University Hospital, Lille

This phase 3 trial tests whether adding N-acetylcysteine or extending prednisolone treatment beyond the standard 30 days can improve outcomes for people with severe alcoholic hepatitis. About 477 participants will be enrolled. The goal is to see if these strategies increase the n…

This study tests whether Diroximel Fumarate, a drug already used for multiple sclerosis, can reduce harmful brain swelling that often occurs after a hemorrhagic stroke. The swelling, called perihematomal edema, can worsen recovery. The trial will enroll 192 adults who have had a …

This study tests whether the drug rapamycin can shrink large, hard-to-treat lymphatic malformations in the head and neck area of children. Over 6 months, 28 kids will take oral rapamycin, and doctors will measure changes using MRI scans and quality-of-life surveys. The goal is to…

This study compares two surgical approaches for women with urogenital prolapse but without significant posterior vaginal wall prolapse. One group receives a single mesh in the front, while the other gets an additional mesh in the back as a preventive measure. The goal is to see i…

This study tests a simple change at birth: instead of clamping the umbilical cord right away, doctors will keep it intact while helping the baby breathe. The goal is to see if this improves heart and lung function in full-term infants with congenital diaphragmatic hernia (CDH), a…

This study tests a 4-week prehabilitation program combining exercise, nutritional supplements, and psychological support for patients with sarcopenia (muscle loss) who are about to have pancreatic cancer surgery. The goal is to see if this program reduces serious complications li…

This study tests whether a step-by-step care plan (algorithm) can lower the chance of another serious stomach or nose bleed in people with von Willebrand disease. About 66 adults who have had such a bleed will be randomly assigned to either the new plan or standard care. The goal…

This study follows 900 adults with severe chronic sinusitis and nasal polyps who are taking biologic drugs. Researchers will track how these treatments affect quality of life, symptoms, and side effects over 5 years. The goal is to see which patients benefit most based on their h…

This study looks at the best way to treat a rare and aggressive stomach cancer called signet ring cell adenocarcinoma. It compares two strategies: starting with surgery or starting with chemotherapy before surgery. About 314 patients will take part to see which approach helps peo…

This study compares virtual reality exposure therapy (VRET) to standard imaginal exposure therapy for people with gambling disorder. Both treatments are combined with cognitive-behavioral therapy (CBT) over 12 sessions. The goal is to see if VRET is as good as or better than imag…

This study looks at whether regular exercise can improve how well blood vessels work in adults with type 1 diabetes who do not yet have complications. About 34 participants will be randomly assigned to an exercise program or usual care. The main goal is to see if exercise helps b…

This study tests whether a personalized blood transfusion approach, based on oxygen levels, is better than the standard method for people on a heart-lung machine (ECMO) due to severe heart failure. About 236 adults will be randomly assigned to one of two strategies to see which r…

This study is testing a new device called PAGETEX that uses light therapy (photodynamic therapy) to treat a rare skin condition called vulvar Paget's disease. The disease often comes back after surgery, so researchers want to see if this light treatment can control it better. Abo…

This study looks at whether surgically removing deep endometriosis from the bowel before IVF improves pregnancy rates compared to IVF alone. It includes 120 women with infertility and pain from deep endometriosis. Participants are randomly assigned to either have surgery then IVF…

This study tests if weight-loss surgery is better than standard medical treatment for making nonalcoholic steatohepatitis (NASH) with advanced liver scarring disappear without making the scarring worse. It involves 100 obese adults with NASH and significant liver fibrosis. Partic…

This phase 3 trial tests whether adding myo-inositol (a natural supplement) to standard clomiphene citrate treatment helps women with polycystic ovary syndrome (PCOS) ovulate more successfully. 276 women who want to become pregnant will be randomly assigned to receive either the …

This study looks at people with an irregular heartbeat (atrial fibrillation) who have had a brain bleed. Doctors are unsure if blood thinners are safe for them. The trial compares two options: the blood thinner apixaban or a procedure to close a part of the heart (left atrial app…

