Cheap pills could stop prediabetes in its tracks, new study hopes
NCT ID NCT06446531
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests several affordable oral medications—including semaglutide, empagliflozin, metformin, and pioglitazone—to see if they can reverse prediabetes, promote weight loss, and lower heart disease risk in Hispanic adults. Researchers will monitor blood sugar, body fat, and heart function over time. The goal is to find cost-effective treatments that prevent progression to full-blown diabetes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Semaglutide, Empagliflozin, Metformin, Pioglitazone
What this could lead to
If successful, this could point toward affordable drug combinations that help people with prediabetes return to normal blood sugar and lose weight, reducing their risk of diabetes and heart disease.
What could go wrong
This is a very early Phase 1 trial with only 64 participants, so results may not apply to everyone. The drugs can cause side effects like nausea, diarrhea, or low blood sugar, and it's unknown if the benefits will last long-term.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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University of Texas Health Science Center at San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••