Can a single stitch beat a double closure for TAVI patients?

NCT ID NCT07743697

Not yet recruiting Disease control Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This trial compares two methods for closing the main artery in the leg after a TAVI procedure, which replaces a heart valve without open surgery. Half of the participants will have the artery closed with a single suture device, while the other half will receive a hybrid approach that adds a plug-based device. The goal is to see which method leads to fewer bleeding complications and faster recovery. Adults scheduled for transfemoral TAVI are eligible to join.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A single suture-based vascular closure device (Perclose ProGlide or Perclose ProStyle) compared with a hybrid approach adding a plug-based closure device.
What this could lead to: If a single suture works as well as the hybrid method, it could simplify the procedure, shorten recovery, and lower the risk of bleeding after TAVI.
What could go wrong: The trial is still testing the idea, and results may not show a clear benefit. There is also a risk that using only a suture could lead to more bleeding or vessel damage in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis Hemorrhage Postoperative Complications Vascular System Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE STENOSIS HEMORRHAGE POSTOPERATIVE COMPLICATIONS VASCULAR SYSTEM INJURIES

Contacts and locations

Locations

University Heart Center Basel, University Hospital Basel

Basel, Canton of Basel-City, 4031, Switzerland

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