Cardiovascular disorder

This study looks at whether taking omega-7 oil (palmitoleic acid) can improve cholesterol levels and help control appetite in healthy adults. About 110 participants will take omega-7 capsules daily for 24 weeks and have their blood and health checked. The goal is to see if this n…

This early-phase trial tests giving radiation therapy before surgery to people whose adrenal cancer has come back. The goal is to find a safe radiation dose and see if it helps shrink tumors before removal. About 32 adults with resectable recurrent ACC will receive daily radiatio…

This trial tests whether inhaling a sedative called dexmedetomidine can reduce the brain's oversensitivity that drives chronic migraine. Researchers will measure changes in pain-related biomarkers and nerve signals in people with early chronic migraine. The goal is to see if this…

This study will test a device called EkoSonic in 30 Chinese patients with acute pulmonary embolism (blood clots in the lungs). The device uses ultrasound to help break up clots while delivering clot-busting medicine. The main goal is to see if it improves heart function within 48…

This study tests an experimental drug called ATV-1601 in people with moderate to severe HHT, a condition that causes frequent nosebleeds and anemia. The trial has two parts: first, participants receive either the drug or a placebo to check safety and effectiveness; then, all elig…

This early-stage trial tests an experimental drug called RO7663498, given as an injection into the eye, for people with diabetic retinopathy. The main goal is to check safety and how the drug moves through the body. About 30 participants will receive multiple doses to see if it i…

This trial tests whether a new transcatheter heart valve (Myval) works as safely and effectively as two existing valves (Sapien and Evolut) in people with severe aortic stenosis, a condition where the heart's main valve narrows. About 768 patients who are eligible for valve repla…

This phase 2 study tests whether spironolactone, a drug already used for fluid retention, can improve exercise capacity and blood vessel function in people with pulmonary arterial hypertension (PAH). About 70 adults with PAH will receive either spironolactone or a placebo for 24 …

This study tests whether adding extra scar lines in the heart, along with the standard vein isolation procedure, helps people with persistent atrial fibrillation stay in normal rhythm longer. About 640 adults aged 18–80 with symptomatic, drug-resistant persistent AFib will be ran…

This trial tests whether planning coronary artery bypass grafting (CABG) using a non-invasive CT scan (CCTA) works as well as the standard invasive angiography (CAG). About 826 people with blocked heart arteries will be randomly assigned to have their surgery planned with one of …

This study looks at whether taking just one blood thinner (a P2Y12 inhibitor) is as safe and effective as taking two blood thinners (dual antiplatelet therapy) for people with stable heart disease who have a drug-coated balloon procedure without a stent. About 2,170 adults will b…

This study tests a new virtual reality (VR) walking therapy for people who have had a stroke within the past 1 to 6 months. Participants will use either a fully immersive VR system that lets them walk over ground in realistic environments, or a semi-immersive VR system on a tread…

This study follows 125 people who received a special stent graft (GORE TAG TBE) to treat a tear or bulge in the main artery near the heart (aortic arch). The goal is to see how well the device works and how safe it is over 5 to 10 years. Participants are treated as part of their …

This trial is testing an experimental drug called HS235 in obese adults who have both pulmonary hypertension and heart failure with preserved ejection fraction. The study aims to see if the drug is safe, how it moves through the body, and whether it can improve heart and lung fun…

This trial is testing an experimental drug called HS235, given as a shot under the skin, in adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and can strain the heart. The study aims to see if adding HS2…

This study tests whether exercise using electrical stimulation can improve muscle strength and endurance in people with lower limb paralysis from conditions like spinal cord injury, stroke, or multiple sclerosis. Participants will use devices that send electrical signals to their…

This early-stage trial is testing a new drug called DNL952 in 32 adults with late-onset Pompe disease. The main goal is to check if the drug is safe and how the body processes it. Participants will receive the drug through an IV infusion at different doses.

This first-in-human study tests a new device called Pulse IVL that uses sound waves to break up calcium buildup in heart arteries. Up to 15 people with coronary artery disease will receive the treatment before getting a stent. The goal is to see if the device is safe and helps op…

This study tests whether inclisiran, a twice-yearly injection that lowers cholesterol, can prevent major heart and limb events in 6,000 people who recently had artery-opening procedures. Participants receive either inclisiran or a placebo shot at the start, at 90 days, and every …

This trial is investigating whether adding a clot-removal procedure, called endovascular treatment, to standard medical care can improve outcomes for people who have had a severe stroke caused by a blockage in the basilar artery, a major vessel at the back of the brain. The study…

This study tests an oral drug called KT-621 in 264 adults with moderate to severe eosinophilic asthma that is not well controlled by current treatments. Participants will take either KT-621 or a placebo daily for several weeks. Researchers will measure changes in lung function an…

This trial tests whether a computer-based rehabilitation system called NeuroTechR3 can help people improve arm and hand function after a stroke. Participants will play upper extremity rehabilitation games on a computer for 30 minutes, three times a week. The study measures change…

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with standard treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will get either the BrioVAD or an existing pump to see if the n…

This study tests a new device called the VDyne System, which is placed inside the heart through a tube in a blood vessel to replace a leaky tricuspid valve. The trial will include 730 people with severe symptoms who have not improved with medication. Researchers will compare the …

This study tests whether opening blood vessels (vasodilation) or removing fluid (diuretics) is better for treating sudden fluid buildup in the lungs from heart failure. About 1,100 adults with severe shortness of breath and low oxygen levels will receive one of three treatments i…

This trial asks whether giving children a low-dose ketamine infusion after heart surgery can protect their brains from damage. Children aged 1 to 60 months undergoing surgery for certain congenital heart defects will receive either ketamine at one of two doses or no ketamine. Res…

This trial investigates whether adding either metolazone or acetazolamide to standard loop diuretics helps adults hospitalized with acute heart failure and fluid overload. Participants are randomly assigned to one of three treatment arms, and the study tracks days alive and out o…

This study tests whether providing home-delivered low-sodium meals and short-term dietary counseling helps older veterans with heart failure recover better after a hospital stay. About 1,400 veterans aged 60 and older will be randomly assigned to receive either the meals plus cou…

This study looks at whether doing a small surgery early to remove blood from a deep brain bleed helps patients more than standard medical care. About 600 adults aged 18 to 70 with a specific type of brain bleed will take part. The goal is to see which approach leads to better rec…

This Phase 3 trial tests whether DYNE-101 can improve muscle function and daily life in 150 adults with myotonic dystrophy type 1 (DM1). Participants receive either the drug or a placebo by IV every few weeks for 48 weeks. The study measures how quickly people can stand from a ch…

This trial is testing two different ways to perform varicocele embolization, a procedure that blocks off enlarged veins in the scrotum to relieve pain and improve fertility. Thirty men with varicocele will receive the procedure either through a vein in the neck (transjugular) or …

This Phase 3 study tests a drug called nucresiran in 1250 people with ATTR amyloidosis, a rare disease where abnormal proteins damage the heart. Participants receive either nucresiran or a placebo every 6 months. The goal is to see if the drug reduces deaths and heart-related hos…

This phase 3 trial is testing atogepant, a daily pill already approved for adults, to prevent episodic migraines in children aged 6 to 17. About 450 participants will receive either a low or high dose of the drug or a placebo for 12 weeks. The goal is to see if it safely reduces …

This study tests a one-time gene therapy called surabgene lomparvovec (Sura-vec) for diabetic retinopathy, a common eye problem from diabetes that can lead to blindness. About 576 adults with moderate-to-severe non-proliferative diabetic retinopathy will receive either the gene t…

This study is checking how well a new drug-coated stent (Coroflex ISAR NEO) works in people with coronary artery disease. Researchers will follow 3,000 patients who get the stent during a routine procedure to see if it keeps arteries open safely. The goal is to confirm the stent …

This study looks at whether a gentle laser treatment (SLT) works as well as the standard version for people with glaucoma or high eye pressure. It also tests if getting the gentle laser once a year can delay or prevent the need for daily eye drops. About 790 adults will take part…

This study explores whether a robotic device that amplifies a person's own walking movements can help improve balance in people who have had a stroke. Participants with chronic stroke (more than 6 months ago) will do two treadmill walking sessions—one in a normal environment and …

This Phase 3 trial tests a gene therapy called FLT201 for adults with Gaucher disease type 1. The goal is to see if a single dose can keep blood counts stable so patients can stop their regular enzyme replacement or substrate reduction therapy. The study will enroll 45 people who…

This study tests a device that creates a small opening between the heart's upper chambers to relieve pressure in people with chronic heart failure. Unlike other shunts, this one leaves no permanent implant behind. The trial will compare the device to a sham procedure in 700 patie…

This study is testing a device that uses sound waves to break up calcium buildup in the leg arteries of people with peripheral artery disease. The goal is to improve blood flow, reduce pain, and help people walk better. About 50 participants will be followed for one year to see i…

This early-stage trial tests an experimental drug called RO7823653, given as an eye injection alone or with an approved drug (faricimab), for people with diabetic macular edema—a condition where diabetes causes fluid buildup and vision loss in the center of the eye. The study wil…

This study is checking the long-term safety of a drug called avacopan for people with ANCA-associated vasculitis, a rare disease where the immune system attacks blood vessels. About 300 adults who need treatment for a new diagnosis or flare-up will take avacopan or a placebo. The…

This study tests the drug acalabrutinib in people with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. Researchers want to see if acalabrutinib causes fewer heart-related side effects compared to other standard treatments. About 60 adults will t…

This study tests a new device that creates a small passage in the heart to relieve pressure, without leaving a permanent implant. It is for 350 people with heart failure and reduced pumping ability. The goal is to see if it reduces deaths, need for a heart pump or transplant, and…

This study compares two standard procedures—minimally invasive TAVR and open-heart surgery (SAVR)—for replacing a diseased aortic valve in people with a bicuspid aortic valve. About 1,200 participants aged 50 and older with severe aortic stenosis will be randomly assigned to one …

This study tests a stem cell transplant using the patient's own blood cells to treat severe scleroderma (systemic sclerosis) that hasn't improved with standard drugs. The goal is to see if this high-dose therapy is safe and can stop the disease from getting worse. The trial enrol…

This phase 2 trial is testing whether TAK-755, a lab-made protein that helps break up blood clots, is safe and effective for people who have had an acute ischemic stroke. About 222 adults aged 18 to 80 will receive either TAK-755 or a placebo, along with standard stroke care, and…

