University Hospital, Lille

This study follows one Parkinson's patient who has been receiving A-dopamine directly into the brain via a pump for years. The goal is to monitor safety during long-term use and manage a gradual, individualized dose reduction until the treatment stops, switching to an alternative…

This study looked at whether gastric bypass surgery or the best medical care is more effective for obese people with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, and costs. The go…

This study tested whether using blood biomarkers (beta-D-glucan and mannan) can help doctors safely stop antifungal drugs earlier in critically ill patients suspected of a fungal infection. 192 ICU patients were randomly assigned to either a biomarker-guided strategy or standard …

This early study tested a new approach for people with advanced Parkinson's disease who have severe motor fluctuations despite optimized oral medication. A pump placed in the abdomen delivered a special form of dopamine (A-dopamine) directly into the brain's fluid spaces, aiming …

This study tested whether a drug called deferiprone can safely reduce harmful iron buildup in the brains of people with early-stage Parkinson's disease. Forty participants took either deferiprone or a placebo for six months. The goal was to see if lowering brain iron could slow t…

This phase II trial tested a combination of pomalidomide and dexamethasone in 84 patients with advanced multiple myeloma whose cancer had worsened despite treatment with bortezomib and lenalidomide. The goal was to see if this drug pair could shrink tumors and control the disease…

This study tested whether sildenafil (the drug in Viagra) can help heal painful finger ulcers in people with scleroderma, a disease that damages blood vessels. 84 participants took either sildenafil or a placebo three times daily for 90 days. The main goal was to see if the ulcer…

This study tested a new combination of chemotherapy drugs for children and young adults with acute lymphoblastic leukemia (ALL) that had returned or not responded to first treatment. The goal was to find the safest dose of clofarabine when given with other medicines. Twenty parti…

This study tested the drug vismodegib given before surgery to people with advanced basal cell carcinoma (a type of skin cancer). The goal was to see if the drug could shrink the tumor enough to allow for a smaller, less invasive surgery. 55 participants took the drug for a period…

This study tested two doses of tranexamic acid (a drug that helps blood clot) to see if it could reduce blood loss during cesarean deliveries when heavy bleeding occurs. 225 women who experienced significant bleeding during a planned or non-emergency C-section were randomly given…

This study looked at whether a high-fat diet changes how children with mitochondrial disease burn energy. 36 children aged 5 to 21 were randomly assigned to eat either a normal or high-fat diet for a month, then switched. Researchers measured their resting energy use and body com…

This study looked at how well a special knee replacement (MUTARS) works after removing bone cancer. Nine patients were checked to see if they could lock their new knee and walk actively. The goal was to understand if the prosthesis helps with daily movement and walking.

This study compared two surgical methods for removing esophageal cancer: open surgery versus a less invasive approach using a laparoscope. The goal was to see if the laparoscopic method reduces serious complications within 30 days after surgery. The trial involved 207 patients wi…

This study tested whether the antifungal drug fluconazole could lower levels of certain antibodies (ASCA) and prevent Crohn's disease from returning after bowel surgery. Thirty-five adults with Crohn's disease who had recent ileal or ileocecal resection were randomly assigned to …

This study tested whether continuously monitoring and adjusting the pressure in the breathing tube's cuff (the balloon that seals the airway) could reduce stomach fluid from leaking into the lungs. The study involved 122 critically ill patients on ventilators who were receiving t…

This study tested whether giving people with alcohol dependence a one-month course of diazepam (40 mg per day) after detoxification could reduce the chance of relapsing into drinking within the next three months. The standard detoxification treatment is usually about one week. Th…

This study tested a freeze-dried plasma product that can be mixed with water in 6 minutes, avoiding the long thaw time of standard plasma. It included 42 trauma patients with severe bleeding who needed blood transfusions. The goal was to see if faster plasma delivery could improv…

This study tested whether using special fungal markers (biomarkers) could help doctors safely stop antifungal drugs earlier in ICU patients. The goal was to reduce the length of treatment and avoid unnecessary side effects. The study included 110 critically ill adults who needed …

This study compared two surgical techniques—laparoscopic sacropexy and vaginal mesh surgery—for repairing a cystocele (a type of pelvic organ prolapse). Researchers followed 220 women for four years to see which approach provided better symptom relief and fewer complications. The…

This study compared two surgical techniques for repairing a cystocele, a type of pelvic organ prolapse where the bladder bulges into the vagina. The two methods were laparoscopic sacropexy (keyhole surgery using a mesh) and vaginal mesh surgery. The trial enrolled 262 women and l…

This phase 2 study tested a weekly dose of the drug carfilzomib combined with two standard chemotherapy drugs (melphalan and prednisone) in 32 elderly patients (65 years or older) with newly diagnosed multiple myeloma. The goal was to find the safest effective dose and see how we…

This study tested a drug called daratumumab combined with dexamethasone in 64 people with multiple myeloma that had stopped responding to three other treatments. The goal was to see how many patients' tumors shrank or disappeared. The treatment is not a cure, but aims to control …

This phase 2 trial tested the safety of P28GST, a protein from a parasite, in 10 adults with moderate Crohn's disease. Participants received three injections over three months. The goal was to see if the protein could safely control inflammation, especially after intestinal surge…

This study tested whether deferiprone, a drug that removes excess iron, could safely slow the progression of ALS. Researchers gave the drug to 23 adults with ALS for several months. The goal was to see if reducing iron buildup in the brain might protect nerve cells and delay wors…

This study looked at 652 heart failure patients who had a special heart device (CRT). One group received standard remote monitoring, while the other got more detailed monitoring that also tracked heart rhythm issues and symptoms. The goal was to see if the extra monitoring could …

This pilot study tested whether adding intrapleural photodynamic therapy (PDT) to standard surgery and chemotherapy is safe and feasible for patients with malignant pleural mesothelioma. Six participants received a light-sensitive drug followed by laser light inside the chest cav…

This study tested whether a drug called deferiprone, which removes extra iron from the body, could slow down Parkinson's disease. 372 adults with early Parkinson's took either the drug or a placebo for 9 months. The goal was to see if the drug could reduce both movement and non-m…

This pilot study tested whether a light-activated drug (5-ALA) could be safely used during brain surgery to treat glioblastoma, an aggressive brain cancer. Ten adult patients received this experimental therapy in addition to standard surgery and chemoradiation. The main goal was …

This study tested a combination of pomalidomide and dexamethasone in 63 patients with multiple myeloma that had returned or stopped responding to treatment, and who had specific high-risk genetic changes. The goal was to see how well the drugs controlled the disease and what side…

