Drug combo for lung disease gets safety check in healthy volunteers
NCT ID NCT07173738
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed Phase 1 study looked at how two drugs, BIA 5-1058 and furosemide, affect each other when taken together. 44 healthy adults received each drug alone and then together, under fasting conditions. The goal was to measure drug levels and safety, not to treat any disease. This information will help guide future studies for pulmonary arterial hypertension.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- BIA 5-1058 and furosemide
- What this could lead to
- If successful, this study will show how these two drugs interact, helping design safer combination treatments for pulmonary arterial hypertension.
- What could go wrong
- This is an early Phase 1 study in healthy people, not patients. It only measures drug levels and safety, not whether the combination actually helps treat the disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Simbec Research Ltd (Simbec)
Merthyr Tydfil, CF48 4DR, United Kingdom
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