University Hospital, Lille

This study tested whether a drug called deferiprone could slow the progression of Parkinson's disease. The drug works by removing excess iron from the brain, which researchers believe may contribute to the disease. The trial involved 372 adults with early-stage Parkinson's who we…

This study tested whether a combination of two drugs, pomalidomide and dexamethasone, could help control a hard-to-treat form of blood cancer called multiple myeloma. It focused on 63 patients whose cancer had specific genetic features linked to poorer outcomes and had come back …

This study tested whether patients with malignant pleural mesothelioma could complete an intensive combination treatment. The treatment included surgery to remove visible tumors, a special light-activated drug therapy during surgery, followed by chemotherapy and radiation. Resear…

This study tested whether deferiprone, a drug that removes excess iron from the body, could slow the progression of amyotrophic lateral sclerosis (ALS). Researchers enrolled 372 people with early-stage ALS and randomly assigned them to receive either deferiprone or a placebo for …

This study compared two approaches for treating infected abdominal hernias that develop after surgery. 110 patients were randomly assigned to receive either a biological mesh implant or standard wound care without mesh. Researchers tracked infection rates, hernia recurrence, heal…

This study tested whether personalized phone and text message coaching could help children with type 1 diabetes who struggle with adjusting their insulin treatment. Researchers worked with 106 children under 18 years old who had difficulty managing their blood sugar levels. The g…

This study tested whether a more comprehensive remote monitoring system could help heart failure patients with special pacemakers stay healthier and avoid hospital visits. Researchers compared two different remote monitoring approaches over 27 months to see which was better at pr…

This study tested whether a special education program led by nurses could help stroke patients manage their recovery better than standard follow-up care. The program involved teaching patients and a family member or caregiver about managing high blood pressure and stroke recovery…

This small pilot study tested whether adding a special light treatment during surgery is safe and practical for patients with glioblastoma, a serious brain cancer. Ten patients received the experimental light therapy right after their main tumor was removed, in addition to standa…

This study tested whether using a rapid diagnostic test (Unyvero®) could help doctors stop unnecessary antibiotic treatment sooner in patients with suspected pneumonia who are on a breathing machine. The goal was to reduce the overuse of broad-spectrum antibiotics, which can lead…

This study tested a new hospital computer system designed to prevent serious side effects from medications, specifically sudden kidney failure and high potassium levels, in older patients. The system used smarter alerts that were reviewed by pharmacists before being sent to docto…

This study tested whether the drug nilotinib could help control chronic graft-versus-host disease in patients who had already tried and failed treatment with imatinib. The trial involved 65 adults who had received stem cell transplants and developed this serious complication wher…

This study tested whether adding a common antibiotic (amoxicillin-clavulanic acid) to the standard steroid treatment could help more people survive severe alcoholic hepatitis. It focused on patients at very high risk of dying within two months. The main goal was to see if the ant…

This study aimed to find a safe and effective dose of the drug lenalidomide for adults with Waldenstrom Macroglobulinemia, a rare and incurable blood cancer, whose disease had returned or was not responding to other therapies. It involved a small group of 17 participants to first…

This study tested whether transplanting insulin-producing cells (islets) could help patients with type 1 diabetes who already had a kidney transplant. The goal was to help these patients become independent from insulin injections and better control their blood sugar. Researchers …

This study tested whether a guided physical activity program could improve bone mineral density in children and teenagers with chronic inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Researchers worked with 15 young patients who had IBD for at least six m…

This study tested a new electronic device designed to automatically keep the pressure in a breathing tube just right for ICU patients. When the pressure is wrong, it can cause stomach fluids to leak into the lungs or damage the windpipe. Researchers compared how well the device w…

This study tested whether a personalized 'SOS Plan' could help people with schizophrenia avoid hospital stays. The plan was created by the patient, their doctor, and family members to outline what to do during a mental health crisis. Researchers compared 124 patients who used the…

This study tested whether a personalized online program could help pregnant women with obesity manage their weight gain and improve their birth experience. Over 850 women were randomly assigned to either use the web-based program, which offered diet, exercise, and lifestyle coach…