This study tested whether using a biological mesh (made from human or animal tissue) during surgery for infected ventral hernias leads to fewer wound problems than standard wound care alone. About 110 adults with infected hernias were randomly assigned to receive either the mesh …

This study tested a personalized telemedicine coaching program for children with type 1 diabetes who have difficulty adjusting their insulin therapy. Over 100 children received phone and secure message coaching from nurses for 6 months. The goal was to improve blood sugar control…

This study looked at 40 patients aged 18-25 who had a first-time shoulder dislocation. Half received arthroscopic surgery to repair torn tissue, while the other half were treated with a sling for 3 weeks. The goal was to see which approach better prevents repeat dislocations over…

This study tested whether freezing eggs (oocyte cryopreservation) could help preserve fertility in women with benign ovarian cysts that often come back, like endometriomas. The 82 participants had cysts that required multiple surgeries, which can damage the ovaries. Researchers m…

This study looked at whether early liver transplantation can help people with severe alcoholic hepatitis who did not get better with medical treatment. Researchers compared alcohol relapse rates in 284 patients who received early transplants to those transplanted after a 6-month …

This study tested the drug nilotinib in 65 adults with chronic graft-versus-host disease (GVHD) who did not respond to imatinib. GVHD is a complication after a stem cell transplant where donor cells attack the patient's body. The goal was to see if nilotinib could help control th…

This study tested whether adding an antibiotic (amoxicillin-clavulanic acid) to the usual steroid treatment could improve survival in people with severe alcoholic hepatitis. About 300 adults at high risk of death within two months took part. The goal was to see if the antibiotic,…

This study tested an electronic device that automatically keeps the air pressure in a breathing tube's cuff steady. In 18 critically ill patients, the device was compared to manual checks over two 24-hour periods. The goal was to see if the device reduces dangerous over- or under…

This study tested whether stroke patients over 60 with high blood pressure benefit from extra nurse-led education and follow-up, compared to standard care. About 290 patients took part, each bringing a family member or friend to help. The main goal was to see if this approach low…

This study tested whether a personalized crisis plan, called the SOS Plan, could reduce hospitalizations in people with schizophrenia or schizoaffective disorder. 124 patients worked with their doctors and loved ones to create a plan outlining what to do in a crisis. The goal was…

This pilot study tested whether giving a sodium lactate solution to people with septic shock could help manage their fluid balance. Septic shock is a life-threatening condition where blood pressure drops dangerously due to infection. The study involved 59 participants and compare…

This study tested an online personalized program for pregnant women with obesity to help them gain the right amount of weight and reduce the need for delivery interventions like C-sections or forceps. Over 800 women participated, using a secure website to communicate with dietiti…

This completed Phase 2/3 trial tested whether deferiprone, a drug that removes excess iron from the body, can slow the progression of ALS (Lou Gehrig's disease). 372 people with early-stage ALS took either deferiprone or a placebo for 12 months. The study measured changes in phys…

This phase 2 trial tested whether increasing the light dose during a special type of therapy called photodynamic therapy (PDT) is safe for people with glioblastoma, an aggressive brain cancer. Fourteen patients received a drug (5-ALA) before surgery, then a red laser was shone on…

This study tested whether acupuncture-moxibustion, a non-invasive technique, can safely turn a breech baby before birth. 328 pregnant women with a single baby in breech position received either the real treatment or a placebo. The goal was to see if this method could reduce the n…

This study tested whether transplanting insulin-making islet cells could help people with type 1 diabetes who already had a kidney transplant. Fourteen participants received up to three infusions of donor islet cells along with steroid-free immunosuppression. The goal was to see …

This study tested the drug lenalidomide in 17 people with Waldenstrom macroglobulinemia, a rare blood cancer, that had returned or stopped responding to prior treatments. The main goal was to find the safest dose by monitoring side effects. Researchers also looked at how many pat…

This study looked at 30 adults with lung cancer that had spread to the brain. Researchers compared two standard MRI sequences (T1 and T2*) to see which one better detects and tracks brain metastases after chemotherapy or targeted therapy. The goal is to improve diagnosis and moni…

This study tested a new blood test called LLIFT to see if it can accurately diagnose fatty liver disease and its severe form, NASH, without needing a liver biopsy. Researchers enrolled 158 people at high risk for metabolic syndrome. The LLIFT test combines patient information lik…

This study tested whether a hand-held dynamometer (a small device) can accurately measure the strength of a key foot muscle (the posterior tibial tendon) in healthy adults. Researchers compared results from the hand-held device to a larger, more precise machine. If proven reliabl…

This study looked at whether changes in central venous pressure (CVP) during breathing can predict if ICU patients need more fluids. 68 spontaneously breathing patients were monitored. The goal was to find a simple way to avoid giving too much or too little fluid, which can be ha…

This study tested a new wearable patch called TOCONAUTE that sticks to a mother's belly during labor. The patch measures the baby's heart rate and the mother's contractions, just like the standard monitors but without wires. Researchers compared the patch's readings to the usual …

This study tested a new approach to diagnose peroxisomal disorders, a group of rare genetic diseases. The strategy uses advanced metabolic and genetic tests to find the cause faster in people with suspicious symptoms or lab results. Researchers included 8 participants from four h…

This study tested a device called KASPARD that uses remote sensors to detect falls and nighttime activity in nursing homes. Researchers compared fall rates over 100 nights with the alarm on versus 100 nights with the alarm off. The goal was to see if the system could reduce falls…

This study tested whether giving an antibiotic (clindamycin) to pregnant women with bacterial vaginosis (a common vaginal infection) before 13 weeks of pregnancy could lower the chance of very early preterm birth. Over 3,000 pregnant women took part. The goal was to see if early …

This study tested whether using a smaller amount of a weaker numbing medicine (ropivacaine) during a shoulder nerve block could reduce the risk of temporary diaphragm paralysis. 60 adults having shoulder surgery took part. The goal was to see if the low-dose approach could still …

This study tested whether aromatherapy with essential oils can reduce anxiety in adults before elective upper limb surgery. 289 participants were randomly assigned to either receive aromatherapy or not. The goal was to see if the scent helped people feel calmer in the operating r…

This study tested whether high doses of methylphenidate (Ritalin) could improve walking and attention in 69 people with advanced Parkinson's disease who still had severe gait problems despite standard treatments. Participants received either methylphenidate or a placebo for three…

