University Hospital, Lille

This study tests two versions of gastric bypass surgery in 396 severely obese adults with type 2 diabetes. The goal is to see which method—longer alimentary or longer biliary limb—leads to diabetes remission without medication. Participants must have a BMI of 35 or higher and be …

This study looks at whether draining large ovarian cysts (6 cm or bigger) caused by endometriosis, followed by hormone therapy, can lower the chance of cysts coming back and help preserve fertility. About 62 women of childbearing age will take part. The goal is to find a better t…

This study tests whether Diroximel Fumarate, a drug already used for multiple sclerosis, can reduce harmful brain swelling that often occurs after a hemorrhagic stroke (a type of stroke caused by bleeding in the brain). The swelling can worsen recovery, and there is currently no …

This study tests a two-step procedure for people with pancreatic or related cancers who are at high risk of complications from standard surgery. Instead of the usual partial removal, doctors remove the entire pancreas and transplant the patient's own insulin-making cells into the…

This study tests whether a blood filtering procedure called rheopheresis can help heal painful skin ulcers caused by calciphylaxis in people on dialysis. About 138 adults with end-stage kidney disease and at least one ulcer will receive either standard care plus rheopheresis or s…

This study looks at the best way to prevent strokes in people with an irregular heartbeat (atrial fibrillation) who have already had a brain bleed. It compares three options: taking blood thinners, closing a part of the heart to prevent clots, or avoiding both. The goal is to fin…

This study tests two drug combinations (teclistamab plus daratumumab or lenalidomide) in people aged 65 and older who have newly diagnosed multiple myeloma and cannot have a stem cell transplant. The goal is to see if these combos are safe and can shrink the cancer to very low le…

This study looks at whether having surgery to remove endometriosis from the bowel before IVF helps women with infertility get pregnant. About 120 women with painful, deep endometriosis will be randomly assigned to either surgery plus IVF or IVF alone. The main goal is to see whic…

This study tests whether giving a short course of focused radiation before surgery for a single liver cancer tumor is safe and practical. The goal is to see if this approach can reduce the chance of the cancer coming back after surgery. About 30 adults with a single liver tumor w…

This study tests a new treatment for a rare and aggressive lung cancer called malignant pleural mesothelioma. The treatment combines a light-activated therapy (photodynamic therapy) given during a procedure inside the chest, followed by an immunotherapy drug (nivolumab) that help…

This study tests a new combination for people with advanced non-small cell lung cancer that no longer responds to standard immunotherapy or chemotherapy. The treatment adds EXL01, a healthy gut bacterium, to the immunotherapy drug nivolumab. The goal is to see if this combination…

This study tests if the drug rapamycin can reduce the size of large, hard-to-treat lymphatic malformations in the face and neck of children. About 28 children aged 0 to 18 will take rapamycin by mouth for 6 months. The goal is to see if the malformations shrink by at least one-fi…

This study tests whether adding radiation therapy after targeted pills (sonic hedgehog inhibitors) can stop advanced basal cell skin cancer from returning. About 82 adults whose cancer fully disappeared on the pills will either get radiation or not. The goal is to see if radiatio…

This early-phase study tests whether specially engineered immune cells (CD19 CAR-T cells) are safe for adults with relapsed or treatment-resistant acute myeloid leukemia (AML) that carries a specific marker (CD19). Only 5 participants will be enrolled. The main goal is to check f…

This study follows one Parkinson's patient who has been receiving A-dopamine directly into the brain for years. The goal is to monitor long-term safety and carefully reduce the dose to avoid sudden withdrawal. Researchers will also help transition to an alternative treatment if n…

This study tests if weight-loss surgery is better than standard medical treatment for making nonalcoholic steatohepatitis (NASH) disappear without worsening liver scarring. It includes 100 obese adults with advanced liver fibrosis. The main goal is to see if surgery leads to a he…

This study tests a new way to follow patients after weight-loss surgery. Instead of regular clinic visits, patients use a connected scale at home to track their weight. The care team then adjusts follow-up based on the results. The goal is to help more people maintain healthy wei…

This study tests whether a short self-report questionnaire called T-ACE can accurately identify pregnant women who may be drinking alcohol at risky levels. Researchers will compare the questionnaire results with a blood test that measures alcohol use over the past three weeks. Ab…

This study tests how well a simple scale used by family doctors can spot frailty in independent adults over 65. Researchers will compare the scale to a detailed geriatric assessment. The goal is to help doctors catch frailty early and improve care for older patients.