This study tests a blood filtering procedure called rheopheresis to treat calciphylaxis, a rare condition causing painful skin wounds in people on dialysis. About 138 participants will receive either rheopheresis or a sham procedure to see if it helps wounds heal completely withi…

This study tests a new way to follow patients after weight-loss surgery. Instead of yearly check-ups, patients use a connected scale at home, and doctor visits are scheduled based on weight changes. The goal is to see if this personalized approach helps patients maintain weight l…

This study compares two versions of Roux-en-Y gastric bypass surgery to see which one is better at putting type 2 diabetes into remission in severely obese patients. The trial will enroll 396 people with a BMI of 35 or higher and type 2 diabetes. Participants will be randomly ass…

This early study tests whether giving focused radiation to a liver tumor a few weeks before surgery is safe and practical. The goal is to kill microscopic cancer cells around the tumor that often cause the cancer to return after surgery. Thirty patients with a single liver cancer…

This study looks at a treatment for large ovarian cysts caused by endometriosis (6 cm or bigger). The approach involves draining the cyst during a keyhole surgery and then using hormone therapy to lower the chance of the cyst coming back and to protect the ovaries. The goal is to…

This study is testing an inhaler called BGF 160 (also known as Breztri Aerosphere) in 35 adults with stable COPD. The goal is to see how the medicine changes the complexity and variability of breathing patterns over 30 days. Participants will use the inhaler twice daily, and rese…

This early-phase study tests whether specially engineered immune cells (CAR-T cells) that target a protein called CD19 are safe for adults with acute myeloid leukemia (AML) that has come back or not responded to treatment. Only patients whose leukemia cells show high levels of CD…

This study is for people with advanced basal cell skin cancer that has completely disappeared after taking targeted pills (vismodegib or sonidegib). The problem is that the cancer often returns when the pills are stopped. Researchers want to see if giving a short course of radiat…

This early-phase trial tests whether a capsule containing a healthy gut bacterium (EXL01) can boost the effectiveness of the immunotherapy drug nivolumab in people with advanced non-small cell lung cancer that has stopped responding to prior immunotherapy. The study will enroll 2…

This study tests a two-step surgery for people with pancreatic or related cancers. Instead of the standard partial removal, doctors remove the entire pancreas and then transplant the patient's own insulin-making cells into the liver. The goal is to prevent a common complication (…

This study tests a new two-step treatment for people with malignant pleural mesothelioma, a rare and serious cancer of the lung lining. First, doctors use a special light therapy during a scope procedure to kill cancer cells. Then, patients receive an immunotherapy drug called ni…

This study is testing a new drug called teclistamab, given as a shot, together with either daratumumab (another shot) or lenalidomide (a pill) in people aged 65 and older who have just been diagnosed with multiple myeloma and cannot have a stem cell transplant. The goal is to see…

Mucormycosis is a serious fungal infection with a high death rate, and early treatment is critical. This study is testing a new blood test that looks for a unique sugar marker from the fungus. Researchers will compare results from 100 people—those with the infection, those at hig…

This study tests whether a quick blood test (CT-ADP) can help doctors detect and fix leaks around a new heart valve during a minimally invasive TAVI procedure. Currently, doctors often use general anesthesia and an ultrasound probe in the throat to check for leaks, but this study…

This study is testing whether two substances in the blood, called TFPI-1 and TFPI-2, can tell the difference between people who have colorectal cancer and those who don't. About 303 adults aged 50 to 75 will take part, including some with suspected cancer and some without symptom…

This study looks for a specific immune problem called SPAD in adults aged 18-65 who get frequent or severe bacterial infections. By testing the immune response to a pneumonia vaccine, researchers hope to find the hidden cause and see if treatments like antibiotics or immunoglobul…

This study is checking whether a short self-report questionnaire called T-ACE can accurately identify pregnant women who drink alcohol at high-risk levels. About 2,425 pregnant women in three French hospitals will fill out the questionnaire and then give a blood sample to measure…

