New drug candidate targets Hard-to-Treat lung condition
NCT ID NCT06137742
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage study by Pfizer tests a new drug called PF-07868489. First, it will be given to healthy volunteers to check safety and how the body processes it. Then, people with pulmonary arterial hypertension (PAH) will receive repeated doses over 24 weeks to see if it helps their condition. The main goal is safety, but researchers will also measure effects on blood pressure in the lungs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PF-07868489
What this could lead to
If it works, this could point toward a new treatment option for pulmonary arterial hypertension, a serious lung condition.
What could go wrong
This is a very early Phase 1/2 trial with only 97 participants. The drug may not prove safe or effective, and side effects are unknown.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AHEPA University General Hospital of Thessaloniki
Thessaloniki, Central Macedonia, 54636, Greece
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Anaheim Clinical Trials, LLC
Anaheim, California, 92801, United States
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CHRU de Brest
Brest, Finistère, 29200, France
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CHRU de Brest
Brest, Finistère, 29609, France
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Center for Advanced Lung Care
Providence, Rhode Island, 02904, United States
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Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord
Saint Priest En Jarez, Pays de la Loire Region, 42270, France
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Chu Grenoble Alpes
La Tronche, 38700, France
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Eastowne 100 Medical Office Building
Chapel Hill, North Carolina, 27514, United States
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Eastowne Medical Office Building - Clinical Research Unit
Chapel Hill, North Carolina, 27514, United States
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Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
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Fondazione IRCCS San Gerardo dei Tintori
Monza, Monza E Brianza, 20900, Italy
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Gachon University Gil Medical Center
Namdong-gu, Incheon-gwangyeoksi [incheon], 21565, South Korea
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Golden Jubilee National Hospital
Clydebank, G81 4DY, United Kingdom
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Guangdong Provincial People's Hospital
Guangzhou, Guangdong, 510080, China
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Hammersmith Hospital
London, London, CITY of, W12 0HS, United Kingdom
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario La Paz
Madrid, Madrid, Comunidad de, 28046, Spain
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Hospital Universitario Marqués de Valdecilla
Santander, Cantabria, 39008, Spain
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ISMETT Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
Palermo, 90127, Italy
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Icahn school of medicine at Mount Sinai
New York, New York, 10029, United States
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Institut Klinicke a Experimentalni Mediciny
Prague, 140 21, Czechia
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Investigational Drug Services Pharmacy
Morrisville, North Carolina, 27560, United States
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Kobe University Hospital
Kobe, Hyōgo, 650-0017, Japan
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London Health Sciences Centre - University Hospital
London, Ontario, N6G 2M3, Canada
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London Health Sciences Centre - Verspeeten Family Cancer Centre
London, Ontario, N6A 5W9, Canada
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Medical University of South Carolina - Nexus
Charleston, South Carolina, 29425, United States
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Medical University of South Carolina - Radiology
Charleston, South Carolina, 29425, United States
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Mount Sinai Hospital
New York, New York, 10029, United States
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National Hospital Organization Okayama Medical Center
Okayama, 701-1154, Japan
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Norton Hospital
Louisville, Kentucky, 40202, United States
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Norton Pulmonary Specialists
Louisville, Kentucky, 40202, United States
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Onassis Hospital
Kallithea, Attica, 17674, Greece
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Pulmonary Hypertension Research Queensland Pty Ltd
Auchenflower, Queensland, 4066, Australia
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Rhode Island Hospital
Providence, Rhode Island, 02903, United States
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Royal Brompton Hospital
London, SW3 6NP, United Kingdom
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Royal Free London NHS Foundation Trust, Royal Free Hospital
London, NW3 2QG, United Kingdom
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Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050, Australia
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Samsung Medical Center
Seoul, Seoul-teukbyeolsi [seoul], 06351, South Korea
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Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea
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Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [seoul], 03722, South Korea
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Shanghai Pulmonary Hospital
Shanghai, Shanghai Municipality, 200433, China
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St. Marianna University Hospital
Kawasaki, Kanagawa, 216-8511, Japan
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The Second Xiangya Hospital of Central South University
Changsha, Hunan, 410011, China
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Thoraxklinik-Heidelberg gGmbH
Heidelberg, Baden-Wurttemberg, 69126, Germany
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Tohoku University Hospital
Sendai, Miyagi, 980-8574, Japan
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UC Davis Health Medical Center
Sacramento, California, 95817, United States
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UCI Health - Costa Mesa
Costa Mesa, California, 92627, United States
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UCI Health Center for Innovative Health Therapies (CIHT)
Orange, California, 92868, United States
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UCSF Health St. Mary's Hospital
San Francisco, California, 94117, United States
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UCSF Helen Diller Medical Center at Parnassus Heights
San Francisco, California, 94143, United States
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UKGM Gießen/Marburg
Giessen, Hesse, 35392, Germany
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UNC Health - Eastowne Medical Office
Chapel Hill, North Carolina, 27514, United States
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UNC Hospitals
Chapel Hill, North Carolina, 27514, United States
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UZ Leuven
Leuven, Vlaams-brabant, 3000, Belgium
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Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
Dresden, Saxony, 01307, Germany
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University General Hospital "ATTIKON" - General Hospital of West Attica "H AGIA VARVARA"
Chaïdári, Attikí, 12462, Greece
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University Of Alberta Hospital
Edmonton, Alberta, T6G 2B7, Canada
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University of California Davis Health
Sacramento, California, 95817, United States
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University of California, Irvine Medical Center
Orange, California, 92868, United States
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University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045, United States
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Universitätsklinikum Regensburg
Regensburg, Bavaria, 93053, Germany
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Universitätsmedizin Greifswald
Greifswald, Mecklenburg-Vorpommern, 17475, Germany
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Université Libre de Bruxelles - Hôpital Erasme
Brussels, Bruxelles-capitale, Région de, 1070, Belgium
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Vseobecna fakultni nemocnice v Praze
Prague, 12808, Czechia
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Wesley Research Institute
Auchenflower, Queensland, 4066, Australia
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Yokohama City University Hospital
Kanagawa, 236-0004, Japan
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Zhongda Hospital Southeast University
Nanjing, Jiangsu, 210009, China