University Hospital, Lille

This study looked at whether giving people with alcohol dependence a longer course of diazepam (one month instead of the usual week) during detoxification could help them avoid relapsing into drinking. 26 participants were followed for three months after starting detox. The goal …

This study looked at how well a special knee replacement (MUTARS) works after removing bone cancer. Nine patients were checked to see if they could actively lock their new knee joint to walk properly. The goal was to understand how the prosthesis helps with daily movement and wal…

This study tested a freeze-dried plasma product, originally developed for military use, in 42 trauma patients with severe bleeding. The goal was to see if this quick-to-prepare plasma could help control bleeding better than standard frozen plasma. The approach aims to make life-s…

This study looked at the drug lenalidomide in 17 people with Waldenstrom macroglobulinemia, a rare blood cancer that had returned or stopped responding to other treatments. The main goal was to find a dose that is safe and tolerable. Researchers measured side effects and how many…

This study tested whether transplanting insulin-producing cells (islets) could help people with type 1 diabetes who already had a kidney transplant. Fourteen participants received islet cells along with steroid-free drugs to prevent rejection. The goal was to see if they could st…

This small pilot study tested whether adding a special light-based treatment during surgery is safe for people with glioblastoma, an aggressive brain cancer. Ten patients received the treatment along with standard care (surgery, radiation, and chemotherapy). The main goal was to …

This study tested the drug vismodegib in 55 people with advanced basal cell carcinoma (a type of skin cancer) to see if taking it before surgery could make the tumor smaller and allow for a less extensive operation. Participants took the drug for a period before their planned sur…

This study tested a new drug called P28GST, made from a parasite enzyme, to see if it is safe for people with moderate Crohn's disease. Ten adults with Crohn's took part, some before or after bowel surgery. The goal was to check for side effects and see if the drug could help con…

This study tested whether the antifungal drug fluconazole could lower certain antibodies (ASCA) and prevent Crohn's disease from coming back after bowel surgery. 35 adults with Crohn's disease who had recent ileal or ileocecal resection were randomly assigned to receive fluconazo…

This study tested two doses of tranexamic acid, a drug that helps blood clot, to see if it could reduce blood loss in women having a C-section who were already bleeding heavily (over 800 mL). The trial involved 225 participants and compared the drug to a placebo. The goal was to …

This study tested whether stroke patients with high blood pressure benefit from extra support from a nurse, including education and follow-up, compared to usual care. About 290 patients over 60 who had a first stroke and had high blood pressure took part. The main goal was to see…

This study looked at whether a high-fat diet changes how children with mitochondrial disease burn energy. Thirty-six kids aged 5 to 21 tried both a normal diet and a high-fat diet for one month each. Researchers measured their resting energy use and body composition to see if the…

This study compared two types of surgery—laparoscopic sacropexy and vaginal mesh—for repairing a bladder prolapse (cystocele) in 220 women. The goal was to see which surgery worked better and was safer over four years. Researchers measured symptom relief, quality of life, and sid…

This study tested a new way to deliver dopamine directly into the brain using a pump for people with advanced Parkinson's disease who have severe movement ups and downs. Twelve participants received either the brain pump or their usual oral medications for one month, then switche…

This study looked at whether a quick selection process for early liver transplantation could help people with severe alcoholic hepatitis who aren't getting better with medical treatment. Normally, patients must wait 6 months without drinking to qualify, but these patients are ver…

This study tested whether using a special biological mesh during surgery helps people with infected belly-button hernias heal better than standard wound care alone. About 110 adults with infected hernias were randomly assigned to one of the two treatments. The main goal was to se…

This study tested whether an electronic program could help pregnant women who are overweight or obese gain a healthy amount of weight and reduce the need for delivery procedures like C-sections or forceps. About 857 women participated. The program provided personalized guidance t…

This study tested whether adding photodynamic therapy (PDT) to surgery, chemotherapy, and radiation is safe and doable for people with malignant pleural mesothelioma, an aggressive cancer of the lung lining. Six participants received the full combination treatment. The main goal …

This study compared two surgical techniques for fixing a cystocele (bladder prolapse) in 262 women. One method used a laparoscopic (keyhole) approach, the other used a vaginal mesh. The goal was to see which had fewer complications after one year. The results help doctors choose …

This study tested a combination of pomalidomide and dexamethasone in 63 patients with relapsed or refractory multiple myeloma who have specific high-risk genetic changes (deletion 17p or translocation 4;14). The goal was to see how well the treatment controls the disease and to c…

This study tested a drug called nilotinib in 65 adults with chronic graft-versus-host disease (GVHD), a complication after a stem cell transplant where donor cells attack the patient's body. Participants had already tried imatinib without success. The goal was to see if nilotinib…

This study tested whether a drug called deferiprone, which removes extra iron from the body, could slow the worsening of Parkinson's disease. 372 adults with early Parkinson's took either the drug or a placebo for 9 months. Researchers measured changes in movement and non-movemen…

This study tested whether a more detailed remote monitoring system could reduce deaths or hospital stays for heart failure patients who have a special pacemaker (CRT). Over 650 adults were followed for 27 months. The goal was to see if comprehensive monitoring works better than s…

This study tested whether acupuncture-moxibustion, a gentle, non-invasive technique, can help turn a breech baby (feet-first position) before birth. 328 pregnant women with a single baby in breech position received either real or fake acupuncture. The goal was to see if the treat…

This study tested a drug called daratumumab combined with dexamethasone in 64 people with multiple myeloma that had stopped responding to three other treatments. The goal was to see if the combination could shrink tumors and how safe it was. Results showed some patients responded…