This study tests whether people with schizophrenia who hear voices that medication doesn't help can learn to quiet them using a special brain-training technique. Participants get real-time feedback from an fMRI scanner to help them shift their brain activity away from the halluci…

This study looks at whether a new shoe called CHUT OTONOM® can improve walking and lower the risk of falls in people aged 65 and older who have fallen at least once in the past six months. Participants will walk with their own shoes and then with the study shoes so researchers ca…

This study looks at whether endoscopic sinus surgery can improve sleep in people with chronic sinusitis and nasal polyps. Researchers will measure sleep quality before and after surgery in 30 participants. The goal is to see if removing polyps and opening blocked sinuses helps wi…

This study tests whether taking caffeine for 30 weeks can slow down memory and thinking problems in people with early-to-moderate Alzheimer's disease. About 248 adults aged 50 and older will receive either caffeine pills or a placebo (dummy pill) to see if caffeine helps keep the…

This study compares a new surgical technique called TOETVA, which removes the thyroid through the mouth leaving no visible scar, to the standard anterior neck surgery. About 616 adults needing thyroid removal will be randomly assigned to one of the two procedures. The main goal i…

This study tests a non-invasive treatment called transcutaneous tibial neuro-stimulation (TTNS) to help people with multiple sclerosis who have trouble emptying their bladder. Participants will use a device at home for 30 minutes each day for 12 weeks. The goal is to see if this …

This study tests a tool called PARKINSUN that helps people with Parkinson's disease communicate better with their doctors during visits. 120 participants will be split into two groups: one uses PARKINSUN during appointments, the other does not. The goal is to see if the tool impr…

This study tests a new phototherapy device called BUBOLight® for treating jaundice in newborns. Jaundice causes yellowing of the skin and, if severe, can lead to brain damage. The device uses two removable strips of light-emitting fabric to deliver phototherapy. The study will en…

This study looks at whether treating gestational diabetes early (before 24 weeks) is better than waiting until the standard 24-28 week screening. About 2,010 pregnant women with mild early high blood sugar will be randomly assigned to either start intensive treatment right away o…

This study follows 1,500 French patients with advanced cutaneous squamous cell carcinoma (a type of skin cancer) who need systemic treatment (medication that works throughout the body). Researchers will collect information from medical records and ongoing visits to see how treatm…

This study collects blood and tumor samples from 700 adults receiving approved CAR-T therapy for blood cancers. Researchers will analyze these samples to identify biological markers that predict whether the therapy will work or if the cancer will return. The goal is to improve fu…

This study is looking at whether a blood test measuring DNA methylation can predict the risk of silent brain injury in elderly patients undergoing TAVR, a minimally invasive heart valve replacement. About 542 people over age 70 with severe aortic stenosis will have their DNA test…

This study looks at why teenagers who had surgery for a diaphragmatic hernia right after birth may find it hard to take part in sports and physical activities. Researchers will interview 20 teens and their parents, and use questionnaires to identify what helps or hinders their pa…

This study is building a large French database of patients with three rare skin cancers: Merkel cell carcinoma, advanced basal cell carcinoma, and cutaneous adnexal carcinomas. Researchers will track up to 9,000 participants to learn how these cancers behave, what factors affect …

This study follows 20 people from families with a genetic risk for frontotemporal dementia (FTD), including those already diagnosed and those at risk. Over five years, researchers will track changes in health and brain function to better understand how the disease develops. The g…

This study looks at whether a quick ultrasound of the heart can help doctors decide how much fluid to give children after major surgery. Giving too much fluid can be harmful, but there aren't good tools to guide this in kids. The researchers will measure blood flow changes in the…

This study looks at 100 adults with catatonia, a severe movement and mood disorder. Researchers want to see if the amount of lorazepam in the blood after 3 days of treatment can predict who will get better. They also check if certain genes affect how the body processes the drug, …

This study looks at how inflammation and liver repair differ in people with alcoholic hepatitis versus those with alcoholic cirrhosis or healthy livers. Researchers will collect blood, liver tissue, and fluid samples from 450 participants. The goal is to better understand what dr…

