Blood test may replace anesthesia for heart valve fix

NCT ID NCT03728049

Recruiting now Diagnosis Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a quick blood test (CT-ADP) can help doctors detect and fix leaks around a new heart valve during a minimally invasive TAVI procedure. Currently, doctors often use general anesthesia and an ultrasound probe in the throat to check for leaks, but this study avoids that. About 944 people with aortic stenosis will be randomly assigned to have the blood test or not, and researchers will track complications over one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CT-ADP blood test
What this could lead to: If successful, this blood test could replace the need for general anesthesia during TAVI while still catching dangerous leaks, making the procedure safer and less invasive.
What could go wrong: This is a large but early-stage trial testing a new use for an existing test. The test may not be accurate enough to replace current methods, and the study's success depends on many factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve insufficiency aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE INSUFFICIENCY AORTIC VALVE STENOSIS

Contacts and locations

Locations

CHU de Nimes
NOT_YET_RECRUITING

Nîmes, France
CHU de Toulouse
RECRUITING

Toulouse, France
Chru Rennes Site Pontchaillou
NOT_YET_RECRUITING

Rennes, France
Chu Montpellier
NOT_YET_RECRUITING

Montpellier, France
Hopital Civil / Nouvel Hopital Civil - Strasbourg
NOT_YET_RECRUITING

Strasbourg, France
Hopital Estaing - Chu63 - Clermont Ferrand
RECRUITING

Clermont-Ferrand, France
Hopital Haut-Leveque - Chu - Pessac
RECRUITING

Pessac, 33604, France
Hu Pitie Salpetriere Aphp - Paris 13
NOT_YET_RECRUITING

Paris, France
Institut Coeur-Poumon, CHU
RECRUITING

Lille, 59037, France

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