrome (a condition causing dangerous low blood sugar after meals) happens in babies born with esophageal atresia, a birth defect where the esophagus doesn't connect to the stomach. Researchers will monitor 15 infants' blood sugar and heart rate …

This study looks at why some people with catatonia do not respond to the standard drug lorazepam. Researchers will measure drug levels in the blood after 72 hours and check for genetic differences that affect how the drug is broken down. The goal is to find early clues to identif…

This study compares standard 2D X-ray guidance with a 3D imaging technique called OCT during leg artery procedures. About 166 adults with blocked leg arteries will be randomly assigned to one of two groups. The goal is to see if OCT helps doctors place stents and inflate balloons…

This study looks at how having inflammatory bowel disease (Crohn's or colitis) as a child affects job and education in adulthood. Researchers will survey 460 adults diagnosed before age 17 to compare their work and school achievements with the general population. The goal is to u…

This study follows 300 teenagers aged 13-14 who were born with esophageal atresia, a condition where the esophagus is not fully formed. Researchers will collect health data and biological samples to learn about long-term problems like acid reflux, eating difficulties, and breathi…

This study looks at how a treatment called sacral neuromodulation (SNM) affects the body's automatic nervous system in people with overactive bladder. Researchers will measure heart rate changes during stimulation to see if they can predict who will respond well to the therapy. A…

This study is testing whether cameras, microphones, and wearable sensors can objectively measure how severe a person's depression is. Researchers will record interviews with 300 hospitalized adults with severe depression, analyzing facial expressions, voice, movement, heart rate,…

This study follows 417 older adults (65+) with mild cognitive impairment (MCI) for one year to identify what factors predict falls. Falls are common in this group and can speed up memory loss. The goal is to develop better, personalized fall prevention strategies. Participants wi…

This study is testing a simple food questionnaire called EvalSel to see how accurately it measures salt intake in hospitalized patients with high blood pressure or kidney disease. Researchers will compare the questionnaire results with a 24-hour urine test, the gold standard for …

This study looks at anxiety levels in men with low-risk prostate cancer who choose active surveillance (regular check-ups instead of immediate treatment) and their partners. Researchers will use questionnaires to measure anxiety and find out what factors contribute to it. The goa…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that control sugar and fat metabolism. Researchers will collect biological samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more abou…

This study aims to find out how common eyelid eczema is in adults with atopic dermatitis (eczema). Researchers will examine 550 adults in France to describe the eyelid symptoms and look for related factors like allergies or other health issues. The goal is to better understand th…

This study looks at 50 women aged 25-35 who lost their periods after breast cancer chemotherapy. Researchers want to see if factors like body weight, physical activity, and sleep patterns affect when menstruation returns. The goal is to better predict fertility recovery after can…