Heinrich-heine University, Duesseldorf

This study tests whether a 'treat-to-target' approach—where doctors adjust treatment every 6 weeks to aim for remission—works better than usual care for people with lupus. About 606 participants who are not in remission will be followed for 120 weeks. The goal is to see if this s…

This phase II trial is testing whether robot-assisted surgery to remove lymph nodes in the abdomen can help predict and prevent cancer recurrence in men with stage II seminoma. About 60 participants will undergo the procedure, with the option of one round of chemotherapy afterwar…

This study is testing whether a special type of scan (PET/MRI) combined with artificial intelligence can accurately tell if HER2-positive breast cancer has been completely eliminated after chemotherapy. Researchers will scan 460 women before, during, and after treatment, then com…

This study tests a new, less invasive way to check if testicular cancer has spread. Doctors inject a dye into the testicle, then use a robot to find and remove the first lymph node that drains the tumor. The goal is to see if this method is accurate enough to replace more extensi…

This study checks if a treatment called transcranial pulse wave stimulation (TPS) is safe for people with Alzheimer's disease. About 100 adults aged 18 to 85 will receive TPS sessions, and researchers will track any side effects and changes in memory and thinking. The goal is to …

This study looks at whether repairing blocked leg blood vessels within 48 hours helps heal foot ulcers in people with type 2 diabetes faster than waiting for a scheduled procedure. About 200 adults with diabetic foot sores will be randomly assigned to early or standard treatment.…

This study investigates why some people with moderate aortic valve stenosis get worse while others remain stable. Researchers will analyze immune system markers and detailed heart images from about 938 participants to find patterns that predict disease progression. The goal is to…

This study looks at whether smartwatches can help monitor chronic inflammatory demyelinating polyneuropathy (CIDP), a rare nerve disease that causes weakness and numbness. 35 adults with CIDP who use subcutaneous immunoglobulin therapy at home will wear a smartwatch for 12 months…

This study looks at whether a special blood test (liquid biopsy) can find tumor cells in people with paraneoplastic neurological syndromes (PNS), a condition where the immune system attacks the nerves due to an undetected cancer. Researchers will collect blood from 60 participant…

This study looks at how sleep issues contribute to tiredness and thinking problems in people with multiple sclerosis (MS). About 382 MS patients and a control group without MS will have overnight sleep tests, thinking assessments, and questionnaires. The goal is to better underst…

This study looks at why diabetes can damage the heart even without clogged arteries. Researchers will examine heart tissue and use advanced imaging in 500 adults with heart failure, with or without type 2 diabetes. The goal is to find early warning signs and new treatment targets…

This study follows 270 heart transplant recipients to track how their heart and body metabolism change over time. Researchers will use imaging, blood tests, and biopsies to monitor heart function, rejection, kidney health, infections, and cancer risk. The goal is to better unders…

This study is following 1,000 people who have had a severe type of heart attack called STEMI. Researchers are collecting detailed medical data to understand how different organs talk to each other during recovery. The goal is to find key signals that could lead to better treatmen…

This study looks at why swallowing problems happen in Parkinson's disease, a common issue that can lead to serious health risks like pneumonia. Researchers will study 100 people with Parkinson's using swallowing tests, brain scans, and blood tests to understand the underlying cau…

This study looks at whether using a swallow gel or a semi-solid vehicle can help people with neurological conditions swallow pills more easily and safely. Researchers will observe 500 participants, including patients with swallowing disorders and healthy volunteers, as they swall…

This registry collects information from 1,000 patients who have had or will have a heart rhythm procedure at University Hospital Düsseldorf. The goal is to track safety and success of these standard procedures in everyday care. No new treatments are being tested; instead, researc…

This study follows 100 people with relapsing-remitting multiple sclerosis who are taking anti-CD20 drugs like ofatumumab or rituximab. Researchers will track changes in immune cells, proteins, and brain scans over time to understand how these therapies work long-term. The goal is…