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Cheap pills could stop prediabetes in its tracks, new study hopes

NCT ID NCT06446531

Recruiting now Disease control Sponsor: The University of Texas Health Science Center at San Antonio Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests several affordable oral medications—including semaglutide, empagliflozin, metformin, and pioglitazone—to see if they can reverse prediabetes, promote weight loss, and lower heart disease risk in Hispanic adults. Researchers will monitor blood sugar, body fat, and heart function over time. The goal is to find cost-effective treatments that prevent progression to full-blown diabetes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Semaglutide, Empagliflozin, Metformin, Pioglitazone
What this could lead to
If successful, this could point toward affordable drug combinations that help people with prediabetes return to normal blood sugar and lose weight, reducing their risk of diabetes and heart disease.
What could go wrong
This is a very early Phase 1 trial with only 64 participants, so results may not apply to everyone. The drugs can cause side effects like nausea, diarrhea, or low blood sugar, and it's unknown if the benefits will last long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Body Weight cardiovascular disorder glucose intolerance obesity disorder prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASES PRE-DIABETES WEIGHT, BODY

Contacts and locations

Locations

  • University of Texas Health Science Center at San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

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