This study tested a light-based therapy given during surgery for glioblastoma, an aggressive brain cancer. It aimed to find the safest and most effective dose of light to use alongside standard surgery and chemo-radiation. The goal was to see if this combined approach could bette…

This study tested whether using specific blood tests (fungal biomarkers) could help doctors safely stop antifungal medication sooner in critically ill ICU patients who started the drugs as a precaution. It involved 110 adult ICU patients who were started on antifungal treatment w…

This study looked at how doctors adjust treatment for adults with chronic hives (urticaria) who take the medication omalizumab (Xolair). Researchers followed 163 patients to see how often doctors increased the dose or gave shots more frequently to improve control. The main goal w…

This study tested whether a gentle, needle-based therapy called acupuncture-moxibustion could help turn breech babies to a head-down position before the final weeks of pregnancy. Researchers compared the real therapy to a fake light treatment in 328 pregnant women to see which wa…

This study tested whether carefully selected patients with severe alcoholic hepatitis who don't respond to medical treatment could safely receive early liver transplants. Researchers compared 284 patients to see if those getting early transplants had similar rates of returning to…

This study tested a new weekly dosing schedule of a drug called carfilzomib, combined with standard medications, for older adults newly diagnosed with multiple myeloma. The main goals were to find the safest, most effective dose and to see how well the treatment controlled the ca…

This study tested if a freeze-dried version of blood plasma, developed for military use, can help control life-threatening bleeding in civilian trauma patients faster than standard frozen plasma. It involved 42 adults with severe injuries who needed urgent blood transfusions. The…

This study tested whether a protein from a parasite could help control inflammation in people with moderate Crohn's disease. Ten patients received three monthly injections of P28GST to check if it was safe and might prevent the disease from returning after surgery. Researchers mo…

This pilot study tested whether infusing sodium lactate, compared to normal saline, could help better manage fluid levels in patients with septic shock. It involved 59 critically ill patients and measured how the treatment affected fluid balance, organ failure, and survival over …

This small pilot study tested whether a drug called deferiprone, which removes excess iron from the body, is safe and might help slow the progression of ALS. The study involved 23 people with ALS and looked for changes in their symptoms and functional abilities over time. The mai…

This study tested whether immediate surgery or simple sling immobilization works better to prevent repeat shoulder dislocations in young adults after their first dislocation. Researchers randomly assigned 40 patients aged 18-25 to either surgery to repair torn tissues or wearing …

This small, preliminary study looked at whether doing more physical therapy *before* surgery for a torn ACL (a common knee ligament injury) could help athletes recover better afterward. Researchers measured leg muscle strength in 6 adults with recent ACL tears to see if a specifi…

This study tested whether watching how a patient's central blood pressure changes when they take a deep breath can predict if giving them more IV fluids will help their heart pump better. Researchers worked with 68 awake, breathing patients in intensive care who already had speci…

This study aimed to develop a computer algorithm that can automatically detect epileptic seizures by continuously analyzing a person's heart signals (electrocardiogram or ECG). Researchers tested the algorithm using existing recordings from 40 patients with epilepsy who had under…

This study tested a new, non-invasive blood test called the LLIFT to see if it could accurately diagnose fatty liver disease (NAFLD) and its more severe form (NASH). It involved 158 people at high risk for metabolic problems like obesity and diabetes. The goal was to find a simpl…

This study tested a simple, non-invasive heart rate monitor (called ANI) to see if it could accurately detect pain and discomfort in patients who are unable to communicate, such as those receiving end-of-life palliative care. Researchers compared the monitor's readings to pain as…

This study tested a new strategy to diagnose rare genetic conditions called peroxisomal disorders more quickly and accurately. It involved 8 patients, both children and adults, who showed symptoms or had family history of these diseases. The approach used a broader set of initial…

This study tested if using a faster diagnostic machine (Unyvero®) could help doctors choose the correct, targeted antibiotic for pneumonia patients in the ICU more quickly. Currently, doctors often have to wait days for lab results, leading to initial treatment with broad-spectru…

This study tested whether a small, handheld device could reliably measure the strength of a key foot muscle. Researchers compared measurements from this portable tool against a large, specialized lab machine, which is considered the best method. They tested 46 healthy adults to s…

