Aortic valve stenosis

This trial tests whether a new transcatheter heart valve (Myval) works as safely and effectively as two existing valves (Sapien and Evolut) in people with severe aortic stenosis, a condition where the heart's main valve narrows. About 768 patients who are eligible for valve repla…

This study compares two standard procedures—minimally invasive TAVR and open-heart surgery (SAVR)—for replacing a diseased aortic valve in people with a bicuspid aortic valve. About 1,200 participants aged 50 and older with severe aortic stenosis will be randomly assigned to one …

This study follows 550 patients whose first TAVI heart valve has failed. Researchers will compare a second TAVI procedure (redo TAVI) with open-heart surgery or medication alone. The goal is to see which approach works best and why, helping doctors make better decisions for futur…

This trial is testing a new heart valve called SAPIEN X4/X4S in over 1,200 people with severe aortic stenosis, a condition where the heart's aortic valve narrows. The valve is inserted through a catheter, avoiding open-heart surgery. Researchers are measuring how many patients di…

This study will track 100 people with severe aortic stenosis who receive the Hydra THV heart valve through a less invasive procedure (TAVR). The goal is to see how well the valve works and how safe it is in everyday practice. Participants will be followed for short- and mid-term …

This trial tests whether an eight-week digital cardiac rehabilitation program using the Peloton app can improve physical activity and recovery in people who have had a transcatheter aortic valve replacement (TAVR). Participants are randomly assigned to either the digital rehab pr…

This registry will follow 500 adults with severe aortic stenosis who receive a SAPIEN 3 Ultra Resilia heart valve through a minimally invasive procedure. Researchers will track how well the valve works and how safe it is over 10 years. The goal is to see if this newer valve desig…

This trial compares two single antiplatelet therapies—ticagrelor versus aspirin—in people who have just undergone transcatheter aortic valve implantation (TAVI) for severe aortic stenosis. The goal is to see which drug better prevents serious complications like stroke, heart atta…

This study tests a new device called Rapidlink, used during open surgery to repair or replace blood vessels in the chest. It involves 150 adults already scheduled for aortic surgery. The goal is to see if the device reduces major complications like stroke or death. Participants w…

This study is testing a new heart valve called the SAPIEN X4 in 200 people whose existing artificial aortic valve is failing. The valve is placed using a thin tube through an artery, avoiding open-heart surgery. The goal is to see if it is safe and effective at improving survival…

This study is testing the Navitor heart valve in 1000 people with severe aortic stenosis, a condition where the heart's main valve narrows. Participants receive the valve through a catheter, and researchers track survival and complications for one year. The goal is to see how wel…

This study tests a drug called inclisiran in children aged 2 to 12 who have a rare genetic condition that causes extremely high cholesterol. The goal is to see if the drug safely lowers their bad cholesterol compared to a placebo. Participants will receive either inclisiran or pl…

This study compares two approaches for people with severe aortic stenosis who have no symptoms: early valve replacement (surgery or TAVI) versus watchful waiting. About 2,844 participants will be followed for at least 3 years to see which strategy reduces heart-related death and …

This study is testing a new CT-based sizing algorithm (the ABC Bicuspid Sizing Algorithm) to help doctors choose the right valve size and procedure for people with bicuspid aortic stenosis who need a transcatheter aortic valve replacement (TAVR). About 290 participants will have …

This study compares a new heart valve, the DurAVR®, to standard TAVR valves in up to 1650 people with severe aortic stenosis. The valve is designed to mimic natural blood flow. Participants are randomly assigned to get the new valve or a standard one and are followed for up to 10…

This study is testing the safety and performance of the Navitor TAVI system, a device used to replace a narrowed heart valve (aortic stenosis) without open-heart surgery. About 1,000 participants who are eligible for the procedure will receive the Navitor valve and be followed fo…

This study tests whether a special method to expand a new heart valve during TAVI can reduce harmful thickening of the valve leaflets. About 620 people with severe aortic stenosis who do not have atrial fibrillation will be randomly assigned to either the optimized expansion meth…

This study tests whether a newer blood thinner (rivaroxaban) works as well as the standard drug (warfarin) for preventing clots and bleeding in people who have a mechanical aortic valve. About 1,300 adults who had valve surgery at least 3 months ago will take one of the two pills…

