CARDIOVASCULAR DISEASES

This study tests whether using focused ultrasound to modify fat around the kidney can lower blood pressure in people with essential hypertension. About 30 adults with mild high blood pressure despite medication will be randomly assigned to the ultrasound treatment or a sham proce…

This study looks at whether having a heart doctor (cardiologist) check patients during a hospital stay for a COPD flare-up can find and treat hidden heart problems early. 150 adults with COPD will be split into two groups: one gets standard lung care, the other also gets a heart …

This study looks at whether a lower dose of aspirin (50 mg daily) works as well as the standard dose (100 mg) to prevent heart attacks and strokes in people aged 60 and older with heart disease. It involves over 5,400 Chinese participants who will be followed for about 6 years. T…

This study tests whether adding a new inhaled drug, mosliciguat, to an existing treatment (treprostinil) is safe for people with high blood pressure in the lungs caused by lung scarring. About 20 adults with this condition will receive the combination and be monitored for side ef…

This study tests a 9-month program for women who had preeclampsia in their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and lifestyle coaching. Researchers want to see if it lowers blood pressure and helps w…

This study is testing whether getting healthy, DASH-diet groceries delivered to your home, along with help from a dietitian, can lower blood pressure in adults with high blood pressure. About 150 people in Florida, Georgia, and Tennessee will take part. Participants will eat only…

This study tests whether nattokinase, an enzyme from fermented soy (natto), can reduce inflammation and improve heart health markers in people with high cholesterol. About 48 adults with dyslipidemia will take nattokinase or a placebo for two months. Researchers will measure chan…

This study tests a school-based program called Strong Teens for Healthy Schools Change Club. It empowers middle school students to improve their physical activity and healthy eating habits, with the goal of reducing heart disease risk. About 500 students from diverse backgrounds …

This study tracks 1,000 Medicare patients with hard-to-control high blood pressure to see if a procedure called renal denervation (RDN) plus standard care works better than standard care alone. Researchers will compare blood pressure changes and heart events over two years using …

This study follows 1,000 adults with high blood pressure that remains high despite lifestyle changes and medication. Participants receive a one-time procedure using the Paradise System, which uses ultrasound to calm overactive kidney nerves. The goal is to see if the device safel…

This study tests whether a daily pill called empagliflozin, originally used for diabetes, can improve heart function in 80 older adults with high blood pressure and obesity who are at risk for heart failure. Participants take either the drug or a placebo for 9 months, and doctors…

This study looks at whether a 3-month cooking class program can help seniors from diverse backgrounds improve their heart health and mental well-being. Participants will learn to cook tasty, healthy meals based on the Mediterranean diet. The goal is to see if this 'food as medici…

This study tests whether drinking traditional kefir for 12 weeks can improve blood sugar control and heart health in people who are overweight and either at risk for or already have type 2 diabetes. Researchers will measure changes in HbA1c (average blood sugar) and other health …

This study looks at whether omega-3 supplements can reduce inflammation and improve heart health differently depending on a person's genetic background. About 200 healthy adults of African or European ancestry will take omega-3 capsules or a placebo for 12 weeks each, then switch…

This study tests a program for 500 Philadelphia residents aged 35-75 who have heart disease risk factors and unmet social needs. Participants will either join group sessions and meet with a community health worker, or receive standard services. The goal is to see if the program i…

This study looks at whether a dual bronchodilator (a type of inhaler that opens airways) can improve both breathing and heart function in people newly diagnosed with moderate-to-severe COPD. Researchers will measure exercise capacity, quality of life, and lung function over 12 we…

This study tests whether remote exercise programs (using a smartphone app, live virtual classes, or in-person sessions) can help adults over 45 who are at risk for heart disease become more active. Participants will be randomly assigned to one of four exercise groups for 12 weeks…

This study compares two imaging methods to guide stent placement in people with calcium buildup in their heart arteries. About 700 adults with signs of reduced blood flow to the heart will be randomly assigned to have their procedure guided by either a coronary CT angiogram or th…

This study tests whether adding digital coaching—like a private social media group and video chats—to home-based cardiac rehab helps veterans complete more rehab sessions and improve their heart health. About 150 veterans with heart disease will take part. The goal is to see if v…

This study tests a face-to-face program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The goal is to help them build skills and motivation to successfully participate in home-based cardiac rehab.…

