New drug shows promise for rare lung condition in early trial

NCT ID NCT00993408

Completed Disease control Sponsor: Actelion Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a new drug called ACT-293987 (NS-304) in 43 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure damages the lungs. The trial had two parts: first, a single dose to check how it affects blood flow, then 21 weeks where some people got the drug and others got a placebo. The goal was to see if the drug is safe and improves blood vessel function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ACT-293987 (NS-304)
What this could lead to: If it works, this could point toward a new treatment option for pulmonary arterial hypertension, helping to control the disease and improve symptoms.
What could go wrong: This is a small, early Phase 2 study with only 43 people. It is designed to test safety and basic effectiveness, so results may not lead to a proven treatment. The drug may not work better than placebo or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary arterial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY ARTERIAL HYPERTENSION

Contacts and locations

Locations

Department of Respiratory Medicine, Hannover Medical School

Hanover, 30625, Germany
Gasthuisberg University Hospital, Pneumology

Leuven, 3000, Belgium
Hammersmith Hospital

London, W12 0HS, United Kingdom
Hopital Antoine Beclere, Pneumologie

Paris, France
Hospital Sant'Orsola Malpighi, Cardiology's Department

Bologna, 40138, Italy
Instytut Gruzilcy i Chorob Pluc, Klinika Chorob Wewnetrznych Klatki Piersiowej

Warsaw, 01-138, Poland
Medizinische Universitat Wien, Universitatsklinik fur Innere Medizin II, Kardiologie

Vienna, 1090, Austria
Semmelweis University, Clinic of Pulmonology

Budapest, H-1125, Hungary

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