This study compares aspirin to the blood thinner warfarin in 1058 people who just had a bioprosthetic heart valve replacement. For 6 months after surgery, participants take either daily aspirin or warfarin. The goal is to see if aspirin is just as safe and effective at preventing…

This study tests whether a daily medication called ataciguat can slow the progression of moderate aortic valve stenosis, a condition where the heart's aortic valve becomes narrowed. About 1,276 adults aged 50 and older will receive either ataciguat or a placebo for up to 3 years.…

This registry is following 500 adults in Portugal who have severe aortic stenosis and are getting a new type of heart valve replacement called the Medtronic Evolut FX+ TAVI system. The goal is to see if using a standardized procedure makes the treatment safer and more effective. …

This study compares aspirin and clopidogrel to prevent leaflet thrombosis (blood clots on the valve) in 254 people who had a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. After 4 weeks of both drugs, participants take either aspirin or clopidogrel alon…

This study tests whether a drug called enavogliflozin can prevent major heart problems or worsening heart failure in people who have had a heart valve replacement (TAVR) and still have heart failure. About 1,040 participants will receive either the drug or a placebo, in addition …

This study tests a new device called EmStop that captures debris during a heart valve replacement procedure (TAVR) for aortic stenosis. About 663 people will be randomly assigned to receive either the EmStop device or a standard device. The goal is to see if EmStop reduces the ri…

This study is testing a new type of biological heart valve that features an 'easy change' system, designed to make future replacements simpler. Researchers will implant these valves in 500 people with aortic valve disease and track complications like blood clots, infections, and …

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study tests whether using just one Perclose device to close the artery after TAVR is as safe and effective as the usual two devices. Researchers will measure bleeding time and complications in 300 adults undergoing TAVR. The goal is to see if a simpler approach can reduce pr…

This study tests a monthly injection called pelacarsen to see if it can slow the worsening of calcific aortic valve stenosis, a condition where the heart valve becomes stiff and narrow. About 502 adults aged 50-79 with high levels of lipoprotein(a) and mild-to-moderate valve dise…

This study tests a new device called CHORDS that catches loose debris during a heart valve replacement procedure (TAVR). The debris can travel to the brain and cause a stroke. The trial will compare CHORDS to an existing device in 240 people with severe aortic stenosis. Participa…

This study compares two different devices (Allegra and Sapien) used to replace a failing surgically implanted aortic heart valve without open-heart surgery. About 104 adults with a deteriorated biological aortic valve will be randomly assigned to get one of the two devices. The m…

This study follows 1,200 people who received special fabric tubes (grafts) to repair or replace damaged arteries in the neck, belly, or legs. Researchers want to see how well the grafts work over time and how often problems like blockages or infections happen. It is an observatio…

This study tests a pre-set treatment plan for managing heart rhythm issues that can occur after transcatheter aortic valve replacement (TAVR). The goal is to reduce the number of patients who receive a permanent pacemaker while ensuring no one is put at risk of sudden cardiac dea…

This study tests whether giving two steroids (hydrocortisone and fludrocortisone) to high-risk patients before heart surgery can lower the chance of serious complications like kidney injury and lung problems. The trial will include 196 adults with a EuroSCORE II above 4% who are …

This study is testing whether a common heart valve procedure called TAVI can be performed safely in hospitals that do not have on-site cardiac surgery backup. About 1,600 patients with severe aortic stenosis will be randomly assigned to get TAVI either at a center with or without…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study is for people whose first TAVR heart valve is failing. Doctors will place a new TAVR valve inside the old one. The goal is to see if this 'redo' procedure is safe and works well. About 225 people will take part, and researchers will check how the valve performs at 30 d…

This study is testing the Navitor heart valve, a device used to replace a narrowed aortic valve without open-heart surgery. It will include 100 people in Japan with severe aortic stenosis. Researchers will check how many patients die within 30 days and whether the valve leaks aft…

This study looks at how safe and effective a less invasive heart valve replacement (called Sapien 3 TAVR) is for younger patients (ages 50-70) in China with severe aortic stenosis. Researchers will track 450 participants for up to 5 years to see survival rates and complications. …