This Phase 2 trial tests whether adding ALE.F02 to standard therapy can protect kidney function in people with ANCA-associated vasculitis, an autoimmune disease that attacks small blood vessels, often damaging the kidneys. About 80 participants will receive either a low, high, or…

This trial tests whether placing a stent in a narrowed or blocked neck artery during emergency stroke treatment helps people recover better than just removing the clot in the brain. About 15-20% of severe strokes involve both a brain clot and a neck artery blockage. The study wil…

This study follows 550 patients whose first TAVI heart valve has failed. Researchers will compare a second TAVI procedure (redo TAVI) with open-heart surgery or medication alone. The goal is to see which approach works best and why, helping doctors make better decisions for futur…

This study tests a single dose of an experimental drug called ALN-AGT01 in adults with mild to moderate high blood pressure who have already been treated with another drug, zilebesiran. The goal is to see if it safely helps control blood pressure by measuring changes in blood pre…

This phase 3 trial tests an inhaled drug called treprostinil palmitil in 344 adults with pulmonary hypertension caused by interstitial lung disease. Participants take the drug or a placebo once daily for 24 weeks. The main goal is to see if the drug helps them walk farther in six…

This trial investigates whether a five-week vegetarian diet can dampen the inflammatory response of the immune system in people who recently had a heart attack, as well as in healthy volunteers. Participants will follow a vegetarian diet for five weeks, then return to their usual…

This study follows 1,500 people who received a GORE® TAG® stent graft to treat aortic conditions like aneurysms or dissections. Researchers will monitor device performance and patient outcomes for up to 10 years. The goal is to confirm that this minimally invasive procedure remai…

This study is tracking 1000 people with atrial fibrillation who receive the WATCHMAN FLX Pro device, a small implant that closes off a part of the heart to prevent blood clots from causing strokes. The goal is to see how safe and effective the device is in everyday medical practi…

This study is testing a new, wire-free pacemaker called LivIQ in 325 people who need a pacemaker for a slow heartbeat. The goal is to see if it is safe and works well to keep the heart beating at the right pace. Participants will be followed for several months to check the device…

This study tests whether empagliflozin, a diabetes medicine, can improve right heart function in 78 adults with pulmonary arterial hypertension (PAH). Participants continue their usual PAH treatments and receive either empagliflozin or a placebo. The main goal is to see if the dr…

This study tests a single injection of stem cells (B2065) given within 36 hours of a stroke. The goal is to see if it is safe and might help patients recover better. Fifty-four adults with moderate to severe stroke will receive either the stem cells or a placebo, and be followed …

This study tests a new device called the VDyne System, which is placed through a tube in a blood vessel to replace the tricuspid valve in the heart. It is for people with severe tricuspid regurgitation, a condition where the valve does not close properly, causing blood to leak ba…

This trial is testing whether a higher dose of adenosine, a drug used during cardiac MRI to stress the heart, improves blood flow imaging compared to the standard dose. The study includes 180 adults with suspected or known coronary artery disease or heart failure. By comparing th…

This study tests whether the drug CardiolRx can prevent another episode of pericarditis (inflammation around the heart) in people who have had repeated attacks. About 110 adults who have been stable on an IL-1 blocker for at least a year will stop that medication and receive eith…

This trial tests whether slowly lowering the speed of a Left Ventricular Assist Device (LVAD) — a mechanical pump that helps a failing heart — can encourage the heart muscle to work harder and recover. The study enrolls people with end-stage heart failure who are waiting for a he…

This trial tests whether combining aerobic exercise with a targeted reading therapy, called Phono-Motor Therapy, can improve reading skills in people who have reading difficulties after a stroke. Participants will receive both interventions, and researchers will measure changes i…

This phase 3 study tests the long-term safety of an inhaled drug called treprostinil palmitil for people with pulmonary hypertension caused by interstitial lung disease. About 344 adults who completed an earlier trial will take the drug for up to 2 years. Researchers will track s…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This study tests whether placing a stent in a blocked pelvic vein can help heal chronic leg ulcers in people with post-thrombotic syndrome, a complication of deep vein thrombosis. Twenty adults with non-healing venous ulcers will receive the stenting procedure plus standard ulcer…

This Phase 3 trial is testing whether adding BDB-001 to standard treatments (cyclophosphamide, azathioprine, rituximab, or prednisone) helps more people with ANCA-associated vasculitis achieve remission. The study plans to enroll 300 adults with active GPA or MPA. Participants wi…

This study is testing a device called FlowTriever that removes blood clots from the lungs in people with a severe, high-risk pulmonary embolism. About 200 participants will be randomly assigned to get either the device or standard care. The goal is to see if the device reduces de…

This study tests whether a personalized blood-thinner plan can reduce bleeding in people with coronary artery disease who have received a heart stent. About 3,944 participants will either get the usual dual antiplatelet therapy (two blood thinners) or a shorter course followed by…

This study tests a stent graft that doctors modify to fit each patient's unique aneurysm in the chest and abdomen. The goal is to see if this less invasive approach is as safe and effective as traditional open surgery. About 80 people aged 50 and older with large aneurysms will t…

This study looks at whether taking melatonin for 12 weeks can help lower blood pressure in women going through menopause who already have high blood pressure. Researchers will measure nighttime blood pressure and check for changes in stress markers. The goal is to find a simple, …

This study is a registry that follows about 960 people with coronary artery disease who are treated with a special balloon coated with a drug called sirolimus. The balloon is used to open blocked heart arteries. Researchers will track heart-related events like death, heart attack…

This study follows 580 adults with atrial fibrillation who are treated with the PulseSelect PFA system, a device that uses electrical pulses to fix irregular heartbeats. Researchers will monitor participants for 36 months to see how well the procedure prevents heart rhythm proble…

This early trial tests a device that keeps donor hearts cool and oxygenated during transport, instead of the usual ice cooler. The goal is to see if this method is safe and works for heart transplants from both brain-dead and circulatory-death donors. Twenty adult patients awaiti…

This study tests whether starting inclisiran early during a hospital stay for a heart attack can lower bad cholesterol more than a placebo, when both are added to standard care. About 300 adults hospitalized for a heart attack will receive either inclisiran or a placebo shot at t…

This trial tests whether nurse-led motivational interviewing—a counseling style that helps people find their own motivation to change—can improve blood pressure control in adults with hypertension. Participants are randomly assigned to usual care, individual counseling, or counse…

This study is testing a pacemaker lead placed in a specific area of the heart called the left bundle branch area. The goal is to see if this placement is safe and helps the heart beat more naturally in people with slow heart rates. About 140 participants will get the lead and be …

This study tests whether a single dose of rituximab, a drug that calms the immune system, can help the heart pump better six months after a severe type of heart attack called an anterior STEMI. About 372 adults who have just had such an attack will receive either rituximab or a p…

This study looks at whether successfully restoring blood flow in the brain using the Tigertriever device, a tool that removes clots during a stroke, may also help protect cognitive abilities like memory and attention. Researchers will follow 424 adults aged 18 to 75 who had a lar…

This trial tests whether a non-invasive mapping system called VIVO can help doctors locate the source of a dangerous heart rhythm called ventricular tachycardia (VT) before an invasive procedure. Patients with structural heart disease who need catheter ablation will be randomly a…

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This trial asks whether clamping the umbilical cord at 120 seconds after birth is better than clamping at 30 seconds for babies born with congenital heart disease. About 500 infants with a prenatal heart defect diagnosis will be randomly assigned to one of the two timings. Resear…

This study compares different ways to give blood pressure cuffs and training to adults with uncontrolled high blood pressure during routine primary care visits. Participants receive a cuff either in the clinic or by mail, and training either hands-on or through written instructio…

This trial tests whether starting respiratory physiotherapy within one hour of breathing tube removal after elective coronary artery bypass surgery improves lung function and reduces complications compared to waiting until the next day. Forty adults undergoing planned heart surge…

This study follows 118 people getting a special device called Pipeline Vantage to treat brain aneurysms. The device is placed inside the blood vessel to block the aneurysm and prevent rupture. Researchers will check how well it works and if there are any problems one year after t…

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This study tests a new device that uses extreme cold to destroy small areas of heart tissue causing a dangerous fast heartbeat called ventricular tachycardia. The trial will include 100 adults with this condition who have not responded to medication. Researchers will check if the…

This study tests whether a newer, less invasive procedure called transcatheter aortic valve replacement (TAVR) using the J-VALVE device is as safe and effective as traditional open-heart surgery for people with severe aortic regurgitation (a leaky heart valve). About 1,250 adults…

This early trial tests a new device called the iHub stent-graft in 10 adults with iliac artery aneurysms. The device is placed through a small incision to seal off the aneurysm while keeping blood flowing to the internal iliac artery. Researchers will check for serious problems w…

This trial tests an implantable device called the Shockwave Reducer for people with severe, persistent chest pain (refractory angina) who cannot have standard treatments like stents or bypass surgery. About 380 participants will either receive the device or a sham procedure. The …

This program provides access to an experimental oral medication called deucrictibant for people with hereditary angioedema (HAE) who have no satisfactory alternative treatments for acute attacks. Eligible participants, aged 12 to 75, take the capsule as needed to manage swelling …

This trial tests whether a gentle electrical stimulation applied to the ear—called transcutaneous auricular vagus nerve stimulation—can help people recover consciousness after surgery for a spontaneous brain hemorrhage. The study will include 160 adults aged 18 to 75 who remain i…

This study is tracking 1,000 patients with high blood pressure who receive the Paradise Ultrasound Renal Denervation treatment. The procedure uses ultrasound energy to calm overactive nerves near the kidneys, which can help lower blood pressure. Researchers are monitoring blood p…

This study follows 255 patients of any age (weighing over 3 kg) who receive a device called the Occlutech PDA Occluder to close a common heart defect called patent ductus arteriosus (PDA). The device is inserted through a blood vessel, avoiding open-heart surgery. Researchers wil…

This study compares a new balloon coated with everolimus to standard paclitaxel-coated balloons for opening blocked leg arteries in people with peripheral artery disease. About 410 participants will be randomly assigned to one of the two balloons. The goal is to see if the new ba…

This Phase 2 study tests an oral drug called RLY-2608 in adults and children with overgrowth conditions (like CLOVES or Klippel-Trenaunay syndrome) caused by PIK3CA gene mutations. The drug is designed to block the faulty protein driving abnormal tissue growth. The trial will enr…