This study looked at 40 people aged 18-25 who had a first-time shoulder dislocation. It compared surgery to repair the torn tissue versus the standard approach of wearing a sling. The goal was to see if surgery lowers the chance of the shoulder popping out again within 2 years. R…

This study tested a joint crisis plan, called the SOS plan, to see if it could reduce hospitalizations in people with schizophrenia or schizoaffective disorder. The plan involves the patient, their healthcare team, and family members working together to create a personalized plan…

This early-phase study tested a new combination of chemotherapy drugs, including clofarabine, in 20 children and young adults whose acute lymphoblastic leukemia had returned or did not respond to initial treatment. The goal was to find the safest dose and see if the combination c…

This study tested a drug called deferiprone in 23 people with ALS (Lou Gehrig's disease). The drug works by removing extra iron from the brain, which may help protect nerve cells. The goal was to see if the drug is safe and if it can slow down the disease's progression. Participa…

This pilot study tested whether giving a sodium lactate solution to people with septic shock could help manage their fluid balance. Septic shock is a life-threatening condition where blood pressure drops dangerously due to infection. The study involved 59 participants and compare…

This study tested whether adding an antibiotic (amoxicillin-clavulanic acid) to standard steroid treatment could improve survival in people with severe alcoholic hepatitis. About 300 adults at high risk of death within 2 months took part. The goal was to see if the antibiotic com…

This study tested a new way to treat glioblastoma, an aggressive brain cancer. During surgery to remove the tumor, doctors used a special light therapy (photodynamic therapy) to kill remaining cancer cells. The goal was to find the highest safe light dose. 14 patients took part, …

This study tested whether the drug deferiprone, which removes extra iron from the body, could slow the progression of ALS (Lou Gehrig's disease). The trial included 372 adults with early-stage ALS. Researchers measured changes in daily function and survival over 12 months to see …

This study tested a weekly dose of the drug carfilzomib combined with two standard chemotherapy drugs (melphalan and prednisone) in 32 older adults (65+) newly diagnosed with multiple myeloma. The goal was to find the safest dose and see how well the combination worked at shrinki…

This study tested whether giving the drug EXACYL before surgery can reduce bleeding during and after corrective jaw surgery (orthognathism). 157 adults with healthy blood levels took part. Half received EXACYL, half a placebo. The goal was to see if the drug safely lowers blood l…

This study tested whether personalized phone and text coaching could help children with type 1 diabetes who struggle with adjusting their insulin treatment. 106 children and their families received remote support from nurses over 6 months. The goal was to see if this coaching imp…

This study looked for new markers in the blood that could help doctors diagnose hypereosinophilic syndrome more easily and accurately. Researchers used a protein analysis method to compare samples from 41 participants. The goal is to make diagnosis simpler and more reliable than …

This study tested a rapid test called Unyvero to quickly identify bacteria causing aspiration pneumonia in patients on breathing machines. The goal was to see if using this test could help doctors stop unnecessary antibiotics sooner. The trial involved 266 patients and compared s…

This study looked at 30 adults with lung cancer that spread to the brain. Researchers compared two types of MRI scans (T1 and T2*) to see which one works better for finding and tracking brain tumors during treatment. The goal was to improve how doctors diagnose and monitor these …

This study tested a new rapid test (Unyvero) to identify the bacteria causing pneumonia in ICU patients on breathing machines. The goal was to see if using this test helps doctors choose the right antibiotics within 24 hours, compared to standard lab cultures that take days. 161 …

This study tested a new approach to diagnose peroxisomal diseases, a group of rare genetic disorders. The strategy uses advanced metabolic and genetic testing in patients with suspected symptoms. Researchers aimed to reduce the long delays in diagnosis. The study included 8 parti…

This study looked at whether changes in central venous pressure (CVP) during a deep breath can predict if a patient will benefit from extra IV fluids. Researchers tested 68 intensive care patients who were breathing on their own. The goal was to find a simple, non-invasive way to…

This study tested a new blood test called LLIFT to see if it can accurately diagnose fatty liver and NASH without needing a liver biopsy. Researchers studied 158 people at high risk due to obesity, diabetes, or high blood pressure. The goal is to find a simple, non-invasive way t…

This study tested whether a small, handheld device (dynamometer) can accurately measure the strength of a key foot muscle in adults with flatfoot. Researchers compared results from the handheld tool to those from a large, specialized machine in 46 healthy adults. If proven reliab…

This study tested whether giving an antibiotic (clindamycin) to pregnant women with bacterial vaginosis before 13 weeks could lower the chance of very early delivery. Over 3,000 women took part. The goal was to see if treating this infection early could prevent late miscarriages …

This study tested a system called KASPARD, which uses non-contact sensors to detect falls, wandering, and nighttime activity in nursing homes. The goal was to see if it could reduce falls in residents aged 65 and older who are at high risk. The system alerts staff via phone or co…

This study tested whether a specially shaped tracheal tube cuff could better seal the airway in critically ill patients on breathing machines. Researchers wanted to see if this tapered shape reduced the leakage of stomach and mouth fluids into the lungs, a problem that can lead t…

This study compared two surgical methods for esophageal cancer: open surgery and a less invasive approach using a laparoscope. The goal was to see if the laparoscopic method could reduce major complications within 30 days after surgery. About 207 adults with esophageal cancer too…

This study tested a fast-recovery program for people having minimally invasive kidney surgery (laparoscopic or robotic) to remove part or all of a kidney due to early-stage cancer. The goal was to see if the program could shorten hospital stays by at least one day without increas…

This study looked at whether two sessions of hypnosis could help lower anxiety in pregnant women who experienced preterm premature rupture of membranes (PPROM). 60 women took part, with some receiving hypnosis and others standard care. The goal was to see if hypnosis could improv…

