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New hope for japanese PAH patients: experimental drug shows promise in phase 3 trial

NCT ID NCT05818137

Completed Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called sotatercept (MK-7962) in 46 Japanese adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took the drug alongside their usual treatments. The main goals were to see if it improved blood flow in the lungs and to check for side effects. The study was completed and focused on safety and effectiveness in this specific population.

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Conditions

The condition(s) this trial relates to.

pulmonary arterial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY ARTERIAL HYPERTENSION

Contacts and locations

Locations

  • Chiba Saiseikai Narashino hospital ( Site 2004)

    Narashino, Chiba, 275-8580, Japan

  • Chiba University Hospital ( Site 2003)

    Chiba, 260-8677, Japan

  • Hamamatsu University Hospital ( Site 2016)

    Hamamatsu, Shizuoka, 431-3192, Japan

  • Hokkaido University Hospital ( Site 2001)

    Sapporo, Hokkaido, 060-8648, Japan

  • International University of Health and Welfare Mita Hospital ( Site 2008)

    Tokyo, 108-8329, Japan

  • Keio university hospital ( Site 2007)

    Tokyo, 1608582, Japan

  • Kobe University Hospital ( Site 2012)

    Kobe, Hyōgo, 650-0017, Japan

  • Kure Kyosai Hospital ( Site 2017)

    Kure, Hiroshima, 7378505, Japan

  • Kurume University Hospital ( Site 2014)

    Kurume, Fukuoka, 830-0011, Japan

  • Kyorin University Hospital ( Site 2005)

    Mitaka, Tokyo, 181-8611, Japan

  • Kyushu University Hospital ( Site 2015)

    Fukuoka, 812-8582, Japan

  • Nagoya University Hospital ( Site 2010)

    Nagoya, Aichi-ken, 466-8560, Japan

  • National Cerebral and Cardiovascular Center ( Site 2011)

    Suita, Osaka, 564-8565, Japan

  • National Hospital Organization Okayama Medical Center ( Site 2013)

    Okayama, 701-1192, Japan

  • Sapporo Medical University Hospital ( Site 2018)

    Sapporo, Hokkaido, 060-8543, Japan

  • The University of Tokyo Hospital ( Site 2006)

    Bunkyo-ku, Tokyo, 113-8654, Japan

  • Tohoku University Hospital ( Site 2002)

    Sendai, Miyagi, 980-8574, Japan

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