University Hospital, Lille

This early-stage study is testing the safety of a personalized cell therapy called CD19 CAR-T for adults with acute myeloid leukemia (AML) that has returned or not responded to standard treatments. The therapy involves collecting a patient's own immune cells, genetically modifyin…

This study is testing how an inhaled medication called BGF 160 affects breathing patterns in people with stable COPD. Researchers will measure changes in how patients breathe and their lung function after using the medication. The study involves 35 participants aged 40-75 with mo…

This study is testing whether a blood-filtering procedure called rheopheresis can help heal painful, hard-to-treat skin ulcers caused by calciphylaxis in people on dialysis. Researchers will compare the new treatment plus standard care against standard care alone in 138 patients.…

This study is testing whether adding a specific gut bacteria supplement (EXL01) to an immunotherapy drug (nivolumab) can help control advanced lung cancer that has stopped responding to standard treatments. It will involve about 21 patients who have already tried and progressed o…

This study is testing a new two-step approach for a common type of liver cancer. First, patients receive a short, intense course of focused radiation. Then, they have surgery to remove the tumor. The main goal is to see if this combined approach is safe and doesn't cause delays o…

This study is testing a new, gentle pressure technique on a child's neck during anesthesia to prevent air from going into the stomach. It aims to make mask ventilation safer for children aged 2-10 having elective surgery. Researchers will use ultrasound to see if the technique wo…

This study is testing a new follow-up plan for people who had weight-loss surgery. Instead of standard yearly check-ups, patients will use a connected scale at home to track their weight. Their care team will then schedule appointments based on this data, aiming to help them keep…

This study is testing a combination treatment for large ovarian cysts caused by endometriosis. Researchers want to see if draining the cyst during a simple keyhole surgery, followed by hormone therapy, can reduce the chance of the cyst coming back while better preserving a woman'…

This study is testing if a drug called rapamycin can shrink severe lymphatic growths in the face and neck of children. It involves 28 young patients taking the oral medication for six months. Doctors will use MRI scans to see if the growths shrink by at least 20% and will also ch…

This study follows people for 10 years after they had a specific type of weight loss surgery called omega gastric bypass. Researchers want to see if one version of the surgery (with a 150cm loop) is safer than another (with a 200cm loop) over the long term. They are looking at se…

This study aims to find out if having complete surgery to remove colorectal endometriosis before starting IVF treatment leads to better pregnancy rates compared to starting IVF treatment alone. It will involve 120 women with this specific type of endometriosis who are struggling …

This study is testing a two-part surgery for certain pancreatic cancers. First, surgeons completely remove the pancreas to eliminate a dangerous complication called a fistula. Then, they transplant the patient's own insulin-producing cells into the liver to try to prevent severe …

This study is testing whether a regular exercise program can improve the health of blood vessels in adults with type 1 diabetes. It aims to see if exercise can help prevent future heart and circulation problems before they start. The research will measure how well blood vessels e…

This study is testing whether a special 3D imaging technique (called OCT) can help doctors perform better artery-opening procedures for blocked leg arteries. It compares the standard 2D imaging method against using both 2D and 3D imaging to guide the procedure. The goal is to see…

This study is testing a new light therapy device called BUBOLight® for treating jaundice in newborns. Researchers want to see if this new design, which uses flexible light strips, is safe and comfortable for babies and easier for parents and nurses to use. They will monitor 10 he…

This study is testing the safety and effectiveness of two different drug combinations for older adults newly diagnosed with multiple myeloma, a blood cancer. It is for patients aged 65 and older who are not eligible for a stem cell transplant. The goal is to see if these combinat…

This study follows Parkinson's patients who have been receiving an experimental brain treatment for several years. Researchers want to safely help patients stop this treatment by gradually reducing their dose and switching to alternative medications. The main goal is to monitor s…

This study compares two versions of a weight-loss surgery (gastric bypass) to see which one is better at putting type 2 diabetes into remission for severely obese patients. Researchers are testing if changing the lengths of different intestinal segments during the operation impro…

This small pilot study is testing whether a two-part treatment is safe and feasible for people with advanced, inoperable mesothelioma that has worsened after standard chemotherapy. First, doctors use a special light therapy during a minimally invasive chest surgery to target canc…