This study tested whether adding ketamine to the antidepressant milnacipran helps reduce depression in people with severe, progressive diseases (like advanced cancer). 42 hospitalized patients in palliative care received either ketamine plus milnacipran or a placebo plus milnacip…

This study tested whether combining a low dose of methylphenidate (a drug used for ADHD) with computer-based cognitive training could improve thinking skills in healthy older adults. Thirty-one volunteers without memory problems took part in a 6-week program. The goal was to see …

This study tested a non-invasive device called ANI that measures heart rate patterns to assess comfort in 20 non-communicating patients receiving end-of-life palliative care. The goal was to see if the ANI could reliably detect pain or stress during routine care, compared to a st…

This study tested whether wearing a special pressure sleeve for 6 months could improve hand function in children with cerebral palsy. The study included 101 children aged 5 to 10 years. The sleeve was designed to provide gentle pressure to the arm, and the researchers measured ch…

This study tested a new device called Flexitheralight against the usual light therapy for actinic keratosis, which are rough, scaly spots caused by sun damage. About 29 adults with at least 10 spots on their forehead or scalp took part. The goal was to see if the new device works…

This study tested whether teaching people with chronic low back pain about how pain works in the brain and body (pain neuroscience education) reduces disability better than standard education about spine anatomy. 88 adults with back pain for over a year took part. The goal was to…

This study looked at whether Ericksonian hypnosis can reduce chronic pain in people with Parkinson's disease. 33 adults with Parkinson's and ongoing pain were split into two groups: one received hypnosis sessions for 2 months, the other continued with their usual care. The main g…

This study looked at whether aesthetic therapy (like beauty and relaxation sessions) can help reduce anxiety and improve quality of life for patients with acute leukemia or those who had a stem cell transplant. These patients are isolated in a protected hospital area for at least…

This study tested whether sildenafil (the drug in Viagra) can speed up healing of painful finger ulcers in people with scleroderma. 84 participants received either sildenafil or a placebo for 90 days. The main goal was to see how long it took for the ulcers to heal.

This study tested whether methylphenidate (Ritalin), a drug used for ADHD, could improve walking problems and attention in people with advanced Parkinson's disease. 69 participants with severe gait issues and freezing episodes were given either the drug or a placebo for 3 months.…

This study looks at whether a new pain management protocol can reduce pain for people undergoing in vitro fertilization (IVF). Researchers compared pain scores from 206 patients who received the new protocol to data from an earlier study. The goal is to see if the new approach he…

This study looked at whether a physical activity program could help improve bone density in children and teenagers with inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis. Kids with IBD often have lower bone density due to inflammation, medication, or…

This study tested a new device called the Hypnos-Pro mask, which uses lights and sounds to help patients relax during prostate biopsies. 88 men received local anesthesia and used the mask to see if it lowered their pain and anxiety. The goal was to make the procedure more comfort…

This study tested two 5-week stress management programs for people diagnosed with adjustment disorder with anxiety. One group used a computer-based program, another met with a therapist face-to-face, and a third group received no treatment. The goal was to see if the programs cou…

This study tested two pain relief methods after liver surgery: continuous wound infiltration with local anesthetics and spinal analgesia. The goal was to see which method reduces the need for morphine and lowers the chance of long-term pain. 186 adults having liver surgery took p…

This study tested whether injecting the numbing drug ropivacaine into the nose during sinus surgery could lower pain afterward. 184 adults having endoscopic sinus surgery took part. The goal was to see if this simple step could reduce the need for painkillers and improve recovery…

This study tested whether a special education program could help people with early-stage Parkinson's disease become more physically active in their daily lives. 89 participants either received the program or were placed on a waiting list. The program focused on changing habits to…

This study tested a non-invasive brain stimulation technique called rTMS in 85 people with schizophrenia who still had severe hallucinations despite medication. By using MRI scans to precisely target the brain areas causing the hallucinations, researchers aimed to reduce how ofte…

This study tested whether a clonidine nasal spray helps calm children aged 1 to 5 before minor surgery. Researchers compared the spray to a placebo in 90 kids to see if it reduces anxiety and helps them accept the anesthesia mask. The goal is to find a simple, needle-free way to …

This study looked at whether a pulmonary rehabilitation program could help people with Stage IV pulmonary sarcoidosis (advanced lung scarring) become more active in their daily lives. 38 adults took part and were followed for one year. The program aimed to improve exercise abilit…

This study tested whether a custom rehabilitation program could improve daily function and quality of life for 80 adults with dermatomyositis or polymyositis, two rare diseases that cause muscle inflammation and weakness. Participants had stable muscle problems but still struggle…

This study tested whether a special monitor (called ANI) that tracks the body's pain balance during anesthesia can help doctors give just the right amount of pain medicine. 37 adults having laparoscopic surgery took part. The goal was to see if using the monitor reduced episodes …

This study looked at whether medical hypnosis can lower stress and make hospitalization less upsetting for people with chronic diseases. Twenty-four adults staying in an internal medicine unit took part. One group received a hypnosis technique called "the place of safety," while …

This study looked at whether medical hypnosis can lower anxiety and pain during an electroneuromyography (ENMG), a nerve test that can be uncomfortable. Six anxious adults were enrolled to compare hypnosis with standard care. The goal was to see if hypnosis helps patients feel ca…

This study tested if therapeutic body wraps (wet or dry) can reduce severe injurious behaviors in 48 children and teens with autism. The goal was to see if this non-drug approach could lower aggression and self-harm. It was an early-stage trial comparing wet versus dry wraps.