This study tested whether combining two brain scan techniques (EEG and fMRI) helps doctors more accurately locate the area causing seizures in people with hard-to-treat focal epilepsy. The goal was to see if this combined scan could improve decisions about who is a good candidate…

This study tested whether using a special vaginal ultrasound during surgery helps surgeons make better decisions. It involved 10 patients with endometriosis affecting the rectum who were scheduled for a specific surgical procedure. The goal was to see if the live ultrasound image…

This study tested a specific ultrasound method to help doctors decide if a patient needs more IV fluids after major heart surgery. Researchers compared a standard scan under the ribs to a different scan through the liver area, which is often easier to do after surgery. The goal w…

This study tested if a simple, bedside lung ultrasound scan could spot breathing problems early in patients recovering from esophageal cancer surgery. Researchers followed 274 patients to see if the scan, done right after waking up from surgery, was better than standard methods a…

This study tested a medical device called the ANI monitor to see if it could accurately measure pain in sedated and ventilated children in the pediatric intensive care unit. Researchers enrolled 50 children to see if the device's readings matched up with standard behavioral pain …

This study tested a new wireless patch placed on a mother's belly during labor. The goal was to see if it could accurately measure the baby's heart rate and the mother's contractions, comparing it to the standard hospital monitor. It involved 60 women in labor with single, head-d…

This study tested whether egg freezing could help preserve fertility in women with recurring benign ovarian cysts. Researchers enrolled 82 women at risk of infertility from multiple cyst surgeries to see how many healthy eggs could be collected and frozen. The goal was to prevent…

This large study tested whether treating a common vaginal infection (bacterial vaginosis) early in pregnancy could prevent premature birth and late miscarriage. Over 3,100 pregnant women were randomly assigned to receive either an antibiotic (clindamycin) or a placebo. The goal w…

This study tested if a specially shaped breathing tube cuff could better seal the airway and reduce the leakage of stomach and mouth fluids into the lungs of critically ill patients on ventilators. The goal was to see if this new design could help prevent ventilator-associated pn…

This study tested whether offering an at-home HPV self-sampling kit could help more women get screened for cervical cancer. It focused on women aged 30-65 in France who had not been screened in over three years. Family doctors either offered the usual Pap test or gave women the o…

This study tested whether a 5-week stress management program works better when delivered by computer or in-person with a therapist. It involved 120 adults diagnosed with adjustment disorder and anxiety. Researchers compared both approaches to see which was more effective at reduc…

This study tested whether teaching patients about the biology of pain, combined with rehabilitation, works better than traditional back education for reducing disability from chronic low back pain. Researchers compared these two educational approaches in 88 adults who had experie…

This study tested whether a special training program could help cancer survivors improve their emotional skills. People who had finished treatment for stomach or lung cancer were randomly assigned to either learn emotional skills or practice relaxation techniques. Researchers mea…

This study tested whether keeping a diary in the intensive care unit (ICU) could help prevent post-traumatic stress disorder (PTSD) in patients who survived a sudden cardiac arrest and their family members. Researchers compared a group of patients who received the diary to a grou…

This study tested a new medical device called 'Hypnos-Pro' to see if it could reduce pain and anxiety for men undergoing prostate biopsies. The device is a mask with lights and headphones designed to help patients enter a relaxed, hypnotic state during the procedure. Researchers …

This study tested whether wearing a special, tight-fitting sleeve on the arm for six months could help children with cerebral palsy use their affected hand and arm more effectively. Researchers enrolled 101 children aged 5 to 10 years old to see if the sleeve improved their abili…

This study tested whether a special education program could help people in the early stages of Parkinson's disease become more physically active in their daily lives. Researchers compared 89 patients who received the program to those on a waiting list, measuring their activity le…

This study tested whether a digital platform could help patients recover after major surgery for throat or esophageal cancer. It aimed to improve quality of life, reduce pain, and prevent complications through personalized exercise and support programs. The main goal was to see i…

This study tested whether a non-invasive brain stimulation technique could help people with schizophrenia who experience persistent hallucinations that don't respond to medication. Researchers used detailed MRI brain scans to precisely target the stimulation, hoping this approach…

This study tested a new computer system designed to automatically give patients a strong painkiller (remifentanil) during surgery. The system used the patient's heart rate, blood pressure, and a special pain index to decide when to give the drug. Researchers wanted to see if this…

