Could new hormone creams protect menopausal Women's hearts?

NCT ID NCT07394049

Not yet recruiting Knowledge-focused Sponsor: Heinrich-Heine University, Duesseldorf Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular events. Researchers will track health outcomes over time to understand how these hormones affect heart health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hormone replacement therapy (creams, gels, sprays)
What this could lead to: If successful, this study could clarify whether newer HRT delivery methods lower heart disease risk in menopausal women.
What could go wrong: This is an observational registry, not a controlled trial, so it can show links but not prove cause and effect. Results may take years and could be inconclusive.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder cerebrovascular disorder coronary artery disorder peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASES HORMONE REPLACEMENT THERAPY HORMONE REPLACEMENT THERAPY, POST-MENOPAUSAL MENOPAUSE

Contacts and locations

Locations

Clinic for Cardiology, Angiology and Intensive Care at Charité Mitte Berlin

Berlin, Germany
University Hospital Duesseldorf

Düsseldorf, 40225, Germany

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