This study looked at 186 pregnant women with type 1 or type 2 diabetes to understand how fats (lipids) in the mother's and baby's blood relate to birth weight. Even when blood sugar is well-controlled, babies of diabetic mothers are often larger than average, which can cause deli…

This study tested a short 10-question screening tool called DEPITAC to help nurses identify post-traumatic stress disorder (PTSD) in people hospitalized after a road accident. About 274 participants completed the questionnaire within two weeks of their accident. The goal was to s…

This study looked at 298 children under 6 with early tooth decay in the Hauts-de-France region. Researchers collected data through dental exams and parent questionnaires to understand what factors—like family background, dental habits, and stress—are linked to more severe cavitie…

This study looked at 58 pregnant women with and without PCOS to understand how hormones like AMH and leptin might pass the condition from mother to child. Researchers measured hormone levels during pregnancy to see if they affect the baby's future risk. The goal is to learn more …

This study set up a national registry in France to track babies born with esophageal atresia, a birth defect where the esophagus is not fully connected. Researchers collected data on about 1,460 newborns to understand how common the condition is, what other health issues may occu…

This study looked at 70 people with asthma, chronic sinusitis with nasal polyps, or both, plus healthy volunteers. Researchers measured specific markers on blood eosinophils to identify different patient types. The goal was to help doctors choose the right immunotherapy for each …

This study tested a new rule to help doctors tell which children with fever and low white blood cells after chemotherapy are at risk for a serious infection. About 1900 children aged 1 to 18 with cancer or blood disorders took part. The goal was to see if the rule works well in m…

This study looked at 90 sepsis patients with low blood pressure to see if changes in vein and artery size during breathing can predict who needs more fluids. Doctors often give fluids to improve circulation, but too much can be harmful. The goal was to find a simple, non-invasive…

This study looked at 180 people with anorexia nervosa to understand why they lose bone density. Researchers measured bone mineral density and checked levels of fat-related hormones like leptin and adiponectin every two years for up to six years. The goal was to find connections b…

This study looked at brain activity in women with Polycystic Ovary Syndrome (PCOS) using high-resolution MRI scans. Researchers compared 52 women—some with PCOS and some healthy—to see if there were differences in a brain region called the hypothalamus. The goal was to better und…

This study looked at how different types of fat distribution—too much, too little, or in the wrong places—affect the body's response to insulin and the immune system. Researchers measured various immune markers, especially interleukin-7, in 126 adults who were normal weight, obes…

This study looked at 30 women with PCOS who had trouble ovulating. Researchers measured a hormone called AMH during low-dose FSH treatment to see if a drop in AMH helps a follicle grow. The goal was to better understand why ovulation fails in PCOS, not to test a new treatment.

This study followed 250 children under 4 with suspected congenital glaucoma to see how early diagnosis affects vision at age 4. Researchers found that delays in diagnosis lead to worse eyesight. The goal is to create awareness programs for doctors and teachers to improve long-ter…

This study followed 73 people with autoimmune diseases like rheumatoid arthritis or multiple sclerosis who were starting treatment with rituximab, a drug that suppresses the immune system. The goal was to track how many developed serious infections and identify who was most at ri…

This study looked at how strong and long-lasting the immune response from the COVID-19 vaccine is in elderly people living in care homes. Researchers compared their immune cells and antibody levels at 3 and 9 months after vaccination to those of younger adults aged 40-65. The goa…

This study tested whether adding a simple AI-written summary to brain MRI reports helps people understand the results. Over 2700 adults read fictional reports and answered questions about what they found. The goal was to see if the AI summary improved understanding and reduced co…

This study looked at how thoracic outlet syndrome—a condition that can cause nerve, artery, or vein problems in the neck and shoulder area—affects people's ability to work. Researchers surveyed 101 employed or formerly employed adults who had a confirmed artery blockage during ar…

This study looked at how breast cancer treatment affects sexual health in 25 women with non-metastatic breast cancer. Participants filled out anonymous questionnaires about their sexual function, quality of life, and emotional well-being before and after chemotherapy. The goal wa…

This study used blood cells from 90 people with Parkinson's disease, ALS, or healthy volunteers to see how the drug deferiprone affects cell stress and energy. The goal was to learn more about the disease process, not to treat patients. Results may guide future research.

This small study looked at teeth from 14 adults living in areas with either high or low rates of Crohn's disease. Researchers measured metals and other environmental chemicals in the teeth to see if differences might help explain why some areas have more Crohn's disease. The goal…

This study tested a medical device that automatically gives a pain medicine (remifentanil) during surgery, based on the patient's heart rate, blood pressure, and a pain index. 52 adults having burn surgery took part. The goal was to see if the device could reduce the total amount…

This study followed 147 French children with confirmed peanut or tree nut allergies to see how often they accidentally had an allergic reaction in real life. Researchers also looked at what triggered the reaction, how severe it was, and what risk factors might be involved. The go…

This study looked at whether giving women a self-collection kit for HPV testing at their family doctor's office would increase screening participation. It involved 308 women aged 30-65 who had not been screened in over 3 years. The goal was to see if this approach works better th…

This study tested a computer system that alerts doctors and pharmacists when older hospital patients are at risk for acute kidney failure or dangerously high potassium levels. The goal was to reduce these serious side effects by making alerts more specific and having a pharmacist…

This study looked at the stressful life events teens experienced in the year before a suicide attempt. Researchers compared 39 teens who had attempted suicide with teens who had never had suicidal thoughts. They wanted to see if there were patterns in how these stressful events b…

This study followed 29 people with Parkinson's disease to learn more about speech and movement issues that don't respond to standard medication. Researchers used brain scans (fMRI) and other tests to compare patients with healthy volunteers and people with a similar condition. Th…