This study tested whether relaxing aesthetic care sessions could help patients feel better during difficult hospital stays. It involved 70 adults with acute leukemia or receiving a stem cell transplant, who had to stay in a protected isolation room for weeks. Researchers used que…

This study tested whether a low dose of a medication used for ADHD (methylphenidate), when combined with 6 weeks of computerized brain training, could improve thinking skills and simulated driving performance in healthy older adults. The goal was to see if this combined approach …

This study tested a special recovery program designed to help patients go home faster after minimally invasive kidney cancer surgery. The program included detailed patient education, reduced pain medication use, and encouraged eating, drinking, and moving soon after the operation…

This study tested if injecting a numbing medicine (ropivacaine) into the nose at the end of sinus surgery helps reduce pain afterward. It was a Phase 3 trial involving 184 patients who had surgery for chronic sinus problems. Researchers compared the injection to a placebo (saltwa…

This study tested whether a nasal spray containing the drug clonidine could safely reduce anxiety in young children before minor surgery. It compared the spray to a placebo (a spray with no medicine) in 90 children aged 1 to 5 years old. The main goal was to see if children who r…

This study tested whether a personalized, 4-week exercise program could improve daily function and quality of life for people with dermatomyositis or polymyositis. 80 adults with stable muscle weakness were randomly assigned to either receive the exercise program or continue with…

This study tested two alternative pain management methods for patients recovering from liver surgery. Researchers compared continuous local anesthetic injection near the surgical site with continuous spinal pain relief to see which better reduces morphine use after surgery. The t…

This study looked at whether hypnosis sessions could help reduce anxiety for pregnant women experiencing early water breaking (PPROM). Researchers compared two sessions of hypnosis support against usual care in 60 participants. They also examined how this stressful pregnancy comp…

This study tested whether Ericksonian hypnosis could help reduce chronic pain in people with Parkinson's disease. Thirty-three participants were divided into two groups: one received a two-month hypnosis program, while the other received standard care. Researchers measured change…

This study tested whether a new pain management protocol could better help women undergoing in vitro fertilization (IVF). Researchers compared 206 patients using the new approach to data from previous patients to see if it reduced pain during treatment. The study focused particul…

This study tested whether medical hypnosis could help patients feel less pain and anxiety during a common nerve and muscle function test called an ENMG. Researchers compared patients who received hypnosis during the test to those who received standard care. The goal was to see if…

This study tested whether a medical hypnosis technique could help reduce stress and improve the hospital experience for patients with chronic diseases. Researchers compared a group that received a hypnosis session focused on creating a 'safe place' with a group that received no s…

This study tested whether adding the drug ketamine to a standard antidepressant could help control depression symptoms faster in patients with serious, progressive illnesses who are receiving palliative care. It involved 42 hospitalized patients with moderate-to-severe depression…

This study aimed to understand how the body processes the common pain medication paracetamol (acetaminophen) after major liver surgery. Researchers followed 90 patients who had liver operations, measuring drug levels in their blood for five days after surgery. The goal was to lea…

This study used MRI scans to look at how knee surgery for torn ACL ligaments heals over time. Researchers followed 24 patients for more than a year after their ACL reconstruction surgery. They specifically examined whether the bone tunnels created during surgery widened and how t…

This study followed 250 young children in France with congenital glaucoma to understand how the timing of diagnosis affects their vision. Researchers tracked the children's eye pressure and vision over time to see if finding the condition earlier leads to better long-term eyesigh…

This study aimed to understand how Parkinson's disease affects speech, movement, and brain function over time. Researchers followed 29 Parkinson's patients and compared them to healthy volunteers using brain scans, speech assessments, and movement tests. The goal was to map brain…

This study aimed to understand if a type of white blood cell called an eosinophil plays a role in causing the scarring (fibrosis) seen in scleroderma. Researchers compared blood and skin samples from 70 people, including scleroderma patients and healthy volunteers. The goal was t…

This study followed up with 72 young adults who were part of a large European health survey as teenagers 10 years ago. Researchers aimed to understand how diet, physical activity, and other lifestyle factors during adolescence influence the risk of developing heart problems in ea…