This study tests whether adding vicadrostat to the standard medicine empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and existing heart disease. About 11,800 participants will be randomly assigned to receive either vicadros…

This study tests whether starting cholesterol-lowering care in the emergency department can reduce heart risks for adults aged 40-75 who are at risk for heart disease but not yet on treatment. About 130 participants will receive a guideline-based program to lower their cholestero…

This study watches 2000 heart disease patients who receive a special drug-coated stent (VIVO ISAR) and take blood thinners for 3 months or less after a procedure to open blocked arteries. The goal is to see if this shorter blood thinner plan is safe and works well in everyday med…

This study is testing a smartphone app called HeartSteps to help people with heart disease become more physically active and stay active long-term. Sixty adults who are finishing or have recently finished cardiac rehab will wear a Fitbit and use the app for 3 months. The goal is …

This study tests a prescription wrist device called NightWare in 125 veterans with PTSD who have frequent nightmares. The device aims to improve sleep quality, which may also reduce the risk of heart disease. Researchers will measure sleep, blood vessel health, and nervous system…

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on reducing heart risks. The goal is to s…

This study compares two drugs, vicadrostat and spironolactone, both given with empagliflozin, to see how they affect kidney function and protein levels in blood and urine. About 100 adults with chronic kidney disease and heart disease or heart failure will take one of the two com…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after a serious brain bleed (aneurysmal subarachnoid hemorrhage) and aneurysm clipping surgery. RIC uses a blood pressure cuff on the arm to create short, harmless …

This study is a registry that will follow about 960 people with coronary artery disease who are treated with a special balloon coated with a drug called sirolimus. The balloon is used to open blocked arteries and release medicine to keep them open. Researchers will track heart-re…

This study tests a special balloon coated with a drug (sirolimus) to open up small arteries in the heart. About 1,600 adults with coronary artery disease will take part. The balloon is inflated to push plaque aside and release medicine to keep the artery open, aiming to improve b…

This study is testing whether a special clinic focused on heart health and weight management can help obese adults with heart disease lose weight and improve their health. Researchers will track weight, body mass index, and belly fat over 12 months. The study involves 60 particip…

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys that can raise blood pressure. The goal is to see if the quicker approach works as well as the standard method for lowering blood pressure in peop…

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with other treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will take part to see if this device is as safe and effective as a…

This study is testing a new device called the TRiCares Topaz system to replace a leaky heart valve (tricuspid valve) without open-heart surgery. It is for 80 adults with severe leakage who are at high risk for traditional surgery. The goal is to see if the device is safe and work…

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue standard medical …

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will do weekly physical activity and health education, and work with a coach and community health worker. The goal is to see if the program improves heart health and r…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV who are on effective treatment. About 121 adults aged 40 and older with controlled HIV and at least one heart risk factor will receive …

This study tests whether a church-based program led by community health workers can help Black adults in New Orleans lower their risk of heart disease, high blood pressure, diabetes, and high cholesterol. About 800 participants aged 40 and older with at least three heart risk fac…

This study looks for the best ways to help people from under-resourced groups keep up healthy behaviors after finishing cardiac rehabilitation. About 400 adults who have completed at least 6 rehab sessions will try different support programs, from low- to high-intensity. The goal…

This study looks at whether taking blood pressure medication in the morning or evening can help restore the natural day-night blood pressure rhythm in people with obesity. Obese individuals often have high nighttime blood pressure, which increases heart risks. Researchers will co…

This study looks at how well two types of heart stents (Synergy XD and Synergy Megatron) work in everyday medical practice. About 2000 adults with coronary artery disease will receive these stents to open blocked arteries. Researchers will track deaths, heart attacks, and the nee…

This study is for adults aged 65 and older whose high blood pressure is not well controlled with medication. It uses a procedure called ultrasound renal denervation, which quiets overactive kidney nerves that can raise blood pressure. Researchers will track blood pressure changes…

This study looks at how healthy diets with different plant oils, especially cottonseed oil, affect heart and metabolic health. About 52 adults with higher LDL cholesterol and overweight will eat controlled diets for 4 weeks each. Researchers will measure changes in cholesterol an…

This study tests a new device called SoniCracker that uses shockwaves to break up calcium buildup in heart arteries. It aims to help doctors place stents more safely and effectively in patients with hardened arteries. The study will enroll 40 adults with moderate to severe calciu…

