New inhaled drug shows promise for Long-Term control of rare lung disease

NCT ID NCT06274801

Recruiting now Disease control Sponsor: Gossamer Bio USA, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This study looks at the long-term safety of an inhaled medication called seralutinib for people with pulmonary arterial hypertension (PAH), a serious condition where high blood pressure damages the arteries in the lungs. About 316 participants who finished a previous seralutinib trial will continue taking the drug via an inhaler. Researchers will track side effects and measure changes in walking distance and heart stress markers over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: seralutinib (inhaled powder)
What this could lead to: If successful, this could confirm seralutinib as a safe long-term treatment option for pulmonary arterial hypertension, potentially improving exercise capacity and heart function.
What could go wrong: This is an open-label extension with no placebo group, so results may be less reliable. Side effects are still being monitored, and the drug may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

pulmonary arterial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY ARTERIAL HYPERTENSION

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

"Evangelismos" General Hospital of Athens, 1st Department of Clinical Care and Pulmonary Hypertension Clinic
RECRUITING

Athens, Greece
"Niculae Stancioiu" Emergency Heart Institute for Cardiovascular Diseases, Cardiology 1 Department
RECRUITING

Cluj-Napoca, Romania
A.O.U. Policlinico Umberto I
RECRUITING

Roma, Italy
AHEPA University General Hospital of Thessaloniki, 1st Cardiology Clinic
RECRUITING

Thessaloniki, Greece
ATTIKON University Hospital, 2nd Critical Care Department
RECRUITING

Athens, Greece
Aarhus Universiteshospital
RECRUITING

Aarhus, Denmark
Amsterdam UMC, location VU mc
COMPLETED

Amsterdam, Netherlands
Asan Medical Center
RECRUITING

Seoul, South Korea
Azienda Ospedaliera Dei Colli - Ospedale Monaldi
RECRUITING

Naples, Italy
CHI St. Luke's Health Baylor College of Medicine Medical Center
RECRUITING

Houston, Texas, 77030, United States
CHU Bicetre, Service de Pneumologie et Reanimation Respiratorie
RECRUITING

Le Kremlin-Bicêtre, France
CHU de Nice - Hopital Pasteur
COMPLETED

Nice, France
CHU de Poitiers
RECRUITING

Poitiers, France
Cardiologia Palermo
RECRUITING

Buenos Aires, Argentina
Centre Hospitalier REgional Universitaire de Lille Hopital Cardiologique - Institut Coeur Poumon Service de Cardiologie
RECRUITING

Lille, France
Centro de Investigacion Clinica UC-CICUC
RECRUITING

Santiago, Chile
Complexo de Prevencao, Diagnostico, Terapia e Reabilitacao Respiratoria - Hospital Dia di Pulmao
RECRUITING

Blumenau, Brazil
Department of Veterans Affairs Greater Los Angeles Healthcare System
RECRUITING

Los Angeles, California, 90073, United States
Enroll SpA
RECRUITING

Santiago, Chile
Erasmus MC
WITHDRAWN

Rotterdam, Netherlands
Europejskie Centrum Zdrowia Otwock Sp.zo.o. Szpital im. Fryderyka Chopina Oddzial Kardiologiczny
RECRUITING

Otwock, Poland
Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, Italy
Freeman Hospital
RECRUITING

Newcastle, United Kingdom
Fundacion Abood Shaio
RECRUITING

Bogotá, Colombia
Fundacion Neumologica Colombiana
RECRUITING

Bogotá, Colombia
Golden Jubilee National Hospital
RECRUITING

Clydebank, United Kingdom
Hammersmith Hospital
COMPLETED

London, United Kingdom
Hopital Erasme
WITHDRAWN

Anderlecht, Belgium
Hospital Clinic I Provincial
RECRUITING

Barcelona, Spain
Hospital Provincial Dr. Jose Maria Cullen
RECRUITING

Santa Fe, Argentina
Hospital Universitario 12 De Octubre
RECRUITING

Madrid, Spain
Hospital Universitario Marques de Valdecilla
RECRUITING

Santander, Spain
Hospital Universitario Virgen del Rocio
COMPLETED

Seville, Spain
Hospital Universitario de Toledo
COMPLETED

Toledo, Spain
Hospital of Lithuanian University of Health Sciences Kauno klinikos
RECRUITING