This study is for people with a difficult-to-treat form of skin cancer (locally advanced basal cell carcinoma) who have successfully cleared their tumor with special pills (Sonic Hedgehog inhibitors). Because the cancer often comes back after stopping the pills, researchers want …

This study aims to improve the diagnosis of endometriosis by using a special type of MRI scan that measures how much pelvic organs move when a woman pushes. Researchers will scan 52 women with suspected endometriosis to see if reduced organ mobility is linked to common symptoms l…

This study aims to develop a new blood test to diagnose mucormycosis, a severe and often fatal fungal infection. Researchers will test 100 patients, including those with the infection and control groups without it, to see if a specific marker in the blood can accurately identify …

This study is testing a new questionnaire designed to quickly and accurately measure how much salt patients with high blood pressure or kidney disease are eating. Researchers will compare the questionnaire results against a 24-hour urine test, which is the gold standard for measu…

This study is testing whether an artificial intelligence (AI) tool can help doctors diagnose kidney diseases more accurately and confidently. 100 medical students and doctors will solve 10 online kidney case studies each, with half getting AI suggestions and half working alone. R…

This study is testing whether measuring two proteins in blood (TFPI-1 and TFPI-2) can help identify colorectal cancer. Researchers will compare blood samples from 303 adults aged 50-75 who are already scheduled for colonoscopy. The goal is to see if these blood markers can accura…

This study is testing a short questionnaire that family doctors can use to spot early signs of frailty in independent seniors over 65. Researchers want to see if this quick office test works as well as a much longer, specialized geriatric evaluation. The goal is to help doctors i…

This study is testing a non-contact sensor system called KASPARD to see if it can help prevent falls in nursing home residents. It will involve 40 elderly residents who are at high risk of falling. The system uses remote sensors to monitor nighttime activity and aims to alert sta…

This study is testing if a daily probiotic lozenge can help prevent red, swollen gums in teenagers who wear braces. Braces make brushing difficult and can lead to gum inflammation. Researchers will compare the probiotic against a placebo to see if it reduces gum bleeding and chan…

This study is comparing two ways to perform thyroid surgery. The new method (TOETVA) goes through the mouth to avoid a visible neck scar, while the standard method uses a neck incision. Researchers want to see if the scarless method is as safe and leads to better quality of life …

This study is testing whether a gentle electrical stimulation device placed on the ankle can help people with Multiple Sclerosis (MS) empty their bladders more completely. It aims to see if this daily, at-home treatment can improve bladder function and potentially allow some part…

This study is testing if providing gentle breathing support while removing the breathing tube after abdominal surgery helps patients maintain better oxygen levels. It will compare the standard method to two new techniques that use slight air pressure. The goal is to reduce episod…

This study is testing a new communication aid called PARKINSUN, designed to help people with Parkinson's disease have better conversations with their doctors. About 120 participants will be randomly assigned to either use the tool or not during their regular check-ups over seven …

This study aims to understand how spinal anesthesia affects a baby's nervous system during planned C-sections. Researchers will use a special device to continuously track the baby's heart rate and calculate a 'Fetal Stress Index' while also monitoring the mother's blood pressure …

This study aims to understand if high pressure inside the belly is linked to more fluid from the stomach getting into the lungs of critically ill patients with liver cirrhosis who are on breathing machines. Researchers will monitor belly pressure and test fluid from patients' bre…

This study aims to learn more about chronic hypereosinophilia, a condition where people have persistently high levels of a specific type of white blood cell. Researchers will observe 600 patients of all ages to map out how the disease affects different organs, how it progresses o…

This study aims to find blood markers that can predict which elderly patients are at higher risk of having a stroke or cognitive decline after a TAVR procedure, a common minimally invasive heart valve replacement. Researchers will enroll 542 patients over age 70 and analyze their…

This study aims to understand why weight-loss surgery is so effective by examining the relationship between two key body chemicals: cortisol (a stress hormone) and bile acids (digestive chemicals). Researchers will measure these chemicals in 30 obese women before and after they u…