This study tests whether a CT scan 3 months after TAVI (aortic valve replacement) can help doctors decide who needs blood thinners and who can stop them. Currently, patients take aspirin for life, which can cause bleeding. The trial will enroll 2,500 people and compare this perso…

This study tests a drug called inclisiran in children aged 6 to 12 who have a genetic condition that causes very high cholesterol. The drug is given as a shot under the skin and aims to lower 'bad' LDL cholesterol. The trial compares inclisiran to a placebo for one year, then eve…

This study tests a home-based cardiac rehabilitation program delivered through a custom app for people who have had a heart valve procedure. Participants who choose not to attend center-based rehab are randomly assigned to usual care, the app with self-guided content, or the app …

This study tests whether a newer, less-invasive valve replacement (Myval THV) works as well as traditional open-heart surgery in people aged 65 to 75 with severe aortic stenosis. About 1,180 participants will be randomly assigned to one of the two procedures. The goal is to see i…

This study is testing a new device called the Hydra Transcatheter Aortic Valve System in 500 people with severe aortic stenosis, a condition where the heart's aortic valve becomes narrow. The device is implanted through a catheter, avoiding open-heart surgery. Researchers will tr…

This study is testing a new heart valve called Hydra for people with severe aortic stenosis, a condition where the heart's main valve becomes narrow. About 250 participants will get the valve through a tube in an artery, and researchers will check how safe and effective it is for…

This study is testing a new heart valve called Hydra in 50 people with severe aortic stenosis, a condition where the heart's main valve narrows. The goal is to see if the valve is safe and works well for up to one year after a minimally invasive replacement procedure. Researchers…

This trial compares two different TAVI devices (Evolut FX and Sapien 3 Ultra Resilia) used to replace a narrowed heart valve in people with aortic stenosis. About 1,346 patients will be randomly assigned to get one device or the other. Researchers will track deaths, strokes, valv…

This study tests whether replacing a narrowed heart valve right away (within 12 hours) helps people with severe aortic stenosis who are in cardiogenic shock, compared to the usual approach of stabilizing them in the ICU first. Thirty participants will be randomly assigned to one …

This study follows 225 adults who have the Ross procedure, a surgery that replaces a diseased aortic valve with the patient's own pulmonary valve. Researchers will track survival, hospital readmissions, and need for repeat surgeries over 1, 5, and 10 years. The goal is to confirm…

This study tests whether a special heart scan called CT-FFR can help doctors make better decisions about treating blocked arteries before valve replacement surgery. 300 patients with severe aortic stenosis will be randomly assigned to have their treatment guided by either standar…

This study tests a new balloon device used during a minimally invasive heart valve replacement procedure (TAVI) for people with severe aortic stenosis. The main goal is to see if the balloon causes fewer heart rhythm problems, like blockages that might need a pacemaker. About 93 …

This study tests a new device called the Siegel TAVR System to replace a narrowed heart valve in people with severe aortic stenosis. About 1,025 participants with symptoms will receive the device. Researchers will track deaths, strokes, and heart-related hospitalizations for one …

This study compares two types of pacemaker settings in people who need a pacemaker after a TAVI procedure (a minimally invasive heart valve replacement). The two methods are 'physiological pacing' (which tries to mimic natural heart activation) and standard 'right ventricular pac…

This study compares a newer, minimally invasive heart-lung machine (MiECC) to the standard machine used during heart surgery. Researchers want to see if the newer machine reduces serious problems like heart attack, stroke, or kidney injury. About 1,300 adults having elective hear…

This study is tracking 150 people who receive a new type of heart valve (SAPIEN 3 Ultra RESILIA) to see how well it works over time. The valve has special features to prevent calcium buildup and improve durability. Researchers will use echocardiograms to measure valve function an…

This study tests a special balloon that uses shockwaves to crack calcium buildup in the iliac arteries, making it possible to deliver large aortic stents. About 40 adults with severe aortic disease and hardened arteries will be enrolled. The goal is to see if this approach is saf…

This study tests whether using remote monitoring devices after a heart valve procedure (TAVI) allows patients to safely go home the same day instead of staying in the hospital. 216 adults who are eligible for same-day discharge will be randomly assigned to either standard care or…