This study is testing whether two substances in the blood, called TFPI-1 and TFPI-2, can tell the difference between people who have colorectal cancer and those who don't. Researchers will compare blood samples from about 300 adults aged 50 to 75—some with cancer and some healthy…

This study is testing a new blood test to diagnose mucormycosis, a serious fungal infection that can be deadly if not treated quickly. Researchers will measure a specific sugar molecule from the fungus in blood samples from 100 people, including those with the infection and those…

This study is testing whether an artificial intelligence (AI) tool can help doctors diagnose kidney diseases more accurately and confidently. 100 medical students and doctors will solve 10 online kidney case studies each, with half getting AI suggestions and half working alone. R…

This study tests a system called KASPARD that uses remote sensors (no cameras) to detect falls, wandering, and nighttime activity in nursing homes. Researchers want to see if it reduces falls in residents aged 65 and older who are at high risk. The system alerts staff via phone o…

This study looks at whether taking probiotics (good bacteria) along with regular tooth brushing can prevent gum inflammation in teenagers who have braces. Braces can make it harder to clean teeth, leading to gum problems. The study will involve 116 teens and will compare the effe…

This study looks at whether a regular exercise program can improve how well blood vessels work in adults with type 1 diabetes who do not yet have complications. About 34 participants will be randomly assigned to exercise or usual care. The main goal is to see changes in blood ves…

This study tests whether adding myo-inositol (a natural supplement) to the standard fertility drug clomiphene citrate helps women with polycystic ovary syndrome (PCOS) ovulate more successfully. About 276 women who want to get pregnant will be randomly assigned to receive either …

This study tests a device that sends mild electrical pulses to a nerve in the leg to help people with multiple sclerosis (MS) empty their bladder more completely. About 68 adults with MS who currently use a catheter to urinate will either receive real stimulation or a placebo (no…

This study is for adults with chronic sinusitis and nasal polyps whose symptoms haven't improved with medication. Researchers want to see if endoscopic sinus surgery can improve sleep quality, especially deep sleep. Thirty participants will have their sleep measured before and th…

This study tests whether taking caffeine for 30 weeks can slow down memory and thinking problems in people with early-to-moderate Alzheimer's disease. About 248 adults aged 50 and older will receive either caffeine pills or a placebo (dummy pill) to see if caffeine helps keep the…

This study tests a new phototherapy device called BUBOLight® for treating jaundice in newborns. Jaundice is common and usually harmless, but high bilirubin levels can be dangerous. The device uses flexible light strips placed on the baby's body. The study will enroll 15 full-term…

This study compares a newer surgery called TOETVA, which removes the thyroid through the mouth leaving no visible scar, to the standard surgery that leaves a neck scar. About 616 adults needing thyroid removal will be randomly assigned to one of the two methods. The goal is to se…

This study is testing a new communication tool called PARKINSUN designed to improve conversations between Parkinson's patients and their doctors. Researchers will compare two groups of 120 patients—one using the tool during regular checkups and one not using it—over seven months.…

This study follows 320 people who had omega gastric bypass surgery 10 years ago to compare serious side effects between two surgical techniques. Researchers want to find out which method is safer over the long term. The goal is to improve future obesity surgeries and reduce risks…

This study looks at whether a quick, painless scalp exam (called trichoscopy) can reveal clues about the severity of systemic scleroderma. Researchers will compare scalp features of 200 people with scleroderma to healthy volunteers. The goal is to see if certain scalp patterns ar…