This study examined a type of immune cell called 4BL B cells in 125 people with multiple sclerosis (MS) and compared them to healthy controls. The goal was to see if these cells are more common in MS and might contribute to inflammation. No treatment was given; the study was pure…

This study tested a personalized follow-up plan called ALGOS for people who had just attempted suicide. The goal was to see if this plan could reduce the number of repeat suicide attempts compared to standard care. Over 1,000 adults who survived a suicide attempt took part, and r…

This study looked at how the pain medicine sufentanil travels from the amniotic sac to the fetus and mother. Eight pregnant women who were ending their pregnancy due to a fetal problem took part. The goal was to learn more about giving pain relief to unborn babies, which is not w…

This completed study looked at how often joint pain occurs in people with ovarian, colorectal, or lung cancer who are taking the drug bevacizumab. 71 participants filled out questionnaires about their joint pain over 6 months. The goal was to better understand this side effect, n…

This study looked at how people with post-traumatic stress disorder (PTSD) predict their emotional reactions to future events. Researchers compared 97 adults with and without PTSD to see if those with PTSD tend to expect more intense negative emotions than they actually experienc…

This study looked at whether a bedside lung ultrasound can help predict serious breathing complications after surgery for esophageal cancer. Researchers followed 274 adults who had their esophagus removed. They checked ultrasound images right after surgery and the next day to see…

This study looked at whether combining two brain scans (EEG and fMRI) can better pinpoint the exact spot in the brain causing seizures in people with hard-to-treat focal epilepsy. About 102 patients who were already being considered for surgery took part. The goal was to see if t…

This study looked at over 3,500 older adults (75+) after a hospital stay in an acute geriatric unit. Researchers used special statistical models to better predict the chances of death, returning to the hospital, or moving to a nursing home. The goal is to help doctors and familie…

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections. Researchers screened 120 adults aged 18-65 who had repeated respiratory infections or at least one serious infection requiring hospital care. The goal was to see how oft…

This study looked at 48 adults with severe heart failure who were on a heart-lung machine (ECMO). Researchers compared oxygen levels measured from different parts of the body to see if they matched. The goal was to improve how doctors monitor these patients.

This study looked at 45 post-menopausal women with knee osteoarthritis who needed knee replacement surgery. Researchers compared fat from inside the bone (bone marrow fat) with fat from under the skin (belly fat) to see which one releases more harmful substances that damage joint…

This study looked at 60 adults having surgery to see if a special heart monitor (called ANI) could predict how they would react when a breathing tube was placed. Researchers gave a mild electric shock to the arm and watched the heart's response, then compared it to the patient's …

This study looked for simple blood markers that could predict which patients with suspected COVID-19 would get worse after visiting the emergency room. Researchers followed 373 adults to see if routine lab tests could help identify those at risk of needing intensive care. The goa…

This study looked at whether it is safe to reduce or stop antifungal drugs early in immunocompromised patients in the ICU who are being treated for a suspected candida infection. Researchers tracked 275 patients across 14 ICUs to see how often treatment was reduced and what facto…

This study followed 38 children who survived acute respiratory distress syndrome (ARDS) to see how their lungs were doing one year later. Researchers measured lung stiffness, breathing symptoms like cough and wheeze, and looked at CT scans for any lasting damage. The goal was to …

This study looked at how breathing pure oxygen under high pressure (hyperbaric oxygen therapy) changes the smallest blood vessels in the body. Fifteen healthy volunteers were exposed to different oxygen levels and pressures while researchers measured blood flow using special came…

This pilot study looked at whether the COVID-19 virus can spread through the air during abdominal surgery on infected patients. Only 2 people took part. Researchers measured virus particles near the surgical site and around the room to understand risks to healthcare workers. The …

This study looked at how people with PTSD pay attention to their surroundings. Researchers used a change blindness test to see if patients are quicker to notice sudden changes, especially emotional ones. 80 adults with PTSD completed the study, which measured response times and e…

This study looked at how back muscles use oxygen during exercise in people with chronic low back pain compared to healthy volunteers. Researchers measured muscle oxygen levels and breathing to see if pain changes muscle metabolism. The goal was to better understand why back pain …

This study looked at how type 1 diabetes and long-term blood sugar control (HbA1c) affect the body's ability to deliver and use oxygen during exercise. Researchers compared 79 participants—some with type 1 diabetes and some healthy—to understand why people with diabetes often hav…

This study looked at whether patients with COVID-19 who are on breathing machines get more lung infections than those with the flu or no viral pneumonia. Researchers tracked over 1,500 intensive care patients to compare infection rates. The goal was to understand how COVID-19 aff…

This study looked at whether adding an islet transplant after a kidney transplant helps people with type 1 diabetes keep their kidney working longer. Researchers reviewed records of 327 kidney transplant recipients in France from 2000 to 2017. They compared those who also got isl…

This study looked at 500 people with ALS (a serious nerve disease) to find biological clues, called biomarkers, that can predict how the disease will progress and how long patients may live. Researchers collected medical tests, brain scans, and other health data to better underst…

This study looked at physical fitness in 100 children aged 10-17 with chronic inflammatory bowel disease (like Crohn's or ulcerative colitis) and compared them to healthy children of the same age, size, and sex. Researchers measured things like heart-lung fitness, muscle strength…

This study followed 134 people who had a first episode of neurological symptoms (clinically isolated syndrome) that could lead to multiple sclerosis. Researchers used MRI scans and eye exams to detect and track nerve damage over time. The goal was to develop better ways to predic…