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart conditions. Researchers want to see if the women-only approach leads to better attendance and heart health improvements. About 60 women aged 40-80 will partic…

This study tests whether a digital heart health program (app and online sessions) added to standard care can lower cholesterol and reduce heart attacks better than standard care alone. About 1,100 adults with heart disease or high cholesterol who are already on statins will be fo…

This study looks at whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as using two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 partici…

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein near the heart to help the valve close better. The goal is to see if it improves symptoms, walking ability, and reduces ho…

This study tests a home-based cardiac rehabilitation program delivered through a custom mobile app for people with heart failure. About 100 participants will be randomly assigned to either the app-based program or usual care. The goal is to see if the app helps increase physical …

This study tests a program called Inspire HER, designed to help Black women improve their heart health through education, physical activity, and social support. Researchers will enroll 90 Black women aged 30-79 with heart, kidney, or metabolic conditions in the Birmingham, AL are…

This study looks at whether whole milk or nonfat milk is better for body composition and heart health in children ages 9 to 12 who have a higher BMI. Researchers will measure body fat, lean muscle, and other health markers over one year. The goal is to help guide healthy milk cho…

This study is testing whether colchicine (a drug used for gout) and non-enteric coated aspirin, taken alone or together, can reduce the risk of serious heart problems like heart attacks and strokes in people with type 2 diabetes. The trial will include 10,000 adults aged 55 to 80…

This study tests a device that uses energy to calm overactive nerves in the kidney and liver, which may help lower blood pressure. It is for adults aged 18 to 80 with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The goal is to…

This study tests whether taking low-dose aspirin for 6 months after childbirth can help women who had preeclampsia recover their blood vessel health and lower their blood pressure. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple tr…

This study tests whether a tailored exercise program, combined with health screenings, can reduce falls, fractures, and heart problems in people aged 65+ with type 1 or type 2 diabetes. 490 participants will be assigned to either the exercise program or usual care and followed fo…

This study looks at whether adding stair climbing to daily routines can lower blood pressure more than brisk walking alone. About 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk wa…

This study tests whether adding a specially trained doula to standard care helps women who had high blood pressure during pregnancy get their blood pressure under control after giving birth. About 454 women will be randomly assigned to either usual blood pressure monitoring at ho…

This early study tests a new device called the TRiCares Topaz to replace a leaky tricuspid heart valve in 15 adults with severe regurgitation who are at high risk for surgery. The main goals are to check if the device is safe and works well right after the procedure. Researchers …

This study looks at whether adding occupational therapy and dietitian services to home-delivered meals can reduce fall risk in older adults who have trouble leaving home. About 750 people aged 60 and older will receive either meals alone, meals with dietitian support, meals with …

This study tests whether simple home-based strategies and wearable devices can reduce the negative health effects of evening screen time. Researchers will enroll 30 adults who are overweight, inactive, and spend at least 3 hours of recreational screen time after 5pm. Participants…

This study aims to see if voice recordings can help detect pulmonary hypertension, a serious heart and lung condition. Researchers will compare voice patterns with standard echocardiogram results in 7,000 adults. If successful, this could lead to a simple, non-invasive screening …

This study is testing a new imaging agent called [68Ga]Ga-NI-FAPI-04 for PET/CT scans to see if it can better detect diseases linked to fibroblast activation, such as tumors, heart conditions, and pulmonary fibrosis. About 30 participants, including patients and healthy volunteer…

This study tests a new smartphone-based 12-lead ECG device to see if it can accurately detect heart attacks (STEMI and NSTEMI) compared to standard hospital ECGs. About 1,000 adults with chest pain will be enrolled in emergency departments. The goal is to validate the device as a…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to quickly identify patients with a large vessel occlusion stroke who need to go directly to a hospital equipped for clot removal. About 275 adult…

This study looks at whether taking aspirin and high-intensity statins can prevent serious heart problems like heart attacks and strokes in people aged 40-70 who have a high amount of calcium in their heart arteries (score of 300 or more). About 5,000 participants will be randomly…

This study looks at whether telling people their genetic risk for heart disease, along with personalized advice, helps them adopt healthier habits. About 650 hospital staff members aged 40 and older will get genetic testing and a one-on-one meeting with a heart doctor. The goal i…