This study looks at whether certain molecules can fix nonsense mutations in the CFTR gene, which cause cystic fibrosis. Researchers will take cells from the noses of 85 people with cystic fibrosis and test different molecules to see which ones can restore the function of the CFTR…

This study follows 1,000 people who had bariatric surgery 5 years ago to learn why some maintain significant weight loss while others do not. Researchers will track weight, type of surgery, and other factors to improve patient counseling and tailor surgical choices. The goal is t…

This study is collecting blood samples and health data from 10,000 hospitalized patients with metabolic diseases like diabetes, obesity, or metabolic syndrome. Researchers will analyze genetic and other markers to create a personalized risk profile for death. The goal is to impro…

This study follows 270 young women treated for lymphoma with chemotherapy to see how their ovaries recover over 5 to 10 years. Researchers measure hormone levels and egg counts to understand long-term fertility and pregnancy rates. The goal is to help doctors give better advice o…

This study follows 7,500 heavy drinkers over time to learn how alcoholic liver disease develops and worsens. Researchers will use non-invasive tests like ultrasound and blood markers to identify who is at risk for cirrhosis and liver cancer. The goal is to improve screening and e…

This study uses brain MRI scans to look for tiny old bleeds (microbleeds) in 200 adults with severe hemophilia or von Willebrand disease. Researchers want to see how common these microbleeds are and whether they are linked to memory or thinking difficulties. Participants will als…

This study follows 417 older adults (65+) with mild cognitive impairment (MCI) for one year to identify what factors predict falls. Participants will be monitored through diaries and monthly calls. The goal is to develop better fall prevention strategies for this vulnerable group…

This study is building a large collection of blood, tumor tissue, and fecal samples from 500 people with lung cancer. Researchers will track how patients respond to standard treatments and look for biological clues that predict success or failure. The goal is to better understand…

This study looks at people who use nitrous oxide (laughing gas) for fun, some with and some without nerve problems like trouble walking or numbness. Researchers want to find blood markers that show how the gas harms the body, which could lead to better monitoring and care. About …

This study follows 180 infants who had COVID-19 around birth to see if the infection affects hormone levels and development. Researchers focus on a temporary hormone surge called minipuberty, which is important for growth. By measuring hormones and developmental milestones, they …

This study is observing heavy drinkers with jaundice to learn more about alcoholic hepatitis, a serious liver condition. Researchers will track survival and liver function over 12 months, and collect genetic samples to better understand the disease. The goal is to improve diagnos…

This study compares three types of hip replacement surgery—traditional total hip arthroplasty, a neck-preserving Minihip, and hip resurfacing—to see which one best restores the hip's natural biomechanics. Researchers will use CT scans and X-rays before and after surgery to measur…

This study is testing a new, non-invasive method to predict bleeding risk in people with von Willebrand disease and other inherited bleeding disorders. Researchers will use a special microscope to look at tiny blood vessels under the tongue. The goal is to see if the density of t…

This study uses blood samples from over 1,100 people to create artificial clots in the lab, mimicking brain hemorrhages. Researchers test a modified clot-busting drug (rtPA) to find the best dose for different bleeding risks. The goal is to improve clot removal and guide future t…

This study looks at whether special brain cells called tanycytes play a role in Alzheimer's disease and frontotemporal dementia. Researchers will measure hormone levels in blood and spinal fluid from 102 participants to see if these cells help control metabolism and hormone signa…

This study will observe 1,000 critically ill patients in European ICUs to see if those with weakened immune systems are more or less likely to pick up drug-resistant bacteria. Researchers want to understand if current isolation measures are working and how to better control the s…

This study looks at how a single session of exercise changes blood markers related to brain health in people who use cannabis regularly compared to those who don't. Researchers will measure endocannabinoids and other substances in the blood, along with cognitive tests. The goal i…

This study tests whether a phone-based check-in system can improve mental health outcomes for women who have experienced violence. Researchers will call some participants a few weeks after their forensic exam and offer support, while others receive standard care. The goal is to s…

