Can a new injection slow pulmonary arterial hypertension?
NCT ID NCT07143448
First seen Aug 17, 2026 ยท Last updated Aug 17, 2026
Summary
This trial is testing an experimental drug called HS235, given as a shot under the skin, in adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and can strain the heart. The study aims to see if adding HS235 to standard PAH treatments is safe and helps improve how well patients function. About 90 adults will be randomly assigned to receive either HS235 or a placebo, with different doses being evaluated. The main focus is on safety and how the drug affects the body, with the hope that it may offer a new way to manage this serious disease.
What this could mean
Our plain-language read of the trial. This is informational only โ not medical advice or a prediction.
- Active substance
- HS235, an experimental activin signaling inhibitor given as a subcutaneous injection
- What this could lead to
- If successful, HS235 could offer a new add-on treatment to help manage pulmonary arterial hypertension, potentially improving exercise capacity and slowing disease progression.
- What could go wrong
- This is an early-phase trial with a small number of participants, so safety and effectiveness are not yet established. The drug may not work better than placebo, and side effects are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PULMONARY ARTERIAL HYPERTENSION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Investigational Site-102
RECRUITINGTampa, Florida, 33620, United States
-
Investigational Site-305
RECRUITINGBarcelona, 08035, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new pill ease the strain of pulmonary arterial hypertension?
- Could a gut bacteria transplant ease a rare lung disease?
- Can a diabetes drug help the heart burn fuel better in pulmonary hypertension?
- Can a smartwatch replace the clinic walk test for lung disease patients?
- Blood particles may reveal hidden clues to scleroderma complications
- Heart scans may soon replace Needle-Based catheter tests