PULMONARY ARTERIAL HYPERTENSION

This study tests whether empagliflozin, a drug currently used for diabetes, can help people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe. About 72 adults will take either empagliflozin or a placebo daily f…

This study looks at whether spironolactone, a drug already used for fluid retention, can help people with pulmonary arterial hypertension (PAH) exercise longer and improve blood vessel function. About 70 adults with PAH will take either spironolactone or a placebo for 24 weeks. R…

This study tests the safety of a new inhaled drug called L608, which is being developed for pulmonary arterial hypertension (a type of high blood pressure in the lungs). It involves 32 healthy volunteers aged 18 to 65 who will receive either a single dose of L608 or a placebo. Th…

This study tests an experimental drug called IKT-001 for people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and move. The trial will compare IKT-001 to a placebo in 486 adults to see if it improves blood …

This study tests an experimental drug called APL-9796, given as injections under the skin, for people with pulmonary hypertension (high blood pressure in the lungs). The trial will include up to 48 adults and aims to check the drug's safety, how well it works, and whether the bod…

This early study tests a small device called the V-Wave shunt in 20 people with severe pulmonary arterial hypertension (PAH). The shunt is placed in the heart to relieve pressure on the right side. The main goal is to check safety and see if it might improve symptoms and exercise…

This study tests a medicine called sotatercept in 42 children aged 1 to 17 who have pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to pump blood. The goal is to see if the drug is safe and how the body processes it over 24 weeks. All children w…

This study tests a new device for people with pulmonary hypertension and right heart dysfunction. The device is implanted to help blood flow better in the lungs. About 30 adults will take part to see if it is safe and works well. The goal is to improve symptoms and heart function…

This study tests whether valsartan, a drug already used for high blood pressure, can help people with pulmonary arterial hypertension (PAH). About 60 adults with PAH will receive either valsartan or a placebo for 24 weeks. Researchers will measure how far they can walk in six min…

This study gives continued access to the inhaled drug TPIP for people with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (PH-ILD). Only those who finished earlier open-label studies of TPIP can join. The goal is to keep provid…

This study looks at the long-term safety of the medicine sotatercept when added to standard treatments for pulmonary arterial hypertension (PAH), a condition where lung blood vessels narrow, making breathing and activity difficult. About 815 adults who completed earlier sotaterce…

This study tests a drug called sotatercept in 20 adults with pulmonary arterial hypertension (PAH), a disease that strains the right side of the heart. Unlike standard treatments that only widen blood vessels, sotatercept targets the root cause by helping reverse blood vessel thi…

This study tests a new type of PET scan that uses a special tracer to see if it can detect early signs of pulmonary arterial hypertension (PAH), a serious lung blood vessel disease. PAH is often diagnosed late, leading to worse outcomes. The study will involve 71 adults with or a…

This study is testing whether a special MRI that uses xenon gas (129Xe MRI) can better diagnose and track pulmonary arterial hypertension (PAH), a serious lung condition. About 20 adults with PAH will get this MRI along with standard tests like blood work and a 6-minute walk. The…

This study looks at whether starting a 12-week home exercise program soon after diagnosis can improve how far people with pulmonary hypertension can walk and how they feel mentally and emotionally. About 40 adults will either start exercise right away or wait a few months, so res…

This study tests whether a mobile health program can help adolescents with pulmonary arterial hypertension increase their daily step count. Participants aged 10-21 will use a Fitbit and receive remote coaching to encourage more physical activity. The goal is to see if this approa…

This study tests whether a 12-week group exercise program can improve exercise capacity, quality of life, and daily activity in adults with pulmonary arterial hypertension (PAH), a rare disease that narrows lung arteries and makes breathing hard. Researchers will enroll 20 stable…

This study looks at how long it takes for people with pulmonary arterial hypertension (PAH) to get a correct diagnosis after their first symptoms appear. Researchers will review medical records from 139 adults in Brazil to find out what causes delays, such as seeing many differen…

This study looks at what happens when people with pulmonary arterial hypertension (PAH) switch from one medication (ambrisentan) to another (bosentan). Researchers will track 121 adults to see if their risk scores improve, worsen, or stay the same 3 to 6 months after the switch. …

This study tests whether a special type of MRI, using inhaled xenon gas, can show how well the drug sotatercept is working in people with pulmonary arterial hypertension (PAH). PAH is a serious condition where blood vessels in the lungs narrow, making the heart work harder. The s…

This study looks at how genes influence the risk of pulmonary hypertension, a serious lung condition. Researchers aim to enroll 10,000 adults in the US, with or without the disease. Participants complete online health surveys and provide a saliva sample by mail. The goal is to fi…

This study aims to find genes that may increase the risk of developing pulmonary arterial hypertension (PAH) in people born with heart defects like atrial or ventricular septal defects. Researchers will test blood samples from 21 participants to look for known and new gene mutati…

This study is a large national registry that collects information from 3,000 people with pulmonary hypertension (high blood pressure in the lungs) at specialized centers across the U.S. Researchers track how patients are diagnosed, what treatments they receive, and how their heal…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already taking these drugs as part of their regular care, or have had a recent CO…

This early-stage study tests whether transplanting gut bacteria from healthy donors is safe and possible for people with pulmonary arterial hypertension (PAH). 24 adults with PAH will receive either the bacteria transplant plus fiber, the transplant alone, or a placebo. Researche…

This study aims to find a noninvasive way to detect changes in lung blood vessels in people with a type of pulmonary hypertension (Group 3 PH) caused by lung diseases like COPD or interstitial lung disease. Researchers will use a special MRI technique (hyperpolarized 129Xe MRI) t…