This study tested whether memantine, a drug that reduces overactive brain signals, can improve walking and attention in people with advanced Parkinson's disease. Twenty-eight non-demented patients with severe gait issues took memantine or a placebo for three months. The goal was …

This study tested a program that teaches people with early-stage Parkinson's disease how to add more physical activity into their daily lives. 89 participants either received the program or were placed on a waiting list. Researchers measured their daily moderate-to-vigorous activ…

This study tested whether wrapping children with autism in sheets (wet or dry) can reduce severe injurious behaviors like self-harm or aggression. 48 children took part, and researchers compared wet wraps to dry wraps. The goal was to see if this gentle, drug-free approach could …

This study tested a new device called Flexitheralight against the usual light therapy for actinic keratosis, which are rough spots caused by sun damage. About 29 adults with at least 10 spots on their forehead or scalp took part. The goal was to see if the new device works just a…

This study tested a special monitor that tracks the body's pain balance during general anesthesia for laparoscopic (keyhole) surgery. The goal was to see if using this monitor to adjust painkiller doses could reduce side effects like low blood pressure, slow heart rate, or sudden…

This study tested whether giving EXACYL before surgery can reduce bleeding during and after jaw realignment surgery. 157 adults took part in a double-blind, placebo-controlled Phase 3 trial. The goal was to see if the drug makes surgery safer and more comfortable.

This study looked at whether a pulmonary rehabilitation program helps people with Stage IV pulmonary sarcoidosis (advanced lung scarring) become more active in their daily lives. 38 adults took part and were followed for one year. The program aimed to improve exercise ability, re…

This study tested a medical device that automatically gives the pain drug remifentanil during surgery, based on heart rate, blood pressure, and a pain index. 52 adults having burn surgery took part. The goal was to see if the device could reduce the total amount of pain medicine …

This study looked at whether medical hypnosis can lower stress and make a hospital stay better for people with chronic diseases. 24 adults staying in an internal medicine unit took part. One group received a hypnosis technique called "the place of safety," while the other group r…

This study tested whether a non-invasive brain stimulation technique called rTMS, guided by MRI scans, could reduce severe hallucinations in people with schizophrenia who don't respond to medication. 85 participants received either MRI-guided or standard rTMS over 5 days. The goa…

This study looked at whether two sessions of hypnosis could lower anxiety in pregnant women with preterm premature rupture of membranes (PPROM). 60 women took part, with some receiving hypnosis and others standard care. The goal was to see if hypnosis helps reduce anxiety and imp…

This study looks at whether a new pain management approach helps people going through in vitro fertilization (IVF) feel less pain. Researchers will compare pain scores from 206 patients to those from an earlier study. The goal is to see if the updated care plan reduces discomfort…

This study tested whether a personalized exercise program can improve daily function and quality of life for people with dermatomyositis or polymyositis, two rare diseases that cause muscle weakness and inflammation. 80 adults with stable muscle impairment took part. The program …

This study tested whether a clonidine nasal spray can calm young children (ages 1-5) before minor surgery. Researchers compared it to a placebo spray in 90 kids. The goal was to see if the spray reduces anxiety and helps children accept the anesthesia mask more easily.

This study tested whether teaching people with chronic low back pain about how pain works in the brain and body (pain neuroscience education) helps them move better and feel less disabled compared to standard education about spine anatomy. 88 adults with back pain for over a year…

This study tested a special mask that uses lights and sounds to help patients relax during a prostate biopsy. The goal was to see if it reduces pain and anxiety compared to standard care. 88 men took part, and researchers measured their pain levels and satisfaction after the proc…

This study tested two ways to manage stress for people with adjustment disorder and anxiety: a 5-week online program (Seren@ctif) and a face-to-face program, compared to no treatment. 120 adults participated. The goal was to see if either program could reduce anxiety symptoms. Th…

This study tested whether injecting the numbing drug ropivacaine into the nose can reduce pain after endoscopic sinus surgery. 184 adults having sinus surgery were randomly given either ropivacaine or a saltwater placebo injection. The main goal was to measure pain intensity and …

This study tested whether wearing a special pressure sleeve for 6 months could improve hand function in children with cerebral palsy. 101 children aged 5 to 10 took part. The sleeve, made of a stretchy material, was designed to provide gentle pressure to the arm. The main goal wa…

This study tested whether medical hypnosis can reduce anxiety and pain in patients undergoing electroneuromyography (ENMG), a nerve test that can be uncomfortable. Six anxious adults were enrolled and received either hypnosis or standard care. Researchers measured pain and anxiet…

This study tested whether aesthetic therapy sessions (like skincare or makeup) could reduce anxiety and improve quality of life for patients with acute leukemia or those who had a stem cell transplant. These patients are isolated in a protected hospital area for at least 28 days.…

This study tested a fast-recovery program for people having minimally invasive kidney surgery (laparoscopic or robotic) to remove tumors. The goal was to see if the program could safely shorten hospital stays by at least one day. Sixty patients took part, and researchers tracked …

This study looked at two methods to control pain after liver surgery: continuous wound infiltration with a local anesthetic (ropivacaine) and a single spinal injection of morphine. The goal was to see which approach reduces the need for additional morphine and lowers the chance o…

This study looked at whether a tailored physical activity program could improve bone density in 15 children and teens with inflammatory bowel disease (IBD). Kids with IBD often have weaker bones due to inflammation, medication, and lower activity levels. The program focused on mo…

This study tested whether a single dose of ketamine plus daily milnacipran can reduce depression in people with severe, progressive diseases. 42 participants in palliative care were split into two groups: one received the drug combo, the other a placebo plus milnacipran. The goal…

This study tested a digital platform designed to help patients recover physically and mentally after major surgery for esophageal or laryngeal cancer. The platform offered short daily exercise sessions. The study included 30 patients and focused on whether they would use the tool…

This study tested whether combining a low dose of methylphenidate (a drug used for ADHD) with computer-based cognitive training could improve thinking skills in healthy older adults. Thirty-one volunteers without memory problems took part in the 6-week program. The goal was to se…

This study tested whether teaching emotional skills (like identifying and managing feelings) can help people who finished cancer treatment. 26 patients with digestive or lung cancer took part. Some received emotional skills training, others did relaxation exercises. The goal was …

This study tested whether Erickson hypnosis can reduce chronic pain in people with Parkinson's disease. 33 participants were split into two groups: one received weekly hypnosis sessions for 2 months, the other got usual care. The main goal was to see if pain intensity changed fro…