This study aimed to understand how COVID-19 might spread through the air during abdominal surgery. Researchers tested air and surfaces in operating rooms where COVID-positive patients underwent surgery. The goal was to gather evidence to create better safety guidelines for surgic…

This study aimed to test and validate a new questionnaire called the 'Serenat' scale, which measures well-being at work. Researchers gave the 20-question survey to 226 working adults, including a group with mental health conditions, to see if it was a reliable tool. The goal was …

This study aimed to understand how a severe lung complication, called diffuse infiltrating pneumonia, changes over time in people with systemic sclerosis (scleroderma). Researchers followed 56 patients for two years, measuring their lung function to see how it declined. The goal …

This study aimed to understand how different types of nerve damage affect walking and balance. Researchers compared 67 people with hereditary nerve disorders to those with recently acquired nerve damage. They used motion-capture technology and balance tests to measure differences…

This study looked at whether newer biologic drugs for severe asthma help people be more productive at work. Researchers followed 174 employed adults with severe asthma for 6 months after starting a biologic treatment. The main goal was to see if their ability to work effectively …

This study aimed to see if a substance in the blood called ADMA could be a simple way to check for early blood vessel problems in children. It involved 23 children with growth hormone deficiency or who were born small, comparing them to healthy children. Researchers measured ADMA…

This study aimed to understand what life events lead teenagers to attempt suicide. Researchers followed 39 young people aged 15-24 who had recently attempted suicide, comparing them to peers without suicidal thoughts. They tracked stressful life events over a year to identify pat…

This study observed how often doctors reduced or stopped antifungal medications in critically ill patients with weakened immune systems who were suspected of having a serious yeast infection. Researchers tracked 275 patients across 14 intensive care units to see if this 'de-escal…

This study aimed to find a better way to predict how aggressive colorectal cancer might be. Researchers measured levels of a protein called tissue factor in the blood of 26 adults before and after cancer surgery. They wanted to see if this protein level could indicate the cancer'…

This study aimed to find simple blood markers that could predict which patients arriving at the emergency room with suspected COVID-19 would later get much worse. Researchers followed 373 patients to see if standard blood test results, taken early, could forecast who might need i…

This study tested if a special pain monitor could predict how a patient's body would react when a breathing tube was placed. Researchers gave 60 surgery patients a small, controlled electric shock while they were under anesthesia and watched their monitor readings. They then chec…

This study aimed to see if a special type of MRI scan, taken soon after a person has an episode of optic neuritis, can predict how much vision they might lose a year later. Researchers followed 46 people who had a recent first-time attack of optic neuritis. They compared the size…

This study aimed to understand why people with stomach or esophageal cancer sometimes wait to see a doctor after their first symptoms appear. Researchers surveyed 258 patients in France to learn if personal feelings, thoughts, or social factors influenced this delay. The goal is …

This study aimed to understand how oral health issues like gum disease, cavities, and tooth loss affect the daily life and well-being of people with Crohn's disease or ulcerative colitis. Researchers compared survey responses from 138 adults with IBD to people without IBD. The go…

This study aimed to understand how common painful skin calcium deposits are in people with systemic sclerosis (scleroderma). Researchers used hand and foot X-rays to check 214 patients for these deposits. They also investigated whether having these calcium deposits is linked to d…

This study aimed to understand if environmental factors, like exposure to metals, might be linked to why some areas have more cases of Crohn's disease than others. Researchers compared the chemical makeup of teeth from 14 adults living in high-incidence and low-incidence areas of…

This study aimed to better understand APECED syndrome, a rare genetic disorder that causes multiple autoimmune problems. Researchers analyzed 29 French patients to see how different gene mutations relate to the specific symptoms and antibody patterns they develop. The goal was to…

This study aimed to understand how a strong pain medication moves between a pregnant person and their fetus. It involved eight people undergoing pregnancy termination due to severe fetal malformations after 24 weeks. Researchers injected the medication into the amniotic fluid and…

This study investigated whether having heart surgery in the morning or afternoon affects how well heart muscle tolerates changes in blood flow. Researchers examined small heart tissue samples from 88 patients undergoing scheduled heart surgery. The goal was to understand if time …

