PULMONARY ARTERIAL HYPERTENSION

This study tested the safety of a fully implantable pump system designed to deliver medication directly into the bloodstream for people with pulmonary arterial hypertension (PAH). The system aimed to provide more convenient, long-term treatment while reducing infection risks comp…

This study continues testing ralinepag, an experimental medication for pulmonary arterial hypertension (PAH), to understand its long-term safety and effectiveness. It enrolls 1,000 participants who have already taken ralinepag in previous studies and are already on standard PAH m…

This study is testing if starting a specific medication called treprostinil early and increasing the dose quickly can improve heart function and potentially reverse heart damage in people with pulmonary arterial hypertension (PAH). It will involve about 52 participants who are al…

This study aims to find the right dose of the medication selexipag for children with pulmonary arterial hypertension (PAH), a serious lung and heart condition. It will test the drug's safety and how it moves through the body in about 60 children aged 2 to 18. The goal is to contr…

This study is testing whether a specific diet and exercise program can help people with pulmonary arterial hypertension (PAH) by improving how their bodies process sugar. Researchers enrolled 34 adults with PAH to see if these lifestyle changes can reduce strain on the heart and …

This study is testing if a higher dose (75 mg) of the drug macitentan is better than the standard dose (10 mg) at delaying serious health problems or death in adults with pulmonary arterial hypertension (PAH). About 935 participants with symptomatic PAH will be randomly assigned …

This study continues monitoring patients with pulmonary arterial hypertension who previously took the inhaled medication GB002. Researchers want to understand the long-term safety and whether the drug continues to help patients walk farther. The study includes 74 people who compl…

This study follows patients with pulmonary arterial hypertension (PAH) who continue taking an experimental inhaled powder medication called treprostinil palmitil. The main goal is to check the long-term safety and side effects of this treatment. Researchers will also monitor whet…

This study is testing whether the drug sotatercept, taken for 36 weeks, improves how the heart and lungs work together during exercise in people with pulmonary arterial hypertension. Researchers will measure heart function, blood flow, and oxygen delivery in 30 participants while…

This study continues testing an inhaled medication called seralutinib for people with pulmonary arterial hypertension (PAH) who completed earlier trials. It aims to understand the long-term safety and effectiveness of this treatment. The study will monitor patients' ability to wa…

This study is testing the safety and side effects of an inhaled medication called L606 for adults with pulmonary hypertension, a serious condition where blood pressure is too high in the lungs. The trial follows 28 patients for up to a year to see how well they tolerate switching…

This study continues testing sotatercept, an investigational medicine for pulmonary arterial hypertension (PAH), to check its long-term safety when given in weight-based doses. It's open only to people who completed a previous trial of this drug and haven't started commercial tre…

This early-stage study is testing a new drug, PF-07868489, to see if it is safe and how it works in the body. First, healthy volunteers receive a single dose. Then, people with pulmonary arterial hypertension (PAH), a serious condition of high blood pressure in the lungs, receive…

This study is testing if a medication called empagliflozin, already used for diabetes and heart failure, can help improve heart function in people with pulmonary arterial hypertension (PAH). About 78 adults with PAH who are already on stable treatment will take either the drug or…

This study is testing whether a drug called satralizumab can help patients with pulmonary arterial hypertension (PAH) who haven't responded well to current treatments. It will involve about 20 patients in Japan who have a specific immune-related profile. The main goal is to see i…

This study is testing whether an investigational drug called CS1 can improve the structure and function of small blood vessels in the lungs of people with pulmonary arterial hypertension (PAH). It uses a special, non-invasive imaging scan to see if long-term use of CS1 leads to p…

This study is testing whether a 12-week program of simple, low-resistance exercises done at home is safe and can help improve daily life and physical ability for people with pulmonary arterial hypertension (PAH), a serious lung condition. Researchers are enrolling 20 adults with …

This study aimed to test if a simple, non-invasive finger cuff device could accurately measure how well the heart is pumping in patients with severe lung blood pressure conditions (PAH or CTEPH). Researchers planned to compare the finger cuff readings against standard, more invas…

This study aims to create a new, more precise understanding of pulmonary hypertension, a condition affecting blood vessels in the lungs. Researchers are collecting a wide range of detailed health data from about 1,200 adults to identify patterns and potential markers of the disea…

This study aims to understand if and how pulmonary arterial hypertension (PAH), a rare lung and heart disease, affects memory, attention, and other thinking skills. Researchers will compare computer-based thinking tests from about 30 people with PAH to tests from a similar group …