This study looked at 172 patients in the intensive care unit after surgery who needed insulin. It compared two different ways of giving insulin through a vein to see which one kept blood sugar levels more stable. The goal was to find out if using a separate line just for insulin …

This study examined spinal fluid from 32 children with tethered spinal cord to see if inflammation plays a role in the condition. Researchers collected fluid samples during surgery and looked for markers of inflammation. The goal was to better understand how the spinal cord gets …

This study tested a new method to measure bladder fullness using heart signals. Researchers placed sticky patches (electrodes) on the body to record the heart's electrical activity during a standard bladder test. The goal was to develop a computer algorithm that could estimate bl…

This study looked at how people with schizophrenia perceive familiarity when looking at faces. Researchers showed 30 participants blended images of familiar and unfamiliar faces and asked them to press a button when they felt a sense of familiarity. The goal was to understand how…

This completed study aimed to understand how genes influence jaw and bite problems (malocclusions). Researchers analyzed gene activity in jaw muscle samples from patients having corrective surgery. The goal was to find links between specific genes and different types of misalignm…

This study investigates whether changes in DNA methylation—a kind of chemical switch—might cause certain rare limb malformations that appear without a family history. Researchers will compare DNA samples from 40 people with Amelia (missing two or four limbs) or Femur Fibula Ulna …

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This study looked at genetic changes in prostate cancer samples from 84 men who had surgery. The goal was to find DNA markers that could predict if the cancer would come back or spread. By identifying these markers, doctors may one day better tailor follow-up care and treatment f…

This study looked at whether using a video capsule endoscopy (a small camera pill) along with standard scopes can better find the source of gut bleeding in people with von Willebrand disease. Researchers reviewed records of 50 patients who had gut bleeding between 2015 and 2017. …

This study looked at 343 adults who were diagnosed with inflammatory bowel disease (Crohn's disease or ulcerative colitis) before age 17. Researchers compared their employment rates and education levels to the general population to understand how the disease may affect long-term …

This study looked at how certain heart devices change a blood-clotting protein called von Willebrand factor. Researchers studied 500 adults with heart failure or aortic stenosis who received a mechanical heart pump or a valve replacement. The goal was to understand when these pro…

This study looked back at 37 patients who had surgery for webbed fingers (congenital syndactyly) between 2005 and 2019. The goal was to see how well the Gilbert dorsal commissural flap worked, focusing on whether the web space tightened up again and how the scars healed. Doctors …

This study looked at 100 women with Polycystic Ovary Syndrome (PCOS) to understand how the condition impacts their quality of life and mental health. Researchers examined factors like age, weight, how long it took to get a diagnosis, and history of anxiety or depression. Particip…

This study looked at 50 ICU patients with acute respiratory failure to see if a heart ultrasound test (measuring how the main vein collapses) could predict who would die or need a breathing tube. The goal is to help doctors give fluids more safely. It was an observational study, …

This study looked at nearly 700 men and women entering prison in northern France to find out how common mental health and substance use problems are. Researchers compared these rates to the general population. The goal was to understand the health needs of new prisoners, not to p…

This completed study looked at how common fish allergy is among people who work with fish, like fishermen and fish-processing factory workers, compared to other workers. Researchers surveyed 486 people in Boulogne-sur-Mer, France, asking about allergic symptoms and exposure to fi…

This study looked at 84 children and teens with inflammatory bowel disease (IBD) to see if daily physical activity is linked to better bone density. Participants wore activity monitors and had bone scans. The goal is to understand if staying active could help prevent bone loss, a…

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study looked at whether getting an islet transplant after a kidney transplant helps people with type 1 diabetes avoid kidney failure or death. Researchers reviewed data from 327 people in France who had a kidney transplant between 2000 and 2017. They compared those who also …

This study looked at how the COVID-19 pandemic and related public health measures changed asthma control in children aged 3 to 16. Researchers compared asthma control and flare-ups in 577 children during the pandemic to data from before the pandemic. The goal was to see if lockdo…

This study tested a 10-item questionnaire called DEPITAC, designed for nurses to screen road traffic accident patients for post-traumatic stress disorder (PTSD) while they are still in the surgical unit. Researchers enrolled 274 hospitalized accident victims to see if the simple …

This study looked at 158 people with Parkinson's disease to see if different thinking patterns are linked to differences in brain structure and activity. Researchers grouped participants based on their cognitive profiles and compared brain scans and EEG readings. The goal was to …

This study looked at how type 1 diabetes and long-term blood sugar control (HbA1c) affect the body's ability to deliver and use oxygen during exercise. Researchers compared 79 people with and without diabetes to understand why fitness levels may be lower in those with high blood …

This study looked at whether certain gene changes (in the TCF7L2 gene) make ICU patients with organ failure more likely to develop high blood sugar. Nearly 1,000 adults in the ICU were checked for these gene changes and their blood sugar levels. The goal was to understand the lin…

This study looked at over 3,500 older adults (75+) after they left the hospital to better predict their risks of dying, being readmitted, or moving to a nursing home. Researchers used advanced statistical models to account for how these events affect each other. The goal is to he…

This study looked at how people with PTSD pay attention to their surroundings. Researchers used a change blindness test to see if patients are quicker to notice changes, especially emotional ones. 80 adults with PTSD and healthy controls participated. The goal was to understand t…

This study looked at different questionnaires that patients fill out after hip or knee surgery to see how well they measure recovery. Researchers wanted to find better ways to compare results across studies and understand what counts as a meaningful improvement for French patient…

This study tested a personalized follow-up plan (called ALGOS) for people who survived a suicide attempt. The goal was to see if this plan could reduce the number of people who try again within 6 months, compared to usual care. Over 1,000 adults took part, and researchers tracked…

This study looked at different types of immune cells (eosinophils) in the blood of people with asthma, chronic sinusitis with nasal polyps, or both, compared to healthy volunteers. The goal was to find patterns that could help doctors choose the best targeted therapy for each pat…

This study analyzed data from nearly 3,000 patients who had surgery for esophageal cancer between 2000 and 2010. Researchers looked at factors like patient health, treatment approach, and surgical technique to see what influences cancer recurrence and survival. The goal is to bet…

This study evaluated VigilanS, a program that provides coordinated follow-up care for people in northern France who have survived a suicide attempt. Researchers tracked over 12,000 participants to see if the program reduced repeat attempts and improved care coordination. The goal…