This study is testing a program called Healthy School Recognized Campus in Texas public schools. The goal is to help kids in 4th through 9th grade become more physically active and eat healthier foods. Researchers will measure changes in body mass index (BMI) and fruit/vegetable …

This study tests new, low-cost treatments to help Hispanic adults with prediabetes and obesity. The goal is to bring blood sugar back to normal, help with weight loss, and lower the risk of heart problems. Researchers will check how these treatments affect metabolism and body fun…

This study tests a program called Mom♥Health to help mothers of young children lower their risk of heart disease. About 40 moms will take part to see if the program is easy to use and helpful. The goal is to find ways to support busy moms in staying heart-healthy.

This study tests whether getting a flu vaccine (outside flu season) can lower inflammation in the arteries of people who recently had a heart attack. About 90 adults who had a specific type of heart attack and a stent procedure will be randomly assigned to receive either the flu …

This study tests whether adding extra support to a church-based exercise program helps Latinas become more active and stay active. About 560 Latina women aged 18-65 who are not very active will take part. The program includes training church leaders, tailoring messages, and using…

This study is testing whether taking atorvastatin (a statin) can prevent dementia, disability, and death in healthy adults aged 75 and older who do not have heart disease or dementia. About 20,000 participants will receive either the drug or a placebo. The goal is to see if this …

This study looks at older adults (50+) with PTSD and ongoing insomnia. After a talk therapy for PTSD, those with remaining sleep issues will get a non-drug sleep program. Researchers will check if this improves sleep, PTSD symptoms, heart health markers like blood pressure, and q…

This study looks at whether adding extra support—like booster sessions and a website—to an 8-week mindfulness program delivered by phone can help reduce stress, anxiety, and depression in people with heart disease or risk factors. About 160 participants will be enrolled. The goal…

This study tests whether a 12-session home-based talk therapy called Behavioral Activation can improve social functioning and mood in veterans recently hospitalized for heart disease. About 132 veterans will either receive this therapy or standard post-discharge care. Researchers…

This study looks at how two different virtual exercise programs affect exercise ability in women with coronary heart disease. Participants will be randomly assigned to either high-intensity interval training or moderate-intensity continuous training, exercising twice a week for 1…

This study tests a non-invasive spinal stimulation technique to help people with a recent spinal cord injury (within 30 days) manage blood pressure drops when sitting up. Participants will receive both real and sham stimulation during a sit-up test to see if it can prevent dizzin…

This early study tests a device called the A-FLUX Reducer, placed in a heart vein, to improve chest pain in 30 adults with microvascular angina (small vessel heart disease). The goal is to see if it is safe and can reduce symptoms. Participants must have had persistent chest pain…

This study tests whether a personalized, sensor-based exercise program can reduce symptoms in people with atrial fibrillation (AF). Researchers will enroll 120 adults with paroxysmal AF who are not very active. Participants will use a digital health tool to guide their exercise, …

This study is testing whether a special video game that involves physical activity (exergaming) can help people with heart failure sit less and move more. 750 inactive heart failure patients will either get standard activity advice or a tailored exergame program for 3 months. The…

This study tests whether adding a special program for sleep and stress (called RESST) to standard cardiac rehabilitation helps people with heart disease recover better. About 200 adults who have sleep or stress issues will take part. Researchers will measure sleep quality, stress…

This study tests whether gentle electrical stimulation on the back can help people with chronic spinal cord injury maintain healthy blood pressure when they sit up. Participants will lie on a tilt table while their blood pressure is measured with and without stimulation. The goal…

This study tests whether giving iron through a vein can improve quality of life and walking ability in older adults who have iron deficiency and just had a heart valve replacement. About 402 participants will be randomly assigned to receive either iron infusions or standard care.…

This study tests a new type of stroke rehabilitation that combines mirror therapy with other techniques to help people who have had a stroke regain movement in their arm and hand. About 81 adults who had a stroke at least 3 months ago will participate. The goal is to see if this …

This study looks at whether a whey protein-enriched milk fat globule membrane supplement can improve heart and brain health after a high-fat meal. Sixteen postmenopausal women with overweight and moderate heart disease risk will drink either the supplement or a placebo. Researche…