This study tests a less invasive method to replace a narrowed heart valve in 20 people with severe aortic stenosis. Instead of using X-rays, doctors will guide the procedure using only ultrasound, which may reduce radiation exposure. The goal is to see if this approach is safe an…

This study looks at whether a special type of pacemaker, called cardiac resynchronization therapy (CRT), can help people with heart failure who develop a heart block after having their aortic valve replaced. The trial will include 360 adults who have a new, persistent heart block…

This study is testing the RENATUS transcatheter aortic valve in 800 people with severe aortic stenosis, a condition where the heart's aortic valve narrows and makes it hard to pump blood. The valve is implanted through a catheter, avoiding open-heart surgery. Researchers are trac…

This study looks at people with severe aortic stenosis who need a new heart valve (TAVI). Normally, doctors do a coronary angiogram first to check for blocked arteries. But this test can cause kidney damage or bleeding, especially in older patients. The trial will compare the usu…

This study tests a new surgical technique called the 'Y incision' for people with a small aortic annulus (the ring where the heart valve sits) who need aortic valve replacement. The standard methods often limit how large a replacement valve can be placed, which can lead to poor b…

This registry will follow 150 people in Portugal who receive the Myval heart valve through a minimally invasive procedure called TAVI. The goal is to see how safe and effective the valve is for treating severe aortic stenosis. Researchers will track complications like death, stro…

This study tests whether using a heart-lung machine (ECMO) before a high-risk aortic valve replacement can prevent death, cardiac arrest, or emergency surgery. It includes 30 adults with severe aortic stenosis who are unstable or have complex anatomy. Participants receive ECMO su…

This study is testing a new heart valve replacement system (VitaFlow Liberty) in 122 people with severe aortic stenosis who are too high-risk for open-heart surgery. The goal is to see how safe and effective the valve is over 12 months, focusing on preventing death and disabling …

This study compares two approaches for people aged 65+ with moderate aortic stenosis (a narrowed heart valve): either getting a new valve placed through a thin tube (TAVR) or just having regular check-ups. The goal is to see if early treatment prevents death or heart failure bett…

This study tests a new device called the Encompass F2, which is designed to catch debris that might travel to the brain during a common heart valve replacement procedure (TAVR). The goal is to see if it reduces the risk of stroke and brain damage compared to standard care. About …

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The program starts in the hospital and continues at home, helping patients build skills and motivation to do cardiac rehab…

This study tests whether using one stitch device (Perclose) is as safe and effective as using two to close the leg artery after a minimally invasive heart valve replacement (TAVR) in people with severe aortic stenosis. About 876 participants will be randomly assigned to one of th…

This study tests whether using a slightly smaller artificial heart valve (downsizing) works better than the standard method for people with a bicuspid aortic valve—a heart valve with only two flaps instead of three. About 206 adults with severe narrowing of this valve will be ran…

This early study tests a new device called GEMINUS, which replaces a narrowed heart valve without open-heart surgery. It involves 30 people with severe aortic stenosis. The goal is to see if the procedure is safe and feasible, with follow-up for up to 5 years.

This study is testing whether an artificial intelligence (AI) program can detect aortic stenosis—a narrowing of the heart's main valve—from a standard electrocardiogram (ECG). Researchers will compare the AI's results with traditional diagnosis in 5,000 adults. If successful, thi…

This study investigates whether a blood test measuring clotting and clot-busting markers can predict complications in patients undergoing aortic valve replacement. Researchers will follow 750 adults with aortic stenosis who receive either surgical or catheter-based valve replacem…

This study investigates whether using a lower dose of iodine contrast dye in CT scans can still produce high-quality images needed to plan a heart valve replacement procedure (TAVR). Normally, 100 ml of contrast is used, but reducing the dose may help avoid kidney injury and save…

This study tests whether artificial intelligence can analyze standard ultrasound images of the heart to measure calcium buildup on the aortic valve. If accurate, this could help doctors diagnose severe aortic stenosis without the extra cost and radiation of a CT scan. The study w…