This study tested whether adding an AI-generated summary to brain MRI reports helps people understand the results. Over 2700 adults read six fictional reports and answered questions about what they found. The goal was to see if the simple summary improved understanding compared t…

This study looked at how nerve cells in the eye are lost in people with multiple sclerosis (MS) even when there is no active inflammation. Researchers followed 64 adults with relapsing-remitting MS who were already part of a larger study. By using special eye scans over time, the…

This completed study looked at how the drug deferiprone affects blood cells from 90 people with Parkinson's disease, ALS, or healthy volunteers. Researchers measured markers of oxidative stress and iron levels in the lab. The goal was to better understand these diseases, not to t…

This study screened 233 children aged 6 to 66 months with congenital heart disease for neurodevelopmental disorders like delays in communication, movement, and problem-solving. Researchers used a parent questionnaire to identify children at risk. The goal is to better understand …

This study looked at how older adults with and without Alzheimer's disease move in time with music. Researchers wanted to understand if this rhythmic movement relates to emotional expression and communication. The study involved 240 participants and measured how accurately they t…

This completed study followed 550 people who had a stroke within the last 48 hours. Researchers wanted to understand why some patients recover better than others by looking at their medical history, lifestyle, and blood markers. The goal is to find out what factors protect the br…

This study looked at 30 women with PCOS who had trouble ovulating. Researchers measured a hormone called AMH while giving low doses of FSH to see if a drop in AMH happens when an egg follicle starts to grow. The goal was to better understand why ovulation fails in PCOS, not to te…

This study looked at 42 infants who had surgery for a rare birth defect called esophageal atresia type III. Researchers gave the babies a sugary drink to see how often they developed dumping syndrome, a condition causing rapid blood sugar changes. The goal was to find out how com…

This study examined a type of immune cell called 4BL B cells in people with multiple sclerosis (MS) and compared them to healthy controls. Researchers wanted to see if these cells are more common in MS and might contribute to inflammation. The study involved 125 participants and …

This completed study of 500 people with ALS (Lou Gehrig's disease) aimed to find biological signs, or biomarkers, that can predict how the disease will progress. Researchers collected clinical, imaging, and lab data to better understand different forms of ALS. The goal is to help…

This study looked at how skin changes from systemic sclerosis affect a person's feelings about their appearance. Researchers compared 170 patients with the disease to healthy people using surveys about body image and emotional distress. The goal was to understand the burden of th…

This completed trial tested whether using positive pressure while removing the breathing tube (extubation) can prevent low oxygen levels after abdominal surgery. 264 adults undergoing scheduled visceral or urological surgery were randomly assigned to standard extubation or one of…

This study set up a national registry in France to track babies born with esophageal atresia, a birth defect where the esophagus is not fully formed. Researchers collected data on about 1,460 newborns to understand how common the condition is, what other health issues may occur, …

This completed study looked at how often joint pain occurs in 71 people with ovarian, colorectal, or lung cancer who were taking the drug bevacizumab. Participants filled out a questionnaire about their joint pain over 6 months. The goal was to better understand this side effect.

This study tested whether a special 3D X-ray done in the operating room can replace standard CT scans after repairing an abdominal aortic aneurysm. 427 patients were randomly assigned to either the new 3D scan or the usual approach. The goal was to see if the new method reduces r…

This study tested a device called NIPE that measures heart rate changes to detect pain in very premature babies (born before 34 weeks) who are sedated and on ventilators. Researchers compared NIPE readings before and during care procedures in 50 infants. The goal was to see if th…

This study tested whether a non-invasive device called ccNexfin can accurately measure cardiac output (how much blood the heart pumps) in pregnant women. 100 pregnant women past 32 weeks participated. The goal was to see if this device could replace or supplement standard ultraso…

This study looked at whether using a Foley catheter at home can safely start labor in first-time mothers whose pregnancy has gone past the due date. 43 women took part. The catheter was placed in the hospital and then the women went home for 24 hours. The goal was to see if this …

This study examined whether being in the ICU with COVID-19 made patients more likely to pick up dangerous, drug-resistant bacteria. Researchers tracked 368 critically ill adults to compare infection rates before and during the pandemic. The goal was to understand if COVID-19 chan…

This study looked at two scoring systems (PAWS and PEWS) to see how well they measure illness severity in children admitted to intermediate care units. Over 3,000 children in French hospitals were monitored. The goal was to find a simple, reliable way to track a child's condition…

This completed study from France compared over 1,500 ICU patients on ventilators to see if those with COVID-19 develop more lung infections than patients with influenza or no viral pneumonia. Researchers tracked cases of ventilator-associated pneumonia and tracheobronchitis. The …

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This study followed 38 children who survived acute respiratory distress syndrome (ARDS), a severe lung condition. One year after leaving the hospital, researchers checked for lasting breathing problems like cough, wheeze, and lung stiffness using scans and tests. The goal was to …

This study tested a new decision rule to help doctors tell which children with fever and low white blood cells after chemotherapy are at high risk for a serious infection. Researchers looked at 1,900 children aged 1 to 18 with cancer or blood disorders. The goal was to see if the…

This study looked at 195 overweight or obese pregnant women to understand what factors influence their decision to join a 12-week program combining nutritional counseling and physical activity. The program included three diet workshops and weekly exercise sessions. Researchers an…

This study looked at 48 adults on ECMO for severe heart shock to see if oxygen levels measured from different spots in the body agree. Doctors checked blood from the ECMO machine, a neck vein, and a lung artery. The goal was to improve monitoring without adding risk.

This study looked at whether changing a patient's body position during surgery affects a device called the Analgesia Nociception Index (ANI), which is used to measure pain under anesthesia. Thirty neurosurgery patients were monitored as their bed was tilted head-up or head-down. …

This study followed 700 Parkinson's patients who received deep brain stimulation to see which factors predict a meaningful improvement in quality of life after 1, 3, and 5 years. Researchers analyzed clinical, imaging, and genetic data to identify who benefits most. The goal is t…

This study looked at how thoracic outlet syndrome—a condition that can cause nerve, artery, or vein problems in the shoulder and neck area—affects people's ability to work. Researchers used a questionnaire to check work performance in 101 employed or previously employed adults wh…

This study looked at the needs and challenges of family caregivers who help older adults (70+) with cancer. Researchers interviewed 78 caregivers to understand their social and personal situations, and tested a personalized support program with phone follow-ups. The goal was to s…

This completed study looked at how muscle oxygen levels change during exercise in people with various neuromuscular diseases compared to healthy volunteers. Seventeen participants did a knee-extension exercise while a device measured muscle oxygen. The goal was to understand diff…

