PULMONARY ARTERIAL HYPERTENSION

This study tested whether adding a new drug called Sotatercept to existing treatments could help Japanese adults with pulmonary arterial hypertension (PAH), a serious condition where high blood pressure damages the lungs and heart. The 46 participants received Sotatercept injecti…

This study tested an inhaled drug called treprostinil in people with high blood pressure in their lungs caused by scarring lung disease. Researchers wanted to understand how the drug helps during exercise and affects quality of life after three months of use. The study involved 2…

This study tested whether a hormone called DHEA could improve heart function in people with pulmonary arterial hypertension (PAH), a serious condition causing high blood pressure in the lungs. Twenty-six participants took either DHEA or a placebo for 18 weeks, then switched, whil…

This Phase 3 study tested whether an inhaled drug called seralutinib could help adults with pulmonary arterial hypertension (PAH), a serious condition affecting blood vessels in the lungs and heart. The main goal was to see if the drug improved patients' ability to walk and delay…

This study tested whether a common heart medication, nitroglycerin, could be safely given as a mist to breathe in to relax tightened blood vessels in the lungs of people with pulmonary arterial hypertension. It involved 20 adult patients with this serious condition. The goal was …

This large, completed Phase 3 trial tested whether a new oral medication called selexipag could safely delay serious health events or death in adults with pulmonary arterial hypertension (PAH), a severe lung blood vessel disease. The study involved over 1,150 patients and compare…

This study tested a drug called macitentan in Japanese children with pulmonary arterial hypertension (PAH), a serious condition where high blood pressure damages the lungs and heart. The main goal was to see if taking the drug for 24 weeks improved how well the heart and lungs wo…

This study tested whether using portable oxygen during exercise helps people with serious lung blood vessel diseases walk farther. Forty Swiss patients with pulmonary hypertension walked for six minutes with and without oxygen to compare results. Researchers wanted to see if usin…

This study tested whether adding a new drug called ralinepag to standard treatments could help people with pulmonary arterial hypertension (PAH), a serious lung and heart condition. It involved 687 adults with PAH who were already on stable medication. The main goal was to see if…

This study tested two different ways to calculate the dose of a medication called sotatercept for people with pulmonary arterial hypertension (PAH), a serious lung disease. Researchers compared the standard weight-based dosing to a simpler weight-banded method in 164 participants…

This study tested whether adding the drug sotatercept to standard treatments could help people with severe pulmonary arterial hypertension (PAH), a life-threatening lung disease. It involved 173 participants with advanced PAH who were at high risk of death. Researchers compared s…

This study tested whether dapagliflozin, a medication typically used for diabetes, could help people with pulmonary arterial hypertension. Fifty-two patients with stable symptoms took either the drug or a placebo for several months while researchers measured their exercise capaci…

This study tested whether a procedure called pulmonary artery denervation (PADN), which disrupts nerves around the lung artery, could help people with pulmonary arterial hypertension (PAH). 128 adults with PAH were randomly assigned to receive either the real PADN procedure plus …

This study tested a medication called macitentan in children with pulmonary arterial hypertension (PAH), a serious condition causing high blood pressure in the lungs. It compared the drug to standard care to see if it was safe, worked well in children's bodies, and could help con…

This study tested a new oral medication called ACT-293987 for adults with Pulmonary Arterial Hypertension (PAH), a serious condition causing high blood pressure in the lungs. It first checked the drug's immediate effects on heart and lung pressures, then gave it to some participa…

This study tested whether adding KER-012 injections to standard medications helps adults with pulmonary arterial hypertension, a serious condition where blood pressure is high in the lungs. 113 participants received either KER-012 or a placebo shot every 4 weeks for 24 weeks whil…

This study tested whether training the breathing muscles could help people with pulmonary hypertension feel better and be more active. Thirty-two patients with the condition were assigned to either do special breathing exercises or fake (sham) exercises for eight weeks. Researche…

This study tested a single inhaled dose of an experimental drug called RT234 in people with pulmonary arterial hypertension (PAH). The main goal was to see if the drug could safely improve how well participants could exercise and reduce their feeling of breathlessness during phys…

This study aimed to understand how a new drug for pulmonary arterial hypertension (BIA 5-1058) interacts with a common diuretic (furosemide) in the body. It involved 44 healthy volunteers who took both drugs separately and together to measure their levels in the blood. The goal w…

This study looked at whether long-term exposure to air pollution makes pregnancy more dangerous for women who already have high blood pressure in their lungs (pulmonary hypertension). Researchers analyzed medical records from 1,200 pregnant women with this condition to see if wor…

This small, early-stage study explored whether a nutritional supplement called carnitine could help the heart in people with pulmonary arterial hypertension (PAH), a serious lung condition. Researchers first checked how much carnitine people with PAH get from their diet, then gav…

This study aimed to understand how the body's own immune system might be involved in causing or worsening pulmonary arterial hypertension (PAH), a serious condition of high blood pressure in the lungs. Researchers compared blood samples from over 600 people, including patients wi…