This trial tests whether taking inulin, a type of dietary fiber, for two weeks can improve cardiovascular health, muscle function, and the balance of gut and vaginal bacteria in perimenopausal women who are overweight or have obesity. Participants will take either inulin or a pla…

This study compares standard medical care to a new, less invasive surgery for people with a severe bleeding stroke. The surgery uses a small tube to drain the blood clot and delivers clot-busting medicine directly into the brain. Researchers want to see if this approach helps pat…

This trial tests whether adding metacognitive training—exercises that help people think about their own thinking—to standard word-finding rehabilitation can improve language skills in people with chronic aphasia after a stroke. The study involves 18 participants who will receive …

This study looks at whether spinal cord stimulation, a device already used for chronic pain, can also reduce blood pressure in people with hypertension and low back pain. Researchers will measure blood pressure changes and pain levels, and explore how different stimulation patter…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This trial is testing a new heart valve called SAPIEN X4/X4S in over 1,200 people with severe aortic stenosis, a condition where the heart's aortic valve narrows. The valve is inserted through a catheter, avoiding open-heart surgery. Researchers are measuring how many patients di…

This trial investigates whether giving a low dose of the clot-busting drug alteplase directly into the brain artery, right after successful mechanical clot removal, can improve recovery in people with a severe stroke caused by a large vessel blockage. About 416 adults who have ha…

This study tests a drug called mirivadelgat in people with high blood pressure in the lungs caused by lung scarring (PH-ILD). The goal is to see if it improves blood flow in the lungs, exercise ability, and overall well-being. About 126 participants will take the drug or a placeb…

This study tests an injected drug called KPL-387 in 165 people with recurrent pericarditis, a condition where the sac around the heart becomes inflamed again and again. The goal is to see if KPL-387 can reduce flare-ups and pain better than a placebo. Participants must have sympt…

This study tests a new drug called KPL-387 in 80 people with well-controlled recurrent pericarditis (inflammation around the heart). The goal is to see if patients can safely switch from their current treatments to KPL-387 alone and still prevent flare-ups. The trial will measure…

This study tests a small device called C-MIC that is implanted without open-heart surgery to help people with heart failure. It includes 22 adults with weak heart pumping (ejection fraction between 25% and 50%) despite standard medications. The device delivers microcurrents to th…

This trial tests an experimental therapy called CTX340, which uses CRISPR gene editing to disable a gene in the liver that regulates blood pressure. It is designed for adults with uncontrolled hypertension despite taking multiple blood pressure medications. The study will first a…

This trial tests whether adding self-administered hand therapy at home, using a videogame controller called the Twirlstone, can improve hand dexterity and coordination in stroke survivors. Participants, who are within six weeks of a stroke and have arm or hand weakness, will eith…

This study tests whether treating mild high blood pressure (stage 1 hypertension) during pregnancy can improve baby birth weight. 74 pregnant people with blood pressure between 130-139/80-89 mmHg will be randomly assigned to either active treatment with blood pressure medication …

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This trial tests whether a non-invasive device that stimulates the vagus nerve through the ear can reduce harmful spasms in brain arteries that often occur days after an aneurysm rupture. The study will enroll 10 adults who have had this type of bleeding in the brain and will rec…

This study will screen 1,500 people with early signs of heart disease (plaque in arteries) to see if two common drugs—rosuvastatin and colchicine—can reduce or stabilize that plaque over two years. Participants will take pills daily and get heart-healthy lifestyle advice. The goa…

This trial tests whether a gentle electrical stimulation applied to the ear—a technique called low-level transcutaneous vagus nerve stimulation—can help older adults with systolic heart failure. The study will compare daily one-hour sessions of real stimulation versus a sham (ina…

This study tracks people who experienced a suspected cardiac arrest and had a HeartStart HS1 defibrillator applied. The goal is to see how accurately the device detects shockable heart rhythms and delivers the right amount of energy, especially in children. By collecting data fro…

This study tests a new device called the RevCore Thrombectomy Catheter to treat blocked stents in the leg veins. About 100 adults with stents that have been in place for at least 6 weeks will be enrolled. The device is inserted into the vein to remove the blockage and restore blo…

This study tests a new drug called ARO-DM1 in 78 adults aged 18-65 with type 1 myotonic dystrophy, a genetic muscle disorder. The goal is to check safety and how the body processes the drug. Participants receive either ARO-DM1 or a placebo by IV or injection. It is an early-stage…

This trial tests whether adding a low-dose blood thinner (rivaroxaban) to standard antiplatelet therapy for the first three months after a heart stent procedure can reduce the risk of future heart attacks, strokes, and other cardiovascular events in high-risk patients. Participan…

This phase 3 trial studies whether patients with acute decompensated heart failure who are already taking an SGLT2 inhibitor like empagliflozin should continue it during hospitalization. About 536 participants will either keep taking empagliflozin or switch to a placebo while in …

This study tests a new drug, BBD-1, against standard steroids for IgA vasculitis, a disease that causes purple spots on the skin, joint pain, and can damage the kidneys. The trial will enroll 30 adults with confirmed IgA vasculitis. The goal is to see if BBD-1 can clear skin spot…

This study tests two blood-thinning strategies in people with severe aortic regurgitation who have had a new heart valve placed without open surgery. Participants receive either daily aspirin for a year or warfarin for six months followed by aspirin. The goal is to see which appr…

This study tests whether a structured rehabilitation program called HABIT-ILE, which combines intensive arm, hand, and leg exercises, can improve balance and coordination in people recovering from a stroke. The trial will include 44 stroke survivors aged 40 to 60, who will be ran…

This study looks at whether people with giant cell arteritis (GCA) who are in remission can safely stop or lower their dose of tocilizumab (Actemra). About 78 adults who have been on high-dose tocilizumab for at least a year and off steroids for three months will either stop the …

This study is testing a device called the WavelinQ EndoAVF System that creates a connection between an artery and a vein (AV fistula) in people who need dialysis. The goal is to make it easier to start and continue dialysis with fewer complications. About 280 adults with end-stag…

This study tests a special heart valve that can be adjusted to fit children as they grow. It involves 36 kids aged 1.5 to 16 years with congenital heart disease who need a new pulmonary valve. The valve is placed during surgery and can later be expanded without another operation.

This long-term study follows people with pulmonary arterial hypertension (PAH) who previously took part in sotatercept trials. Sotatercept is a targeted therapy that aims to stop PAH from getting worse. Researchers will monitor safety, side effects, and how well patients tolerate…

This trial investigates whether a new dual energy catheter system can safely and effectively treat ventricular arrhythmias—abnormal heart rhythms that can be life-threatening. The system uses both radiofrequency and pulsed field energy to ablate the heart tissue causing the probl…

This study compares two procedures used to treat unruptured wide-neck brain aneurysms: flow diverter stents and stent-assisted coiling. Researchers will follow 274 adults from three centers in China who receive one of these treatments as part of routine care. The main question is…

This study tests a small sensor implanted in a large vein near the heart to help doctors monitor fluid buildup in people with heart failure. The sensor sends daily readings so treatment can be adjusted early. The trial will compare standard care plus sensor guidance to standard c…

This study tests whether bromocriptine, a drug that stops breastfeeding, can improve heart function in women newly diagnosed with peripartum cardiomyopathy (a type of heart failure after childbirth). 200 women will receive either bromocriptine or a placebo, plus standard heart fa…

This study is testing a device called a flow modulator to treat wide-necked brain aneurysms. The device is placed inside the artery to redirect blood flow away from the aneurysm, helping it close off. Researchers will check if the device is safe and effective in 214 adults over 1…

This study tests whether taking semaglutide (Wegovy) for at least three months before a first-time atrial fibrillation ablation can improve heart rhythm outcomes. 200 overweight or obese adults scheduled for ablation will be randomly assigned to either standard care or semaglutid…

This trial compares two blood thinners, edoxaban and apixaban, in people who have both atrial fibrillation (an irregular heartbeat) and coronary artery disease (narrowed heart arteries). Both drugs help prevent blood clots, but they are taken differently and may have different ri…

This trial tests whether fexofenadine, a common allergy medication, can help the heart heal better after a severe type of heart attack called STEMI. Participants will receive either fexofenadine or a placebo for six months, alongside standard care, after undergoing a procedure to…

This early-stage trial tests a single dose of SGT-501, a gene therapy given by IV, in 18 people with a rare inherited heart condition called CPVT that can cause dangerous fast heartbeats during exercise or stress. The main goal is to check safety and find the right dose in adults…

This study looks at how a special balloon called the OPN balloon is used to open severely hardened or blocked heart arteries. Researchers will track 300 adults who need this procedure to see how well it works and what problems might happen. The goal is to learn the best ways to u…

This study tests whether the drug vericiguat can help children with heart failure caused by a weak left heart chamber. About 342 children aged 1 month to 18 years will receive either vericiguat or a placebo for 16 weeks. The main goal is to see if the drug lowers a key heart stre…

This study tests whether a personalized, home-based exercise program can help people who have had a moderate-to-severe pulmonary embolism (a blood clot in the lungs) improve their physical capacity and quality of life. Participants will be randomly assigned to receive the exercis…

This study compares two medicated stents (tiny mesh tubes) used to open blocked heart arteries in people having a heart attack or unstable angina. About 2,100 participants will receive either a sirolimus-eluting stent (ihtDEStiny) or an everolimus-eluting stent (Xience). Research…

This trial tests a new device called the MRace implant, designed to reduce severe mitral regurgitation—a condition where the heart's mitral valve leaks blood backward. The implant is placed via a catheter through a vein in the leg, avoiding open-heart surgery. The study will enro…

This study tests whether starting inclisiran early after a heart attack can lower bad cholesterol and reduce the risk of another heart attack or stroke. About 300 adults in Russia who had a recent heart attack and have high cholesterol will receive inclisiran injections. Research…

This study tests whether vestibular-oriented balance training or motor dual-task training, added to standard physiotherapy, better improves balance and reduces fall risk in people who had a stroke at least six months ago. About 50 participants will be randomly assigned to one of …

This study tests a compact heart-lung machine called Cardiohelp in 50 children with severe heart failure. The device supports the heart for up to 30 days while kids recover or await a transplant. The trial also compares two blood thinners to see which causes fewer bleeding or clo…