This study is building a large database of 15,000 patients with esophageal or gastric cancers in France. Researchers will look back at medical records to see how patients fared after surgery, focusing on how long they stayed cancer-free. The goal is to learn more about survival, …

This study follows 320 people with small-to-moderate thoracic aortic aneurysms for up to 5 years. Researchers will track major complications like rupture or need for surgery, and look for factors such as high blood pressure or sleep problems that might speed up aneurysm growth. T…

This study follows 1,500 people who are scheduled for heart surgery or a less invasive valve procedure. Researchers want to learn what factors predict major heart problems later, like heart failure or stroke. No new treatment is being tested—the goal is to gather information to i…

This study will test if cameras, microphones, and wearable sensors can help doctors measure how severe a person's depression is. About 300 adults hospitalized for severe depression will be recorded during interviews and while wearing devices that track movement, heart rate, and b…

This study aims to understand how sacral neuromodulation (a nerve-stimulating device) changes the autonomic nervous system in people with overactive bladder. Researchers will measure heart rate variability in 40 adults during the device implantation procedure. The goal is to find…

This study is building a large database and biobank from 2200 people with chronic inflammatory diseases like lupus, multiple sclerosis, severe asthma, and psoriasis. Researchers will collect blood samples and track disease activity over time using standard medical scores. The goa…

This study looks at how social and emotional thinking skills relate to everyday behavior in people with Alzheimer's disease and similar conditions. Researchers will give 120 participants tests of social cognition and ask their study partners to complete behavior checklists. They …

This study looks at how a focal seizure (a seizure starting in one part of the brain) temporarily changes a person's ability to pay attention. Researchers will test 100 adults with epilepsy before and after a seizure using attention tasks and brain wave recordings. The goal is to…

This study looks at whether brain wave tests (EEG) done before and after heart surgery in babies under 1 year old can predict later learning or behavior problems, such as autism or ADHD. About 50 infants will be followed to age 2. The goal is to find early warning signs so that c…

This study follows 300 teenagers born with esophageal atresia, a condition where the esophagus is not fully formed at birth. Researchers will track common long-term problems like acid reflux, breathing issues, and growth, and collect blood and tissue samples to look for biologica…

This study looks at how swelling around a brain bleed affects recovery in 500 stroke patients. Researchers will use MRI scans and blood tests to understand the swelling's role. The goal is to find new ways to treat this devastating type of stroke.

This study looks at how cystic fibrosis patients who take the drug combination Elexacaftor-Tezacaftor-Ivacaftor (ETI) breathe during exercise. Researchers will measure lung function while patients walk or step, aiming to find out how many have limited breathing capacity. The resu…

This study aims to understand how a type of white blood cell called eosinophils contributes to DRESS syndrome, a severe and potentially life-threatening drug allergy. Researchers will compare blood and skin samples from 80 adults with DRESS, other drug rashes, and healthy volunte…

This study looks at whether a simple, non-invasive scalp exam called trichoscopy can help predict how severe systemic scleroderma is and whether it affects internal organs. Researchers will compare scalp images from 200 scleroderma patients and healthy volunteers. The goal is to …

This study follows 750 people with atrial fibrillation (an irregular heartbeat) who are getting a procedure called catheter ablation. The main goal is to learn why the heart rhythm problem returns in up to 45% of patients within a year after the procedure. Researchers will track …

This study looks at how two types of bariatric surgery (RYGB and SG) change bone marrow fat and bone loss in 40 postmenopausal women with obesity. Researchers will measure bone marrow fat before and after surgery and check for links to hormones, blood sugar, and bone markers. The…

This study follows 500 children from birth to age 4 to understand how breastfeeding influences gut health. Researchers collect stool samples and track digestive symptoms, focusing on a key immune marker called secretory IgA. The goal is to learn how early nutrition shapes long-te…

This study is collecting information from 600 people with chronically high levels of eosinophils (a type of white blood cell) or related organ damage. Researchers want to describe the different symptoms, disease patterns, and genetic factors involved. The goal is to better unders…