This small pilot study looked at whether taking metformin before a meal (instead of during) affects how much carbohydrate the body absorbs. Researchers planned to test obese adults with prediabetes or type 2 diabetes by giving them sugar drinks with metformin taken 30 or 60 minut…

This study tested whether a non-invasive device called ccNexfin can accurately measure cardiac output (how well the heart pumps blood) in pregnant women. Researchers compared it to standard ultrasound in 100 women past 32 weeks of pregnancy. The goal was to see if this simpler, c…

This study tested whether a device called the ANI monitor can measure pain in sedated children aged 2 and older in the pediatric intensive care unit. Researchers observed 50 children to see if the monitor's readings matched behavioral pain scales. The goal was to find a reliable …

This study looked at how the body handles the hormone cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if a specific enzyme that reactivates cortisol is more active in these patients, which might contribute …

This study looked at ovarian tissue from 9 young women with acute myeloid leukemia (AML) who had it frozen to preserve fertility before a stem cell transplant. The goal was to see if any leukemia cells remained in the tissue after the cancer was in remission. The findings help do…

This study looked at whether a special liver scan (hepatobiliary scintigraphy) can predict the risk of liver failure after removing a large part of the liver. 326 adults with non-cirrhotic livers who needed major liver surgery took part. The goal was to see if the scan gives bett…

This study tested whether a 3D X-ray technique (3D rotational angiography) can replace standard 2D imaging after fixing an abdominal aortic aneurysm. 427 patients were randomly assigned to either the new 3D method or the usual 2D scans. The goal was to see if 3D imaging reduces r…

This study looked at whether measuring how people with Parkinson's disease walk at home can help track how their condition changes over time. Researchers used special insoles to record walking data from 83 participants over 10-day periods. The goal was to see if these home-based …

This study looked at 451 children with asthma in northern France to see if mold in their homes made their asthma harder to control. Doctors checked asthma control using standard guidelines and questionnaires. The goal was to understand the link between mold exposure and asthma sy…

This study looked at 757 adult patients treated for COVID-19 at Lille University Hospital to find out which factors best predict death within 28 days. Researchers collected medical, lab, and imaging data to understand why some patients died. The goal is to help doctors identify h…

This study looked at 46 people who had a first episode of optic neuritis, an inflammation of the eye nerve. Researchers used MRI to measure the length of the nerve lesion and checked how much nerve tissue was lost in the retina after 12 months. The goal was to see if the MRI meas…

This study looked at how skin changes from systemic sclerosis (scleroderma) affect a person's feelings about their appearance and overall well-being. Researchers compared 170 patients with the disease to healthy volunteers using surveys about body image and distress. The goal was…

This study aimed to find genes and environmental factors that raise the risk of developing Parkinson's disease. Researchers compared DNA and lifestyle data from over 2,200 people, including those with Parkinson's, related brain diseases, and healthy volunteers. No treatment was g…

This study looked at how the COVID-19 pandemic and related public health measures changed asthma control in children aged 3 to 16. Researchers compared asthma control and flare-ups in 577 children before and during the pandemic. The goal was to understand if lockdowns, mask-weari…

This study tested whether a digital platform could help people recover physically and emotionally after surgery for esophageal or laryngeal cancer. Thirty patients used the platform after their operation, and researchers measured how many people agreed to join and how often they …

This study looked at 29 people with APECED syndrome, a rare autoimmune disease. Researchers examined their genes and symptoms to find patterns. The goal was to better understand the condition, not to test a new treatment.

This study followed 51 people with idiopathic pulmonary fibrosis (IPF) for 6 months to understand how their shortness of breath changes over time. Researchers measured both the physical sensation and emotional impact of breathlessness using questionnaires. The goal was to link th…

This study tested whether continuously controlling the pressure in the breathing tube's cuff (the balloon that seals the airway) could reduce stomach fluid from leaking into the lungs. Researchers measured pepsin (a stomach enzyme) in the lung fluid of 122 critically ill patients…

This study looked at whether children and teens (ages 10-18) move differently when they know they are wearing an activity tracker. Half of the 80 participants were told the device measures physical activity, while the other half were told it measures posture. The goal was to see …

This study looked at 700 people with Parkinson's disease to find clues that predict whether deep brain stimulation will improve their quality of life. Researchers checked factors like brain scans, genetics, and health records before treatment and then followed patients for up to …

This study measured prolactin levels in 71 people with systemic sclerosis (scleroderma) to see if high levels are common. Researchers compared results with healthy volunteers matched by age and sex. The goal was to understand if prolactin plays a role in the disease, not to test …

This study looked at how different types of nerve diseases (inherited vs. acquired) affect a person's balance and walking. Researchers tested 67 people using a balance platform and a timed walk test. The goal was to find clear differences that could help doctors tell the two type…

This study tested two bedside scoring tools (PAWS and PEWS) to see how well they detect worsening illness in children admitted to intermediate care units. Over 3000 children took part across multiple French hospitals. The goal was to validate these scores and develop a simpler wa…

This study looked at 214 people with systemic sclerosis (scleroderma) to find out how often calcium deposits form under the skin, especially in the hands and feet. Researchers used X-rays to detect these deposits and checked if they were linked to damage in organs like the lungs,…

This study looked at how fat cells in bone marrow may contribute to bone loss in osteoporosis. Researchers took bone samples from 20 adults undergoing hip replacement and tested how secretions from fat cells affected bone-forming cells in the lab. The goal was to better understan…

This study looked at whether keeping a diary during intensive care can reduce post-traumatic stress disorder (PTSD) in people who survived sudden cardiac arrest and their families. About 173 participants were involved. The goal was to see if writing down what happened helps with …

