University Hospital, Lille

This study compares two weight-loss surgeries for people with severe obesity: sleeve gastrectomy with transit bipartition (SG+TB) and Roux-en-Y gastric bypass (RYGB). About 320 adults will be followed for two years to see which surgery leads to more weight loss and fewer side eff…

This study tests whether adding daratumumab (given as a shot under the skin) to the standard drug lenalidomide helps frail older adults with newly diagnosed multiple myeloma live longer without their cancer getting worse. About 294 participants aged 65 and older who cannot have a…

This study tests whether transplanting insulin-producing cells into the arm muscle can prevent diabetes after partial or full pancreas removal. About 35 adults with non-cancerous pancreas conditions will receive their own islet cells injected into one arm. The goal is to see if t…

This study compares two types of replacement heart valves used in a procedure called TAVI for people with a narrowed aortic valve. About 1,960 participants will be randomly assigned to receive either a balloon-expandable or self-expanding valve. The goal is to see which design le…

This study tests a 2-year personalized program to help overweight children aged 6-10 avoid obesity. The program includes education and support tailored to each child's needs. Researchers will measure changes in BMI and compare results to a group of children who did not receive th…

This study tests whether a nerve block called erector spinae plane block (ESPB) can reduce the need for morphine after minimally invasive spinal fracture surgery. 86 adults will be randomly assigned to receive either the nerve block or a placebo. The main goal is to see if the bl…

This study tracks 62 adults with severe eosinophilic asthma to see if 6 months of mepolizumab treatment improves their daily physical activity and exercise tolerance. The main measure is the number of steps taken each day. Researchers want to learn if the drug not only reduces as…

This study planned to collect extra blood and urine samples from people with scleroderma during their regular checkups. Researchers wanted to find biological markers that could predict if the disease would get worse over the next 10 years. The study was withdrawn before any parti…

This study looks at 2000 people who had a heart attack to see if measuring the stiffness of their blood vessels one month later can help predict future problems like heart failure, another heart attack, or stroke. Participants are enrolled within 48 hours of their heart attack an…

This study tests whether a rapid PCR test can help doctors choose the right antibiotics sooner for immunocompromised patients in the ICU who have pneumonia. Standard lab tests take days, so patients often get broad-spectrum antibiotics that may not be ideal. The goal is to see if…

This study was designed to collect information about pain in people having orthopedic, chest, or gynecological surgery. Researchers planned to use questionnaires to understand pain and find out who might be at risk for long-term pain. However, the study was withdrawn before any p…

This study follows 1,000 older adults (65+) who have fallen and were assessed at a special hospital clinic in France. Researchers will combine medical records with national health data to identify factors that lead to unplanned hospital stays. The goal is to better understand fal…

This study aims to understand the patterns of swelling attacks in people with bradykinin-mediated angioedema, a rare condition that causes sudden, sometimes life-threatening swelling. Participants will use a smartphone app daily to report if they have an attack and what happened …

This study involves 500 women in northern France diagnosed with invasive breast cancer in 2024. Researchers want to understand why some women wait longer between noticing a symptom and starting treatment. Participants fill out a one-time questionnaire about their feelings, behavi…

This study examines inflammation in preschool children (ages 1 to 5) hospitalized for a severe asthma attack. Researchers compare different wheezing patterns to see if the type of inflammation varies. The goal is to better understand these patterns and how they affect the child's…

This study planned to check how the COVID-19 quarantine affected the mental health of people already being treated by a psychiatrist. Researchers wanted to measure symptoms of post-traumatic stress disorder (PTSD) and other mental health issues during quarantine and a few months …

This study follows 100 adults with severe chronic sinusitis and nasal polyps who are starting biologic treatments. Researchers will track how these drugs affect quality of life, symptoms like nasal blockage and smell loss, and any side effects over six months. The goal is to see …