Can immune and imaging clues predict heart valve disease progression?

NCT ID NCT05851209

Recruiting now Knowledge-focused Sponsor: Heinrich-Heine University, Duesseldorf Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study investigates why some people with moderate aortic valve stenosis get worse while others remain stable. Researchers will analyze immune system markers and detailed heart images from about 938 participants to find patterns that predict disease progression. The goal is to identify high-risk patients earlier and potentially guide future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors identify which patients with moderate aortic stenosis are at highest risk of worsening, enabling earlier intervention.
What could go wrong: This is an observational study, not a treatment trial, so it will not directly improve health. The findings may not lead to new therapies or change current care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve calcification aortic valve stenosis Aortic Valve, Calcification of Disease Progression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC STENOSIS AORTIC VALVE CALCIFICATION DISEASE PROGRESSION GENETICS IMAGING PATHOGENESIS

Contacts and locations

Locations

University Hospital Cologne
RECRUITING

Cologne, 50937, Germany
University-Hospital Bonn
RECRUITING

Bonn, 53127, Germany
University-Hospital Düsseldorf Division of Cardiology, Pulmonary Disease and Vascular Medicine
RECRUITING

Düsseldorf, 40225, Germany

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