This trial compares two blood pressure medications—midodrine and droxidopa—against compression stockings and a placebo to see which best stabilizes blood pressure in people with spinal cord injury. Participants have a traumatic injury between C1 and T6, are at least a year post-i…

This study tests whether starting the drug finerenone early during a hospital stay for acute heart failure can improve outcomes. About 550 adults with heart failure and preserved ejection fraction will receive either finerenone or a placebo. Researchers will track deaths, worseni…

This study tests whether using a CT scan to guide heart stent placement is better than the current standard (IVUS ultrasound) for people with hardened, calcified coronary arteries. About 700 adults with evidence of reduced blood flow to the heart will be randomly assigned to one …

This early study tests a new device called the SATURN TS TMVR System, which is implanted through a catheter to replace the mitral valve in people with severe mitral regurgitation. Up to 15 patients who are too high-risk for open-heart surgery will be enrolled. The goal is to see …

This study tests an experimental oral drug called ROC-101 in 40 adults with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (ILD-PH). Participants take the drug alongside their standard care for 24 weeks, with a long-term follow…

This trial tests whether an adapted CPR bundle can increase the chance of restarting the heart in adults who suffer cardiac arrest outside a hospital. Participants are randomly assigned to receive either standard advanced life support or a modified approach that includes mechanic…

This early study tests a new device called HyperQure that uses a keyhole surgery to disable certain nerves around the kidneys. The goal is to help people with resistant hypertension—high blood pressure that stays high despite taking three or more medications. The study will enrol…

This pilot study tests whether a left-sided stellate ganglion block using bupivacaine can lower the rate of atrial fibrillation after esophagectomy, pneumonectomy, or lobectomy. 48 adults aged 18-85 undergoing these surgeries will receive either the nerve block or a saline placeb…

This pilot study tests whether adding powder made from Chardonnay grape skins and seeds to the daily diet can improve gut and heart health. The study includes postmenopausal women aged 45-70 with excess weight and high triglycerides. Participants will consume the powder daily, an…

This study tests whether doing strength exercises one limb at a time (unilateral) or both limbs together (bilateral) makes a bigger difference in heart rate variability, muscle strength, and daily function for adults with high blood pressure. Adults aged 40-75 with hypertension w…

This study investigates whether aggressive lipid-lowering therapy can reduce plaque buildup in the heart arteries of melanoma patients starting immune checkpoint inhibitors (ICIs). Participants with plaque detected on a heart CT scan are randomly assigned to either usual care or …

This trial tests whether a 3-month program of virtual visits and remote monitoring can improve recovery in adults recently hospitalized for heart failure. Participants receive either virtual heart failure care or routine care, and researchers track medication optimization, health…

This study tests a drug called lepodisiran in 252 adults with high levels of Lp(a), a protein linked to heart disease. Participants must have heart disease or be at risk for a first heart event. The drug is given as an injection and compared to a placebo to see if it reduces plaq…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study is testing whether fexofenadine, a common allergy medication, can reduce the risk of serious heart and brain events in people who have recently had a heart attack. About 2,800 participants will receive either fexofenadine or a placebo for 24 months. The goal is to see …

This study is testing a device called the Indigo Aspiration System to remove blood clots from leg arteries in people with acute limb ischemia, a condition where a clot suddenly blocks blood flow. About 300 participants will undergo a procedure where the device sucks out the clot.…

This study tests a device called the Artix Thrombectomy System to remove blood clots from leg arteries in people with sudden blockages. About 250 adults with symptoms lasting up to 14 days will be enrolled. The goal is to see if the device can safely restore blood flow and preven…

This Phase 3 trial tests an oral drug called muvalaplin in over 10,000 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease and stroke. Participants either have had a prior cardiovascular event or are at high risk for a first one. The study measures …

This trial is testing a device designed to remove blood clots from the deep veins of the legs, a condition called deep vein thrombosis (DVT). The study will enroll about 167 adults with acute or subacute DVT to see if the device can safely and effectively clear the blockage. Part…

This study tests a new device and technique (ADAPT 2.0) for removing blood clots in people having an acute ischemic stroke. The goal is to see if it can restore blood flow more completely and safely than current methods. About 750 adults who are already scheduled for clot removal…

This study tests whether adding pelacarsen to inclisiran can further lower a type of cholesterol called Lp(a) in people with heart disease. About 340 adults with high Lp(a) and LDL-C will receive either pelacarsen or a placebo, plus inclisiran. The main goal is to see if Lp(a) le…

This trial asks whether cooling the body to 33-34°C after a cardiac arrest treated with ECMO improves survival and brain function compared to keeping a normal temperature. It includes adults aged 18-75 who had an out-of-hospital cardiac arrest with certain heart rhythms. Particip…

This study compares catheter ablation (a procedure to fix irregular heartbeats) with standard medical care in 646 adults who have both atrial fibrillation and a recent brain bleed. The goal is to see if ablation reduces the risk of death, stroke, or blood clots. Participants must…

This trial tests whether using a supraglottic airway (a mask-like device) instead of a breathing tube during heart surgery can reduce lung complications and speed recovery. Adults having elective heart valve surgery or bypass will be randomly assigned to either the nonintubated a…

This early-stage study tests whether a drug called anisodine hydrobromide is safe for people having a stroke caused by a blocked large artery in the brain. About 92 adults aged 18 to 80 who are already scheduled for a clot-removal procedure will receive the drug. The main goal is…

This phase 3 trial tests whether metformin, a diabetes drug, can safely prolong pregnancy in women with preterm preeclampsia. Currently, the only treatment is early delivery, which risks the baby's health. The study will enroll 294 women across Nordic countries, giving them metfo…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This phase II trial tests whether adding the immunotherapy cemiplimab to the targeted drug cabozantinib works better than cabozantinib alone for advanced adrenocortical cancer. About 48 adolescents and adults whose cancer has spread or cannot be removed will take part. The study …

This study tests whether the drug clevidipine can lower blood pressure quickly and steadily in people having a bleeding stroke (intracerebral hemorrhage). High blood pressure can make the bleeding worse, so getting it under control fast is critical. The trial will compare clevidi…

This early-stage trial tests a single dose of a gene therapy called NVC-001 in 21 adults with a genetic form of dilated cardiomyopathy (LMNA mutation). The therapy uses a harmless virus to deliver a modified gene into heart cells, aiming to protect the heart muscle. The main goal…

This study compares two approaches for people with mild-to-moderate carotid artery stenosis (narrowing of the neck arteries): a standard statin regimen versus a statin plus a PCSK9 inhibitor (evolocumab) given as biweekly injections. The main goal is to see whether the combinatio…

This study tests a new treatment called NKX019 for people with autoimmune diseases like systemic sclerosis, rheumatoid arthritis, and vasculitis. NKX019 uses specially engineered immune cells to target and calm overactive B cells that cause the disease. The goal is to see if it i…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This clinical trial is testing an experimental drug called CRD-4730 in people with heart failure with reduced ejection fraction (HFrEF), a condition where the heart's main pumping chamber is weak. The drug works by blocking a protein called CaMKII, which is thought to contribute …

This study tests whether closing a small pouch in the heart (the left atrial appendage) with a device is safer and as effective as long-term blood thinners for people with atrial fibrillation who have already had a brain bleed. About 530 participants will be randomly assigned to …

This Phase 3 study tests whether adding vicadrostat to the standard drug empagliflozin helps adults with chronic heart failure and a weak heart pump (ejection fraction below 40%). About 4200 participants will take either vicadrostat or a placebo, plus empagliflozin, once daily fo…

This study tests whether adding vicadrostat to the standard medicine empagliflozin helps people with heart failure who have a preserved ejection fraction (heart pumps normally but is stiff). About 6000 adults with symptoms will take either vicadrostat plus empagliflozin or a plac…

This study looks at two ways to treat a type of stroke caused by a blockage in a smaller branch of a brain artery. One group receives a procedure to remove the clot (thrombectomy) plus standard medical care, while the other group receives medical care alone. The goal is to see if…

This study tests a small implanted device that sends gentle electrical signals to strengthen heart contractions in people with heart failure whose hearts still pump fairly well (ejection fraction 40-70%). Researchers will compare the device to a sham (inactive) implant in 1,500 p…

This study tests a lab-made human protein called CYT107 in 55 people with HIV and Kaposi sarcoma. The protein aims to boost T cells, which may help shrink cancer tumors. Participants receive weekly injections for up to 4 weeks, with follow-up for 3 years.

This phase 3 study tests an intravenous C1 esterase inhibitor (C1-INH) in people with hereditary angioedema (HAE) to treat acute attacks and prevent attacks before medical procedures. About 124 participants, aged 2 and older, will receive either the drug or a placebo. The main go…

This study tests an oral medication called BI 1815368 in 300 adults with center-involved diabetic macular edema, a common cause of vision loss in diabetes. Participants take tablets twice daily for about 11 months, and doctors compare vision changes between those on the drug and …

This early study tests whether a liquid form of the drug avacopan can be safely given through a feeding tube to critically ill patients with ANCA vasculitis who have severe lung bleeding and need a ventilator. The main goal is to measure how the drug levels change in the blood ov…

This study tests an experimental drug, REGN7508, to see if it works better than the standard blood thinner apixaban for treating and preventing blood clots in people with cancer. The trial will include about 1,600 participants with or without cancer who have deep vein thrombosis …

This study tests a new type of stent (a small mesh tube) for people with heart disease who also take blood thinners. These patients have a high risk of bleeding when they also need anti-clotting drugs after stent placement. The new stent is designed to allow a shorter course of a…

This trial tests whether vericiguat, a drug that relaxes blood vessels, can protect the body during heart surgery. About 170 adults scheduled for open-heart surgery will receive either vericiguat or a placebo starting two days before the operation. Researchers will measure blood …

This Phase 3 study tests whether the drug mavorixafor can reduce serious infections and increase neutrophil levels in people with chronic neutropenia—a condition where the body doesn't make enough infection-fighting white blood cells. About 176 participants will receive either ma…

This study tests whether early referral to a cardio-oncology specialist can lower heart risks in prostate cancer patients receiving long-term hormone therapy (ARPI). About 80 men with high-risk or advanced prostate cancer and additional heart risk factors will be assigned to eith…

