New drug cocktail aims to tame myeloma in seniors

NCT ID NCT05572229

Recruiting now Disease control Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is testing a new drug called teclistamab, given as a shot, together with either daratumumab (another shot) or lenalidomide (a pill) in people aged 65 and older who have just been diagnosed with multiple myeloma and cannot have a stem cell transplant. The goal is to see if these combinations are safe and can shrink the cancer significantly after four cycles of treatment. About 74 participants will be enrolled across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Teclistamab (a drug given as a shot under the skin) combined with either daratumumab (shot) or lenalidomide (pill)

What this could lead to

If successful, this could offer a new, effective treatment option for elderly patients with newly diagnosed multiple myeloma who cannot undergo a stem cell transplant.

What could go wrong

This is a Phase 2 trial with only 74 participants, so results are preliminary. The combination may cause side effects or not work as well as hoped.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Aphp - Chu Henri Mondor
ACTIVE_NOT_RECRUITING

Paris, France
Aphp - Hopital Saint Antoine
NOT_YET_RECRUITING

Paris, France

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Aphp - Hopital Saint Louis
NOT_YET_RECRUITING

Paris, France

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Aphp Hopital Avicenne
NOT_YET_RECRUITING

Bobigny, France

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Centre Hospitalier de La Cote Basque
RECRUITING

Bayonne, France

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Centre Hospitalier de Versailles
RECRUITING

Le Chesnay, France

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Centre Leon Berard
NOT_YET_RECRUITING

Lyon, France

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Ch D'Avignon
ACTIVE_NOT_RECRUITING

Avignon, France
Ch de Dunkerque
ACTIVE_NOT_RECRUITING

Dunkirk, France
Chr Metz-Thionville
RECRUITING

Metz, France

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Chru Angers
RECRUITING

Angers, France

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Chru Bretonneau
RECRUITING

Tours, France

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Chru de Nancy, Hopitaux de Brabois
RECRUITING

Nancy, France

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Chu Amiens - Hopital Sud
RECRUITING

Amiens, France

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Chu Bordeaux
RECRUITING

Pessac, France

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Chu Dijon Bourgogne
RECRUITING

Dijon, France

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Chu Limoges
ACTIVE_NOT_RECRUITING

Limoges, France
Chu Montpellier
RECRUITING

Montpellier, France

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Chu Pontchaillou
ACTIVE_NOT_RECRUITING

Rennes, France
Chu de Besancon
RECRUITING

Besançon, France

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Chu de Caen
RECRUITING

Caen, France

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Chu de Grenoble
RECRUITING

La Tronche, France

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Chu de Lille, Hopital Claude Huriez
RECRUITING

Lille, France

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Chu de Nantes Site Hotel Dieu
ACTIVE_NOT_RECRUITING

Nantes, France
Chu de Poitiers
RECRUITING

Poitiers, France

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Chu de Reims
NOT_YET_RECRUITING

Reims, France

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Hopital E. Muller- Ghrmsa
NOT_YET_RECRUITING

Mulhouse, France

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Hopitaux Universitaire de Strasbourg - Hopital Hautepierre
RECRUITING

Strasbourg, France

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Oncopole Chu Toulouse
RECRUITING

Toulouse, France

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