Kaunas, Lithuania
Houston Methodist Outpatient Center
COMPLETED

Houston, Texas, 77030, United States
INTEGRIS Cardiovascular Physicians
ACTIVE_NOT_RECRUITING

Oklahoma City, Oklahoma, 73112, United States
IRCCS Azienda Ospedaliero Universitaria Di Bologna - Policlinico S. Orsola-Malpighi - UOC Cardiologia
RECRUITING

Bologna, Italy
Inova Fairfax Medical Campus
RECRUITING

Falls Church, Virginia, 22042, United States
Institut klinicke a experimentalni mediciny Klinika kardiologie Ambulance plicni hypertenze
RECRUITING

Prague, Czechia
Instituto Medico Rio Cuarto
RECRUITING

Río Cuarto, Argentina
Instituto Nacional de Cardiologia Ignacio Chavez
RECRUITING

Mexico City, Mexico
Instituto das Pequenas Missionarias de Maria Imaculada - Hospital Madre Teresa
RECRUITING

Belo Horizonte, Brazil
Instituto de Cardiologia de Corrientes Juana Francisca Cabral
RECRUITING

Corrientes, Argentina
Instituto do Coracao do Hospital das Clinicas da Faculdade de medicina da Universidade de Sao Paulo
RECRUITING

São Paulo, Brazil
Institutul De Urgenta Pentru Boli Cardiovasculare Prof. Dr. C. C. Iliescu Cardiology 2
RECRUITING

Bucharest, Romania
Instuto de Investigacion Clinicas Quilmes
RECRUITING

Quilmes, Argentina
Intermountain Medical Center
RECRUITING

Murray, Utah, 84107, United States
Irmandade da Santa Casa de Misericórdia de Porto Alegre
RECRUITING

Porto Alegre, Brazil
Keio University Hospital
RECRUITING

Shinjuku-Ku, Japan
King Fahad Medical City
COMPLETED

Riyadh, Saudi Arabia
King Faisal Specialist Hospital and Research Center
COMPLETED

Riyadh, Saudi Arabia
Klinikum Würzburg Mitte gGmbH Medizinische Klinik mit Schwerpunkt Pneumologie und Beatmungsmedizin
RECRUITING

Würzburg, Germany
Klinikum der LMU Medizinische Klinik und Poliklinik V
RECRUITING

Munich, Germany
Krakowski Szpital Specjalistyczny Im. Sw. Jana Pawla II, Oddzial Kliniczny Chorob Serca i Naczyn z Pododdzialem Intensywnego Nadzoru Kardiologicznego
RECRUITING

Krakow, Poland
Krankenhaus Neuwittelsbach
RECRUITING

München, Germany
Kyorin University Hospital
RECRUITING

Mitaka, Japan
Kyushu University Hospital
RECRUITING

Fukuoka, Japan
Lady Davis Carmel Medical Center
RECRUITING

Haifa, Israel
London Health Sciences Centre - Victoria Hospital
RECRUITING

London, Canada
Mater Misericordiae University Hospital
RECRUITING

Dublin, Ireland
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Medical University of South Carolina - Nexus Research Center
RECRUITING

Charleston, South Carolina, 29425, United States
NHO Okayama Medical Center
RECRUITING

Okayama, Japan
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Nagoya University Hospital
RECRUITING

Nagoya, Japan
National Cerebral and Cardiovascular Center
RECRUITING

Suita, Japan
National Heart Centre Singapore
RECRUITING

Singapore, Singapore
National University Heart Centre
WITHDRAWN

Singapore, Singapore
Northside Hospital - Atlanta
RECRUITING

Atlanta, Georgia, 30342, United States
Norton Pulmonary Specialists
RECRUITING

Louisville, Kentucky, 40202, United States
Nucleo de Gestao de Pesquisa/Hospital Sao Paulo - SPDM/UNIFESP
ACTIVE_NOT_RECRUITING