This study tested whether removing a breathing tube with extra air pressure (positive pressure) helps prevent low oxygen levels after abdominal surgery. 264 adults having planned abdominal surgery took part. The goal was to see if this technique reduces oxygen drops compared to t…

This study aimed to create an algorithm that can detect epileptic seizures by continuously analyzing the heart's electrical activity (ECG). Researchers studied 40 patients with epilepsy who were already undergoing long-term video-EEG monitoring. The goal was to see how well the a…

This study looked at whether the time of day a person has heart surgery affects how well their heart muscle tolerates the stress of the procedure. Researchers took small tissue samples from the hearts of 88 patients scheduled for non-emergency heart surgery, randomly assigning th…

This study looked at 172 patients in the intensive care unit after surgery who needed insulin. Researchers compared two different methods of giving insulin to see which one caused fewer ups and downs in blood sugar levels. The goal was to find out if using a separate line for ins…

This study tested whether using an ultrasound during surgery helps doctors decide the best technique to remove endometriosis from the rectum. Ten women with deep pelvic endometriosis took part. The ultrasound was used before and after the initial shaving procedure to see if a mor…

This study looked at whether a Foley catheter (a small balloon placed in the cervix) could be used at home to start labor in first-time mothers whose pregnancy has gone past the due date. 43 women took part. The goal was to see if this approach is safe and effective compared to w…

This study followed 113 adults with myotonic dystrophy (Steinert disease) for 5 years to find out why some develop low oxygen levels (hypoventilation). Researchers measured lung function, sleepiness, fatigue, and thinking skills. The goal was to better understand the breathing pa…

This study looked at whether measuring certain markers of fungal infection in the blood could help doctors decide to stop antifungal drugs earlier in critically ill patients. The goal was to reduce the number of days patients receive these medications without increasing risk. The…

This study followed 56 people with systemic sclerosis who also have a serious lung condition called diffuse infiltrating pneumonia. Researchers measured lung function at 12 and 24 months to see how it changed and to identify factors that might predict worsening. The goal was to b…

This study looked at 78 family caregivers of older adults (70+) with cancer to understand their needs and how social factors affect their burden. Researchers measured caregiver burden and other factors to see if a personalized support plan could help both the caregiver and the pa…

This study tested a new questionnaire called Serenat to see if it accurately measures well-being at work. 226 adults who were working and had adjustment disorder took part. The goal was to validate the scale for future use in research and workplace health.

This study looked at 258 adults with untreated oeso-gastric cancer to understand why some wait longer to see a doctor after noticing symptoms. Researchers examined social, economic, and personal factors that may cause delays. The goal is to help find ways to encourage earlier dia…

This study tested a special monitor called NIPE that looks at heart rate changes to see if it can measure pain or discomfort in very premature babies (born before 34 weeks) who are on breathing machines and sedated. Researchers watched 50 babies before, during, and after care to …

This study looked at 195 overweight or obese pregnant women to understand what factors influence their decision to join a 12-week program combining nutrition advice and physical activity. The goal was to identify barriers and motivators so future programs can be more effective. R…

This study looked at gut bacteria in 214 people with Crohn's disease, comparing those diagnosed as children (under 17) with those diagnosed after age 40. Researchers wanted to see if the bacteria differ by age and if those differences are linked to genetics. The goal is to better…

This study looked at whether measuring the size of a large vein (the inferior vena cava) using an ultrasound through the liver can predict if a patient needs more fluids. The goal is to avoid giving too much fluid, which can be harmful. The study included 40 adults in the ICU aft…

This study looked at whether a test using 6 different markers from tumor tissue can predict how well people with advanced non-small cell lung cancer respond to a combination of immunotherapy (pembrolizumab) and chemotherapy. The goal was to see if this test is better than the cur…

This study looked at whether freezing eggs (oocyte cryopreservation) is a good option for women with benign ovarian cysts that keep coming back, like endometriomas or dermoid cysts. These women often need multiple surgeries, which can harm their ovaries and reduce fertility. The …

This study looked at whether a blood test for a substance called ADMA can help measure blood vessel health in children with growth hormone deficiency or those who were small at birth. Researchers compared ADMA levels to ultrasound measurements of artery widening in 23 children. T…

This study looked at how muscles use oxygen during exercise in people with different neuromuscular diseases compared to healthy volunteers. Seventeen participants did a knee exercise while a device measured muscle oxygen levels. The goal was to understand if oxygen problems are l…

This study tested whether a small ultrasound probe placed in the throat could help predict how long people with severe lung failure (ARDS) need a breathing machine. Researchers measured a heart-related sign that might show fluid overload or heart strain. 50 adults in intensive ca…

This study tested whether a device that tracks heart rate changes (called the Analgesia Nociception Index) can detect pain in 17 children with cerebral palsy. The children were watched during painful procedures like injections and physical therapy. The goal was to see if this too…

This small study looked at how tofacitinib, a rheumatoid arthritis drug, changes body fat, muscle, and bone density. Ten adults with active RA were followed to measure these changes. The goal was to gather initial data, not to prove a treatment benefit.

This study looked at how inflammatory bowel disease (IBD) affects oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to understand which factors, like medic…

This study observed 257 emergency patients on ECMO (a heart-lung machine) to understand why many experience serious bleeding. Researchers checked for defects in von Willebrand factor, a protein that helps blood clot. The goal was to see how often bleeding happens and if it's link…

This study looked at whether adults with attention deficit hyperactivity disorder (ADHD) are more likely to relapse after completing a residential alcohol detox program. Researchers followed 113 participants for 12 weeks, using both a screening questionnaire and a more thorough d…

This study checked how common emphysema (a type of lung damage) is in people with a rare FLNA gene mutation. Eight participants had a lung exam, breathing tests, and a chest CT scan. The goal was to confirm if the gene mutation is linked to unexplained emphysema.