This study looks at swelling that happens around a brain bleed (called perihaematomal oedema) and how it affects recovery. Researchers will follow 500 people with a brain bleed to see if the swelling leads to worse disability. The goal is to better understand this swelling so fut…

This study looks at how weight-loss surgery changes bone marrow fat in postmenopausal women with obesity. Researchers will compare two types of surgery and check for links to diabetes, hormones, and bone health. The goal is to better understand why bone loss happens after surgery…

This study tests a brain scanning technique called fNIRS to see how children's brains respond to speech. It includes 40 infants and toddlers, some with normal hearing and some with hearing loss who use hearing aids. The goal is to find a better way to measure hearing aid effectiv…

This study compares standard 2D X-ray guidance with a 3D imaging technique called OCT during leg artery procedures. About 166 adults with blocked leg arteries will be randomly assigned to one of two groups. The goal is to see if OCT helps doctors place stents and inflate balloons…

This study looks at how spinal anesthesia, commonly used for planned C-sections, affects the baby's nervous system. Researchers will monitor the baby's heart rate before and after the anesthesia is given to measure stress. The goal is to better understand and improve safety for b…

This study tests a new technique called para tracheal compression to prevent air from entering the stomach during mask ventilation in children aged 2 to 10 under general anesthesia. Researchers will use ultrasound to check if the method works and is safe. The goal is to find a be…

This study looks at how having inflammatory bowel disease (Crohn's or colitis) as a child affects job and education in adulthood. Researchers will survey 460 adults diagnosed before age 17 to compare their work and school achievements with the general population. The goal is to u…

This study is looking at whether certain DNA changes can help predict the risk of brain injury in older adults undergoing a heart valve replacement procedure called TAVR. Researchers will measure DNA methylation in blood samples before and after the procedure and compare it to br…

This study looks at how the timing of diagnosis (before vs. after birth) affects stress and trauma in parents of children with esophageal atresia, a condition where the esophagus doesn't connect properly. Researchers will survey 240 mothers (and some fathers) across 34 hospitals …

This study follows 1000 people who had weight-loss (bariatric) surgery 5 years ago to see what leads to lasting weight loss. Researchers will track how much weight patients kept off and compare different surgery types. The goal is to better predict success and help future patient…

This study looks at why some people with catatonia do not improve with the standard drug lorazepam. Researchers will measure drug levels in the blood and check for genetic differences that might affect how the body processes the medication. The goal is to find early clues to iden…

This study is testing whether cameras, microphones, and wearable sensors can objectively measure how severe a person's depression is. Researchers will record interviews with 300 hospitalized adults with severe depression, analyzing facial expressions, voice, movement, heart rate,…

This study looks at how sacral neuromodulation (a nerve-stimulating device) changes the autonomic nervous system in people with overactive bladder. Researchers will measure heart rate variability in 40 adults during the device implantation to see if these changes can predict whet…

This study is creating a national database of 600 people with chronic hypereosinophilia (high levels of certain white blood cells) or hypereosinophilic syndrome (which can damage organs). Researchers will track symptoms, organ involvement, and disease patterns over time to learn …

This study follows 417 older adults (65+) with mild cognitive impairment (MCI) for one year to identify what factors predict falls. Falls are common in this group and can speed up memory loss. The goal is to develop better, personalized fall prevention strategies. Participants wi…

This study looks at adults with cystic fibrosis who are taking the medication ETI. Researchers want to find out how many of them have trouble breathing during a 6-minute walk test. The goal is to better understand how well the lungs work during exercise in people on this treatmen…

This study looks at how an inhaled drug called BGF 160 changes the way people with stable COPD breathe. Researchers want to understand the drug's mechanism by measuring breathing complexity and variability. About 35 adults aged 40-75 with moderate to severe COPD will participate.…