This study measured how the immune systems of elderly people living in care homes responded to the Pfizer COVID-19 vaccine compared to younger, healthy adults. Researchers tracked antibody levels and specific immune cells at 3 and 9 months after vaccination in 264 participants. T…

This study aimed to find new, easier-to-use markers in the blood to help doctors diagnose hypereosinophilic syndrome (HES), a rare disorder where the body makes too many of a certain type of white blood cell. Researchers analyzed blood proteins from 41 people with HES to look for…

This study aimed to understand why people with chronic low back pain get tired so quickly. Researchers measured oxygen levels in back muscles during exercise in 33 people with and without back pain. The goal was to see if a rehabilitation program could improve how the muscles use…

This study aimed to understand why people with anorexia nervosa often lose bone density and develop osteoporosis. Researchers followed 180 patients with anorexia for up to 6 years, measuring their bone density every two years. They checked blood and urine for specific hormones fr…

This study tested if telling children and teens that a device they wore tracked their physical activity changed how active they were. Eighty healthy participants aged 10-18 were split into two groups: one was told the device measured activity, and the other was not. Researchers c…

This study tested a new lab analysis using six markers from a patient's tumor sample. The goal was to see if this test could predict, before treatment starts, which patients with advanced non-small cell lung cancer would respond well to a combination of immunotherapy (pembrolizum…

This study aimed to understand how high-pressure oxygen therapy affects the body's smallest blood vessels, called microcirculation. Researchers exposed 15 healthy volunteers to different oxygen levels and air pressures inside a special chamber. They measured blood flow changes to…

This study aimed to understand if people experiencing a suicidal crisis have changes in their thinking skills, like memory and attention. Researchers gave a short paper-and-pencil test to 140 adults hospitalized for suicidal thoughts or a recent suicide attempt. The goal was to s…

This study investigated whether people with post-traumatic stress disorder (PTSD) have difficulty predicting their own emotional reactions to future events. Researchers compared 97 participants across three groups: those with PTSD, those exposed to trauma without PTSD, and health…

This study investigated whether caffeine consumption affects how Huntington's disease progresses in people who carry the gene but don't yet show clear symptoms. Researchers followed 77 adults with the Huntington's gene mutation, measuring brain changes, movement, thinking skills,…

This study aimed to understand why serious bleeding occurs in up to half of patients on ECMO, a machine that supports heart and lung function. Researchers followed 257 emergency patients to see if bleeding was linked to problems with a blood-clotting protein called Von Willebrand…

This study aimed to understand why babies born to mothers with diabetes are often larger, even when blood sugar is well-controlled. Researchers followed 186 pregnant women, including those with type 1 or type 2 diabetes and those without, to see if specific fats in the mother's a…

This study aimed to understand how breast cancer treatments affect patients' sexual health and quality of life over time. Researchers followed 25 women with non-metastatic breast cancer for one year after starting chemotherapy. They used repeated anonymous questionnaires to track…

This study aimed to understand why polycystic ovary syndrome (PCOS) often runs in families. Researchers followed 58 pregnant women, some with PCOS and some without, to measure hormone levels in their blood and placentas. They specifically looked at a hormone called AMH to see if …

This study aimed to develop better tools for tracking nerve damage in people showing early signs of multiple sclerosis (MS). Researchers followed 134 patients who had experienced a single neurological episode to see how their condition changed over time. They used eye scans and b…

This study aimed to understand how common high levels of a hormone called prolactin are in people with systemic scleroderma, a disease that causes hardening and scarring of skin and internal organs. Researchers compared 71 scleroderma patients to healthy volunteers to see if high…

This study aimed to understand how a type of immune cell, called B lymphocytes, might contribute to the scarring (fibrosis) seen in systemic sclerosis (scleroderma). Researchers compared cells from 71 people, including patients and healthy volunteers, to see how patient B cells i…

This study aimed to establish normal measurement ranges for a bedside blood clotting device used during pregnancy and after delivery. Researchers measured 31 healthy pregnant women to understand what typical clotting looks like when there is no bleeding problem. The goal is to us…

This study aimed to find better ways to measure how Parkinson's disease changes over time. Researchers tracked 83 people with Parkinson's and related conditions by having them wear special insoles that recorded their walking patterns at home for 10 days. They compared these walki…