This study explores whether a smartphone can detect aortic valve stenosis, a serious heart condition, by recording heart sounds and chest vibrations. Researchers will compare smartphone data with standard echocardiograms in 500 patients. If accurate, this could lead to a simple, …

This study tests whether a quick blood test (CT-ADP) can help doctors detect and fix leaks around a new heart valve during a minimally invasive TAVI procedure. Currently, doctors often use general anesthesia and an ultrasound probe in the throat to check for leaks, but this study…

This study tests an artificial intelligence (AI) model that can screen for heart valve disease using standard chest CT scans that people already get for other reasons. The goal is to see how well the AI catches moderate-to-severe cases without needing extra tests or contrast dye.…

This study tests whether a portable electronic stethoscope, combined with machine learning, can accurately detect valvular heart disease. About 125 people with and without the condition will use the device and also receive standard heart tests. Researchers will compare the device…

This study explores whether kinocardiography (KCG), a portable device that measures chest vibrations from heartbeats, can diagnose aortic valve disease and thoracic aortic aneurysm. Researchers will compare KCG readings with standard imaging in 180 adults, including those with an…

This study tests whether wearing a portable ECG monitor for 30 days after a heart valve replacement (TAVI) can detect dangerous heart rhythm problems better than the usual 1-2 days of hospital monitoring. 250 patients will be randomly assigned to either the extended monitoring gr…

This study is testing whether a small implantable heart monitor (Reveal LINQ) can detect serious heart block in people who develop a new electrical problem (left bundle branch block) after having their aortic valve replaced (TAVI). About 80 participants will get the monitor and b…

This study at Mayo Clinic is testing whether artificial intelligence can help standard electrocardiograms (ECGs) detect two common heart valve problems: aortic stenosis and diastolic dysfunction. Researchers will enroll 2000 adults aged 60 and older who are already scheduled for …

This study compares two heart imaging methods—echocardiography (ultrasound) and cardiac MRI—to see which measures heart valve disease more accurately. Researchers will enroll 200 adults with suspected moderate or severe valve problems. The goal is to improve how doctors assess va…

This study tests an artificial intelligence (AI) tool to help doctors accurately diagnose severe low-gradient aortic stenosis, a heart valve condition that can be hard to identify. About 300 adults with suspected disease will have their standard echocardiograms analyzed by the AI…

This study is testing whether having a dental checkup before heart valve surgery can prevent serious complications like infection of the heart lining, repeat surgery, or death. About 1,300 adults scheduled for valve surgery will be randomly assigned to either get a dental screeni…

This study tests whether using shockwave therapy on the leg artery before a TAVR heart valve procedure can reduce bleeding and other complications. It involves 100 adults with severe aortic stenosis and heavily calcified arteries. The goal is to make the procedure safer by prepar…

This study looks at two different nerve-block techniques to manage pain during a minimally invasive heart valve replacement called TAVI. About 60 adults having TAVI will receive either a pericapsular nerve group block, a fascia iliaca block, or local anesthesia. The goal is to se…

This study compares two sedation approaches during a minimally invasive heart valve replacement (TAVI) in 80 elderly patients. One group receives dexmedetomidine, a sedative that may cause less breathing depression, while the other gets standard propofol-remifentanil. Researchers…

This study tests whether the type of sedation given during a minimally invasive heart valve replacement (TAVR) affects how well patients recover the next day. 126 adults will be randomly assigned to receive propofol, dexmedetomidine, or midazolam with fentanyl during their proced…

This study tests whether applying mild electrical stimulation to specific acupoints before anesthesia can help maintain stable blood pressure during TAVR heart valve surgery. Researchers will compare two different stimulation frequencies in 150 adults aged 60 and older. The goal …

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests whether giving iron infusions after a minimally invasive heart valve replacement (TAVI) helps patients with aortic stenosis and iron deficiency feel better and walk farther. About 402 older adults will be randomly assigned to receive iron or standard care. Resear…

This study tests a special shockwave balloon (intravascular lithotripsy) to safely widen heavily calcified arteries in the pelvis, allowing a less invasive heart valve replacement (TAVR) in patients who otherwise would need a more risky approach. About 50 adults with severe aorti…