This study tests whether a special nerve block (PIFB) can improve recovery after open-heart surgery. About 123 adults having planned heart surgery will be randomly assigned to one of two pain-block methods. The goal is to see if one method helps patients feel better and recover f…

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients (30 women). Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program includes standing more, using resistan…

This study tests a new program called 'One Mind One Heart' that combines mindfulness and behavior change to help older adults with HIV reduce stress and improve heart health. Researchers will first interview 20 participants to refine the program, then test it in a small group of …

This study tests an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. About 608 couples will be randomly assigned to the program or usual care. The goal is to see if the program improves relationship quality, mental health, quali…

This early study aims to understand how stimulating nerves in the kidney affects the body's response before and after a procedure that quiets those nerves (renal denervation). About 19 adults with high blood pressure will take part. The goal is not to treat the condition directly…

This study is following 2,500 adults aged 30-75 in Puerto Rico to learn how stress, diet, and where they live affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years, including before and after…

This study looks at how small changes in your genes might affect the body's natural ability to control inflammation. Researchers will analyze blood samples from 200 volunteers to measure molecules that help resolve inflammation. The goal is to better understand why some people de…

This study looks at how the environment around you, especially green spaces like parks and trees, may impact your heart health and overall well-being. Researchers will follow 835 adults aged 30-70 living in specific Louisville neighborhoods. They will measure changes in artery st…

This study looks at whether generative AI can help doctors better diagnose complications of rheumatoid arthritis (RA), such as lung disease or heart problems. Researchers will use AI to analyze patient records and suggest possible complications, then see if doctors find these sug…

This study tests a new model called B-COMPASS that uses a 22-question survey to predict how well patients will follow their treatment plans. About 3100 adults with heart disease, diabetes, immune disorders, nerve conditions, cancer, or rare diseases will take part across Europe. …

This study follows 36 people with a rare genetic heart condition called PKP2-ACM to track how the disease progresses over time. Participants receive standard care while researchers monitor heart rhythms, biomarkers, and quality of life. The goal is to better understand the condit…

This study will follow up to 100,000 people with known or suspected heart disease who get a cardiac MRI. Researchers want to see how MRI results help doctors make better treatment decisions and predict long-term health outcomes. The goal is to use this information to improve care…

This study checks the nutrition status of 250 people before heart surgery using questionnaires, blood and urine tests, and strength measurements. Researchers want to see if poor nutrition is linked to longer ICU stays or more complications. The goal is to help doctors identify wh…

This study aims to find the genetic causes of bicuspid aortic valve (BAV), a heart condition where the valve has two flaps instead of three. Researchers will collect blood samples from 700 people with BAV and their relatives to compare DNA. The goal is to identify gene changes li…

This study will follow 600 people with immune-mediated inflammatory diseases (like arthritis or lupus) to see how heart disease develops. Researchers will check blood markers and health records to find early warning signs. The goal is to better predict and prevent heart problems …

This study looks at how symptoms change after exercise in people with ME/CFS (chronic fatigue syndrome) versus those with heart conditions. Researchers will have 80 participants do a cycling exercise test and track their symptoms for a week. The goal is to see if the severe tired…

This study tests a new, non-invasive device called the Cardiac Performance System (CPS) that measures how well the heart is pumping. Researchers will compare its readings to those from a standard invasive test (right heart catheterization) in 1,000 adults. The goal is to see if t…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information so that future researchers can use them to discover what…

This study looks at whether a special heart scan (CTCA) can better predict heart attacks and other heart problems in people waiting for a kidney transplant. Heart disease is the leading cause of death after a kidney transplant, and current risk checks aren't good enough. The stud…

This study looks at how healthy behaviors like exercise, diet, stress, and sleep are linked to heart health measures such as blood pressure and cholesterol. Researchers will collect information from 100 adults and children through questionnaires and simple health checks. The goal…

This study follows 300 babies born early (preterm) and at full term to understand how early birth affects kidney and heart health later in life. Researchers use ultrasound and blood/urine tests to spot early warning signs of kidney disease and high blood pressure. The goal is to …

This study reviews medical records from over 1,200 people with immune thrombotic thrombocytopenic purpura (iTTP), a rare and life-threatening blood disorder. The goal is to understand long-term health issues like heart disease and how new treatments affect survival. No new treatm…

This study is creating a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to study genetic links to heart disease, diabetes, and obesity. The goal is to support future studies, not to test a treatment directly.