This study looks at how spinal anesthesia, commonly used in planned C-sections, affects the baby's nervous system. Researchers will monitor the baby's heart rate and the mother's vital signs in 50 pregnant women. The goal is to better understand and prevent complications like low…

This study tests whether an AI tool can help doctors make more accurate diagnoses in kidney medicine. About 100 doctors will review up to 10 online patient cases. Some doctors will see AI suggestions before giving their final diagnosis, while others will not. Researchers will com…

This study looks at anxiety levels in men with low-risk prostate cancer who are closely monitored instead of receiving immediate treatment, and also checks how their partners are doing. Researchers will use questionnaires to measure anxiety and find out what factors might predict…

This study looks at skin and blood samples from 40 people with systemic sclerosis (scleroderma) to understand why the disease causes scarring. Researchers will analyze individual cells to see how different types of fibroblasts and immune cells behave. The goal is to find new clue…

This study explores whether a brain-scanning technique called fNIRS can measure how well hearing aids help young children with hearing loss. Researchers will compare brain activity in 40 infants (3-18 months old) with normal hearing and those using hearing aids. If fNIRS proves r…

This study looks at whether a toxin called deoxynivalenol (DON), found in grains, might be a risk factor for inflammatory bowel disease (IBD). Researchers will measure DON levels in 100 people—some with Crohn's disease and others without IBD—to see how the body processes it. The …

This study follows 320 people who had omega gastric bypass surgery 10 years ago to compare long-term side effects between two surgical techniques (150 cm vs 200 cm loop). Researchers will check for serious complications, nutritional problems, and weight loss. The goal is to deter…

This study is testing a new food questionnaire called EvalSel to see how well it measures salt intake in hospitalized patients with high blood pressure or kidney problems. Researchers will compare the questionnaire results with a 24-hour urine test, which is the gold standard for…

This study tests whether pressing on the left side of the neck during mask ventilation can prevent air from entering the stomach in children aged 2 to 10. The maneuver is done with two fingers applying gentle pressure to compress the esophagus. Researchers will use ultrasound to …

This study follows 50 women aged 25-35 who lost their periods after breast cancer chemotherapy. Researchers will measure blood markers, physical activity, and sleep patterns to see if these factors are linked to when menstruation returns. The goal is to better understand why some…

This study looks at how well pelvic organs move in women with endometriosis using dynamic MRI. Researchers want to see if measuring this movement can help diagnose the disease better and explain why some treatments don't work. About 52 women with suspected endometriosis will take…

This study aims to find out how often adults with atopic dermatitis (eczema) have eyelid involvement. Researchers will examine 550 patients from two French hospitals using skin exams, allergy tests, and eye check-ups. The goal is to better understand this common but poorly studie…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track their health over time to find early warning signs of heart failure and cognitive decline. The goal is to develop personalized prevention strategies for those …

This study compares standard 2D X-ray imaging with a 3D imaging technique called OCT during leg artery procedures. About 166 adults with blocked leg arteries will be randomly assigned to one of two groups. The goal is to see if OCT helps doctors place stents and inflate balloons …

This study looks at whether high pressure in the belly (intra-abdominal hypertension) causes more fluid to leak into the lungs in people with severe liver disease who are on breathing machines. Researchers will measure fluid markers in the windpipe and track complications like pn…

This study measures and compares post-traumatic stress in mothers (and some fathers) of children born with esophageal atresia, a condition where the esophagus doesn't connect properly. Researchers want to see if learning about the condition before birth (antenatal) versus after b…

This study looks at why some babies born with esophageal atresia develop dumping syndrome, a condition causing dangerous blood sugar drops after feeding. Researchers will monitor 15 infants with continuous glucose and heart monitors and a stomach-emptying scan at 3 months old. Th…

This study looks at how the body processes cortisol (a stress hormone) and bile acids (digestive fluids) in obese women before and after gastric bypass surgery. Researchers want to understand why these changes happen and how they might contribute to weight loss and better health.…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that process sugar and fat. Researchers will collect tissue samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more about the link betw…