This study looked at whether ultrasound measurements of the vena cava and femoral artery can predict which sepsis patients with low blood pressure will benefit from extra fluids. 90 spontaneously breathing adults in intensive care were studied. The goal is to avoid giving too muc…

This study tested whether a special liver scan (hepatobiliary scintigraphy) can predict liver failure in 326 patients undergoing major liver surgery. The scan measures how well the remaining liver works, which may be more useful than just measuring its size. If accurate, it could…

This pilot study tested whether taking metformin 30 or 60 minutes before a meal affects carbohydrate absorption in people with obesity and prediabetes or type 2 diabetes. One participant completed three oral glucose tolerance tests—one without metformin, one with metformin taken …

This completed study looked at how tofacitinib, a rheumatoid arthritis drug, changes body fat, muscle, and bone density in 10 patients. Researchers measured visceral fat, lean mass, and bone marrow fat before and after treatment. The goal was to gather early data, not to prove th…

This study looked at 89 obese pregnant women to find out how common sleep apnea is and whether it is linked to high blood pressure, preeclampsia, or poor fetal outcomes. Participants had a sleep test (polysomnography) to detect apnea. The goal was to understand the connection and…

This study tested whether a miniaturized ultrasound probe placed in the esophagus could help predict outcomes in 50 patients with acute respiratory distress syndrome (ARDS). The probe measures a blood vessel collapse index that may indicate heart strain. Researchers tracked how m…

This study looked at how many people are needed to find usability errors in the Zeneo® auto-injector pen, a device used for severe allergic reactions. 60 healthy volunteers used a demo version during a simulated anaphylactic shock. The goal was to improve device design by catchin…

This study looked at 451 children with asthma in northern France to see if mold in their homes made their asthma harder to control. Doctors checked asthma control using standard guidelines and questionnaires. The goal was to better understand how the environment affects children'…

This study looked at tissue samples from 6 children born with esophageal atresia, a condition where the esophagus doesn't form properly. Researchers compared biopsies taken during surgery with those stored for up to a year to see if storage time changes the molecular information.…

This study looked at 41 people who had early-stage vocal cord cancer and were treated with either surgery or radiation. The goal was to see which treatment led to better voice quality five years later. Patients filled out a questionnaire about their voice, and doctors also measur…

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This study tested whether a heart-rate based index (ANI) can detect pain in 17 children with cerebral palsy during injections and physical therapy. Researchers measured heart rate changes before and after painful procedures and compared them to standard pain scores. The goal was …

This completed study followed 73 people with autoimmune diseases like rheumatoid arthritis or multiple sclerosis who were starting treatment with rituximab. The goal was to track how many developed serious infections and to understand what factors increase that risk. Researchers …

This study followed 51 people with idiopathic pulmonary fibrosis (IPF) for 6 months to understand how their shortness of breath changes over time. Researchers measured both the physical sensation and the emotional impact of breathlessness, and looked at how these relate to lung f…

This study tested whether a rapid test called Unyvero could help doctors choose the right antibiotic sooner for patients with pneumonia who are on breathing machines in the ICU. The test looks for bacteria and their resistance genes in just a few hours, compared to standard lab c…

This study looked at 8 people with a FLNA gene mutation to see how many also had emphysema, a lung condition that damages air sacs. Participants had a chest scan, breathing tests, and a checkup with a lung doctor. The goal was to confirm if this rare genetic change is linked to u…

This study looked at whether the time of day a person has heart surgery changes how their heart muscle tolerates the stress of the procedure. Researchers took small tissue samples from the hearts of 88 patients having planned heart surgery, either in the morning or afternoon. The…

This study looked at whether giving women a self-collection kit for HPV testing at their family doctor's office would encourage more women to get screened for cervical cancer. The study involved 308 women aged 30-65 who were overdue for screening. Some women were offered the usua…

This study looked at whether a bedside lung ultrasound can predict lung complications within an hour after esophageal cancer surgery. Researchers followed 274 patients and compared ultrasound findings to standard methods. The goal is to find a faster, safer way to detect problems…

This study looked for new biological markers to help diagnose hypereosinophilic syndrome (HES), a rare condition where too many eosinophils (a type of white blood cell) cause damage. Researchers compared blood samples from 41 people with HES, those with other causes of high eosin…

This study looked at how breathing pure oxygen under high pressure (hyperbaric oxygen therapy) affects the smallest blood vessels in healthy adults. Fifteen volunteers underwent different oxygen and pressure combinations while researchers measured blood flow using special cameras…

This study looked at the genetic makeup of 29 people with APECED syndrome, a rare autoimmune disorder. Researchers aimed to find common gene mutations and link them to symptoms. The goal was to better understand the disease and improve diagnosis.

This study tested a device called ANI that measures heart rate changes to assess comfort in patients who cannot speak, such as those in end-of-life care. Twenty non-communicating patients in a palliative care unit were monitored during a painful procedure. The device's readings w…

This study looked at how the body processes cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if increased activity of a certain enzyme (11β-HSD1) contributes to the severe metabolic problems seen in this dis…

This study tested whether using an ultrasound during surgery helps doctors decide the best way to remove endometriosis from the rectum. Ten women with deep pelvic endometriosis took part. Doctors performed an ultrasound before and after shaving off the diseased tissue to see if i…

This study looked at how breast cancer treatments affect sexual health in 25 women. Participants filled out anonymous questionnaires about their sexual function, quality of life, and emotional well-being before and after chemotherapy. The goal was to understand how these factors …

This study looked at how inflammatory bowel disease (IBD) affects oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to understand which factors, like medic…

This study looked at whether doing extra leg strengthening exercises before ACL surgery helps patients recover better and return to sports. Six people with recent ACL tears took part. Researchers measured muscle strength and function before and after a special pre-surgery rehab p…

This study tested whether a non-invasive monitor called the Nociception Level (NoL) index can measure pain in children under general anesthesia. Researchers gave 30 children aged 5 to 12 brief, mild electrical stimulations of different strengths before surgery and recorded how th…

This study looked at 263 adults on breathing machines who had signs of pneumonia. Researchers tested their blood and lung fluid to see how many had a serious fungal infection called invasive pulmonary aspergillosis. The goal was to find out how common this infection is in this gr…

This study looked at the stressful life events that happen in the year before a teenager attempts suicide. Researchers compared 39 teens who had a first suicide attempt with teens who never had suicidal thoughts. They wanted to see how different types of stress build up over time…