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and checking for conditions like diabetes, high blood pressure,…

This study will use CT scans to look for scarring and other changes in the heart muscle of 2,200 adults who already need a heart CT for medical reasons. The goal is to see if these CT findings can help predict who might later be hospitalized for heart failure or die. The research…

This study collects blood and tissue samples from 500 people having heart surgery at the University of Chicago Medical Center. Researchers will study these samples to learn more about heart disease and how to improve treatments. Participants must be English-speaking and are not g…

This study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech function in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed in the brain for less than 30 days to deliver mild electrical p…

This study looks at tiny particles called extracellular vesicles that come from fat tissue. Researchers want to understand how these particles carry signals that might affect the heart and liver, especially in people with obesity. About 100 adults having weight-loss surgery will …

This study is testing whether products made from Chardonnay marc (the leftover grape skins and seeds from winemaking) can improve blood vessel function and reduce oxidative stress in 5 adults with higher body weight and slightly reduced blood vessel health. The goal is to gather …

This study looks at how middle-aged adults' hearts and blood vessels respond to a short, challenging mental task. Researchers will measure blood pressure, heart rate, and brain scans to see if stress reactions are linked to brain health. The goal is to understand how stress might…

This study aims to improve how we detect and understand heart disease using advanced MRI scans. Researchers will compare new MRI techniques with standard tests in 1,000 adults, both healthy volunteers and those with various heart conditions. The goal is to find better ways to see…

This study is for adults with psoriasis who want to help researchers understand the link between psoriasis and heart disease. The goal is to see if certain heart tests and blood markers can predict future heart problems. Participants will be followed over time to track heart heal…

This study follows 300 people having metabolic (weight-loss) surgery to see how their gut bacteria change over time and how those changes relate to improvements in heart health, diabetes, and cholesterol. Participants provide stool, blood, and tissue samples before and up to 3 ye…

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart's arteries. About 140 adults with mild heart disease will get either a statin or a placebo, and advanced CT scans will track changes over 3 months. The goal is to understand wh…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and unrelated healthy v…

This study aims to make stress echocardiography—a common heart test—more accurate by using machine learning to analyze the images. Researchers will develop new computer tools to measure heart function during stress, helping doctors better identify who is at risk of a heart attack…

This study follows 10,000 adults aged 18 and older for life to see if simple health measurements can predict how long and how well people age. Researchers will track deaths, diseases, and disabilities to find early warning signs. No treatments or drugs are tested—just observation…

This study looks at how sleep and the body's internal clock influence blood pressure in people with hypertension. Researchers will monitor 32 adults aged 25-64 to understand why some have 'non-dipping' blood pressure that stays high overnight. The goal is to uncover mechanisms, n…

This study aims to see if voice recordings from a smartphone app can help detect heart disease. Up to 1 million adults will record short voice samples and share health data. Researchers will use artificial intelligence to look for links between voice patterns and heart health.

This study collects blood samples from 1,500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or other cardiovascular events. Participants are patients visiting a prevention center, either with or without a prior history …

This study is a Danish national registry that will follow 160 high-risk patients with resistant hypertension and blocked kidney arteries who undergo a procedure called percutaneous transluminal renal angioplasty (PTRA) to open the blockage. The main goal is to measure changes in …

This observational study is looking at how the health of tiny blood vessels in the skin relates to heart disease risk. Researchers will measure blood flow in the skin using special devices and compare it to detailed heart scans in 900 people aged 60-75. The goal is to see if a si…

This study looks at why women who had high blood pressure during pregnancy are more likely to develop high blood pressure and heart disease later in life. Researchers will use MRI scans to measure heart structure in 200 women who gave birth 10 to 25 years ago. The goal is to bett…

This study collects blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. The samples are stored in a biobank for future research on inflammation, metabolism, and other disease pathways. No treatments or interventions are given; the …

This study looks at whether an artificial intelligence (AI) model can predict major heart problems within 30 days after gastrointestinal surgery better than current risk scores. Researchers will review medical records from 5000 adults having surgery at Bach Mai Hospital. The goal…

This study will collect medical data and DNA samples from 1000 adults with panvascular disease (blockages in multiple blood vessel areas). Researchers will analyze this information to better understand what causes these conditions and how they progress. The goal is to improve fut…