São Paulo, Brazil
Onassis Cardiac Surgery Center, Non-Invasive Cardiology Department
COMPLETED

Kallithea, Greece
Pauls Stradins Clinical University Hospital
RECRUITING

Riga, Latvia
Peter Lougheed Center
RECRUITING

Calgary, Canada
Piedmont Physicians Pulmonary & Sleep Medicine of Buckhead
RECRUITING

Atlanta, Georgia, 30309, United States
Pulmonary Associates of Richmond, Inc.
RECRUITING

Richmond, Virginia, 23230, United States
Pulmonary Hypertension Research Queensland
RECRUITING

Auchenflower, Australia
Royal Free Hospital, Clinical Research Facility
RECRUITING

London, United Kingdom
Royal Hallamshire Hospital
RECRUITING

Sheffield, United Kingdom
Royal Hobart Hospital
RECRUITING

Hobart, Australia
Royal Papworth Hospital NHS Foundation Trust
RECRUITING

Cambridge, United Kingdom
Samsung Medical Center
RECRUITING

Seoul, South Korea
Seoul National University Hospital
RECRUITING

Seoul, South Korea
Severance Hospital, Yonsei University Health System
WITHDRAWN

Seoul, South Korea
St Vincent's Hospital (Melbourne)
RECRUITING

Fitzroy, Australia
Stanford Healthcare
RECRUITING

Stanford, California, 94305, United States
Temple Heart and Vascular Institute (Outpatient Clinic)
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
The Emory Clinic
RECRUITING

Atlanta, Georgia, 30322, United States
The Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Thoraxklinik Heidelberg gGmbH am Universitätsklinikum Heidelberg Zentrum für pulmonale Hypertonie
RECRUITING

Heidelberg, Germany
UC Davis Health Medical Center
RECRUITING

Sacramento, California, 95817, United States
UI Health Hospital
RECRUITING

Chicago, Illinois, 60612, United States
UNC Hospitals
COMPLETED

Chapel Hill, North Carolina, 27514, United States
UPMC Presbyterian Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS
RECRUITING

Porto Alegre, Brazil
Unidad de Investigacion Clinica en Medicina, S.C.
RECRUITING

Monterrey, Mexico
Unidade Local de Saude de Santa Maria, E.P.E. Hospital Pulido Valente
RECRUITING

Lisbon, Portugal
Unidade Local de Saude de Santo Antonio, E.P.E. Hospital de Santo Antonio
RECRUITING

Porto, Portugal
Universitatsklinikum Giessen und Marburg GmbH Zentrum fur lnnere Medizin, Med. Klinik und Poliklinik II Studienambulanz fur Pulmonale Hypertonie
RECRUITING

Giessen, Germany
University Clinical Centre of Serbia, Cardiology Clinic
RECRUITING

Belgrade, Serbia
University Health Network, Toronto General Hospital
COMPLETED

Toronto, Canada
University Hospitals of Leuven (Campus Gasthuisberg)
RECRUITING

Leuven, Belgium
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Florida Health
RECRUITING

Gainesville, Florida, 32610, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of New Mexico Health Sciences Center
COMPLETED

Albuquerque, New Mexico, 87131, United States
University of Ottawa Heart Institute
ACTIVE_NOT_RECRUITING

Ottawa, Canada
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
University of Tokyo Hospital
RECRUITING

Bunkyō City, Japan
University of Utah Hospital
RECRUITING

Salt Lake City, Utah, 84132, United States
Universitätsklinikum Dresden, Medizinische Klinik I / Pneumologisches Studiensekretariat
WITHDRAWN

Dresden, Germany
Valley Advanced Lung Diseases Institute
RECRUITING

Fresno, California, 93720, United States
Všeobecná fakultní nemocnice v Praze ll. interní klinika kardiologie a angiologie VFN a 1.LF UK Centrum pro plicní hvpertenzi
RECRUITING

Prague, Czechia
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Zentrum fur Pulmonale Hypertonie, Klinik Ill fur lnnere Medizin (Kardiologie, Pneumologie, lnternistische lntensivmedizin), Herzzentrum der Universitat zu Koln
RECRUITING

Cologne, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.