This study followed 229 adults over age 40 who had a recent stroke to learn what factors might lead to dementia or memory problems later. Researchers looked at medical history, brain scans, and daily living skills. The goal was to identify clues that could help predict or prevent…

This study looked at 174 adults with severe asthma who were starting a new biologic treatment (biotherapy). The goal was to see if their ability to work and be productive at their jobs improved after 6 months of treatment. Researchers measured presenteeism, which means being at w…

This study looked at whether a protein called tissue factor (TF) in the blood can help predict how serious colorectal cancer is and if it might come back. Researchers measured TF levels in 26 adults before and after surgery to remove their tumors. The goal was to see if higher TF…

This study measured how often sleep apnea occurs in obese pregnant women and whether treatment with a CPAP machine improves outcomes for mother and baby. Researchers followed 89 women with a BMI of 35 or higher in their third trimester. The goal was to understand the link between…

This study tested an electronic device that automatically controls the pressure in the cuff of a breathing tube in critically ill patients. The goal was to see if it keeps the pressure in a safe range better than manual checks. 18 ICU patients were monitored for 24-hour periods w…

This study looked at how paracetamol (Tylenol) is processed in the body after major liver surgery. Researchers measured paracetamol levels in the blood over five days in 90 patients who had different amounts of liver removed. The goal was to see if patients with less liver tissue…

This study looked at 41 people with early-stage vocal cord cancer to see whether surgery or radiation therapy leads to better voice quality after 5 years. Participants filled out a questionnaire about how their voice felt, and researchers measured things like how long they could …

This study checked if people having a suicidal crisis have trouble with thinking skills like memory and attention. Researchers used a simple test called MoCA with 140 hospitalized patients. The goal was to see how common these thinking problems are and if they change after treatm…

This study looked at 30 neurosurgery patients to see if changing their body position (tilting head up or down) affects a device called ANI that measures pain during general anesthesia. The goal was to understand if the device's readings change with blood flow shifts, not to treat…

This study looked at whether doing extra leg strengthening exercises before ACL surgery helps patients recover better. Six people with recent ACL tears took part. Researchers measured their muscle strength before and after a special rehab program to see if it reduced weakness aft…

This study looked at 163 adults with chronic hives to see how often doctors needed to increase their Xolair dose or give it more often within the first 3 months. It was an observational study, meaning no new treatment was tested—just real-life medical records were reviewed. The m…

This study tested whether a non-invasive monitor that measures pain levels in adults also works for children during anesthesia. Thirty children aged 5-12 received mild electrical stimulations of different strengths before surgery. The goal was to see if the monitor's readings inc…

This study looked at whether a type of white blood cell called eosinophils plays a role in the scarring (fibrosis) seen in systemic sclerosis, an autoimmune disease. Researchers compared blood and tissue samples from 40 patients with systemic sclerosis and 30 healthy volunteers. …

This study looked at whether having COVID-19 made intensive care patients more likely to pick up dangerous, drug-resistant bacteria. Researchers tracked 368 adults in the ICU to see how many developed these superbug infections. The goal was to understand the impact of the pandemi…

This study used MRI scans to look at how hamstring grafts used to repair the anterior cruciate ligament (ACL) heal and change shape over time. Researchers examined 24 adults who had ACL surgery at least one year earlier. The goal was to understand how often the graft tunnels wide…

This study aimed to find normal blood clotting values for healthy pregnant women before and after childbirth using a new device called Quantra. Postpartum hemorrhage is a leading cause of maternal death, and knowing these normal ranges helps doctors quickly spot and treat dangero…

This study tested a program to help people who finished treatment for stomach or lung cancer better understand and manage their emotions. 26 participants were randomly assigned to either emotional skills training or relaxation sessions. The goal was to see if the emotional traini…

This study tested a new medical device called TOCONAUTE, a patch placed on the mother's belly during labor. It measures the baby's heart rate and the mother's contractions in real time. The goal was to see if this patch works as well as the standard monitor. 60 pregnant women in …

This study looked at how B cells, a type of immune cell, might contribute to scarring in people with systemic sclerosis (scleroderma). Researchers compared blood and skin samples from 71 participants, including patients and healthy volunteers. The goal was to understand the disea…

This study looked at stored tissue samples from 6 infants born with esophageal atresia, a condition where the esophagus doesn't form properly. Researchers compared biopsies taken shortly after birth with those taken later to see if storage time affects genetic and metabolic infor…

This study followed 72 young adults who were part of a larger European study 10 years ago as teenagers. Researchers looked at their current heart disease risk using a special score and compared it to their diet and lifestyle habits from adolescence. The goal was to find which tee…

This study looked at whether drinking caffeine is linked to how Huntington's disease progresses in people who have the gene but do not yet show symptoms. 77 adults with early-stage Huntington's were observed, and researchers measured changes in brain volume and thinking skills. T…

This study looked at how many people are needed to find most of the mistakes people make when using a medical device called Zeneo®. Researchers tested 60 healthy volunteers, some who knew about auto-injector pens and some who didn't. The goal was to improve future device testing,…

This study aimed to find out how often a serious fungal lung infection occurs in hospitalized patients who are on breathing machines and develop suspected pneumonia. Researchers tested fluid from the lungs of 263 adult patients to look for signs of the infection. The goal was to …

Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic agents, and have a high impact on human health. Infestation results from the ingestion of living larvae from contaminated fishes. It can be asymptomatic or sympto…