This study looked at whether a protein called tissue factor (TF) in the blood can help predict how serious colorectal cancer is and if it might come back. Researchers measured TF levels in 26 adults before and after surgery to remove their tumors. The goal was to see if higher TF…

This study looked at teeth from 14 adults living in areas with high or low rates of Crohn's disease. Researchers measured metals and other environmental chemicals in the teeth to see if differences might help explain why some areas have more Crohn's disease. The goal was to gathe…

This study aimed to establish normal blood clotting ranges for healthy pregnant women and new mothers using a new device called Quantra®. Postpartum hemorrhage (heavy bleeding after birth) is a leading cause of maternal death, and knowing what's normal can help doctors detect and…

This completed study looked at 147 French children with confirmed peanut or tree nut allergies to see how often they accidentally have allergic reactions in everyday life. Researchers also recorded how severe those reactions were and what factors might increase risk. The goal is …

This study looked at how well the Pfizer COVID-19 vaccine works in people over 65 living in nursing homes compared to younger adults aged 40-65. Researchers measured immune cells and antibodies at 3 and 9 months after vaccination. The goal was to understand if older adults get th…

This study tested a computer system that alerts pharmacists about potential kidney failure or high potassium risks in older hospital patients. Researchers wanted to see if these alerts, combined with pharmacist reviews, could reduce serious side effects from medications. The stud…

This study looked at whether telling children and teens that a device tracks their physical activity changes how much they actually move. Eighty healthy participants aged 10-18 wore an accelerometer for 4 days. Half were told it measures activity, the other half were told it meas…

This study tested whether a device that measures heart rate patterns (called ANI) can predict pain responses when inserting a breathing tube. Researchers gave 60 patients a mild electric shock to mimic pain, then inserted the tube. They found that changes in the ANI score might h…

This study looked at how paracetamol (a common painkiller) is processed in the body after major liver surgery. Researchers measured paracetamol levels in the blood over five days in 90 patients who had different amounts of liver removed. The goal was to understand if patients wit…

This study looked at whether measuring the inferior vena cava through the liver (transhepatic approach) can predict if a patient needs more fluids after heart surgery. 40 ICU patients were included. The goal was to avoid giving too much fluid, which can be harmful. The study comp…

This study tested whether a simple thinking and memory test (called MoCA) can detect cognitive problems in people hospitalized for a suicidal crisis. Researchers enrolled 140 adults who were either having strong suicidal thoughts or had recently attempted suicide. The goal was to…

This pilot study looked at ovarian tissue from 9 young women with acute myeloid leukemia who had it frozen to preserve fertility before a stem cell transplant. Researchers checked the frozen tissue for any leftover leukemia cells. The goal was to see if the tissue might be safe t…

This completed study from France enrolled 373 people who came to the emergency room with suspected COVID-19. Researchers checked routine blood markers to see if any could predict which patients would later get worse and need intensive care. The goal was to find simple, low-risk t…

This study aims to create an algorithm that detects epileptic seizures by continuously analyzing the heart's electrical activity (ECG). Researchers will use data from 40 epilepsy patients who had seizures recorded during long-term video-EEG monitoring. The goal is to see how accu…

This study tested whether a rapid test called Unyvero could help doctors decide sooner whether to stop or change antibiotics in patients on breathing machines with suspected aspiration pneumonia. The trial involved 266 adults in the ICU. The goal was to see if the test reduced th…

This study looked at whether it's safe to reduce or stop antifungal drugs early in immunocompromised ICU patients suspected of having a fungal infection. Researchers tracked 275 patients across 14 ICUs to see how often doctors de-escalated treatment and what factors influenced th…

This study looked at 186 pregnant women with type 1 or type 2 diabetes to understand how fats in the blood relate to baby birth weight. Researchers measured blood fats, diet, and placenta genes. The goal is to find new ways to prevent babies from being born too large, which can c…

This study measured how well back muscles use oxygen during exercise in people with chronic low back pain compared to healthy individuals. Researchers used special sensors to track muscle oxygen and breathing. The goal was to understand why back pain patients often feel muscle fa…

This study looked at how often doctors increase the dose or give Xolair more frequently for people with chronic hives. Researchers followed 163 adults for 3 months to see how many needed a stronger treatment plan. The goal was to understand real-world use, not to test a new drug.

This study tested whether a combination of 6 markers from tumor tissue could predict how well patients with advanced non-small cell lung cancer respond to first-line treatment with pembrolizumab (immunotherapy) plus chemotherapy. Researchers analyzed tissue samples from 106 patie…

This study looked at 174 adults with severe asthma who were starting biotherapy. Researchers wanted to see if their ability to work (despite health issues) improved after 6 months of treatment. The goal was to understand which factors, like asthma control or other health problems…

This study looked at whether people with systemic sclerosis (scleroderma) have higher levels of the hormone prolactin in their blood. Researchers measured prolactin in 71 patients and compared them to healthy volunteers. The goal was to understand if prolactin plays a role in the…

This study aimed to understand how fat cells in bone marrow contribute to bone loss in osteoporosis. Researchers took bone cells from 20 adults undergoing hip replacement surgery and exposed them to secretions from fat cells in the lab. By measuring changes in gene activity, they…

This study followed 29 people with Parkinson's disease, along with healthy volunteers and people with a similar condition, to better understand speech and movement issues that don't respond to standard Parkinson's medication. Researchers used brain scans, breathing tests, and wal…

This study looked at whether caffeine intake is linked to how Huntington's disease progresses in people who have the gene but not yet symptoms. Researchers followed 77 participants, measuring brain volume changes and thinking skills over time. The goal was to see if caffeine migh…

This study aimed to understand the different types of young children who get early cavities and what factors are linked to more severe decay. Researchers examined 298 children under 6 with early caries and surveyed their parents about dental knowledge, habits, stress, and social …

This study looked at how B cells, a type of immune cell, may contribute to scarring in people with systemic sclerosis (scleroderma). Researchers compared skin and blood samples from 71 participants, including patients and healthy volunteers. The goal was to understand the disease…

This completed study examined whether eosinophils, a type of white blood cell, contribute to fibrosis (scarring) in systemic sclerosis, an autoimmune disease. Researchers compared blood samples from 40 patients with systemic sclerosis and 30 healthy volunteers, with optional skin…

This study tested a new questionnaire called Serenat to see if it accurately measures well-being at work. Researchers asked 226 adults who were working and had adjustment disorder to fill out the 20-question survey. The goal was to validate the scale so it can be used in the futu…