This study aimed to understand if changes in how the body processes the stress hormone cortisol are involved in Familial Partial Lipodystrophy Type 2 (FPL2), a rare genetic disorder that affects where fat is stored and causes serious metabolic problems. Researchers enrolled 25 ad…

This study aimed to find out which factors can predict if a hospitalized COVID-19 patient will die within 28 days. Researchers at Lille University Hospital in France collected detailed medical information from 757 adult patients treated for suspected or confirmed COVID-19. By ana…

This study aimed to understand why some young children develop more severe cavities than others. Researchers examined 298 children under age 6 with early tooth decay and surveyed their parents about family habits, knowledge, and background. The goal was to identify different prof…

This study aimed to understand how muscles use oxygen during exercise in people with different neuromuscular diseases, compared to healthy people. Seventeen participants performed a leg exercise while researchers measured oxygen levels in their muscles using a special light-based…

This small study aimed to see if traces of leukemia could still be found in frozen pieces of ovary taken from young women with acute myeloid leukemia (AML) who were in remission. The goal was to gather information about the safety of this fertility preservation method. Researcher…

This study aimed to discover what makes someone more likely to develop Parkinson's disease. Researchers compared over 2,200 people, including those with Parkinson's, other brain conditions, and healthy individuals. They looked for links between genes, lifestyle, environment, and …

This study aimed to find out how often people with a specific FLNA gene mutation develop emphysema, a serious lung condition. Eight participants with the mutation underwent lung scans and breathing tests. The goal was to gather evidence to confirm if this genetic mutation is link…

This study aimed to identify what factors make someone more or less likely to develop dementia after having a stroke. Researchers followed 229 stroke patients for five years, regularly checking their memory, thinking skills, and brain health with scans and tests. By comparing pat…

This study aimed to understand if Crohn's disease is different in people who develop it as children versus older adults by comparing their gut bacteria. Researchers analyzed stool samples from 214 participants, including patients and healthy controls, to look for patterns linked …

This study aimed to understand how secretions from fat cells might contribute to bone loss in osteoporosis. Researchers collected bone cells from 20 adults undergoing hip replacement surgery and exposed them to fat cell secretions in the lab. They measured how these secretions ch…

This study aimed to find out how often a serious fungal lung infection occurs in critically ill patients on breathing machines who develop suspected pneumonia. Researchers tested fluid from the lungs of 263 adult ICU patients to check for the fungus. The goal was to gather better…

This study aimed to understand how long-term storage affects tissue samples used for research on esophageal atresia, a birth defect where the esophagus doesn't form properly. Researchers compared the molecular signatures of tissue samples taken from six babies during their initia…

This study aimed to understand how different types of body fat might contribute to knee osteoarthritis. Researchers compared fat from inside the bone marrow to fat from under the skin in 45 postmenopausal women who were having knee replacement surgery. The goal was to see if bone…

This study aimed to understand if different methods of checking blood oxygen levels give the same results for patients on a life-support machine called ECMO. Researchers compared measurements taken from three different places in the body of 48 patients with severe heart failure. …

This study followed 113 adults with myotonic dystrophy for five years to understand why some develop serious breathing problems. Researchers tracked changes in breathing tests, sleepiness, fatigue, and thinking skills to identify early warning signs. The goal was to learn which p…

This study aimed to understand if having ADHD affects a person's chances of relapsing on alcohol after completing a detox program. Researchers followed 113 people with alcohol dependence for 12 weeks after detox. They carefully diagnosed ADHD and tracked who returned to drinking …

This study aimed to understand how often children with peanut or tree nut allergies have accidental reactions in daily life. Researchers followed 147 French children with these allergies to track the frequency and severity of reactions. The goal was to identify what factors might…

This study aimed to understand how the brain is involved in polycystic ovary syndrome (PCOS). Researchers used MRI brain scans to compare 52 young women with PCOS to healthy volunteers, both before and after starting hormonal birth control. The goal was to see if changes in the b…

This study tested if a special monitor, which measures a 'nociception level' (NoL), works the same way in children as it does in adults. Researchers used small, controlled electrical stimulations on 30 children aged 5-12 who were under general anesthesia for elective surgery. The…