This study looks at whether giving enalapril, a standard blood pressure medicine, to women who had preeclampsia during pregnancy can help control their blood pressure after childbirth. Researchers will enroll 60 postpartum women and randomly assign them to enalapril or usual care…

This study tests whether moving cardiac arrest survivors to a specialized hospital improves their recovery. About 1,600 adults who were revived after an out-of-hospital cardiac arrest will be randomly assigned to either stay at the nearest hospital or be transferred to a specialt…

This study tests a new device called FARAFLEX that uses electrical pulses to treat atrial fibrillation (AF), a condition where the heart beats irregularly. About 571 adults with AF that hasn't improved with medication will get this procedure. The goal is to see if it safely resto…

This study tests a new device to replace the mitral valve in people with severe mitral regurgitation (a leaky heart valve) who cannot have standard surgery or a less invasive repair. About 1,056 participants will receive the device and be followed for safety and quality of life. …

This study looks at two ways to treat blocked large heart arteries (≥3.5 mm) in people with coronary artery disease. One method uses a drug-coated balloon, the other a drug-releasing stent. The goal is to see which helps the artery relax and function better 8 months after treatme…

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

This study tests whether sending doctors a reminder about IV iron guidelines helps heart failure patients with iron deficiency get the recommended treatment. About 3,000 hospitalized adults with heart failure and low iron will be included. Doctors in the intervention group receiv…

This study tests if delivering oxygen directly into the gut through a thin tube can help people with ischemic-hypoxic bowel disease, a condition where the bowel doesn't get enough oxygen. About 90 adults with symptoms like belly pain, bloating, and trouble pooping will receive ei…

This study will track 100 people with severe aortic stenosis who receive the Hydra THV heart valve through a less invasive procedure (TAVR). The goal is to see how well the valve works and how safe it is in everyday practice. Participants will be followed for short- and mid-term …

This program allows doctors to request NanO₂, an investigational drug that may help deliver oxygen to tissues, for patients with serious or life-threatening conditions like glioblastoma, respiratory distress, or ischemic stroke. It is for patients who have exhausted other treatme…

This study tests a new catheter called VARIPULSE against an already approved one, FARAWAVE, for people with persistent atrial fibrillation (a long-lasting irregular heartbeat). About 466 participants will receive one of the two treatments to see which is safer and better at resto…

This study tests an experimental drug called REGN13335 in 99 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. Participants will receive either the drug or a placebo, on top of their usual PAH medica…

This program provides access to an investigational drug called donidalorsen for people with hereditary angioedema (HAE), a genetic condition that causes sudden, painful swelling in various body parts. The drug is given as a monthly or every-other-month injection under the skin. I…

This study is a registry that will follow about 200 people with brain aneurysms who are treated with a flow diverter device (p64, p64 MW, or p48 MW). The goal is to see how safe and effective these devices are in real-world practice across France. Participants will be monitored f…

This study tests a new medicine called CDR132L in 200 people with a type of heart failure where the heart is stiff and thickened. The goal is to see if it can improve heart structure and function. Participants will receive either the study drug or a placebo by chance, and the stu…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and emergency treatment to open a blocked artery. About 438 participants will be randomly assigned to start blood thinners within 4 days or between 5-14 days after the st…

This study tests a drug called donidalorsen in 20 children aged 2 to 12 with hereditary angioedema (HAE), a condition that causes sudden, painful swelling. The goal is to see if the drug is safe and how it works in young bodies. Researchers will monitor side effects and measure h…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This program gives children with brain disorders like cerebral palsy or stroke access to umbilical cord blood infusions. The treatment uses donated cord blood cells to help repair brain damage. Kids up to age 26 with normal immune function may qualify. The goal is to improve symp…

This trial tests whether a 5-microgram or 10-microgram bolus of norepinephrine is better at quickly raising dangerously low blood pressure during emergency abdominal surgery. Low blood pressure after anesthesia is common in these surgeries and can harm organs if not treated fast.…

This phase 3 trial is testing two experimental drugs, REGN7508 and REGN9933, to prevent serious blood clots in people with peripheral artery disease who recently had leg surgery to improve blood flow. The study will enroll about 7,050 participants and compare the drugs to a place…

This trial tests whether the direction of the needle bevel (up or down) during fistula puncture affects the risk of complications in people on hemodialysis. About 240 adults with end-stage kidney disease who are starting dialysis with a new arteriovenous fistula will be randomly …

This study compares a newer pacing method (Left Bundle Branch Area Pacing) with the standard cardiac resynchronization therapy for people with heart failure. About 850 adults with moderate to severe heart failure will take part. The goal is to see if the newer method reduces deat…

This trial investigates whether combining repetitive transcranial magnetic stimulation (rTMS) with aerobic exercise can treat depression and improve walking in people who have had a stroke. Participants will receive either real or sham rTMS along with exercise sessions over 12 we…

This study tests two ways to treat hardened calcium deposits in heart arteries. After using sound waves to break up the calcium, doctors will either place a drug-coated balloon or a drug-coated stent. The trial will follow 128 patients for 9 months to see which approach keeps art…

This study compares two treatments for small ischemic strokes (lacunar strokes): a combination of antiplatelet drugs (pills) versus the standard clot-busting drug tPA given through an IV. The goal is to see if the pill combo works just as well but causes fewer bleeding problems. …

This study tests a new medicine, EYP-1901, given as an eye injection to people with diabetic macular edema (DME), a condition that causes blurry vision in people with diabetes. The goal is to see if EYP-1901 works as well as the standard treatment (aflibercept) but with fewer inj…

This study tests a drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants receive weekly injections of YN001 or a placebo for 13 weeks. The main goal is to see if YN001 reduces plaque volume in the arteries, as measured by a…

This phase 3 trial tests EYP-1901, a new eye injection, against the standard treatment aflibercept for diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The study will enroll 240 participants and compare how well each drug improves vision …

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests whether a bedside monitoring device, placed on the head right after a mechanical thrombectomy for acute ischemic stroke, can predict which patients will have poor neurological outcomes. The device uses near-infrared spectroscopy to measure brain oxygen levels and…

This study tests whether a special ultrasound technique (SHAPE) can detect high blood pressure in the liver without using a needle. Portal hypertension is a serious condition that can lead to severe liver damage and death. The standard test requires inserting a catheter into a ve…

This study is testing new, lower-radiation CT scan methods for taking pictures of the heart and blood vessels. Researchers want to see if these scans are accurate at finding blocked arteries and predicting future heart problems like heart attacks. About 5,000 adults who need a he…

This study tests a new device that uses a sensor placed on the chest to measure kidney function in 15 adults with heart failure. Participants receive an injection of a fluorescent dye (Relmapirazin) and a standard contrast agent (iohexol), then the sensor tracks how quickly the d…

This study is testing whether a new type of CT scan, called photon-counting CT, can do it all in one go for people who have had a coronary stent placed. The scan aims to check the stent and arteries, measure blood flow to the heart muscle, and assess heart function in a single ex…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study compares two types of CT scans for imaging the buildup of plaque in the carotid arteries, which supply blood to the brain. The newer photon-counting detector CT (PCD-CTA) will be compared with the standard energy-integrating detector CT (EID-CTA) in 100 people with car…

This Phase 3 trial tests whether a new contrast agent called gadopiclenol works as well as the standard agent (Dotarem) for MRI scans to find blocked arteries in the neck, legs, or abdomen. About 315 adults with suspected vascular disease will receive both agents in random order …

This study is testing a chest-patch that uses light to measure blood pressure without a traditional arm cuff. Researchers will compare its readings over 24 hours to the standard cuff-based method in 600 adults with or without high blood pressure. The goal is to see if the patch i…

This study will check how common peripheral artery disease (PAD) is in people who need surgery for lumbar spinal stenosis (LSS). Both conditions can cause leg pain, making PAD hard to spot. Researchers will use a special CT scan to find PAD and compare it with simpler tests like …

This trial is developing an AI-powered device that listens to children's heart, breath, and bowel sounds to identify signs of common diseases like congenital heart disease, bronchopneumonia, and abdominal issues. It will involve 30,000 children aged 0-18, some with these conditio…

This study explores whether performing a cardiac MRI (CMR) before the standard invasive coronary angiography (ICA) can accurately diagnose the cause of a suspected non-ST-elevation heart attack (NSTEMI). Currently, patients with NSTEMI often undergo an invasive angiogram, and if …

This study looks at 200 adults who have had an ischemic stroke or transient ischemic attack (TIA). Each participant will receive two types of imaging: a non-contrast magnetic resonance angiography (NC-MRA) and a carotid Doppler ultrasound. The goal is to see how well these two me…

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This trial evaluates an artificial intelligence system designed to automatically detect signs of diabetic retinopathy in retinal photographs. Researchers will compare the AI's performance against experienced ophthalmologists using a large set of eye images from adults with the co…

This study explored whether a special type of MRI using inhaled xenon gas could detect changes in the small blood vessels of the lungs in people with pulmonary hypertension. The goal was to see if this imaging method could track disease progression or response to treatment. Howev…

This study is testing a new artificial intelligence (AI) tool that analyzes electrocardiograms (ECGs) to find a condition called left ventricular systolic dysfunction (LVSD), a type of heart failure where the heart's main pumping chamber is weak. Researchers will enroll 15,000 ad…

This trial tests whether a machine-learning algorithm can detect atrial fibrillation (AF) early by analyzing pulse wave signals from a wearable sensor. The study involves 200 adults with heart failure, comparing the algorithm's readings against standard ECG results. If it works, …

This observational study is testing whether a combination of non-invasive measurements—including blood pressure monitoring, ultrasound, blood and urine tests, and a light-based technique called photoplethysmography—can detect early damage to blood vessels and organs in adults at …

This study tests whether an artificial intelligence (AI) tool that analyzes a simple ECG can help doctors find undiagnosed pulmonary hypertension (high blood pressure in the lungs) in people with interstitial lung disease. About 900 adults with severe lung scarring will be random…

This study is testing whether a noninvasive imaging technique called pulsatile electrical impedance tomography (EIT) can accurately diagnose acute pulmonary embolism — a life-threatening blood clot in the lungs. Researchers will compare EIT readings with standard CT scans in 275 …

This study is testing a new, noninvasive imaging device called HH-SECTR to see inside the eyes of premature infants with retinopathy of prematurity (ROP), a condition that can affect vision. The goal is to see if this technology can provide clearer, more detailed images of the re…

