New hope for PAH: rapid drug therapy aims to reverse heart damage
NCT ID NCT05203510
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether quickly starting and increasing a medication called treprostinil can lower blood pressure in the lungs and improve the heart's pumping ability in people with pulmonary arterial hypertension (PAH). The trial involves 52 adults with PAH and will measure changes in heart function over 12 months using MRI scans. The goal is to see if this approach can reverse damage to the right side of the heart.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Banner University Medical Center (University of Arizona)
Phoenix, Arizona, 85006, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Carilion Clinic
Roanoke, Virginia, 24014, United States
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
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Community Health Network
Indianapolis, Indiana, 46219, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Georgia Clinical Research
Austell, Georgia, 30106, United States
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Hartford Hospital
Hartford, Connecticut, 06106, United States
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Henry Ford Health System
Detroit, Michigan, 48202, United States
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HonorHealth John C. Lincoln Medical Center
Phoenix, Arizona, 85020, United States
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Indiana University Health North Hospital
Indianapolis, Indiana, 46202, United States
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Integris Baptist Medical Center
Oklahoma City, Oklahoma, 73112, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Morristown Medical Center
Morristown, New Jersey, 07960, United States
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Northwestern Memorial Hospital
Chicago, Illinois, 60611, United States
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Oklahoma Heart Institute
Tulsa, Oklahoma, 74104, United States
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Prisma Health
Greenville, South Carolina, 29605, United States
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Temple Hospital
Philadelphia, Pennsylvania, 19140, United States
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The Ohio State University Wexner Medical Center
Columbus, Ohio, 43210, United States
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USF
Tampa, Florida, 33606, United States
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of California Davis Medical Center
Sacramento, California, 95817, United States
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University of California San Francisco - Fresno
Fresno, California, 93701, United States
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University of California San Francisco Pulmonary, Critical Care, Allergy and Sleep Medicine
San Francisco, California, 94143, United States
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University of Cincinnati
Cincinnati, Ohio, 45267, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
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University of Rochester Medical Center
Rochester, New York, 14623, United States
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