This study is creating a large database and biobank of 2200 people with chronic inflammatory diseases like lupus, multiple sclerosis, and severe asthma. Researchers will track participants over time, collecting health information and samples to find new markers that predict disea…

This study looks at how bariatric surgery affects the way the body handles cortisol (a stress hormone) and bile acids in 30 obese women. Researchers want to understand why these changes happen after surgery and how they might help with weight loss and metabolism. The goal is to l…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track heart function and thinking skills over time to find early warning signs. The goal is to learn who is at risk so doctors can create personalized plans to preve…

This study looks at why some babies born with esophageal atresia develop dumping syndrome, a condition causing dangerous blood sugar drops after feeding. Researchers will monitor 15 infants with continuous glucose and heart monitors and perform a stomach-emptying scan at 3 months…

This study looks at whether high pressure in the belly (intra-abdominal hypertension) causes more fluid to leak into the lungs in people with severe liver disease (cirrhosis) who are on breathing machines. Researchers will measure belly pressure and check for signs of lung fluid …

This study is testing a simple food questionnaire called EvalSel to see how accurately it measures salt intake in hospitalized patients with high blood pressure or kidney disease. Researchers will compare the questionnaire results with a 24-hour urine test, the gold standard for …

This study follows 750 people with atrial fibrillation who are getting a heart procedure called catheter ablation. The goal is to learn why the heart rhythm problem returns in up to 45% of patients within a year. Researchers will track participants for 3 years, looking at medical…

This study looks at anxiety levels in men with low-risk prostate cancer who choose active surveillance (regular check-ups instead of immediate treatment) and their partners. Researchers will use questionnaires to measure anxiety and find out what factors contribute to it. The goa…

This study aims to understand how a type of white blood cell called eosinophils behaves in DRESS syndrome, a serious and potentially life-threatening drug allergy. Researchers will compare blood and skin samples from 80 adults with DRESS, other drug rashes, and healthy volunteers…

This study follows 1,000 elderly patients (65+) who have fallen and were assessed at a fall clinic in one of 12 French hospitals. Researchers will combine clinic data with national health records to identify risk factors for unplanned hospital stays within a year. The goal is to …

This study aims to see if measuring how much pelvic organs move during an MRI can help doctors better diagnose endometriosis and understand why some treatments don't work. Researchers will compare MRI scans taken at rest and while pushing to measure organ movement in 52 women wit…

This study looks at whether brain wave tests (EEG) done before and after heart surgery in babies under 1 year old can predict later learning, attention, or autism problems. About 50 infants will be followed to age 2. The goal is to identify early signs of brain injury so doctors …

This study aims to better understand systemic sclerosis, a disease where the skin hardens and tightens. Researchers will analyze skin and blood samples from 40 adults with the condition to see how different cells behave. The goal is to find new clues that could lead to better tre…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that control sugar and fat metabolism. Researchers will collect biological samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more abou…

This study aims to find out how common eyelid eczema is in adults with atopic dermatitis (eczema). Researchers will examine 550 adults in France to describe the eyelid symptoms and look for related factors like allergies or other health issues. The goal is to better understand th…

This study follows 300 teenagers born with esophageal atresia, a condition where the esophagus is not fully formed at birth. Researchers will track health problems like acid reflux, eating difficulties, and breathing issues that can persist into adolescence. By collecting blood a…

This study looks at 50 women aged 25-35 who lost their periods after breast cancer chemotherapy. Researchers want to see if factors like body weight, physical activity, and sleep patterns affect when menstruation returns. The goal is to better predict fertility recovery after can…

This study looks at whether a toxin called deoxynivalenol (DON), found in contaminated grains, might be a risk factor for inflammatory bowel disease (IBD). Researchers will measure DON levels in 100 people—some with Crohn's disease and some without—who are already scheduled for i…

This study aims to understand how breastfeeding affects children's gut health during their first four years. Researchers will follow 500 newborns, collecting information about feeding practices and stool samples at different ages. The goal is to learn how breastfeeding duration a…