This study tests whether giving high-flow oxygen through special nasal prongs during a less-invasive heart valve replacement (TAVR) can prevent low oxygen levels and breathing complications. About 452 older adults undergoing TAVR under sedation will be randomly assigned to receiv…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study looks at whether advanced imaging can detect a hidden heart condition called cardiac amyloidosis in people with severe aortic valve stenosis. The condition can complicate treatment and recovery. Researchers will use echocardiography, CT, and SPECT/CT scans to check for…

This study looks at whether people with heart rhythm problems after a TAVI procedure can safely leave the hospital early if they wear a non-invasive heart monitor at home. About 100 adults who had a successful TAVI for severe aortic stenosis and have certain conduction disorders …

This study is a large registry that collects data from thousands of patients across Asia who have undergone transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. Researchers will analyze medical records to see how well the valves perform over time and what fac…

This registry will follow 2,500 people who receive Abbott heart devices, such as implants for holes in the heart or replacement heart valves. The goal is to check how safe and effective these devices are when used in everyday hospital practice. Data will be collected from standar…

This study compares different types of heart valve prostheses used to treat severe aortic stenosis in people with a small aortic annulus. Researchers will test the valves in the lab and then in patients using echocardiograms and a special MRI scan that measures blood flow. The go…

This study investigates why some people with moderate aortic valve stenosis get worse while others remain stable. Researchers will analyze immune system markers and detailed heart images from about 938 participants to find patterns that predict disease progression. The goal is to…

This study follows 3,450 patients with aortic valve narrowing (aortic stenosis) to better understand their long-term outlook. Researchers will look at ultrasound measurements and other factors to find what predicts how the disease progresses. The goal is to improve how doctors as…

This study is tracking 500 people who receive the INSPIRIS RESILIA aortic valve during surgery. Researchers will measure how well the valve works by checking blood flow and leakage over time. The goal is to see how the valve performs in everyday medical practice.

This study is looking at whether a simple exercise test and other health factors can predict how well people recover after a procedure called TAVI, which replaces a narrowed heart valve. Researchers will follow 161 patients with severe aortic stenosis to see which factors before …

This study at Mayo Clinic looks at how changes in the blood vessels of the lungs affect people with heart valve disease. Researchers will use echocardiograms during routine heart catheterization to measure these changes in 600 adults scheduled for valve procedures. The goal is to…

This study looks at whether inflammation after a minimally invasive heart valve replacement (TAVI) can cause dangerous heart rhythm problems. Researchers will use a special PET scan to measure inflammation in the heart's electrical pathways. The goal is to better predict which pa…

This study tracks 300 adults with aortic disease to measure how their condition impacts quality of life, fatigue, mental health, and ability to work. Researchers will use questionnaires over 12 months to gather data. The goal is to better understand these challenges and help desi…

This study observes 1000 people with severe aortic stenosis and kidney disease who are getting a TAVI procedure. Researchers want to see how removing the blocked valve affects the kidneys' response to contrast dye used during the procedure. The goal is to understand if TAVI lower…

This study looks at 600 people getting a new heart valve through a tube in the leg (TAVI). Doctors want to know if using a second tube in the arm (radial artery) instead of the groin (femoral artery) causes fewer bleeding or blood vessel problems. The goal is to find the safest w…

This study is examining heart valve tissue from 100 people undergoing surgery for aortic stenosis to see how often ATTR amyloid deposits are present. Researchers will use mass spectrometry to identify the type of amyloid. The goal is to better understand the link between amyloido…

This study will follow 300 people with aortic stenosis who are scheduled for a TAVI procedure to replace their heart valve. Researchers will use heart scans, blood tests, and checkups to measure how the heart's condition changes over time. The goal is to better understand short- …

This study is collecting blood samples and quality-of-life questionnaires from 125 people with aortic stenosis, a heart valve condition. Researchers want to find biological markers (biomarkers) that could signal inflammation or scarring in the heart before symptoms appear. The go…

This study is looking at whether a blood test measuring DNA methylation can predict the risk of silent brain injury in elderly patients undergoing TAVR, a minimally invasive heart valve replacement. About 542 people over age 70 with severe aortic stenosis will have their DNA test…

