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New hope for japanese PAH patients: sotatercept shows promise in phase 3 trial

NCT ID NCT05818137

Completed Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jan 17, 2026 · Last updated May 09, 2026 · Updated 26 times

Summary

This study tested a drug called sotatercept (MK-7962) added to standard therapy for 46 Japanese adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and move. The main goal was to see if the drug improves blood flow in the lungs and to check for side effects over 24 weeks. Results help confirm whether this add-on treatment is safe and effective for Japanese patients.

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Contacts and locations

Locations

  • Chiba Saiseikai Narashino hospital ( Site 2004)

    Narashino, Chiba, 275-8580, Japan

  • Chiba University Hospital ( Site 2003)

    Chiba, 260-8677, Japan

  • Hamamatsu University Hospital ( Site 2016)

    Hamamatsu, Shizuoka, 431-3192, Japan

  • Hokkaido University Hospital ( Site 2001)

    Sapporo, Hokkaido, 060-8648, Japan

  • International University of Health and Welfare Mita Hospital ( Site 2008)

    Tokyo, 108-8329, Japan

  • Keio university hospital ( Site 2007)

    Tokyo, 1608582, Japan

  • Kobe University Hospital ( Site 2012)

    Kobe, Hyōgo, 650-0017, Japan

  • Kure Kyosai Hospital ( Site 2017)

    Kure, Hiroshima, 7378505, Japan

  • Kurume University Hospital ( Site 2014)

    Kurume, Fukuoka, 830-0011, Japan

  • Kyorin University Hospital ( Site 2005)

    Mitaka, Tokyo, 181-8611, Japan

  • Kyushu University Hospital ( Site 2015)

    Fukuoka, 812-8582, Japan

  • Nagoya University Hospital ( Site 2010)

    Nagoya, Aichi-ken, 466-8560, Japan

  • National Cerebral and Cardiovascular Center ( Site 2011)

    Suita, Osaka, 564-8565, Japan

  • National Hospital Organization Okayama Medical Center ( Site 2013)

    Okayama, 701-1192, Japan

  • Sapporo Medical University Hospital ( Site 2018)

    Sapporo, Hokkaido, 060-8543, Japan

  • The University of Tokyo Hospital ( Site 2006)

    Bunkyo-ku, Tokyo, 113-8654, Japan

  • Tohoku University Hospital ( Site 2002)

    Sendai, Miyagi, 980-8574, Japan

Conditions

Explore the condition pages connected to this study.

PULMONARY ARTERIAL HYPERTENSION