This study looked at whether a specially shaped cuff on breathing tubes could reduce the amount of stomach fluid that leaks into the lungs of critically ill patients on ventilators. Researchers measured pepsin levels (a stomach enzyme) in 326 adults to track leakage. The goal was…

This study looked at 258 adults with untreated oeso-gastric cancer to understand how factors like income, education, and personal beliefs affect the time between first noticing symptoms and seeing a doctor. Researchers measured the median delay from symptom onset to first consult…

This pilot study looked at whether the COVID-19 virus can spread through the air during surgery on infected patients. Researchers took air samples and swabbed surfaces in the operating room during two surgeries. The goal was to understand contamination risks so that healthcare wo…

This study followed 72 young adults who were part of a larger European study 10 years ago as teenagers. Researchers looked at their current heart disease risk using a special score and compared it with their diet and lifestyle habits from adolescence. The goal is to find new risk…

This study followed 56 adults with systemic sclerosis (scleroderma) who also had a serious lung complication called diffuse infiltrating pneumonia. Researchers measured lung function at 12 and 24 months to see how it changed and to identify factors that might predict faster decli…

This study looked at 757 adult patients treated for COVID-19 at Lille University Hospital to find out which factors best predict death within 28 days. Researchers collected medical, lab, and imaging data to understand why some patients die and others recover. The goal is to help …

This study looked at 58 pregnant women with and without PCOS to understand how hormones like AMH and leptin might be passed to their babies. Researchers measured these hormones in the mother's blood during each trimester and in the placenta after birth. The goal was to see if hig…

This study tested whether a device called the ANI monitor can measure pain in sedated children aged 2 and older in the pediatric intensive care unit. Researchers watched how the device responded during painful care and compared it to a standard behavioral pain scale. The goal was…

This study looked at gut bacteria in 214 people: children and older adults recently diagnosed with Crohn's disease, plus healthy controls. Researchers compared the bacteria and genetic profiles to see if age-related differences could explain why Crohn's starts at different life s…

This study looked at whether keeping a diary during intensive care can lower the risk of post-traumatic stress disorder (PTSD) in people who survived a sudden cardiac arrest and in their family members. About 173 patients and their relatives took part. Researchers measured PTSD s…

This completed study looked at whether a blood test for a substance called ADMA can measure blood vessel health in children with growth hormone deficiency or those born small for their age. Researchers compared ADMA levels to ultrasound measurements of artery function in 23 child…

This completed study followed 229 stroke survivors over time to understand what factors might lead to dementia or cognitive problems after a stroke. Researchers looked at medical history, brain scans, and medications. The goal was to identify clues that could help predict and pos…

This study used MRI scans to look at how hamstring tendon grafts used to replace a torn anterior cruciate ligament (ACL) heal and change shape over a year after surgery. Researchers checked for ballooning (enlargement of the bone tunnels) and ligamentisation (how the graft turns …

This study looked at whether adults with ADHD are more likely to relapse into drinking after completing a detox program. Researchers followed 113 people for 12 weeks, using interviews and questionnaires to assess ADHD and other mental health conditions. The goal was to see if ADH…

This study used advanced MRI scans to look at the hypothalamus, a brain region that controls hormones, in women with PCOS. Researchers compared 52 women with and without PCOS to see if there were differences in brain structure and chemistry. The goal was to better understand how …

This study looked at 46 people who had a first episode of optic neuritis (inflammation of the optic nerve). Researchers used special MRI scans to measure the length of the damaged nerve area and then checked how much vision-related nerve loss occurred one year later. The goal was…

This study looked at how two types of nerve diseases—inherited and acquired—affect walking and balance. Researchers used motion analysis and simple tests like the Timed Up and Go test in 67 participants. The goal was to find clear differences that could help doctors tell the two …

This study followed 180 people with anorexia nervosa for up to 4 years to see how their bone density changed over time. Researchers measured bone mineral density using a special X-ray scan and also checked blood levels of certain hormones linked to fat tissue. The goal was to und…

This study looked at how people with post-traumatic stress disorder (PTSD) predict their emotional reactions to future events. Researchers compared 97 participants with and without PTSD to see if those with PTSD tend to expect more intense negative emotions than they actually exp…

This study looked at fat cells from bone marrow and belly fat in 45 post-menopausal women having knee replacement surgery for osteoarthritis. Researchers measured gene activity to see if bone marrow fat releases more joint-damaging factors. The goal is to understand how fat contr…

This study followed 113 adults with myotonic dystrophy (Steinert's disease) for 5 years to find out what factors lead to low breathing (hypoventilation). Researchers measured lung function, sleepiness, fatigue, and thinking skills. The goal is to better understand which patients …

This completed study involved 214 people with systemic sclerosis (scleroderma) to find out how often calcium deposits form in the hands and feet. Researchers used X-rays to detect these deposits and checked if they were linked to damage in organs like the lungs or heart. The goal…

This study followed 83 people with Parkinson's disease and healthy volunteers to see if daily walking patterns measured at home can track how the disease progresses. Participants wore special insoles for 10 days at a time to record their gait. The goal was to find simple, real-wo…

This study looked at how the pain medicine sufentanil travels from the amniotic sac into the fetus and mother. Eight women who were ending their pregnancy for medical reasons received a small injection of the drug. Researchers measured drug levels in the fetus, mother, and amniot…

This study followed 250 children under 4 years old with congenital glaucoma in France. Researchers wanted to see if finding the disease earlier leads to better eyesight at age 4. They measured vision and eye pressure to understand how timing of diagnosis affects long-term outcome…

This completed study followed 134 people with a first episode of neurological symptoms (clinically isolated syndrome) to develop better ways to detect nerve damage early. Researchers used MRI scans and eye exams to monitor changes over time. The goal was to help doctors decide wh…

This study looked at whether combining EEG and fMRI scans can better pinpoint the exact brain area causing seizures in people with drug-resistant focal epilepsy. 102 participants who were already being evaluated for surgery had this extra scan. The goal was to see if the combined…

This completed study looked for genetic and environmental factors that increase the risk of developing Parkinson's disease. Researchers compared DNA and lifestyle data from over 2,200 people, including Parkinson's patients, people with related brain diseases, and healthy voluntee…

This study looked at 257 emergency patients on ECMO (a heart-lung machine) to understand why many experience serious bleeding. Researchers measured how often bleeding occurred and checked for defects in von Willebrand factor, a key clotting protein. The goal is to find links betw…