This study looks at why some replacement heart valves (TAVI) may wear out faster than others. Researchers will use special PET-CT scans to detect early signs of valve damage in 180 people who had TAVI about five years ago. They want to see if small blood clots on the valve or the…

This study is a registry that collects information from routine care to see how well minimally invasive heart valve procedures work over 5 years. It includes adults over 18 who have had a transcatheter aortic valve replacement or similar treatment. No new treatments are given; th…

This study tests whether a structured shared decision-making process helps patients with severe aortic stenosis choose between two valve replacement options: TAVR (less invasive) and SAVR (surgery). 140 patients aged 70+ will be randomly assigned to either the structured approach…

This study looks at 82 people with severe aortic stenosis who need open-heart surgery to replace their aortic valve. Before surgery, each person gets a CT scan to measure the valve. During surgery, doctors also measure the valve with special tools. The goal is to see which method…

This study looks at two ways to check for blocked heart arteries in people with severe aortic stenosis who are getting a new heart valve (TAVI). One method is the usual invasive X-ray test; the other uses non-invasive risk management. The goal is to see which approach leads to be…

This early study looks at whether a non-invasive test called impedance cardiography (the HYPERGRAPH test) can detect early signs of heart failure in people with aortic stenosis, a condition where the heart's main valve narrows. Researchers will compare the test results with heart…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study looks at whether filtering out blue light at night in hospital rooms can reduce inflammation, protect thinking skills, and improve mood and sleep in 80 adults having elective heart surgery. Participants will be randomly assigned to wear blue-blocking glasses or regular…

This study looks at people getting a new heart valve (TAVR) for a narrowed aortic valve. It compares two ways of placing the valve: one carefully aligned and one random. The goal is to see if the random method still allows doctors to easily reach the heart arteries later if neede…

This study follows 2500 people who had a TAVR procedure to replace a narrowed heart valve. Researchers will track bleeding and clotting events over time to see how different blood-thinner medicines affect risk. The goal is to find the best treatment plan for each patient based on…

This study tests whether artificial intelligence (AI) can help cardiologists read echocardiograms (heart ultrasounds) more quickly and consistently. Researchers will give AI analysis to doctors in real time as they review heart images from 50 participants with valve disease. The …

This pilot study is testing a new device called HemoCept that measures blood volume and heart efficiency during trans-aortic valve replacement (TAVR) surgery for aortic stenosis. The study will enroll 20 adults aged 18-80 who need TAVR. Researchers want to see if the device's rea…

This study is a registry that will follow up to 2,700 people who have received or will receive a Medtronic heart valve product during surgery. The goal is to monitor the long-term safety and performance of these devices by identifying any unexpected problems or trends. Participan…

This study watches 150 adults with heart valve problems who are getting a procedure (TAVI or M-TEER) to see if it helps their sleep-disordered breathing. Participants take a sleep test before the procedure and again 6 months later. The goal is to learn how fixing heart valves mig…

This registry is tracking 1,350 people with severe low flow, low gradient aortic stenosis who are getting a TAVR procedure. Researchers are collecting data on risks, complications, and survival for up to 5 years. The goal is to better understand who does well with this treatment …

This study compares two self-expanding heart valves used in a procedure called TAVR, which replaces a narrowed aortic valve without open-heart surgery. Researchers will look at how well each valve works one month and six months after the procedure in about 419 patients. The goal …

This study compares two methods—ultrasound (echocardiography) versus direct pressure measurements (catheterization)—to guide additional balloon inflation after valve-in-valve TAVR. About 310 people with failing surgical aortic valves will be randomly assigned to one method. The g…

This study watches which guidewires doctors use during a minimally invasive heart valve replacement (TAVI) and checks if a newer wire, the Savvywire, works better. About 300 people aged 50 or older getting TAVI through the groin will take part. Researchers will collect data from …

This study is testing a new way to use MRI scans to measure how well the heart's main pumping chamber works in people with severe aortic stenosis who are scheduled for valve replacement. Researchers will develop computer models to automatically analyze heart images and compare th…

