Heinrich-heine University, Duesseldorf

This study compares two approaches for replacing a single back tooth with a dental implant: placing the implant right after tooth extraction (immediate digital workflow) versus waiting about 16 weeks for healing (delayed digital workflow). Researchers measure how these methods af…

This study tests whether low-dose radiation to the whole brain can slow down Alzheimer's disease in people with early-onset symptoms. Fifty participants will be randomly assigned to receive either the radiation treatment or a sham procedure. Researchers will track changes in memo…

This study tests a small device called an interatrial shunt that is placed in the heart to relieve pressure. It involves 15 adults with advanced heart failure and reduced pumping ability. Researchers will use advanced heart scans and exercise tests to see if the device improves h…

This study tests a new way to diagnose prostate cancer using PSA tests, digital rectal exams, and MRI scans. Men aged 50-75 with elevated PSA or suspicious exams will get an MRI first. Only those with suspicious MRI results will have a biopsy, and they will be randomly assigned t…

This study will follow 200 people with suspected or confirmed cardiac amyloidosis, a condition where abnormal proteins build up in the heart and cause heart failure. Over two years, participants will undergo heart MRI scans, exercise tests, and blood work at regular visits. The g…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…