This study tests whether taking progesterone early in pregnancy can prevent preeclampsia, a condition that causes high blood pressure and organ damage. Over 600 low-risk pregnant women will either receive nightly vaginal progesterone or standard care. Researchers will track who d…

This trial tests whether personalized health dialogues, combined with lifestyle screening and molecular profiling, can reduce the risk of cardiovascular disease, cancer, and other serious conditions. Adults aged 40, 50, 60, and 70 in Sweden's Skåne region will participate. They w…

This phase 3 study tests whether the drug olpasiran can prevent first major heart events (like heart attacks) in 11,000 people aged 50+ who have high levels of lipoprotein(a), a genetic risk factor. Participants receive either olpasiran or a placebo as a shot under the skin. The …

This study tests a mobile app called m-LIfE designed to help sedentary bank employees in Pakistan become more active and eat better. Over 12 weeks, participants will receive daily reminders, tips, and tracking tools. The goal is to see if the app is practical and can encourage he…

This Phase 2 study tests whether a daily pill called EVO756 can prevent migraines in adults who have not had success with other preventive treatments. About 330 participants will receive either EVO756 or a placebo, and researchers will track how many migraine days they have each …

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half …

This study looks at whether patients and doctors in a family planning clinic find it acceptable to discuss and start PrEP, a daily pill that prevents HIV. About 83 English- or Spanish-speaking patients aged 16 and older, along with their doctors, will take part. Patients will rec…

This trial tests whether adding nitric oxide gas to the heart-lung machine during surgery can prevent acute kidney injury in newborns with congenital heart defects. Up to 60% of these babies experience kidney damage after surgery, which can lead to serious complications. The stud…

This phase 3 trial tests whether acoramidis can prevent or delay transthyretin amyloidosis (ATTR) in 587 adults who carry a faulty gene but have no symptoms yet. ATTR causes sticky plaques to build up in the heart and nerves, leading to heart failure and nerve damage. Acoramidis …

This trial tests whether a single polypill combining three medications—finerenone, empagliflozin, and losartan—can help prevent heart failure and maintain exercise capacity in people with type 2 diabetes who are at high risk. Participants will take either the polypill or the same…

This study looks at whether a diet rich in whole white potatoes can improve blood sugar control and blood pressure in adults aged 50-70 who are at risk for type 2 diabetes. Participants will eat either a potato-rich healthy diet or a typical Western diet for 12 weeks. Researchers…

This study tests whether using shockwave therapy on the leg artery before a TAVR heart valve procedure can reduce bleeding and other complications. It involves 100 adults with severe aortic stenosis and heavily calcified arteries. The goal is to make the procedure safer by prepar…

This study tests whether daily leg heat therapy can improve walking ability and quality of life in people with peripheral artery disease (PAD). About 106 adults over 50 with PAD will use special heated trousers for 90 minutes a day at home for 12 weeks. Researchers will measure c…

This study tests whether Acceptance and Commitment Therapy (ACT), delivered through a smartphone app, can help caregivers of children with RASopathies (like Neurofibromatosis type 1 and Noonan syndrome) cope with parenting stress. The trial is fully remote and involves 70 adult c…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. About 48 participants will receive hypnosis sessions alongside standard care, while researchers monitor brain activity with …

This study tests the long-term safety of rimegepant, a migraine medication taken as a dissolving tablet, in children and adolescents aged 6 to 18. About 600 participants with a history of migraine will take the drug as needed for up to one year. The main goal is to check for side…

This study tests whether a smarter electrical stimulation device can help people recover arm and hand movement after a stroke. Participants with moderate arm weakness will be randomly assigned to receive either standard cyclic stimulation or a new EMG-triggered stimulation that r…

This study tests whether rimegepant, a fast-dissolving tablet, can safely relieve migraine pain in children and adolescents aged 6 to 18. About 2,100 participants will receive either the drug or a placebo during a migraine attack. The main goal is to see if more kids become pain-…

This trial tests whether a 24-week personalized program called MICROFIT—combining high-intensity interval training with a personal trainer and Mediterranean-style dietary advice—is feasible for people with microvascular coronary dysfunction, a condition where small heart blood ve…

This trial investigates whether an experimental, unapproved medical device can help relieve symptoms in people with a specific condition. Researchers are enrolling participants to test the device's effects and safety. The goal is to see if this new approach could offer a drug-fre…

This study tests whether extra support—like personalized mask fitting, monthly phone calls, and a tracking app—helps stroke patients with sleep apnea use their CPAP machine more consistently during rehab. About 250 participants will be randomly assigned to either this intensive s…

This study tests two advanced rehabilitation methods—robot-assisted walking training and visual feedback balance training—to see which better improves balance and walking in people who have had a stroke. About 60 adults with subacute or chronic stroke will participate in 4 weeks …

This study looks at two ways of giving the pain medicine ketorolac to children after heart surgery: as a steady drip or as shots every few hours. The goal is to see if the steady drip reduces the need for stronger opioid pain medicines. About 166 children aged 3 months to 5 years…

This study tests a 10-session program called ViCCY for caregivers of heart failure patients who also have mild to moderate memory problems. About 256 caregivers and 60 patients will take part. The goal is to see if the program improves caregivers' mental health and reduces stress…

This study explores whether listening to music on purpose, for one hour a day, can improve mental health in people who had a stroke at least six months ago. Sixty participants will be randomly assigned to listen to either music or an audiobook at home for four weeks. Researchers …

This trial tests a device called the Pedal Pump, which moves the feet for 10 minutes to help reduce lower leg swelling (edema) in hospitalized patients. The study includes 60 adults with edema due to conditions like heart failure, kidney disease, or chronic venous insufficiency. …

This trial tests whether Occupational Performance Coaching (OPC) can help adults who have had a stroke and finished rehabilitation get back to activities they value. Participants are randomly assigned to receive OPC or an attention control, both delivered virtually. The study mea…

This phase 3 study evaluates the long-term safety of elismetrep (K-304), an oral medication taken as needed for migraine attacks. About 1,000 adults who previously took elismetrep in an earlier trial will continue using it intermittently. Researchers will track side effects over …

This study tests whether adding a mild brain stimulation technique (tDCS) to a standard arm therapy (constraint-induced therapy) helps people who had a stroke more than therapy alone. Forty adults with chronic stroke and mild-to-moderate arm weakness will be randomly assigned to …

This study tests whether a digital program called Sleepio, which uses cognitive behavioral therapy for insomnia, can improve sleep in stroke survivors. Researchers will also see if better sleep helps with learning motor skills overnight. About 100 adults who have had a stroke and…

This study tests whether a gentle electrical current applied to the scalp (tDCS) combined with computer-based cognitive training can improve memory, attention, and thinking in people who had a mild stroke. About 60 participants will receive either real tDCS or a sham (fake) versi…

This study tests whether virtual reality (VR) training in a simulated home environment can improve arm and hand function in people recovering from a stroke. Researchers will compare VR-based task-oriented training to standard therapy in 86 participants. They will also use brain s…

This study tests whether a special breathing exercise program, called inspiratory muscle training, can improve how well the breathing muscles work during exercise in people with heart failure. Researchers will measure blood flow to breathing and leg muscles, and how long particip…

This study tests whether adding inspiratory muscle training (using a device called PowerBreathe) to standard cardiac rehabilitation can improve how well the heart and muscles work during exercise in people with heart failure. Researchers will measure blood flow and oxygen use in …

This study will compare three surgical treatments for severe internal hemorrhoids: laser, energy therapy, and traditional surgery. About 60 adults with grade III hemorrhoids will choose their preferred treatment. The goal is to see which method provides less pain after surgery an…

This study tests a methadone-based recovery plan to improve pain control and reduce opioid use in children after heart surgery. About 500 children aged 3 to 18 will be randomly assigned to either the new methadone plan or standard care. The goal is to see if the new approach lowe…

This study tests a device called the PRIMUS System that uses mild electrical pulses to stimulate nerves in the head and neck. It is for people with chronic or frequent migraine who have not gotten relief from at least three preventive medicines. The goal is to see if the device s…

This study tests whether combining breathing exercises with mild electrical muscle stimulation can help people hospitalized with worsening heart failure. 135 patients will be split into three groups: one gets both treatments plus standard care, one gets breathing exercises only, …

This pilot study tests a care model called Patient Priorities Care (PPC) for older African Americans with heart disease plus other chronic conditions like diabetes or COPD. The approach shifts focus from treating each disease separately to aligning care with what matters most to …

This study tests a once-daily pill called orforglipron in about 1205 people with peripheral artery disease (PAD) who have leg pain when walking. The goal is to see if the drug helps them walk farther without pain and improves their quality of life. Participants will be followed f…

This study compares two methods of releasing a tourniquet (a tight band that stops blood flow) during arm surgery in patients with high blood pressure. The goal is to see which method causes less of a sudden drop in blood pressure. The trial will include 68 adults whose blood pre…

This study tests a new drug, elismetrep, to see if it can quickly stop migraine pain and bothersome symptoms like nausea or light sensitivity. About 1800 adults with frequent migraines will receive either the drug or a placebo. The main goal is to measure how many people are pain…

This trial tests whether a new method of clearing mucus from the airways—using intermittent suction through a breathing tube—works better than the standard continuous suction method in comatose patients who have had a stroke. About 600 participants will be randomly assigned to on…

This study tests whether adding action observation (watching movements) and motor imagery (imagining movements) to standard physical therapy can improve balance, daily function, and quality of life in people who had a stroke within the last year. About 56 participants will be ass…

This study compares two types of nerve blocks (ESPB and SPSIPB) to see which provides better pain relief after coronary artery bypass surgery. About 64 adults aged 45-85 will receive one of the blocks before surgery, and their pain levels, opioid use, and recovery speed will be t…

This study tests whether a home-based telerehabilitation program, using games, exercises, and video calls with therapists, can improve arm function and reduce disability in people who had a stroke 90-150 days ago. 202 participants will be randomly assigned to receive telerehabili…

This study is testing a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help adults who have had a stroke manage anxiety and depression. About 10 participants aged 40-79 will use the app and provide feedback on how easy and helpful it is. The goal is to…

This study will test a new screening program for 3,000 people turning 50 in the Ascoli Piceno province of Italy. Participants will fill out questionnaires and get a blood test to check their risk of developing type 2 diabetes and cardiovascular disease. The goal is to see if this…