This study is looking at how well the Mosaic mitral heart valve works over time in people under 65. Researchers will review medical records of 300 patients who had this valve placed at ProMedica Toledo Hospital. The goal is to understand survival rates, valve stability, and the n…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study looks at whether a special heart ultrasound measurement, called global longitudinal strain (GLS), can predict if a person will have trouble coming off the heart-lung machine during heart surgery. About 213 adults having planned heart surgery will have their hearts meas…

This observational study is testing whether a noninvasive finger imaging device can detect and evaluate two types of heart valve disease: aortic regurgitation and aortic stenosis. Researchers will record arterial waveforms from participants' fingers and see if the patterns can di…

This study looks at whether replacing a narrowed heart valve (TAVI) can reverse damage to the heart muscle in people with severe aortic stenosis. Researchers will use special PET scans to measure scarring and remodeling in the heart before and 6 months after the procedure. The go…

This study aims to find biological differences between men and women with heart valve disease using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe aortic or mitral valve problems. The goal is to better predict how the heart recovers after valv…

This study tests a new imaging tracer called 11C-Martinostat that lights up a specific enzyme (histone deacetylase) in the heart during a PET-MRI scan. Researchers will compare enzyme activity in people with aortic stenosis or diabetes to healthy volunteers. The goal is to see if…

This observational study is testing whether advanced heart imaging (MRI or CT scans) can find blood clots in the heart that standard ultrasound might miss. It involves 125 people who had a stroke of unknown cause and have mild heart disease. The goal is to better understand strok…

This study compares two types of replacement heart valves for people with aortic stenosis (a narrowed heart valve). Researchers will use exercise MRI scans to see which valve type works better during physical activity. About 90 adults who are already scheduled for valve replaceme…

This study looks at how different fluids used to fill the heart-lung machine before heart surgery affect the body's balance. 80 adults having bypass or valve surgery will be split into four groups, each receiving a different priming solution. Researchers will track changes in aci…

This study is following 10,000 adults with heart valve disease to see how their condition changes over time. Researchers will use scans, blood tests, and health records to track progression and the effects of treatments like surgery or medication. The goal is to better predict ou…

This study looks at whether it is safe to temporarily stop taking beta-blockers before a procedure called transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. About 498 adults who are scheduled for TAVR and have been on beta-blockers for at least a month will…

This study looks at whether replacing a narrowed heart valve (TAVI) changes the types of bacteria living in the gut. Researchers will collect stool and blood samples from 40 patients before and after the procedure. The goal is to see if improved blood flow from the new valve help…

This study uses artificial intelligence to analyze data from 21,000 patients who had heart valve procedures. The goal is to make AI tools that can predict surgery outcomes, like which device to use and risks of complications, with over 90% accuracy. This is a non-interventional s…

This study is looking at whether certain substances in the blood, related to inflammation and scarring, can predict if a person will develop heart rhythm problems after a procedure called TAVI (transcatheter aortic valve implantation). TAVI is a less invasive way to replace a nar…

This registry will track 800 adults with valvular heart disease to see if women and men receive different diagnosis, treatment, and follow-up care. Researchers will compare how quickly each group gets guideline-recommended therapies and whether gender, age, or ethnicity affect ou…

This study looks at whether common blood tests for heart damage (troponin and CK-MB) match what an MRI shows after heart valve surgery. Researchers will enroll 100 adults having aortic or mitral valve surgery. The goal is to improve how heart attacks are diagnosed after surgery, …

This observational study in Scotland aims to understand what causes aortic stenosis to worsen and how the heart responds after valve replacement. About 300 participants with mild to severe aortic stenosis or a replacement valve will undergo regular heart scans and imaging over se…

This observational study will follow 1900 people with moderate mixed aortic valve disease (a combination of aortic stenosis and regurgitation) to see how symptoms and heart function relate to survival and the need for valve replacement. Researchers hope to identify which patients…

This study is following 4,000 people with heart valve disease to look for new substances in the body (called metabolites) that might be linked to the disease. Researchers hope to find better ways to predict who will get worse and understand why. No new treatments are being tested…

This study aims to see if CT and echo scans taken before and after a TAVI procedure can help predict how the new heart valve will perform. Researchers will collect scan data from 40 adults with severe aortic stenosis and use it to train a computer algorithm. The goal is to improv…