Can a new injection slow pulmonary arterial hypertension?

NCT ID NCT07143448

First seen Aug 17, 2026 ยท Last updated Aug 17, 2026

Summary

This trial is testing an experimental drug called HS235, given as a shot under the skin, in adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and can strain the heart. The study aims to see if adding HS235 to standard PAH treatments is safe and helps improve how well patients function. About 90 adults will be randomly assigned to receive either HS235 or a placebo, with different doses being evaluated. The main focus is on safety and how the drug affects the body, with the hope that it may offer a new way to manage this serious disease.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
HS235, an experimental activin signaling inhibitor given as a subcutaneous injection
What this could lead to
If successful, HS235 could offer a new add-on treatment to help manage pulmonary arterial hypertension, potentially improving exercise capacity and slowing disease progression.
What could go wrong
This is an early-phase trial with a small number of participants, so safety and effectiveness are not yet established. The drug may not work better than placebo, and side effects are unknown.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Investigational Site-102

    RECRUITING

    Tampa, Florida, 33620, United States

  • Investigational Site-305

    RECRUITING

    Barcelona, 08035, Spain

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