This study is collecting long-term safety and effectiveness data on treatments for various blood disorders, including hemophilia, sickle cell disease, and clotting disorders. It aims to enroll 3000 people of any age with these conditions. Researchers will monitor side effects, co…

This large observational study in Mali is following up to 15,000 pregnant women and children to understand why some get malaria and others don't. Researchers are looking at immune responses, parasite features, and other factors that influence infection and disease severity. The g…

This study is for adults 18 and older who have had a stroke or a transient ischemic attack (TIA), often called a mini-stroke. The goal is to collect information from standard medical tests and some extra research tests, like blood draws and brain scans, to better understand how t…

This study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understa…

This study aims to collect blood and tissue samples from up to 10,000 people with rare genetic vascular or cardiovascular diseases, as well as their healthy relatives. Researchers will use these samples to identify genetic causes and understand how these diseases work. The goal i…

This study is testing a new type of MRI scanner that uses less energy than standard machines. The goal is to see if it can still take clear pictures of the heart, which could help people with metal devices in their body. Healthy volunteers and people with heart disease will have …

This study aims to understand how and why eosinophils (a type of white blood cell) become active in conditions like allergies, asthma, and parasitic infections. Researchers will observe up to 800 people aged 1 to 100 with high eosinophil levels. No experimental treatments are giv…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

This natural history study follows 270 adults with pulmonary arterial hypertension (PAH) and healthy volunteers to track how the disease changes over time. Researchers will use blood tests, heart and lung imaging, and a six-minute walk test to find new markers of disease severity…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study follows up to 4,000 people with vasculitis (a group of diseases that cause blood vessel inflammation) and healthy volunteers over many years. Researchers collect blood, urine, imaging, and genetic samples to learn how the disease develops and changes. The goal is to fi…

This study looks at how certain white blood cells, called monocytes, react to injury from a heart attack or ischemic stroke. Researchers want to learn how these cells sense danger signals and produce substances that might help heart muscle and brain tissue heal. The study involve…

This study looks at whether two proteins released by a struggling heart can be detected in the blood during acute heart failure. Researchers will measure these proteins in about 500 adults—some with stable or worsening heart failure and some healthy—to see if higher levels relate…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study will collect blood samples from 115 adults with cardiac sarcoidosis to look for tiny particles called exosomes that might show whether the disease is active or quiet. The goal is to develop a simple blood test that could help doctors monitor the condition without needi…

This study follows up to 3,500 people with sickle cell disease to learn more about how the condition progresses and what complications arise. Participants receive their usual medical care outside the hospital and visit the clinic for check-ups and research tests. No experimental …

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This study looks at how your genes and your environment—like what you eat, breathe, and experience—work together to influence common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires, genetic data, and other information from 25…

This study is testing a smart device called CONNECTDROP® that clips onto eye drop bottles to track how often glaucoma patients use their medication. About 200 adults with open-angle glaucoma will use the device and a smartphone app for one year. The goal is to see if the technolo…

This study looks at whether two proteins released when heart muscle is damaged can be detected in the blood during a heart attack. Researchers want to see if higher levels of these proteins are linked to a greater chance of developing heart failure afterward. The study includes a…

This study looks at whether tiny particles released by fat cells, called adiposomes, carry harmful fats that damage blood vessels in people with obesity and type 2 diabetes. Researchers will test if a 12-week aerobic exercise program or weight-loss surgery can reduce these harmfu…

This study explores whether a simple, radiation-free scan of the nailbeds—called nailfold capillaroscopy—can help diagnose and monitor pulmonary hypertension (PH), a condition of high blood pressure in the lungs. Researchers will compare nailbed blood vessel measurements with inv…

This study investigates why arteries stiffen and harden faster in children and young people with chronic kidney disease (CKD) and high blood pressure. Researchers will use non-invasive tests to compare arterial stiffness between those with CKD and matched controls, including heal…

This study investigates whether the types and behavior of certain immune cells (neutrophils and monocytes) in the blood are linked to how the heart repairs itself after a heart attack. Researchers will follow 50 adults who have had a severe type of heart attack and are scheduled …

This study aims to develop a standardized questionnaire that lets patients with venous malformations report their own symptoms and treatment outcomes. Venous malformations are abnormal veins that can cause pain, swelling, and emotional distress, and current assessments may miss w…

This study looks at whether liver function and blood clotting tests can help doctors better understand and monitor cardiac transthyretin amyloidosis (ATTR-CA), a condition where abnormal protein builds up in the heart. Researchers will compare these tests in people with ATTR-CA a…

This study tests whether simple reminders—called nudges—sent to doctors and patients can increase the use of genetic testing for people with certain conditions like Parkinson's disease, ALS, or heart problems. The trial will compare different ways of prompting genetic testing, su…

This study looks at how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or no mood disorder. Over two years, participants wear activity monitors and complete smartphone diaries for up to 20 days at a time. The goal is…

This registry is following 1,950 people with atrial fibrillation who are treated with the PulseSelect PFA system, a device that uses electrical pulses to correct irregular heartbeats. Researchers are tracking how well the procedure prevents AFib from coming back and how often ser…

This study looks at how shoulder pain on the paralyzed side after a stroke affects arm movement, trunk control, fear of falling, mobility, and independence. Researchers will assess 62 stroke survivors using standard tests and ultrasound. The goal is to better understand the relat…

This study investigates whether sarcopenia—age-related muscle loss—is common in older adults during the acute phase of ischemic stroke and whether it influences recovery. Researchers will assess muscle mass and function in 400 patients aged 50 and older within 72 hours of stroke …

This study aims to learn more about RASopathies, a group of genetic conditions that can cause developmental issues, birth defects, and increased cancer risk. Researchers will follow up to 500 people of any age who have or may have a RASopathy, along with their family members, for…

This study looks at how partial sleep deprivation affects blood pressure in healthy young adults whose parents have high blood pressure compared to those whose parents have normal blood pressure. Participants will spend 10 days in a sleep lab, with some nights allowing only 5 hou…

This study looks back at the medical records of 1,000 people with coronary artery aneurysms—bulges in the heart's blood vessels. Researchers want to understand how these aneurysms change over time, what factors increase the risk of progression, and whether different treatment str…

This study is checking if a computer model can accurately predict why some people have a prolonged blood clotting time (APTT). The model uses data from routine blood tests to tell if the cause is harmless or a sign of a clotting disorder. Researchers will test it on 1,500 patient…

This study tracks 500 adults with stable coronary artery disease or unstable angina who are undergoing a heart procedure called percutaneous coronary intervention (PCI) using a drug-coated balloon. Researchers are looking at how procedural details—specifically how long the balloo…

This study collects heart tissue and blood samples from people with advanced heart failure who are receiving a mechanical heart pump (LVAD) or a heart transplant. The samples are compared with healthy donor heart tissue to learn more about the biology of heart disease. The goal i…

This study tests whether a new type of CT scan, called ultra-high-resolution photon-counting CT angiography, can accurately check whether stents placed in the brain's venous sinuses are still open. It compares this new scan to the standard CT method and to the more invasive DSA p…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the lab. The goal is to support basic and translational research that co…

This study investigates how a recent stroke affects the ability to learn new motor skills that require using both arms or hands together. Researchers will use robotic devices to measure learning and brain imaging to see which brain areas are involved. The goal is to understand wh…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study tests whether a wearable Holter monitor can detect early signs of fainting in people with orthostatic hypotension or reflex syncope. Forty adults who have already had a tilt-table test will wear the monitor for up to 21 days. The goal is to see if the device can pick u…

This study aims to find how common the KIT D816V mutation is in people with suspected clonal mast cell disease. Researchers will collect blood samples from 450 participants and test them using two sensitive methods. The results may improve understanding and diagnosis of these rar…

This study investigates whether people who had carpal tunnel surgery might have a higher chance of having ATTR amyloidosis, a condition where abnormal proteins build up in tissues, potentially affecting the heart. Researchers will biopsy tissue from about 180 patients who had car…

This study tests whether a clinical decision support (CDS) system can help doctors follow best-practice guidelines for preventing venous thromboembolism (blood clots) in adults with traumatic brain injury. Researchers will compare hospitals that use the CDS system with those that…

This study looks at whether a special CT scan (CT-FFR) can help doctors predict heart attacks and other serious events in people with chronic coronary syndrome. About 3,000 participants in China will be followed for up to 5 years. The goal is to see if abnormal CT-FFR results are…

This study looks at how therapeutic cooling after cardiac arrest affects the body's energy expenditure and which nutrients (sugars, fats, proteins) are burned for fuel. About 40 unconscious patients will be cooled to either 33°C or 36°C and given a fixed nutrition plan. Researche…

This study investigates whether people who recently had a stroke (within 21 days) can learn new arm movements using a rehabilitation robot called REAplan. Researchers will compare their learning ability with healthy individuals and those who had a stroke long ago. The goal is to …

This study is creating a decision aid for people with a rare heart condition called right anomalous aortic origin of a coronary artery (R-AAOCA). The condition raises the risk of sudden cardiac death, but the best management—surgery or careful observation—isn't clear. The aid wil…

This study is looking for tiny molecules in the blood called microRNAs that can help doctors tell if a heart transplant patient's immune system is too active (causing rejection) or too weak (causing infection). Researchers will follow 250 adult heart transplant recipients for one…

This study looks at how much of the migraine drug galcanezumab (Emgality) appears in breastmilk after a mother receives her usual injections. Researchers will measure drug levels in milk samples from 30 women with migraine who are breastfeeding, and also track infant growth, deve…

This registry will follow 1000 adults with pulmonary embolism (blood clots in the lungs) who are treated with Inari Medical devices. Researchers will track device-related complications and deaths to understand how safe these tools are in everyday use. The study is observational, …

This study looks at whether combining a new type of CT scan with a blood test for tiny molecules called microRNAs can better predict heart damage after a heart attack. Researchers will follow 95 patients who had a severe heart attack and measure changes in their heart size over s…

This study uses advanced MRI to measure the fat around the heart in people with a type of heart failure called HFpEF. Researchers want to see if the fat's composition, not just its amount, is linked to disease severity. They will also test if a diabetes drug called semaglutide ch…

This study looks at whether certain fat molecules in the blood, called lipids and ceramides, are linked to atrial fibrillation, a common heart rhythm problem. Researchers will compare blood samples from people with atrial fibrillation to those with other heart conditions but no a…

This study checks whether a free smartphone app called PhysioMaster can reliably measure posture and range of motion in people who have had a stroke. Researchers will compare the app's measurements to those from standard tools like the universal goniometer. Sixty stroke survivors…

This study is an early-stage trial to check the safety of a new drug called RO7763505. It involves 196 participants, first in healthy volunteers and then in people with stable coronary artery disease. The main goal is to see if the drug is safe and how the body processes it, not …

This study is looking at tiny molecules called microRNAs in the blood of children who have had a heart transplant. The goal is to find patterns that can predict which children are at risk for infection or rejection of the new heart. By understanding these patterns, doctors hope t…

This study surveys doctors who use the Liberant system to remove fresh blood clots from leg arteries and veins. About 50 patients aged 22 or older will be treated within 72 hours of their procedure. The goal is to confirm the device is safe and works as intended.

