New drug hope for kids with rare lung disease
NCT ID NCT05587712
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a drug called sotatercept in 42 children aged 1 to 18 who have pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work too hard. The drug is given as a shot every 3 weeks, and the main goal is to see if it is safe and how the body processes it. Researchers will also check if it helps children walk farther and improves heart function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sotatercept (a drug given as an injection under the skin every 3 weeks)
- What this could lead to
- If it works, this could provide a new treatment option for children with pulmonary arterial hypertension, helping control the disease and improve daily life.
- What could go wrong
- This is an early phase 2 study with only 42 children, so results may not apply to all patients. The drug may cause side effects or not work better than current treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PULMONARY ARTERIAL HYPERTENSION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Ankara Bilkent Şehir Hastanesi. ( Site 1403)
RECRUITINGAnkara, 06800, Turkey (Türkiye)
Contact Phone: •••-•••-••••
-
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone ( Site 0303)
RECRUITINGMarseille, Provence-Alpes-Côte d'Azur Region, 13005, France
Contact Phone: •••-•••-••••
-
CHU de Toulouse - Hôpital des Enfants ( Site 0302)
RECRUITINGToulouse, Haute-Garonne, 31059, France
Contact Phone: •••-•••-••••
-
Centrum Zdrowia Dziecka w Warszawie-Klinika Kardiologii ( Site 1103)
RECRUITINGWarsaw, Masovian Voivodeship, 04-730, Poland
Contact Phone: •••-•••-••••
-
Children's Hospital Colorado ( Site 1609)
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-••••
-
Children's Hospital of Philadelphia (CHOP) ( Site 1608)
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-••••
-
Children's National Medical Center ( Site 1600)
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Phone: •••-•••-••••
-
Children's Wisconsin ( Site 1610)
RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact Phone: •••-•••-••••
-
Cincinnati Children's Hospital Medical Center ( Site 1602)
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Phone: •••-•••-••••
-
Clinica Somer-Unidad de Investigacion y Docencia ( Site 0205)
RECRUITINGRionegro, Antioquia, 054040, Colombia
Contact Phone: •••-•••-••••
-
Clínica Imbanaco S.A.S ( Site 0203)
RECRUITINGCali, Valle del Cauca Department, 760042, Colombia
Contact Phone: •••-•••-••••
-
Fundación Valle del Lili ( Site 0200)
RECRUITINGCali, Valle del Cauca Department, 760032, Colombia
Contact Phone: •••-•••-••••
-
Gazi University Health Research and Application Center Gazi -Çocuk Sağlığı ve Hastalıkları Anabilim ( Site 1402)
RECRUITINGAnkara, 06560, Turkey (Türkiye)
Contact Phone: •••-•••-••••
-
Great Ormond Street Hospital For Children NHS Foundation Trust ( Site 1500)
RECRUITINGLondon, London, City of, WC1N 3JH, United Kingdom
Contact Phone: •••-•••-••••
-
HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 1301)
RECRUITINGMadrid, 28007, Spain
Contact Phone: •••-•••-••••
-
Hacettepe Universite Hastaneleri ( Site 1400)
RECRUITINGAnkara, 06100, Turkey (Türkiye)
Contact Phone: •••-•••-••••
-
Hospital Universitari Vall d'Hebron ( Site 1302)
RECRUITINGBarcelona, 08035, Spain
Contact Phone: •••-•••-••••
-
Hospital Universitari i Politecnic La Fe ( Site 1303)
RECRUITINGValencia, Valencia, 46026, Spain
Contact Phone: •••-•••-••••
-
Hospital Universitario Ramón y Cajal ( Site 1300)
RECRUITINGMadrid, Madrid, Comunidad de, 28034, Spain
Contact Phone: •••-•••-••••
-
Hôpital Universitaire Necker Enfants Malades ( Site 0300)
RECRUITINGParis, 75015, France
Contact Phone: •••-•••-••••
-
Klinikum der Universität München Großhadern ( Site 0404)
RECRUITINGMünchen, Bavaria, 81337, Germany
Contact Phone: •••-•••-••••
-
Medizinische Hochschule Hannover ( Site 0405)
RECRUITINGHanover, Lower Saxony, 30625, Germany
Contact Phone: •••-•••-••••
-
Mehmet Akif Ersoy Research and Training Hospital ( Site 1404)
RECRUITINGIstanbul, 34303, Turkey (Türkiye)
Contact Phone: •••-•••-••••
-
Monroe Carell Jr. Children's Hospital ( Site 1601)
COMPLETEDNashville, Tennessee, 37232, United States
-
Schneider Children's Medical Center ( Site 0603)
RECRUITINGPetah Tikva, 4920235, Israel
Contact Phone: •••-•••-••••
-
Seattle Children's Hospital ( Site 1605)
RECRUITINGSeattle, Washington, 98105, United States
Contact Phone: •••-•••-••••
-
Sheba Medical Center ( Site 0601)
RECRUITINGRamat Gan, 5265601, Israel
Contact Phone: •••-•••-••••
-
Stanford University School of Medicine ( Site 1603)
RECRUITINGPalo Alto, California, 94304, United States
Contact Phone: •••-•••-••••
-
The Children's Hospital at Westmead ( Site 0001)
RECRUITINGWestmead, New South Wales, 2145, Australia
Contact Phone: •••-•••-••••
-
The Regents of the University of California - Los Angeles (UCLA Pediatrics) ( Site 1606)
RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-••••
-
UCSF Benioff Children's Hospital San Francisco ( Site 1611)
RECRUITINGSan Francisco, California, 94158, United States
Contact Phone: •••-•••-••••
-
Universitaetsklinikum Heidelberg ( Site 0401)
RECRUITINGHeidelberg, Baden-Wurttemberg, 69120, Germany
Contact Phone: •••-•••-••••
-
University Medical Center Groningen ( Site 0900)
RECRUITINGGroningen, 9713 GZ, Netherlands
Contact Phone: •••-•••-••••
-
Uniwersyteckie Centrum Kliniczne-Klinika Kardiologii Dziecięcej i Wad Wrodzonych Serca ( Site 1102)
RECRUITINGGdansk, Pomeranian Voivodeship, 80-952, Poland
Contact Phone: •••-•••-••••
-
Wits Clinical Research-Chris Hani Baragwanath Hospital ( Site 1201)
RECRUITINGJohannesburg, Soweto, Gauteng, 2013, South Africa
Contact Phone: •••-•••-••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Blood particles may reveal hidden clues to scleroderma complications
- Heart scans may soon replace Needle-Based catheter tests
- Could a new drug free PAH patients from daily pump therapy?
- Could pedaling backward help heart and lung patients get stronger?
- New drug aims to help lungs and heart work better during exercise
- Heart scans could spare patients from invasive catheter procedures