This study aims to understand how much anxiety affects prostate cancer patients who are on active surveillance (watching the cancer instead of immediate treatment) and their life partners. Researchers will survey 432 patient-partner pairs to measure their stress levels and identi…

This study aims to understand how the timing of a serious birth defect diagnosis affects parents' stress and trauma. Researchers will survey 240 mothers and fathers of children who had surgery for esophageal atresia. They will compare stress levels between parents who learned the…

This study aims to find out what factors best predict the risk of falling in older adults who have mild cognitive impairment (MCI), a condition involving early memory changes. Researchers will follow 417 participants in France for one year, collecting detailed information on thei…

This study investigates whether a simple, non-invasive hair and scalp examination called trichoscopy can help predict which scleroderma patients might develop serious organ complications. Researchers will compare scalp images from 200 scleroderma patients with those from healthy …

This study aims to see if a special, safe brain scan can show how a child's brain responds to sound when they wear hearing aids. Researchers will compare brain activity in 40 infants and toddlers, some with normal hearing and some with hearing loss who use hearing aids. The goal …

This study aims to understand why some babies born with esophageal atresia develop dumping syndrome—a condition causing dangerous blood sugar drops after meals. Researchers will monitor 15 infants' heart rates, blood sugar levels, and stomach emptying patterns to uncover the unde…

This study aims to understand why some young women regain their menstrual cycles quickly after breast cancer chemotherapy while others don't. Researchers will follow 50 women aged 25-35 to see if factors like body weight, metabolism, physical activity, and sleep patterns affect o…

This study aims to understand what happens to elderly people after they are assessed for a fall. Researchers will follow 1,000 patients from 12 French hospitals for one year, linking their clinic visit data with national health records. The main goal is to identify which factors …

This study aims to understand why some people develop severe allergic reactions to medications, known as DRESS syndrome. Researchers will examine blood and skin samples from 80 participants with different types of drug reactions to learn how specific immune cells contribute to or…

This study aims to understand the long-term health of teenagers born with esophageal atresia, a rare birth defect where the esophagus doesn't form properly. Researchers will follow 300 French adolescents aged 13-14 to track their digestive health, quality of life, and collect bio…

This study aims to understand how having Crohn's disease or ulcerative colitis as a child affects a person's job prospects and education level as an adult. Researchers will survey 460 adults who were diagnosed as children and compare their career and education outcomes to the gen…

This study aims to understand if a toxin called deoxynivalenol (DON), found in some grains, could be an environmental risk factor for developing inflammatory bowel diseases (IBD) like Crohn's. Researchers will compare samples from 100 people undergoing intestinal surgery—some wit…

This study aims to find out how often adult atopic dermatitis (eczema) affects the eyelids, a common but poorly understood problem. Researchers will observe 550 adult patients with eczema in France to measure eyelid involvement and look for links with allergies, other eye conditi…

This study aims to understand why weight loss surgery works well for some people long-term but not for others. Researchers will follow 1,000 patients for at least five years after their surgery to track their weight loss and health. The goal is to learn which surgical procedures …

This study aims to understand why weight loss surgery causes bone loss in postmenopausal women. Researchers will compare two common surgical techniques (RYGB and SG) to see how they differently affect bone marrow fat. They'll also check if having diabetes makes a difference in th…

This study aims to understand how a person's weight and blood sugar levels affect gene activity in their body tissues. Researchers will collect tissue samples from 20,000 people undergoing abdominal surgery to see how genes are expressed differently in those with obesity, diabete…

This study aims to understand the complex biology of systemic sclerosis, a rare autoimmune disease that causes skin thickening and organ scarring. Researchers will analyze skin and blood samples from 40 adult patients to map the different types of cells involved and how they inte…

This study aims to understand why a standard drug for catatonia, a severe movement disorder, works for most people but not all. Researchers will measure drug levels in the blood and look at genetic factors in 100 adult patients to see if these can predict who will respond to trea…

This study aims to find early signs that predict which people with type 2 diabetes are most at risk for developing heart failure or memory problems. Researchers will follow 600 adults with diabetes over time, measuring their heart function, inflammation, and thinking skills. The …