This study is testing a digital tool called PREVENT that helps doctors and patients work together to improve heart health. It is for low-income, rural adults with obesity who are at risk for heart disease. The tool shows patient information and suggests personalized goals for hea…

This study looks at how a natural heart hormone called atrial natriuretic peptide (ANP) affects metabolism and heart health. Researchers will compare people with a common genetic variation that lowers ANP levels to those with normal levels. Participants will undergo exercise and …

This study aims to learn how the bacteria living in our bodies (the microbiome) are linked to major diseases like cancer and heart disease. Researchers will collect samples and health information from 16,000 adults over age 40. No treatments or medications are given; the goal is …

This study looks at whether a brief conversation in the emergency department can help patients with chest pain understand their future heart attack risk. Researchers will share troponin blood test results and heart health advice with 118 adults who have no prior heart disease but…

This study looks at how aging changes the way our bodies respond to exercise. Researchers will have 26 older adults who previously completed an exercise program do another 6 months of aerobic training. They will measure insulin sensitivity, fitness, and overall health to understa…

This study looks at how genes influence fatty liver disease and related heart and blood clot problems. Researchers will study 2500 blood donors aged 40-65 who are overweight or have related health issues. The goal is to use genetic information to better predict who is at risk and…

This study is a registry that will follow 5,000 people who receive Medtronic heart devices to see how well the devices work and if any safety issues arise in real-world use. It is not testing a new treatment but rather collecting information to confirm the devices are safe and ef…

This study looks at how a park-based fitness program affects the health of adults aged 50 and older in Miami-Dade County. Researchers will measure changes in weight, blood pressure, strength, and mobility in 1,000 participants. The goal is to see if community park programs can he…

This study aims to create a large collection of medical information, DNA, blood, and tissue samples from 15,000 people with and without heart conditions. Researchers will use this biobank to better understand diseases like aortic aneurysm, heart failure, and bicuspid aortic valve…

This study is testing a web-based app called IAMABLE that provides rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological problems. Researchers will give 50 adults aged 45 to 75 either the app or general health information for …

This study follows 650 adults who had pneumonia (including COVID-19) to understand why heart problems like stroke or heart attack become more common after lung infections. Researchers will track participants for up to 3 years, measuring heart fitness and watching for major heart …

This study is testing a virtual patient navigation program for 260 underserved adults who speak English, Chinese, or Spanish and have breast cancer or heart disease. The program uses a phone-based portal to connect patients with navigators who can help them manage their care. The…

This study is creating a massive database of medical images and health information from 50,000 adults. Researchers will use advanced CT and MRI scans to find hidden patterns, or 'signatures,' that could help predict, diagnose, and treat diseases like cancer, heart conditions, and…

This study is like a big health check-up for 600 U.S. Army soldiers. Researchers will look at what they eat, their heart health, body composition, mental well-being, and physical fitness. The goal is to gather information to help improve soldier health and readiness, not to test …

This study is looking for 1,000 people with a genetic heart condition called arrhythmogenic cardiomyopathy (AVC) or their family members. The goal is to discover new genes and blood markers that can predict who will get the disease, how it will progress, and who is at risk for da…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women aged 18-70. Researchers will measure body fat, blood fats, and insulin function to find out why heart disease risk factors differ between African Americans and C…

This study aims to find out how many people with heart disease also have a lung condition called COPD. Researchers will follow 3,000 adults with coronary heart disease, atrial fibrillation, or chronic heart failure to track their health and hospital visits. The goal is to better …

This study is testing a digital app called VIRTUES to help people with heart conditions manage their health at home. The app provides personalized recommendations on medications, diet, exercise, and more. Researchers will enroll 2000 participants to use the app for one month and …

This study is testing whether a special wearable device, guided by artificial intelligence, can help adults with chronic heart failure avoid emergency visits and hospital stays. About 205 participants will either wear the device for six months or receive standard care. The goal i…

This study collects small heart tissue samples from 400 adults with heart conditions to better understand what causes different heart diseases. Researchers will look for new markers in the blood and tissue that could help diagnose heart problems earlier. The goal is to improve fu…

This study looks at why people with hemophilia (a bleeding disorder) are less likely to die from heart disease. Researchers will use a new, detailed CT scanner to compare plaque buildup in the heart arteries of 80 men with hemophilia to men without it. The goal is to understand h…