This study observes how core body temperature changes in adults who experience cardiac arrest outside the hospital. Researchers will measure temperature using a probe inserted into the esophagus during resuscitation and transport to the hospital. They will also track environmenta…

This study is a registry that tracks what happens when the HeartStart FRx, an automated external defibrillator (AED), is used on people suspected of having a cardiac arrest. The goal is to verify the device's safety and performance in real-world situations, such as whether it acc…

This observational study will analyze medical records from over 52,000 people with ATTR amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers want to learn about patients' symptoms, treatments, and outcomes in everyday medical practice. No new treatm…

This study tests a special toilet device that automatically measures urine and stool output in hospital patients. About 54 adults receiving stem cell transplants will use the device during their stay. The goal is to see if the device is as accurate as nurses manually measuring ou…

This study looks at whether using a special heart ultrasound (called TEE) during emergencies helps doctors make better decisions and improves patient outcomes. Researchers will track 1,000 critically ill adults in the ER or ICU who receive this test as part of their care. The goa…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study explores whether a measure called perfusion index (PI), taken from a pulse oximeter on the ear, finger, or toe, can reliably predict changes in blood pressure in people with spinal cord injury (SCI) during a cool temperature challenge. Participants with SCI and healthy…

This study is looking at whether advanced heart imaging, especially cardiac MRI, can help identify the cause of cardiomyopathy and predict risks like death or heart failure in a diverse group of patients. The research focuses on adults in the Bronx, including many from Hispanic a…

This study looks at whether a simple, non-invasive measure called the perfusion index (PI) can predict a sudden drop in blood pressure (hypotension) that often happens during spinal anesthesia for knee surgery. The PI, measured with a standard pulse oximeter on the finger, reflec…

This study aims to understand why some people with heart failure respond well to standard guideline-directed medical therapy while others do not. By analyzing genetic data and biomarkers from a large biobank of 5,000 patients, researchers hope to identify predictors of treatment …

This study aims to learn more about rare disorders that affect how the body processes chemicals called pyrimidines and purines. These disorders can cause problems in the brain, blood, kidneys, and immune system, ranging from mild to life-threatening. Researchers will compare test…

This study looks at whether giving antibiotics for just 24 hours around the time of placing a special antibiotic-coated brain drain works as well as giving them for the whole time the drain is in place. The goal is to find the best way to prevent serious brain infections in peopl…

This study is building a large online registry of US adults who experience sinus, ear, dizziness, and headache symptoms, with or without a migraine diagnosis. Participants answer questions about their symptoms, how these affect daily life, and which treatments they have tried. Th…

This study looks at whether advanced imaging can detect a hidden heart condition called cardiac amyloidosis in people with severe aortic valve stenosis. The condition can complicate treatment and recovery. Researchers will use echocardiography, CT, and SPECT/CT scans to check for…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study looks at whether tyrosine kinase inhibitors (TKIs), the standard treatment for chronic myeloid leukemia (CML), might be linked to erectile dysfunction (ED) in men. Researchers will track 350 male patients who started TKI therapy, using questionnaires and medical record…

This study creates a global registry for people with mitochondrial disorders—rare diseases that affect energy production in cells. By collecting health data from 6,000 participants worldwide, researchers aim to understand how these diseases progress and identify the best ways to …

This study works with Black churches in Washington, D.C. to understand heart health risks like obesity, high blood pressure, and diabetes. About 200 adults will get a health exam, wear an activity monitor for a month, and answer health questions. The results will help design a fu…

This study aims to find out how often exocrine pancreatic insufficiency (EPI) occurs in people with Alagille syndrome who have had a liver transplant. About 30 participants aged 7 to 50 will eat a high-fat diet and collect stool samples for lab testing. The results will help doct…

This study is testing whether a special MRI technique, called 4D Flow MRI, can better detect and predict the growth of unruptured brain aneurysms. Researchers will follow adults with these aneurysms, using the advanced imaging to measure changes in the aneurysm's shape over time.…

This study watches people with blood cancers like CLL who take BTK inhibitors or venetoclax to see how these drugs affect heart rhythm. Researchers will use EKGs, stress tests, and heart monitors to track abnormal rhythms and sudden death risk. The goal is to better understand an…

This study looks at how blood pressure changes when standing affect thinking and brain blood flow in people with Parkinson's disease. About 60 participants, with and without orthostatic hypotension (low blood pressure on standing), will take thinking tests while lying down and st…

This study looks at how the body's innate immune system responds to certain environmental exposures by measuring inflammation markers in blood. Researchers will collect blood samples from up to 725 healthy volunteers aged 18-45 to analyze how specific genes and proteins react. Th…

This study looks at whether measuring the heart's 'reserve'—its ability to pump harder under stress—can predict how patients with advanced heart failure will do. Five patients with weak hearts (ejection fraction 40% or less) will be randomly assigned to receive the drug milrinone…

This study investigates whether high-resolution MRI can identify dangerous plaque features in the middle cerebral artery that might predict a second stroke. Researchers will follow 75 patients who had a first stroke due to significant narrowing of this artery, tracking which plaq…

This study tests a brochure called ASQ-CT that helps patients ask their doctors better questions about clinical trials. About 293 adults with cancer, heart disease, or neurological conditions will use the brochure before a doctor visit. Researchers want to see if it makes patient…

This trial is testing a medical device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works and its safety in people. Participants will be monitored closely, but the device is not yet proven to treat or cure any condition.

This study looks at adults with spinal deformity to understand which factors—like pain, daily functioning, mental health, and frailty—most influence quality of life. It follows 320 people receiving either conservative care, first-time corrective surgery, or a reoperation, using q…

This study looks back at medical records of 105 people who had a minimally invasive surgery called BEVAR to treat complex aortic aneurysms. Researchers want to see if two types of stent grafts (TUVA BX and iCover) are safe and work well. No new treatments are given; the study jus…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This natural history study aims to collect data from 1,200 people with lymphatic anomalies—rare conditions affecting the body's lymph system—over many years. Researchers will track symptoms, perform genetic testing, and gather biospecimens to better understand why these condition…

This study follows 1,000 adults with myotonic dystrophy type 1 (DM1) over time to measure how the disease progresses. Researchers will track walking speed, hand muscle relaxation, grip strength, heart and lung function, and daily activity. The goal is to establish reliable biomar…

This pilot study tests whether a special MRI technique can measure wall shear stress—the force of blood against vein walls—in the pulmonary veins of infants. These veins carry blood from the lungs to the heart, and narrowing them (pulmonary vein stenosis) is a life-threatening co…

This study follows adults who have had a stroke caused by a blockage in a medium-sized blood vessel in the brain. Researchers will track the treatments patients receive and their recovery over time. The goal is to learn which approaches work best in everyday practice, helping doc…

This study follows 30,000 people in Korea who experienced cardiac arrest outside a hospital, tracking their survival and brain function for up to six months. The goal is to understand the factors that influence outcomes, which could help improve emergency care and resuscitation p…

This study will compare two types of heart-lung machines used during coronary bypass surgery to see how they affect blood flow to the brain. Researchers will measure brain pressure using an eye ultrasound and brain oxygen levels with a forehead sensor in 70 patients. The goal is …

This study uses a special eye imaging technique called OCT angiography to look at tiny blood vessels in the retina of people with diabetic retinopathy. Researchers will measure vessel density and other vascular features, then check whether these relate to visual sharpness and blo…

This study aims to learn how type 2 diabetes and obesity in young people affect heart and blood vessel health over time. About 930 participants aged 12 to 25, including those with diabetes, overweight but not diabetic, and healthy lean individuals, will be followed for up to 25 y…

This study aims to create an artificial intelligence (AI) model that can predict complications in children who have a common heart defect called a ventricular septal defect (VSD) repaired with a catheter-based procedure. Researchers will analyze data from over 5,000 children's me…

This study is for breast cancer patients receiving certain chemotherapies that can harm the heart. Researchers want to see if a genetic marker called TRPC6 can predict who will develop heart problems. By analyzing blood samples, they hope to find early warning signs and ways to p…

This study looks at whether stopping certain blood pressure medications (ACE inhibitors or ARBs) before colorectal cancer surgery can reduce the risk of heart injury. Researchers will monitor 156 adults for signs of heart damage after surgery. The goal is to find the safest way t…

This study aims to gather crucial information about stroke in Uganda, where the disease is on the rise. Researchers will look at how common stroke is, what factors increase the risk, and how it affects people's quality of life. The goal is to identify what rehabilitation support …

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study follows about 50 members of a family with a rare inherited condition called familial hypereosinophilia, where high levels of a type of white blood cell can damage the heart and nerves. Researchers will track participants over many years with yearly checkups, blood test…

This study compares people who have had a mitral valve procedure for mitral stenosis with healthy volunteers. Researchers will measure exercise capacity, muscle oxygen levels, and artery stiffness to understand long-term effects. The goal is to gather knowledge that may improve f…

This study collects information from trauma patients who experienced cardiac arrest due to injury. Researchers will review medical records to see how different pre-hospital treatments, like breathing tubes or medications, relate to survival. The goal is to find patterns that coul…

This study looks back at medical records of 100 older adults (60+) who had hip surgery after an injury. Researchers want to see if a simple frailty score or standard heart tests better predict who will have complications or die after surgery. The goal is to find better ways to as…

This study looks at how well a rapid blood test called TEG 6s measures clotting in healthy children. About 125 kids having planned surgery will give a small blood sample for the test. The goal is to find normal values for children and compare them to existing ranges. No treatment…